Dr. Janet Rossant is the Executive Director of the Ontario Institute for Regenerative Medicine (OIRM). This is a research, development and commercialization institute dedicated to the translation of stem cell research into curative therapies for major degenerative diseases.This newly established institute is a collaborative initiative between Ontario Stem Cell Initiative (OSCI) and the Centre for Commercialization of Regenerative Medicine (CCRM). With a focus on high priority diseases to the Ontario health-care system, the OIRM will fund three Disease Challenge Teams to build on existing leading-edge research already ongoing across Ontario:
- fixing damaged hearts with heart muscle derived from stem cells
- restoring vision in macular degeneration through stem cell therapies
- developing novel stem cell strategies for immunotherapy
Our lab works in close collaboration with the Toronto Centre for Phenogenomics (TCP) for a wide variety of mouse services, including gene targeting, generation of chimeras, re-derivation of mouse lines, cryopreservation, etc.
The TCP Transgenic Core is an amalgamation of the Transgenic Facilities at Mount Sinai Hospital and SickKids. These facilities have been operating since the early 1990s and have pioneered innovative technologies such as the production of mouse ES cell chimeras using the aggregation method and tetraploid complementation assay.
Many of our mouse lines that we have generated in the past but no longer use are available through the Canadian Mouse Mutant Repository (CMMR). The CMMR is a central repository for the physical archive of cryopreserved ES cells, spermatozoa, ova, embryos, and tissue DNA generated by Canada’s mouse genome effort. The CMMR is the repository and distribution centre for the North American Conditional Mouse Mutagenesis project (NorCOMM). The CMMR also collects and stores somatic tissue from mouse models in a variety of formats (fixed, embedded, and glass-slide mounted) enabling world wide access to specimens from established mouse models.
Jackson Laboratories is a valuable source for mutant mouse strains. A number of our more popular mouse lines are available directly from them. They are also a great resource for information on all aspects of genetic research of the mouse.
Janet Rossant is a long-standing member of the Society for Developmental Biology (SDB). This is a non-profit professional society dedicated to advancement of the field of developmental biology. Over recent decades, the SDB has grown from a few hundred members to nearly 2,000, and has evolved to provide an international forum for research, education and career development in developmental biology. Lab members are encouraged to join, and regularly attend both national and international meetings of the SDB.