{"id":18,"date":"2020-11-24T22:08:41","date_gmt":"2020-11-24T22:08:41","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/steinberg\/?page_id=18"},"modified":"2021-09-09T18:46:09","modified_gmt":"2021-09-09T18:46:09","slug":"publications","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/steinberg\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"18\" class=\"elementor elementor-18\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-55674f8a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"55674f8a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5f72674c\" data-id=\"5f72674c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4002ad8 elementor-widget elementor-widget-heading\" data-id=\"4002ad8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Publications<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-465fa1b elementor-widget elementor-widget-spacer\" data-id=\"465fa1b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a6d11f elementor-widget elementor-widget-text-editor\" data-id=\"5a6d11f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Most significant publications<\/h2><p><span style=\"color: #000000;\">My research program investigates the interface between the nervous and immune systems in health and disease. The immune system has long been known to impact nervous system function through neuroinflammatory pathways. Importantly and conversely, neural circuits have more recently been shown to control inflammatory responses through direct, structural interfaces between immune and nervous tissues. These cellular and molecular points of engagement are distributed across the body to serve important homeostatic and developmental functions. Their dysregulation, in turn, contribute to disease, including neurodevelopmental disorders. <\/span><\/p><p><span style=\"color: #000000;\">Three primary avenues of my research program have made significant contributions to our growing understanding of the neuro-immune interface:<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6e5ba11 elementor-widget elementor-widget-accordion\" data-id=\"6e5ba11\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1151\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1151\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">1. Pro-inflammatory programmed cell death pathways in disease<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1151\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1151\"><ul><li><span style=\"font-weight: 400;\">Volchuk A, Ye A, Chi L, <\/span><b>Steinberg BE*<\/b><span style=\"font-weight: 400;\"> &amp; Goldenberg NM*.<span style=\"text-decoration: underline;\"> <a href=\"https:\/\/www.nature.com\/articles\/s41467-020-18443-3\">Indirect Regulation of HMGB1 Release by Gasdermin D. <\/a><\/span><\/span><i><span style=\"font-weight: 400;\">Nature Commmunications<\/span><\/i><span style=\"font-weight: 400;\">. 2020; 11(1):4561.\u00a0<\/span><\/li><\/ul><p style=\"padding-left: 40px;\"><span style=\"font-weight: 400;\">In this recent publication from my group on which I am a senior author, we characterized the regulation of danger-associated molecular patterns by the inflammasome executioner protein gasdermin D during pyroptosis. The field had postulated that like interleuin-1\u03b2, which is secreted through gasdermin D pores, intracellular danger molecules (e.g. HMGB1) would be released into the extracellular space to propagate inflammatory response by a similar mechanism. We discovered, in contrast, that HMGB1 release requires gasdermin D but that it does not permeate through its pore. Therefore, this work changed our understanding of how programmed cell death pathways trigger and propagate pro-inflammatory immune responses. These studies emphasize my laboratory\u2019s experience and focus on inflammasome physiology and methodological expertise. We are now advancing these findings to better understand how pro-inflammatory programmed cell death pathways, such as gasdermin D-mediated pyroptosis, impact on neurodevelopment and neurodevelopmental diseases. Our preliminary investigations are revealing an important role for this pathway in the adverse structural and functional consequences of early life tissue injury as experienced by preterm neonates receiving NICU and operative care.<\/span><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1152\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1152\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">2. Neuronal sensing and modulation of inflammation<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1152\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1152\"><ul><li><b>Steinberg BE*<\/b>, Silverman HA*. Robbiati S*, Gunasekaran MK, Tsaava T, Battinelli E, Stiegler A, Bouton C, Chavan SS, Tracey KJ &amp; Huerta PT.\u00a0\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30003120\/\">Cytokine-specific neurograms in the sensory vagus nerve.<\/a>\u00a0<i>Bioelectronic Medicine<\/i>. 2016; 7-17.\u00a0<\/li><\/ul><p style=\"padding-left: 40px;\">This seminal publication focuses on the interface between the immune and nervous systems to delineate how the nervous system monitors inflammation. Using electrical recordings, we demonstrated that sensory nerves are differentially activated by pro-inflammatory molecules (e.g. cytokines and bacterial products). Building on this discovery, we and others are establishing a compendium of cytokine-specific neural signatures to determine whether these unique signatures can be identified in neural recordings from preclinical models of systemic inflammatory disease or infection. This work has implications in the development of new bioelectronic assays and technologies for the diagnosis of neuroinflammatory diseases, responses to therapies, and prognostication.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1153\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1153\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">3. Immune modulation of autonomic nervous system function<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1153\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1153\"><ul>\n<li>Olofsson PS,&nbsp;<b>Steinberg BE<\/b>, Sobbi R, Cox MA, Ahmed MN, Oswald O Szekeres F, Hanes WM, Introini A, Liu SF, Holodick NE, Rothstein TL, L\u00f6vdahl C, Chavan SS, Yang H, Pavlov VA, Broliden K, Andersson U, Diamond B, Miller EJ, Arner A, Gregersen PK, Backx PH, Mak TW &amp; Tracey KJ.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27617738\/\">Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase.<\/a>&nbsp;<i>Nature Biotechnology<\/i>. 2016; 34(10):1066-1071.<\/li>\n<li>Cox MA, Duncan GS, Lin GHY,&nbsp;<b>Steinberg BE<\/b>, Yu LX, Brenner D, Buckler LN, Elia AJ, Wakeham AC, Neiman B, Dominguez-Brauer C, Elford AR, Gill KT, Kubli SP, Haight J, Berger T, Ohashi PS, Tracey KJ, Olofsson PS &amp; Mak TW.&nbsp;&nbsp;<a href=\"https:\/\/science.sciencemag.org\/content\/363\/6427\/639\">Choline acetyltransferase-expressing T cells are required to control chronic viral infection.<\/a>&nbsp;<i>Science<\/i>. 2019; 363(6427):639-644.<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">In these publications, we identify and characterize a unique subset of immune cells that modulate systemic blood pressure and chronic viral infection in mice. Genetically abolishing these cells leads to hypertension, whereas their administration lowers blood pressure. In addition to establishing that immune cells impact the cardiovascular system, this work identifies a novel therapeutic target for the management of hypertension. This same subset of immune cells promotes vasodilation that enhances the migration of lymphocytes into tissue chronically infected with virus, thereby facilitating clearance of viral infections.<\/p>\n<p style=\"padding-left: 40px;\">These and other projects in my laboratory are providing a new understanding of the fundamental interaction between the nervous and immune systems, including in neurodevelopment. We aim to translate our findings toward the treatment of preterm neonates at-risk of adverse neurodevelopmental outcomes and improve their lifelong brain health.<\/p>\n<p style=\"padding-left: 40px;\">We provide the first evidence that a sensory nerve is activated by systemic inflammation in a mediator-specific fashion. This work lays the foundation for an immunological sensory neural code that may allow neural recordings to aid the clinical diagnosis and monitoring of inflammatory disease.<\/p>\n<hr>\n<ul>\n<li>Olofsson PS,&nbsp;<b>Steinberg BE<\/b>, Sobbi R, Cox MA, Ahmed MN, Oswald O Szekeres F, Hanes WM, Introini A, Liu SF, Holodick NE, Rothstein TL, L\u00f6vdahl C, Chavan SS, Yang H, Pavlov VA, Broliden K, Andersson U, Diamond B, Miller EJ, Arner A, Gregersen PK, Backx PH, Mak TW &amp; Tracey KJ.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27617738\/\">Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase.<\/a>&nbsp;<i>Nature Biotechnology<\/i>. 2016; 34(10):1066-1071.<\/li>\n<li>Cox MA, Duncan GS, Lin GHY,&nbsp;<b>Steinberg BE<\/b>, Yu LX, Brenner D, Buckler LN, Elia AJ, Wakeham AC, Neiman B, Dominguez-Brauer C, Elford AR, Gill KT, Kubli SP, Haight J, Berger T, Ohashi PS, Tracey KJ, Olofsson PS &amp; Mak TW.&nbsp;&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30733420\/\">Choline acetyltransferase-expressing T cells are required to control chronic viral infection.<\/a>&nbsp;<i>Science<\/i>. 2019; 363(6427):639-644.<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">In these publications, we identify and characterize a unique subset of immune cells that modulate systemic blood pressure and chronic viral infection in mice. Genetically abolishing these cells leads to hypertension, whereas their administration lowers blood pressure.&nbsp; In addition to establishing that immune cells impact the cardiovascular system, this work identifies a novel therapeutic target for the management of hypertension. This same subset of immune cells promotes vasodilation that enhances the migration of lymphocytes into tissue chronically infected with virus, thereby facilitating clearance of chronic viral infections.<\/p>\n<hr>\n<ul>\n<li>Goldenberg NM*,&nbsp;<b>Steinberg BE*<\/b>, Slutsky AS &amp; Lee WL.&nbsp;<a href=\"https:\/\/stm.sciencemag.org\/content\/3\/88\/88ps25.short\">Broken barriers: a new take on sepsis pathogenesis.<\/a>&nbsp;Science Translational Medicine. 2011; 3(88):88ps25.<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">Therapy for sepsis remains primarily supportive despite intense research into its pathogenesis.&nbsp; Here, we highlight the importance of leaky vasculature and tissue edema in sepsis, and present the endothelium and barrier integrity as a new target for sepsis therapeutics, providing several potential treatment approaches.<\/p>\n<hr>\n<ul>\n<li><b>Steinberg BE<\/b>, Huynh KK, Brodovitch A, Jabs S, Stauber T, Jentsch TJ, &amp; Grinstein S.&nbsp;<a href=\"https:\/\/rupress.org\/jcb\/article\/189\/7\/1171\/35875\/A-cation-counterflux-supports-lysosomal\">A cation counterflux supports lysosomal acidification.&nbsp;<\/a>&nbsp;<i>Journal of Cell Biology.<\/i>&nbsp;2010; 189(7):1171-1186<b>.&nbsp;<\/b><\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">Using multiple cell biological approaches, we deconstruct the ion fluxes within lysosomes that allow for their acidification, In addition to delineating a fundamental cell physiologic process, this work has significant implications on the pathogenesis of cystic fibrosis, particularly patient susceptibility to bacterial infections.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a53540c elementor-widget elementor-widget-text-editor\" data-id=\"3a53540c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Peer-reviewed publications<\/h2><p>\u00a0<\/p><h3>\u00a0 Journal Articles<\/h3><ul><li><span style=\"font-weight: 400;\"> Ghaffari S, Jang E, Nabi FN, Sanwal R, Khosraviani N, Wang C, <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Goldenberg NM, Ikeda J &amp; Lee WL. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33054399\/\">Endothelial HMGB1 is a Critical Regulator of LDL Transcytosis via an SREBP2-SR-BI Axis.<\/a> <\/span><\/span><i><span style=\"font-weight: 400;\">Arterioscler Thromb Vasc Bio<\/span><\/i><span style=\"font-weight: 400;\">. 2020 Oct 15:ATVBAHA120314557.\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Aoyama K, McVey M, Levin D, Siddiqui A, Munshey F, Goldenberg NM, Faraoni D &amp; Maynes JT. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7384726\/\"><span style=\"text-decoration: underline;\">Efficacy and safety of decontamination for N95 respirator reuse: a systematic literature search and narrative synthesis.<\/span><\/a> <\/span><i><span style=\"font-weight: 400;\">Can J Anaesth<\/span><\/i><span style=\"font-weight: 400;\">. 2020 (in press).\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Fergusson DA, Avey MT, Barron CC, Bocock M, Biefer KE, Boet S, Bourque SL, Conic I, Chen K, Dong YY, Fox GM, George RB, Goldenberg NM, Gragasin FS, Harsha P, Hong PJ, James TE, Larrigan SM, MacNeil JL, Manuel CA, Maximos S, Mazer D, Mittal R, McGinn R, Nguyen LH, Patel A, Richeb\u00e9 P, Saha TK,\u00a0<\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Sampson SD, Stewart DJ, Syed S, Vella K, Wesch NL, Lalu MM; <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0215221\"><span style=\"text-decoration: underline;\">Canadian Perioperative Anesthesia Clinical Trials Group. Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature.<\/span><\/a> <\/span><i><span style=\"font-weight: 400;\">PLoS One<\/span><\/i><span style=\"font-weight: 400;\">. 2019; 14(5):e0215221.<\/span><\/li><li><span style=\"font-weight: 400;\"> Goldenberg NM, Rabinovitch M &amp; <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31094755\/\"><span style=\"text-decoration: underline;\">The inflammatory basis of pulmonary arterial hypertension.<\/span><\/a> <\/span><i><span style=\"font-weight: 400;\">Anesthesiology<\/span><\/i><span style=\"font-weight: 400;\">. 2019; 131(4):898-907.\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Levin DN, Strantzas S &amp; <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">.\u00a0 <span style=\"text-decoration: underline;\"><a href=\"https:\/\/bjaed.org\/article\/S2058-5349(19)30019-8\/abstract\">Intra-operative neuro-monitoring in paediatric spinal surgery.<\/a><\/span>\u00a0 <\/span><i><span style=\"font-weight: 400;\">British Journal of Anaesthesia Education<\/span><\/i><span style=\"font-weight: 400;\">. 2019; 19(5):165-171.<\/span><\/li><li><span style=\"font-weight: 400;\"> Goldenberg NM, Hu Y, Hu X, Volchuk A, Zhao YD, de Perrot M, Tracey KJ, Al-Abed Y, <\/span><b>Steinberg BE*<\/b><span style=\"font-weight: 400;\"> &amp; Kuebler WM*. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30939030\/\">Therapeutic targeting of high mobility group box-1 in pulmonary arterial hypertension.<\/a> <\/span><\/span><i><span style=\"font-weight: 400;\">American Journal of Respiratory and Critical Care Medicine<\/span><\/i><span style=\"font-weight: 400;\">. 2019; 199(12):1566-1569.\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Goldenberg NM &amp; <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30994559\/\"><span style=\"text-decoration: underline;\">Inflammation drives pulmonary arterial hypertension.<\/span><\/a> <\/span><i><span style=\"font-weight: 400;\">Anesthesiology<\/span><\/i><span style=\"font-weight: 400;\">. 2019; 130(5):820-821.\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Battinelli Masi E, Valdes-Ferrer SI &amp; <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">. <a href=\"https:\/\/www.nature.com\/articles\/s41366-018-0086-1\"><span style=\"text-decoration: underline;\">The vagus neruo-metabolic interface and clinical disease.<\/span><\/a> <\/span><i><span style=\"font-weight: 400;\">International Journal of Obesity.\u00a0 <\/span><\/i><span style=\"font-weight: 400;\">2018; 42(6):1101-1111.\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Silverman HA, Stiegler A, Tsaava T, Newman J, <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Battinelli Masi E, Robbiati S, Bouton C, Huerta PT, Chavan SS &amp; Tracey KJ. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.nature.com\/articles\/s41366-018-0086-1\">Standardization of methods to record vagus nerve activity in mice.<\/a> <\/span><\/span><i><span style=\"font-weight: 400;\">Bioelectronic Medicine<\/span><\/i><span style=\"font-weight: 400;\">.\u00a0 2018; 4:3.\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Goldenberg NM, <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Rutka JT, Chen R, Kapus A &amp; Lee WL. <a href=\"http:\/\/cmajopen.ca\/content\/4\/3\/E444.full\"><span style=\"text-decoration: underline;\">Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): a cohort study.<\/span><\/a> <\/span><i><span style=\"font-weight: 400;\">CMAJ Open<\/span><\/i><span style=\"font-weight: 400;\">. 2016; 4(3):E444-447.\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Sundman E, Terrando N, Ericsson LI &amp; Olofsson PS. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26982508\/\">The Neural Control of Inflammation: Implications for perioperative and critical care. <\/a><\/span><\/span><i><span style=\"font-weight: 400;\">Anesthesiology<\/span><\/i><span style=\"font-weight: 400;\">. 2016; 124(5):1174-1189.\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Goldenberg NM, Fairn GD, Kuebler WM, Slutsky AS &amp; Lee WL.<span style=\"text-decoration: underline;\"> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26467794\/\">Where has the basic science gone?\u00a0 The decline of biomedical research in the medical literature.<\/a> <\/span><\/span><i><span style=\"font-weight: 400;\">FASEB Journal<\/span><\/i><span style=\"font-weight: 400;\">. 2015; 30(2):515-518.\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Goldenberg NM, <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Lee WL, Wijeysundera D &amp; Kavanagh B. <a href=\"https:\/\/pubs.asahq.org\/anesthesiology\/article\/121\/1\/184\/13826\/Lung-protective-Ventilation-in-the-Operating\"><span style=\"text-decoration: underline;\">Lung Protective Ventilation for the Operating Room.<\/span><\/a> <\/span><i><span style=\"font-weight: 400;\">Anesthesiology<\/span><\/i><span style=\"font-weight: 400;\">. 2014; 121(1):184-188.\u00a0\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Schlam D, Chatilialoglu A, <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Ueyama T, Du G, Grinstein S &amp; Fairn GD. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23814057\/\">Diacylglycerol kinases terminate diacylglycerol signalling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activity.<\/a><\/span>\u00a0 <\/span><i><span style=\"font-weight: 400;\">Journal of Biological Chemistry<\/span><\/i><span style=\"font-weight: 400;\">. 2013; 288(32):23090-23104.\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">*, Goldenberg NM* &amp; Lee WL. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22068147\/\">Do viral infections mimic bacterial sepsis?\u00a0 The role of microvascular permeability: A review of mechanisms and methods.<\/a> <\/span><\/span><i><span style=\"font-weight: 400;\">Antiviral Research<\/span><\/i><span style=\"font-weight: 400;\">. 2012; 93(1):2-15.\u00a0\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Goldenberg NM*, <\/span><b>Steinberg BE*<\/b><span style=\"font-weight: 400;\">, Slutsky AS &amp; Lee WL. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21697528\/\"><span style=\"text-decoration: underline;\">Broken barriers: a new take on sepsis pathogenesis.<\/span><\/a> <\/span><i><span style=\"font-weight: 400;\">Science Translational Medicine<\/span><\/i><span style=\"font-weight: 400;\">. 2011; 3(88):88ps25.\u00a0\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Koivusalo M*, <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">*, Mason D &amp; Grinstein S. <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/j.1600-0854.2011.01215.x\"><span style=\"text-decoration: underline;\"><i><span style=\"font-weight: 400;\">In situ<\/span><\/i><\/span><span style=\"font-weight: 400;\"><span style=\"text-decoration: underline;\"> measurement of the electrical potential across the lysosomal membrane using FRET.<\/span><\/span><\/a>\u00a0<i><span style=\"font-weight: 400;\">Traffic<\/span><\/i><span style=\"font-weight: 400;\">. 2011; 12(8):972-982.\u00a0\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> DiCiccio JE &amp; <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">. <a href=\"https:\/\/rupress.org\/jgp\/article\/137\/4\/385\/42901\/Lysosomal-pH-and-analysis-of-the-counter-ion\"><span style=\"text-decoration: underline;\">Lysosomal pH and the analysis of the counter-ion pathways that support acidification.<\/span><\/a><\/span><i><span style=\"font-weight: 400;\"> Journal of General Physiology<\/span><\/i><span style=\"font-weight: 400;\">. 2011; 189(7):1171-1186.\u00a0\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Huynh KK, Brodovitch A, Jabs S, Stauber T, Jentsch TJ, &amp; Grinstein S. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2894458\/\"><span style=\"text-decoration: underline;\">A cation counterflux supports lysosomal acidification.<\/span><\/a>\u00a0 <\/span><i><span style=\"font-weight: 400;\">Journal of Cell Biology.<\/span><\/i><span style=\"font-weight: 400;\"> 2010; 189(7):1171-1186.\u00a0\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Lee HK, Mattei LM, <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Alberts P, Lee YH, Chervonsky A, Mizushima N, Grinstein S, &amp; Iwasaki A. <\/span><span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20171125\/\"><span style=\"font-weight: 400;\">In vivo<\/span><span style=\"font-weight: 400;\"> requirement for Atg5 in antigen presentation by dendritic cells.<\/span><\/a><\/span> <i><span style=\"font-weight: 400;\">Immunity.<\/span><\/i><span style=\"font-weight: 400;\"> 2010<\/span><i><span style=\"font-weight: 400;\">; <\/span><\/i><span style=\"font-weight: 400;\">32(2):227-239.<\/span>\u00a0<\/li><li><span style=\"font-weight: 400;\"> Goldenberg NM &amp; <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">. <a href=\"https:\/\/cancerres.aacrjournals.org\/content\/70\/4\/1277\"><span style=\"text-decoration: underline;\">Surface charge: a key determinant of protein localization and function.<\/span><\/a> <\/span><i><span style=\"font-weight: 400;\">Cancer Research<\/span><\/i><span style=\"font-weight: 400;\">. 2010; 70(4):1277-1280.\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Huang JJ, Canadian V, Lam GY, <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Dinauer MC, Magalhaes MAO, Glogauer M, Grinstein S, &amp; Brumell JH. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2664152\/\">Activation of anti-bacterial autophagy: a novel function for NADPH oxidases in host defense<\/a><\/span><\/span><i><span style=\"font-weight: 400;\"><span style=\"text-decoration: underline;\">.<\/span> Proceedings of the National Academy of Science U.S.A.<\/span><\/i><span style=\"font-weight: 400;\"> 2009; 106:6226-6231.\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Mohammad-Panah R, Wellhauser L, <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Wang Y, Huan LJ, Liu XD, &amp; Bear CE.\u00a0 <span style=\"text-decoration: underline;\"><a href=\"https:\/\/jcs.biologists.org\/content\/122\/8\/1229.abstract\">An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from <\/a><\/span><\/span><span style=\"text-decoration: underline;\"><i><span style=\"font-weight: 400;\">Clcn4<\/span><\/i><\/span><a href=\"https:\/\/jcs.biologists.org\/content\/122\/8\/1229.abstract\"><span style=\"font-weight: 400;\"><span style=\"text-decoration: underline;\"> null mice.<\/span><\/span><\/a> <i><span style=\"font-weight: 400;\">Journal of Cell Science<\/span><\/i><span style=\"font-weight: 400;\">. 2009; 15:1229-1237.\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\"> &amp; Grinstein S. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18523652\/\"><span style=\"text-decoration: underline;\">Pathogen destruction vs. intracellular survival: the role of lipids as phagosomal fate determinints.<\/span><\/a><\/span><span style=\"font-weight: 400;\">\u00a0<\/span><i><span style=\"font-weight: 400;\">Journal of Clinical Investigation<\/span><\/i><span style=\"font-weight: 400;\">. 2008; 118:2002-2011.\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Birmingham CL, Canadien V, Kaniuk NA, <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Higgins DE, Brumell JH. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.nature.com\/articles\/nature06479\">Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles.<\/a> <\/span><\/span><i><span style=\"font-weight: 400;\">Nature.<\/span><\/i><span style=\"font-weight: 400;\"> 2008; 451(7176):350-354.\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Huynh KK, &amp; Grinstein S. <a href=\"https:\/\/portlandpress.com\/biochemsoctrans\/article-abstract\/35\/5\/1083\/85946\/Phagosomal-acidification-measurement-manipulation?redirectedFrom=fulltext\"><span style=\"text-decoration: underline;\">Phagosome acidification: measurement, manipulation and functional consequences.<\/span>\u00a0 <\/a><\/span><i><span style=\"font-weight: 400;\">Biochemical Society Transactions<\/span><\/i><span style=\"font-weight: 400;\">.\u00a0 2007l 35(Pt 5):1083-1087.\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Touret N, Vargas-Caballero M, &amp; Grinstein S. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.pnas.org\/content\/104\/22\/9523\">In situ measurements of the electrical potential across the phagosomal membrane using FRET and its contribution to the proton-motive force<\/a><\/span><\/span><i><span style=\"font-weight: 400;\"><span style=\"text-decoration: underline;\">.<\/span> Proceedings of the National Academy of Science U.S.A.<\/span><\/i><span style=\"font-weight: 400;\"> 2007; 104:9523-9528.\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\"> &amp; Grinstein S. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17392241\/\">Unconventional roles of the NADPH oxidase: signaling, ion homeostasis, and cell death.<\/a>\u00a0 <\/span><\/span><i><span style=\"font-weight: 400;\">Science STKE<\/span><\/i><span style=\"font-weight: 400;\">.\u00a0 2007; 27;2007(379):pe11.\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Scott CC, &amp; Grinstein S. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/ajpcell.00358.2006\">High-throughput assays of phagocytosis, phagosome maturation and bacterial invasion.<\/a><\/span>\u00a0 <\/span><i><span style=\"font-weight: 400;\">American Journal of Physiology Cell Physiology<\/span><\/i><span style=\"font-weight: 400;\">. 2007; 292:C945-952\u00a0<\/span><\/li><li><span style=\"font-weight: 400;\"> Tabeta K, Hoebe K, Janssen EM, Du X, Georgel P, Crozat K, Mudd S, Mann N, Sovath S, Goode J, Shamel L, Herskovits AA, Portnoy DA, Cooke M, Tarantino LM, Wiltshire T, <\/span><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Grinstein S, &amp; Beutler B. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16415873\/\">The<\/a> <em>Unc93b1<\/em><\/span><span style=\"font-weight: 400;\">\u00a0<span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16415873\/\">mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.<\/a><\/span>\u00a0 <\/span><i><span style=\"font-weight: 400;\">Nature Immunology<\/span><\/i><span style=\"font-weight: 400;\">. 2006; 7:156-164.\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Glass L, Shrier A &amp; Bub G. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsta.2006.1771\">The role of heterogeneities and intercellular coupling in wave propagation in cardiac tissue.<\/a> <\/span><\/span><i><span style=\"font-weight: 400;\">Philosophical Transactions of the Royal Society A<\/span><\/i><span style=\"font-weight: 400;\">.\u00a0 2006; 364:1299-1311.\u00a0<\/span><\/li><li><b>Steinberg BE<\/b><span style=\"font-weight: 400;\">, Wang Y, Huang H, &amp; Miura RM. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20369947\/\">Spatial buffering mechanism: A mathematical model and computer simulation.<\/a><\/span>\u00a0 <\/span><i><span style=\"font-weight: 400;\">Mathematical Biosciences and Engineering<\/span><\/i><span style=\"font-weight: 400;\"> 2005; 2:675-702.\u00a0<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2f633bd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2f633bd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f20f5af\" data-id=\"f20f5af\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3810e1c elementor-align-center elementor-widget elementor-widget-button\" data-id=\"3810e1c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more articles by Dr. Steinberg on Pubmed<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Publications Most significant publications My research program investigates the interface between the nervous and immune systems in health and disease. The immune system has long been known to impact nervous system function through neuroinflammatory pathways. Importantly and conversely, neural circuits have more recently been shown to control inflammatory responses through direct, structural interfaces between immune&hellip;<\/p>\n","protected":false},"author":293,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Publications - The Steinberg Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/steinberg\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications\" \/>\n<meta property=\"og:description\" content=\"Publications Most significant publications My research program investigates the interface between the nervous and immune systems in health and disease. 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