{"id":18,"date":"2016-01-11T21:09:15","date_gmt":"2016-01-11T21:09:15","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/santyr\/?page_id=18"},"modified":"2025-05-05T15:37:24","modified_gmt":"2025-05-05T15:37:24","slug":"home","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/santyr\/","title":{"rendered":"Home"},"content":{"rendered":"

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<\/div><\/div><\/div><\/div>[\/vc_column][\/vc_row][vc_row][vc_column width=”1\/4″][vc_single_image image=”780″ img_size=”300×300″ style=”vc_box_rounded” css=”.vc_custom_1554472832666{margin-top: 30px !important;margin-bottom: 0px !important;border-bottom-width: 0px !important;padding-bottom: 5px !important;}”]
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Dr. Giles Santyr, PhD<\/h5><\/div><\/div>[vc_video link=”https:\/\/www.youtube.com\/watch?v=qH0zblGy19w” el_aspect=”43″][\/vc_column][vc_column width=”3\/4″]
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At a Glance<\/h2><\/div><\/div>[vc_column_text css=”.vc_custom_1643812643533{margin-top: 0px !important;padding-bottom: 10px !important;}”]<\/p>\n

Dr. Giles Santyr is a medical biophysicist working with physicians and engineers to pioneer new techniques for imaging the lungs of children. Magnetic Resonance Imaging (MRI) is an attractive option since it does not involve x-rays, but is challenging in the lung due to very low signal. In the Santyr lab, the lung airways can be safely \u201cilluminated\u201d using MRI of a specially prepared inert gas (called hyperpolarized Xenon-129, or 129<\/sup>Xe) inhaled by the subject. Santyr\u2019s lab is one of a handful in the world that is developing hyperpolarized xenon-129 gas MRI as well as other approaches to allow the exploration of the paediatric lung, providing for safer, earlier and more accurate diagnosis and monitoring of disease progression and treatment response. This research is expected to have a significant impact on the way physicians detect, diagnose and treat paediatric lung diseases such as cystic fibrosis, asthma and lung injury.<\/p>\n

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For additional information on Dr. Santyr’s research:<\/div>\n
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Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease<\/a><\/div>\n
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Check out the Youtube link to the left for a fun, in-depth, and closer look into how a hyperpolarized Xe-MRI study operates!<\/div>\n

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Recent Funding<\/h4><\/div><\/div>[vc_column_text]<\/p>\n
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A warm thank you to our collaborators and funders:<\/p>\n

LiveCovidFree<\/em>: Ontario Together Grant<\/strong><\/p>\n

A collaboration between 5 Ontario sites to investigate lung MRI of the post-sequalae of Covid infection<\/p>\n

BOS<\/em>: Garron Family Cancer Centre<\/strong><\/p>\n

A cross-sectional MRI study of bronchiolitis obliterans in children receiving bone marrow transplant<\/p>\n

Post-LTx CLAD MRI<\/em>: Pettit BTG<\/strong><\/p>\n

An MRI study to determine\u00a0the clinical utility of 129Xe MRI in patient monitoring following<\/span>\u00a0<\/span>Lung Transplant\u00a0to \u00a0facilitate earlier diagnosis of Chronic Lung Allograft Dysfunction (CLAD)<\/span><\/span><\/p>\n

PCD MRI: Primary Ciliary Dyskinesia (PCD) foundation\u00a0<\/strong><\/p>\n

A multi-center study between SickKids and BC Children’s to understand the measurement properties of Hyperpolarized Xenon MRI in pediatric PCD patients<\/p>\n<\/div>\n<\/div>\n

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Useful Links<\/h4><\/div><\/div>[vc_column_text]SickKids Translational Medicine Program<\/a><\/p>\n

SickKids Cystic Fibrosis Centre<\/a><\/p>\n

Respiratory Medicine Division at SickKids<\/a><\/p>\n

Department of Critical Care Medicine at SickKids<\/a><\/p>\n

Department of Diagnostic Imaging at SickKids<\/a><\/p>\n

UofT Medical Biophysics <\/a><\/p>\n

SickKids Research Institute<\/a><\/p>\n

SickKids Research MRI Facility<\/a>[\/vc_column_text][\/vc_column][vc_column width=”1\/3″]

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Congratulations!<\/h4><\/div><\/div>[vc_column_text]<\/p>\n
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Congratulations!<\/h4>\n<\/div>\n<\/div>\n
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Congratulations to the following lab members and students for their achievements!<\/p>\n

Faiyza Alam – <\/b>University of Toronto 2025 Three Minute Thesis WINNER<\/span><\/b><\/p>\n

Watch her presentation in the link below.<\/p>\n<\/div>\n<\/div>\n

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News<\/h4><\/div><\/div>[vc_column_text]Recent publications:<\/p>\n

Application of the defect distribution index to functional lung MRI of pediatric cystic fibrosis lung disease and controls<\/a><\/p>\n

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Assessing\u00a0129<\/sup>Xe multi-breath washout MRI response to elexacaftor\/tezacaftor\/ivacaftor intervention in pediatric CF<\/a><\/p>\n

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Comparison of 3D UTE free-breathing lung MRI with hyperpolarized\u00a0129<\/sup>Xe MRI in pediatric cystic fibrosis<\/a><\/p>\n

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Intra- and Inter-visit Repeatability of\u00a0129<\/sup>\u00a0Xenon Multiple-Breath Washout MRI in Children With Stable Cystic Fibrosis Lung Disease<\/a><\/p>\n

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Inter- and intravisit repeatability of free-breathing MRI in pediatric cystic fibrosis lung disease<\/a><\/p>\n

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Semiautomated Segmentation and Analysis of Airway Lumen in Pediatric Patients Using Ultra Short Echo Time MRI<\/a><\/p>\n

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A 3D stack-of-spirals approach for rapid hyperpolarized\u00a0129<\/sup>\u00a0Xe ventilation mapping in pediatric cystic fibrosis lung disease<\/a><\/p>\n

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Hyperpolarized\u00a0129<\/sup>\u00a0Xe MRI of the rat brain with chemical shift saturation recovery and spiral-IDEAL readout<\/a><\/p>\n

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Hyperpolarized\u00a0129<\/sup>Xe magnetic resonance spectroscopy in a rat model of bronchopulmonary dysplasia<\/a><\/p>\n

[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

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