Strug Lab News
A record of activities in the Strug Lab
2023
New publications:
SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy in Npj Genomic Medicine
A second update on mapping the human genetic architecture of COVID-19. in Nature
New publication titled “A second update on mapping the human genetic architecture of COVID-19” is now available through Nature.
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- Zhang, L, Strug, LJ, Sun, L. Leveraging Hardy-Weinberg disequilibrium for association testing in case-control studies. Annals of Applied Statistics. 17(2): 1764-1781. June 2023.
- Sahakyan, Y, Abrahamyan, L, Ratjen, F, Bear, C, Strug, L, Eckford, PDW, Peel, JK, Krahn, M, and Sander, B. Cost-effectiveness analysis of genetic tools to predict treatment response in patients with cystic fibrosis. Journal of Cystic Fibrosis. S1569-1993(23)00119-4. 24 April 2023. Advance online publication.
- Birimberg-Schwartz, L, Ip, W, Bartlett, C, Avolio, J, Vonk, AM, Gunawardena, T, Du, K, Esmaeili, M, Beekman, JM, Rommens, J, Strug, LJ, Bear, CE, Moraes, TJ, and Gonska, T. Validating organoid-derived human intestinal monolayers for personalized therapy in cystic fibrosis. Life Science Alliance. 6(6). 4 April 2023.
- Zhong, L and Strug, LJ. RoPE: a robust profile likelihood method for differential gene expression analysis. Genetic Epidemiology. 2023:1-15. Advance online publication.
- Yoo, S, Garg, E, Elliott, LT, Hung, RJ, Halevy, AR, Brooks, JD, Bull, SB, Gagnon, F, Greenwood, CMT, Lawless, JF, Paterson, AD, Sun, L, Zawati, MH, Lerner-Ellis, J, Abraham, RJS, Birol, I, Bourque, G, Garant, J-M, Gosselin, C, Li, J, Whitney, J, Thiruvahindrapuram, B, Herbrick, J-A, Lorenti, M, Reuter, MS, Liu, S, Allen, U, Bernier, FP, Biggs, CM, Cheung, AM, Cowan, J, Herridge, M, Maslove, DM, Modi, BP, Mooser, V, Morris, SK, Ostrowski, M, Parekh, RS, Pfeffer, G, Suchowersky, O, Taher, J, Turvey, SE, Upton, J, Warren, RL, Yeung, RSM, Aziz, N, Knoppers, BM, Lathrop, M, Jones, SJM, Scherer, SW, Strug, LJ. HostSeq : A Canadian Whole Genome Sequencing and Clinical Data Resource. BMC Genomic Data. 24(26). 2 May 2023.
- Zhou, YH, Gallins, PJ, Pace, RG, Dang, H, Aksit, MA, Blue, EE, Buckingham, KJ, Collaco, JM, Faino, AV, Gordon, WW,Hetrick, KN, Ling, H, Liu, W, Onchiri, FM, Pagel, K, Pugh, EW, Raraigh, KS, Rosenfeld, M, Sun, Q, Wen, J, Li, Y, Corvol, H, Strug, LJ, Bamshad, MJ, Blackman, SM, Cutting, GR, Gibson, RL, O’Neal, WK, Wright, FA, Knowles, MR. Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole Genome Analysis of 7,840 Patients. American Journal of Respiratory and Critical Care Medicine. 207(10):1324-1333. 27 Feb 2023.
- Abbondanza F, Dale PS, Wang CA, et al. Language and reading impairments are associated with increased prevalence of non-right-handedness. Child Dev. 00:1-16. 13 Feb 2023
- Price KM, Wigg KG, Nigam A, Feng, Y, Blokland, K, Wilkinson, M, Kerr, EN, Guger, SL, Lovett, MW, Strug, LJ, Tripathy, SJ, Barr, CL. Identification of brain cell types underlying genetic association with word reading and correlated traits. Mol Psychiatry. 28: 1719–1730. 7 Feb 2023.
2022
Authors: Eising E, Mirza-Schreiber N, de Zeeuw EL, Wang CA, Truong DT, Allegrini AG, Shapland CY, Zhu G, Wigg KG, Gerritse ML, Molz B, Alagöz G, Gialluisi A, Abbondanza F, Rimfeld K, van Donkelaar M, Liao Z, Jansen PR, Andlauer TFM, Bates TC, Bernard M, Blokland K, Bonte M, Børglum AD, Bourgeron T, Brandeis D, Ceroni F, Csépe V, Dale PS, de Jong PF, DeFries JC, Démonet JF, Demontis D, Feng Y, Gordon SD, Guger SL, Hayiou-Thomas ME, Hernández-Cabrera JA, Hottenga JJ, Hulme C, Kere J, Kerr EN, Koomar T, Landerl K, Leonard GT, Lovett MW, Lyytinen H, Martin NG, Martinelli A, Maurer U, Michaelson JJ, Moll K, Monaco AP, Morgan AT, Nöthen MM, Pausova Z, Pennell CE, Pennington BF, Price KM, Rajagopal VM, Ramus F, Richer L, Simpson NH, Smith SD, Snowling MJ, Stein J, Strug LJ, Talcott JB, Tiemeier H, van der Schroeff MP, Verhoef E, Watkins KE, Wilkinson M, Wright MJ, Barr CL, Boomsma DI, Carreiras M, Franken MJ, Gruen JR, Luciano M, Müller-Myhsok B, Newbury DF, Olson RK, Paracchini S, Paus T, Plomin R, Reilly S, Schulte-Körne G, Tomblin JB, van Bergen E, Whitehouse AJO, Willcutt EG, St Pourcain B, Francks C, Fisher SE.
Title: Expression of cystic fibrosis lung disease modifier genes in human airway models
Authors: He, G, Panjwani, N, Avolio, J, Ouyang, H, Keshavjee, S, Rommens, JM, Gonska, T, Moraes, TJ, Strug, LJ.
Title: Heterogeneity of resting-state EEG features in juvenile myoclonic epilepsy and controls
Authors: Shakeshaft, A, Laiou, P, Abela, E, Stavropoulos, I, Richardson, MP, Pal, DK on behalf of the BIOJUME Consortium.
Authors: Jiafen Gong, Gengming He, Cheng Wang, Claire Bartlett, Naim Panjwani, Scott Mastromatteo, Fan Lin, Katherine Keenan, Julie Avolio, Anat Halevy, Michelle Shaw, Mohsen Esmaeili, Guillaume Côté-Maurais, Damien Adam, Stéphanie Bégin, Candice Bjornson, Mark Chilvers, Joe Reisman, April Price, Michael Parkins, Richard van Wylick, Yves Berthiaume, Lara Bilodeau, Dimas Mateos-Corral, Daniel Hughes, Mary J. Smith, Nancy Morrison, Janna Brusky, Elizabeth Tullis, Anne L. Stephenson, Bradley S. Quon, Pearce Wilcox, Winnie M. Leung, Melinda Solomon, Lei Sun, Emmanuelle Brochiero, Theo J. Moraes, Tanja Gonska, Felix Ratjen, Johanna M. Rommens & Lisa J. Strug
Title: Sex-specific disease modifiers in juvenile myoclonic epilepsy
Authors: Amy Shakeshaft, Naim Panjwani, Amber Collingwood, Holly Crudgington, Anna Hall, Danielle M. Andrade, Christoph P. Beier, Choong Yi Fong, Elena Gardella, Joanna Gesche, David A. Greenberg, Khalid Hamandi, Jeanette Khot, Kheng Seang Lim, Rikke S. Møller, Ching Ching Ng, Alessandro Orsini, Mark I. Rees, Guido Rubboli, Kaja K. Selmer, Pasquale Striano, Marte Syvertsen, Rhys H. Thomas, Jana Zarubova, Mark P. Richardson, Lisa J. Strug, and Deb K. Pal.
Congratulations to PhD Candidate Gengming He for his recent publication in Journal of Cystic Fibrosis!
Title: Expression of cystic fibrosis lung disease modifier genes in human airway models
Authors: Gengming He, Naim Panjwani, Julie Avolio, Hong Ouyang, Shaf Keshavjee, Johanna M. Rommens, Tanja Gonska, Theo J. Moraes, and Lisa J. Strug
Congratulations to PhD Candidate Fan Wang for her recent publication in AJHG! Details on article below.
Authors: Fan Wang, Naim Panjwani, Cheng Wang, Lei Sun, Lisa J. Strug
2021
The Strug Lab is currently looking for a new Research Fellow to join the lab! If you are interested in learning more or applying, please visit the SickKids Careers page.
Scott Mastromatteo and Boxi Lin will be presenting their posters at ASHG 2021 Virtual Meeting. Be sure to check them out!
Exciting News! Strug Lab member Delnaz Roshandel has been chosen to give one of the plenary abstract presentations on Cystic Fibrosis genetics and tandem repeats. Congratulations Delnaz! Learn more on the ASHG event site
2020
Exciting news! “LocusFocus: Web-based colocalization for the annotation and functional follow-up of GWAS” was published in PLOS Computational Biology.