{"id":2185,"date":"2023-12-21T18:44:29","date_gmt":"2023-12-21T18:44:29","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/sparc-molecular-analysis\/?page_id=2185"},"modified":"2023-12-21T18:44:29","modified_gmt":"2023-12-21T18:44:29","slug":"drugs-and-metabolites","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/sparc-molecular-analysis\/analytes\/drugs-and-metabolites\/","title":{"rendered":"Drugs and Metabolites"},"content":{"rendered":"\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
Class:<\/th>Analyte<\/th>Platform<\/th>Panel<\/th>Quantitative<\/th>In-House Extraction<\/th>CAS#<\/th>Pubchem<\/th>\n<\/tr>\n<\/thead>\n
Antibiotics<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
<\/td>Amoxicillin<\/td>LC\/MS\/MS<\/td><\/td>+<\/td>+<\/td>26787-78-0<\/td>33613<\/td>\n<\/tr>\n
<\/td>Vancomycin<\/td>HPLC<\/td>Antibiotics<\/td>+<\/td>+<\/td>1404-90-6<\/td>14969<\/td>\n<\/tr>\n
<\/td>Meropenem<\/td>HPLC<\/td>Antibiotics<\/td>+<\/td>+<\/td>119478-56-7<\/td>441130<\/td>\n<\/tr>\n
<\/td>Cefazolin<\/td>HPLC<\/td>Antibiotics<\/td>No<\/td>+<\/td>25953-19-9<\/td>33255<\/td>\n<\/tr>\n
<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
Antidepressants<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
<\/td>Sertraline<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>79617-96-2<\/td>68617<\/td>\n<\/tr>\n
<\/td>Norsetraline<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>87857-41-8<\/td>114743<\/td>\n<\/tr>\n
<\/td>Norfluoxetine<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>83891-03-6<\/td>4541<\/td>\n<\/tr>\n
<\/td>Fluoxetine<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>54910-89-3<\/td>3386<\/td>\n<\/tr>\n
<\/td>Fluvoxamine<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>54739-18-3<\/td>5324346<\/td>\n<\/tr>\n
<\/td>Lorazepam<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>846-49-1<\/td>3958<\/td>\n<\/tr>\n
<\/td>Paroxetine<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>61869-08-7<\/td>43815<\/td>\n<\/tr>\n
<\/td>Lorazepam Glucuronide<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>32781-79-6<\/td>62966<\/td>\n<\/tr>\n
<\/td>S-didesmethylcitalopram (S-DDCT)<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>62498-69-5<\/td>162976<\/td>\n<\/tr>\n
<\/td>S-desmethylcitalopram (S-DCT)<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>62498-67-3<\/td>146570<\/td>\n<\/tr>\n
<\/td>Paroxetine Catechol<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>1394861-12-1<\/td>71315739<\/td>\n<\/tr>\n
<\/td>Fluvoxamine Acid<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>88699-91-6<\/td>46781630<\/td>\n<\/tr>\n
<\/td>Escitalopram<\/td>LC\/MS\/MS<\/td>Antidepressants<\/td>+<\/td>+<\/td>128196-01-0<\/td>146570<\/td>\n<\/tr>\n
<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
Anitmalarials<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
<\/td>Atovaquone<\/td>HPLC<\/td>Anitmalarials-1<\/td>+<\/td>+<\/td>95233-18-4<\/td>74989<\/td>\n<\/tr>\n
<\/td>Proguanil<\/td>HPLC<\/td>Anitmalarials-1<\/td>+<\/td>+<\/td>500-92-5<\/td>4923<\/td>\n<\/tr>\n
<\/td>Hydroxycholoroquine<\/td>HPLC<\/td>Anitmalarials-2<\/td>+<\/td>+<\/td>747-36-4<\/td>12947<\/td>\n<\/tr>\n
<\/td>Desethylhydroxychloroquine (cletoquine)<\/td>HPLC<\/td>Anitmalarials-2<\/td>+<\/td>+<\/td>4298-15-1<\/td>71826<\/td>\n<\/tr>\n
<\/td>Desethylchloroquine<\/td>HPLC<\/td>Anitmalarials-2<\/td>+<\/td>+<\/td>1476-52-4<\/td>95478<\/td>\n<\/tr>\n
<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
Chelating agents<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
<\/td>Deferiprone<\/td>HPLC<\/td><\/td>+<\/td>+<\/td>30652-11-0<\/td>2972<\/td>\n<\/tr>\n
<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
Chemotherapy<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
<\/td>Methotrexate<\/td>HPLC<\/td><\/td>+<\/td>+<\/td>59-05-2<\/td>126941<\/td>\n<\/tr>\n
<\/td>Doxorubicin (Adriamycin)<\/td>HPLC & LC\/MS\/MS<\/td>Chemo-1, Chemo-4<\/td>+<\/td>+<\/td>23214-92-8<\/td>31703<\/td>\n<\/tr>\n
<\/td>Daunorubicin<\/td>HPLC & LC\/MS\/MS<\/td>Chemo-1, Chemo-4<\/td>No<\/td>+<\/td>20830-81-3<\/td>30323<\/td>\n<\/tr>\n
<\/td>Cyclophosphamide<\/td>LC\/MS\/MS<\/td><\/td>+<\/td>No<\/td>50-18-0<\/td>2907<\/td>\n<\/tr>\n
<\/td>Foretinib (XL880)<\/td>LC\/MS\/MS<\/td>Chemo-2<\/td>+<\/td>+<\/td>937176-80-2<\/td>42642645<\/td>\n<\/tr>\n
<\/td>Cabozantinib (XL184)<\/td>LC\/MS\/MS<\/td>Chemo-2<\/td>+<\/td>No<\/td>849217-68-1<\/td>25102847<\/td>\n<\/tr>\n
<\/td>Paclitaxel<\/td>LC\/MS\/MS<\/td><\/td>+<\/td>No<\/td>33069-62-4<\/td>36314<\/td>\n<\/tr>\n
<\/td>Pazopanib<\/td>LC\/MS\/MS<\/td><\/td>+<\/td>+<\/td>444731-52-6<\/td>11525740<\/td>\n<\/tr>\n
<\/td>Tamoxifen<\/td>LC\/MS\/MS<\/td>Chemo-3<\/td>+<\/td>+<\/td>10540-29-1<\/td>2733526<\/td>\n<\/tr>\n
<\/td>N-Desmethyltamoxifen<\/td>LC\/MS\/MS<\/td>Chemo-3<\/td>+<\/td>+<\/td>31750-48-8<\/td>6378383<\/td>\n<\/tr>\n
<\/td>4-Hydroxytamoxifen<\/td>LC\/MS\/MS<\/td>Chemo-3<\/td>+<\/td>+<\/td>68047-06-3<\/td>449459<\/td>\n<\/tr>\n
<\/td>N-Desmetheyl-4-Hydroxy Tamoxifen(~=Z)<\/td>LC\/MS\/MS<\/td>Chemo-3<\/td>+<\/td>+<\/td>110025-28-0<\/td>130621<\/td>\n<\/tr>\n
<\/td>Topotecan<\/td>LC\/MS\/MS<\/td><\/td>+<\/td>+<\/td>123948-87-8<\/td>60700<\/td>\n<\/tr>\n
<\/td>AZD1152\/HQPA<\/td>LC\/MS\/MS<\/td><\/td>+<\/td>+<\/td>722544-51-6<\/td>16007391<\/td>\n<\/tr>\n
<\/td>Vincristine<\/td>LC\/MS\/MS<\/td>Chemo-4<\/td>+<\/td>+<\/td>57-22-7<\/td>5978<\/td>\n<\/tr>\n
<\/td>Vinblastine<\/td>LC\/MS\/MS<\/td>Chemo-4<\/td>+<\/td>+<\/td>865-21-4<\/td>241903<\/td>\n<\/tr>\n
<\/td>Dacarbazine<\/td>LC\/MS\/MS<\/td>Chemo-4<\/td>+<\/td>+<\/td>4342-03-4<\/td>2942<\/td>\n<\/tr>\n
<\/td>Temozolomide<\/td>LC\/MS\/MS<\/td><\/td>+<\/td>+<\/td>85622-93-1<\/td>5394<\/td>\n<\/tr>\n
<\/td>Sirolimus (Rapamycin)<\/td>LC\/MS\/MS<\/td>Chemo-5<\/td>+<\/td>+<\/td>53123-88-9<\/td>5284616<\/td>\n<\/tr>\n
<\/td>Temsirolimus<\/td>LC\/MS\/MS<\/td>Chemo-5<\/td>+<\/td>+<\/td>162635-04-3<\/td>6918289<\/td>\n<\/tr>\n
<\/td>Ifosfamide<\/td>LC\/MS\/MS<\/td>Chemo-6<\/td>+<\/td>+<\/td>3778-73-2<\/td>3690<\/td>\n<\/tr>\n
<\/td>Trofosfamide<\/td>LC\/MS\/MS<\/td>Chemo-6<\/td>No<\/td>+<\/td>22089-22-1<\/td>65702<\/td>\n<\/tr>\n
<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
Inje Cocktail and Metabolites<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
<\/td>Caffeine<\/td>LC\/MS\/MS<\/td>Inje<\/td>+<\/td>+<\/td>58-08-2<\/td>2519<\/td>\n<\/tr>\n
<\/td>Paraxanthine<\/td>LC\/MS\/MS<\/td>Inje<\/td>+<\/td>+<\/td>611-59-6<\/td>4687<\/td>\n<\/tr>\n
<\/td>Losartan<\/td>LC\/MS\/MS<\/td>Inje<\/td>+<\/td>+<\/td>114798-26-4<\/td>3961<\/td>\n<\/tr>\n
<\/td>Omeprazole<\/td>LC\/MS\/MS<\/td>Inje<\/td>+<\/td>+<\/td>73590-58-6<\/td>4594<\/td>\n<\/tr>\n
<\/td>5-Hydroxy Omeprazole<\/td>LC\/MS\/MS<\/td>Inje<\/td>+<\/td>+<\/td>92340-57-3<\/td>119560<\/td>\n<\/tr>\n
<\/td>Dextromethorphan<\/td>LC\/MS\/MS<\/td>Inje<\/td>+<\/td>+<\/td>125-71-3<\/td>5360696<\/td>\n<\/tr>\n
<\/td>Dextrorphan<\/td>LC\/MS\/MS<\/td>Inje<\/td>+<\/td>+<\/td>125-73-5<\/td>5360697<\/td>\n<\/tr>\n
<\/td>Midazolam<\/td>LC\/MS\/MS<\/td>Inje<\/td>+<\/td>+<\/td>59467-70-8<\/td>4192<\/td>\n<\/tr>\n
<\/td>Hydroxyimidazolam<\/td>LC\/MS\/MS<\/td>Inje<\/td>+<\/td>+<\/td>59468-90-5<\/td>107917<\/td>\n<\/tr>\n
<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
Other<\/td><\/td><\/td><\/td><\/td><\/td><\/td><\/td>\n<\/tr>\n
<\/td>5-aminosalicylic acid<\/td>HPLC<\/td><\/td>+<\/td>+<\/td>89-57-6<\/td>4075<\/td>\n<\/tr>\n
<\/td>Amantadine<\/td>LC\/MS\/MS<\/td><\/td>+<\/td>No<\/td>768-94-5<\/td>2130<\/td>\n<\/tr>\n
<\/td>Morphine<\/td>LC\/MS\/MS<\/td>Morphine<\/td>+<\/td>+<\/td>57-27-2<\/td>5288826<\/td>\n<\/tr>\n
<\/td>Morphine-3-glucuronide<\/td>LC\/MS\/MS<\/td>Morphine<\/td>+<\/td>+<\/td>20290-09-9<\/td>5484731<\/td>\n<\/tr>\n
<\/td>Morphine-6-glucuronide<\/td>LC\/MS\/MS<\/td>Morphine<\/td>+<\/td>+<\/td>20290-10-2<\/td>5360621<\/td>\n<\/tr>\n
<\/td>Nicotine<\/td>LC\/MS\/MS<\/td>Nicotine<\/td>+<\/td>No<\/td>54-11-5<\/td>89594<\/td>\n<\/tr>\n
<\/td>Contine<\/td>LC\/MS\/MS<\/td>Nicotine<\/td>+<\/td>No<\/td>486-56-6<\/td>854019<\/td>\n<\/tr>\n
<\/td>Rivaroxaban<\/td>LC\/MS\/MS<\/td><\/td>+<\/td>+<\/td>366789-02-8<\/td>9875401<\/td>\n<\/tr>\n
<\/td>Aprepitant<\/td>LC\/MS\/MS<\/td><\/td>+<\/td>No<\/td>170729-80-3<\/td>6918365<\/td>\n<\/tr>\n
<\/td>PF-05089711<\/td>LC\/MS\/MS<\/td>PF Drug Prescott<\/td>+<\/td>+<\/td>-<\/td>71554187<\/td>\n<\/tr>\n
<\/td>THC<\/td>LC\/MS\/MS<\/td>THC & Metabolites<\/td>+<\/td>+<\/td>16849-50-6<\/td>2978<\/td>\n<\/tr>\n
<\/td>Cannabinol (CBN)<\/td>LC\/MS\/MS<\/td>THC & Metabolites<\/td>+<\/td>+<\/td>521-35-7<\/td>2543<\/td>\n<\/tr>\n
<\/td>11-OH-delta9-THC (11-OH-THC)<\/td>LC\/MS\/MS<\/td>THC & Metabolites<\/td>+<\/td>+<\/td>36557-05-8<\/td>644022<\/td>\n<\/tr>\n
<\/td>Cannabidiol (CBD)<\/td>LC\/MS\/MS<\/td>THC & Metabolites<\/td>+<\/td>+<\/td>13956-29-1<\/td>644019<\/td>\n<\/tr>\n
<\/td>11-Carboxy-delta9-THC (11-COOH-THC)<\/td>LC\/MS\/MS<\/td>THC & Metabolites<\/td>+<\/td>+<\/td>64280-14-4<\/td>107885<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n","protected":false},"excerpt":{"rendered":"

Class:AnalytePlatformPanelQuantitativeIn-House ExtractionCAS#Pubchem Antibiotics AmoxicillinLC\/MS\/MS++26787-78-033613 VancomycinHPLCAntibiotics++1404-90-614969 MeropenemHPLCAntibiotics++119478-56-7441130 CefazolinHPLCAntibioticsNo+25953-19-933255 Antidepressants SertralineLC\/MS\/MSAntidepressants++79617-96-268617 NorsetralineLC\/MS\/MSAntidepressants++87857-41-8114743 NorfluoxetineLC\/MS\/MSAntidepressants++83891-03-64541 FluoxetineLC\/MS\/MSAntidepressants++54910-89-33386 FluvoxamineLC\/MS\/MSAntidepressants++54739-18-35324346 LorazepamLC\/MS\/MSAntidepressants++846-49-13958 ParoxetineLC\/MS\/MSAntidepressants++61869-08-743815 Lorazepam GlucuronideLC\/MS\/MSAntidepressants++32781-79-662966 S-didesmethylcitalopram (S-DDCT)LC\/MS\/MSAntidepressants++62498-69-5162976 S-desmethylcitalopram (S-DCT)LC\/MS\/MSAntidepressants++62498-67-3146570 Paroxetine CatecholLC\/MS\/MSAntidepressants++1394861-12-171315739 Fluvoxamine AcidLC\/MS\/MSAntidepressants++88699-91-646781630 EscitalopramLC\/MS\/MSAntidepressants++128196-01-0146570 Anitmalarials AtovaquoneHPLCAnitmalarials-1++95233-18-474989 ProguanilHPLCAnitmalarials-1++500-92-54923 HydroxycholoroquineHPLCAnitmalarials-2++747-36-412947 Desethylhydroxychloroquine (cletoquine)HPLCAnitmalarials-2++4298-15-171826 DesethylchloroquineHPLCAnitmalarials-2++1476-52-495478 Chelating agents DeferiproneHPLC++30652-11-02972 Chemotherapy MethotrexateHPLC++59-05-2126941 Doxorubicin (Adriamycin)HPLC & LC\/MS\/MSChemo-1, Chemo-4++23214-92-831703 DaunorubicinHPLC & LC\/MS\/MSChemo-1, Chemo-4No+20830-81-330323 CyclophosphamideLC\/MS\/MS+No50-18-02907 Foretinib (XL880)LC\/MS\/MSChemo-2++937176-80-242642645 Cabozantinib (XL184)LC\/MS\/MSChemo-2+No849217-68-125102847 PaclitaxelLC\/MS\/MS+No33069-62-436314 PazopanibLC\/MS\/MS++444731-52-611525740 TamoxifenLC\/MS\/MSChemo-3++10540-29-12733526…<\/p>\n","protected":false},"author":205,"featured_media":0,"parent":1896,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2185","page","type-page","status-publish","hentry","description-off"],"yoast_head":"\nDrugs and Metabolites - 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