{"id":264,"date":"2017-05-09T18:06:51","date_gmt":"2017-05-09T18:06:51","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/rosenblum\/?page_id=264"},"modified":"2024-12-31T14:11:10","modified_gmt":"2024-12-31T14:11:10","slug":"norm-rosenblum","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/","title":{"rendered":"Leader"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/4&#8243;][vc_empty_space][vc_single_image image=&#8221;269&#8243; img_size=&#8221;medium&#8221; style=&#8221;vc_box_shadow&#8221; css_animation=&#8221;fadeIn&#8221; image_hovers=&#8221;false&#8221;][vc_empty_space][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h3>Dr. Norman Rosenblum<\/h3>\n<ul>\n<li><strong>Paediatric Nephrologist and Senior Scientist<\/strong><br \/>\nDevelopmental, Stem Cell &amp; Cancer Biology Program<br \/>\n<a href=\"http:\/\/www.sickkids.ca\" target=\"_blank\" rel=\"noopener noreferrer\">The Hospital for Sick Children<div class=\"gap\" style=\"line-height: 10px; height: 10px;\"><\/div><\/a><\/li>\n<li><strong>Professor of Paediatrics, Physiology, and Laboratory Medicine and Pathobiology<\/strong><br \/>\n<a href=\"https:\/\/www.utoronto.ca\" target=\"_blank\" rel=\"noopener noreferrer\">The University of Toronto<div class=\"gap\" style=\"line-height: 10px; height: 10px;\"><\/div><\/a><\/li>\n<li><strong>Scientific Director &#8211; CIHR Institute of Nutrition, Metabolism and Diabetes<\/strong><br \/>\n<a href=\"http:\/\/www.cihr-irsc.gc.ca\/e\/13521.html\" target=\"_blank\" rel=\"noopener noreferrer\">Institute of Nutrition, Metabolism and Diabetes<\/a> <div class=\"gap\" style=\"line-height: 10px; height: 10px;\"><\/div><\/li>\n<li><strong>Tier I Canada Research Chair in Developmental Nephrology<div class=\"gap\" style=\"line-height: 10px; height: 10px;\"><\/div><\/strong><\/li>\n<\/ul>\n<p>MD &#8211;\u00a0Dalhousie University, Halifax, Nova Scotia, Canada<br \/>\nPaediatric Residency and Fellowship &#8211; Children&#8217;s Hospital, Boston<br \/>\nPostdoctoral Fellowship &#8211; Bjorn Olsen&#8217;s Lab, Department of Anatomy and Cell Biology, Harvard Medical School[\/vc_column_text][vc_empty_space height=&#8221;20px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/2&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][vc_btn title=&#8221;Biosketch&#8221; shape=&#8221;square&#8221; color=&#8221;black&#8221; align=&#8221;center&#8221; i_icon_fontawesome=&#8221;fas fa-download&#8221; add_icon=&#8221;true&#8221; link=&#8221;url:https%3A%2F%2Flab.research.sickkids.ca%2Frosenblum%2Fwp-content%2Fuploads%2Fsites%2F51%2F2022%2F05%2FDr.-Norman-Rosenblum_Short-Bio_.pdf|title:Dr.%20Rosenblum&#8217;s%20Bio|target:%20_blank|&#8221;][vc_empty_space][\/vc_column][vc_column width=&#8221;1\/4&#8243;][vc_btn title=&#8221;Curriculum Vitae&#8221; shape=&#8221;square&#8221; color=&#8221;black&#8221; align=&#8221;center&#8221; i_icon_fontawesome=&#8221;fa fa-download&#8221; add_icon=&#8221;true&#8221; link=&#8221;url:https%3A%2F%2Flab.research.sickkids.ca%2Frosenblum%2Fwp-content%2Fuploads%2Fsites%2F51%2F2017%2F05%2FRosenblum-CV.pdf|title:Dr.%20Rosenblum&#8217;s%20CV|target:%20_blank&#8221;][vc_empty_space][\/vc_column][vc_column width=&#8221;1\/4&#8243;][vc_btn title=&#8221;Dr. Rosenblum&#8221; shape=&#8221;square&#8221; color=&#8221;black&#8221; align=&#8221;center&#8221; i_icon_fontawesome=&#8221;fa fa-envelope-o&#8221; add_icon=&#8221;true&#8221; link=&#8221;url:mailto%3Anorman.rosenblum%40sickkids.ca|title:Contact%20Dr.%20Rosenblum|target:%20_blank&#8221;][vc_empty_space][\/vc_column][vc_column width=&#8221;1\/4&#8243;][vc_btn title=&#8221;Admin Assistant&#8221; shape=&#8221;square&#8221; color=&#8221;black&#8221; align=&#8221;center&#8221; i_icon_fontawesome=&#8221;fas fa-envelope&#8221; add_icon=&#8221;true&#8221; link=&#8221;url:mailto%3Analma.uy%40sickkids.ca|title:Contact%20Admin%20Assistant|target:%20_blank|&#8221;][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column]<section class=\"shortcode-action-box table shortcode-action-bg block-style-widget fadeIn animate-element\"><div class=\"text-big\"><h4>&#8220;I have been intensely drawn to the cello since the time, at age 14, I heard Bernard Greenhouse play the Tchaikovsky A minor Piano Trio. \u00a0The sound of the cello mimics the range of the human voice and it is able to transmit a huge range of emotions. I find the cello to be an incredible vehicle for expression and am so fortunate to be able to regularly explore musical conversation with my cello in orchestra and chamber music.&#8221;<\/h4>\n<\/div><\/section>[vc_empty_space][\/vc_column][\/vc_row][vc_row type=&#8221;4&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;25px&#8221; padding_top=&#8221;50px&#8221; padding_bottom=&#8221;10px&#8221;][vc_column width=&#8221;3\/4&#8243;][vc_column_text]In my laboratory we study molecular mechanisms that control formation of the normal and malformed kidney. Why bother? Well, kidney malformation is the major cause of kidney failure. Moreover, it is increasingly thought that the number of nephrons (kidney filter and attached tubular segments) that form <em>in utero<\/em> is an important determinant of adult-onset high blood pressure and kidney disease. As a paediatric nephrologist, these issues really trigger my imagination. What are the molecules that guide the complex development of kidney structures? How are these molecular pathways disrupted during kidney development? What causes these disruptions? What can we do about it?[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;357&#8243; img_size=&#8221;162&#215;220&#8243; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_border&#8221; image_hovers=&#8221;false&#8221;][\/vc_column][\/vc_row][vc_row type=&#8221;5&#8243; animation=&#8221;fadeIn&#8221; padding_top=&#8221;50px&#8221;][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;287&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow&#8221; image_hovers=&#8221;false&#8221;][vc_single_image image=&#8221;671&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow&#8221; image_hovers=&#8221;false&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Back in the 1980s, when I chose a postdoctoral fellowship after my clinical training in paediatrics and paediatric nephrology, the science in kidney development didn\u2019t match the huge progress in cell and molecular biology \u2013 those were the days of cDNA cloning and reverse genetics and I wanted to be part of it. Kidney development was still being investigated using classic embryologic approaches such as tissue recombination. And so, I joined the laboratory of Bjorn Olsen, the Hershey Professor of Anatomy at Harvard. Dr. Olsen was busy cloning a multitude of collagen genes and developing a totally new understanding of how extracellular matrices are constructed. I spent over four years learning how to culture different types of glomerular cells, clone collagen genes from cDNA libraries, study collagen expression, and try to purify collagen proteins.<div class=\"gap\" style=\"line-height: 5px; height: 5px;\"><\/div>\n<p>During the final days of my fellowship, I attended a seminar given by Oliver Smithies on gene targeting in mice. As I listened, I realized that the world would never be the same. Shortly thereafter, the first<sup>\u00a0<\/sup>knock-out mice were published including for the Wilms\u2019 Tumor 1 gene, which featured a major kidney phenotype. Around the same time, the opportunity to join SickKids was presented. My decision to leave Boston for Toronto was accompanied by a decision to leave the field of extracellular matrix, which I found to be rather descriptive and somewhat \u2018boring\u2019 (sorry ECM enthusiasts!). I came to Toronto ready to start an independent research program in kidney development, hoping to harness what I had learned in the Olsen lab to study kidney development.[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;4&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;25px&#8221; padding_top=&#8221;50px&#8221;][vc_column width=&#8221;3\/4&#8243;][vc_column_text]<div class=\"gap\" style=\"line-height: 10px; height: 10px;\"><\/div>\n<p>But, how to focus my new research? Just in the nick of time, I heard another seminar in which the <em>Bmp7 KO <\/em>mouse was described \u2013 it had a major kidney phenotype but the functions of BMP7 on specific aspects of kidney development were difficult to discern. Through a new association with Jeffrey Wrana, I decided to harness my knowledge of kidney cell culture and use recombinant BMPs to study tubule morphogenesis <em>in vitro<\/em>, identify BMP receptors and investigate intracellular BMP signaling in kidney tubule cells. Our data, which revealed that BMP signaling was far more complex than originally proposed, set the stage for work we are doing to this day using transgenic mice with BMP receptor deficiency in specific kidney cells at particular stages of development.\u00a0<div class=\"gap\" style=\"line-height: 15px; height: 15px;\"><\/div>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;278&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_border&#8221; image_hovers=&#8221;false&#8221;][\/vc_column][\/vc_row][vc_row type=&#8221;5&#8243; animation=&#8221;fadeIn&#8221; padding_top=&#8221;50px&#8221;][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;282&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow&#8221; image_hovers=&#8221;false&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]There is an old saying, \u201cgo where the science takes you&#8230;as long as it is a smart choice!\u201d Our BMP work taught us how to analyze kidney development in transgenic mice at the level of morphologic, cellular and molecular events. Some of our most interesting data showed us that BMPs interact with the canonical WNT pathway in the embryonic kidney and that control of these interactions is critical to normal kidney development. Indeed, we then realized that canonical WNT signaling is highly perturbed in malformed human kidney and, thus, we have studied WNT signaling in both normal and malformed mouse embryonic kidney. We never expected to study canonical WNTs and beta-catenin but the data took us there and it is important to human kidney malformation.<div class=\"gap\" style=\"line-height: 20px; height: 20px;\"><\/div>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;4&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;25px&#8221; padding_top=&#8221;50px&#8221;][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Another wise piece of advice in science is to &#8220;let your trainees go with their curiosity&#8230;at least until you think they should stop!&#8221; One of my past postdoctoral fellows, Ming Hu, schmoozed with members of the Hui lab and was interested in Hedgehog signaling. Ming realized that kidney development was very abnormal in mice with Sonic Hedgehog signaling and decided to figure out why. Six years later, we are investigating numerous facets of Hedgehog signaling in the kidney and the cerebellum, all because Ming was curious and generated interesting data that got me interested. In so doing, we have discovered that HH signaling controls early kidney patterning, nephron formation and the function of specialized pacemaker cells that control coordinated contraction of the ureter. To our delight, many of our findings relate to human kidney malformed phenotypes and raise the hope that by pursuing these issues we can further understand human disease.<div class=\"gap\" style=\"line-height: 10px; height: 10px;\"><\/div>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;418&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_border&#8221; image_hovers=&#8221;false&#8221;][\/vc_column][\/vc_row][vc_row type=&#8221;5&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;25px&#8221; padding_top=&#8221;50px&#8221;][vc_column width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;690&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow&#8221; image_hovers=&#8221;false&#8221;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Twenty-five to 30 years ago we didn&#8217;t have the tools to approach kidney development at the molecular level. Since then, lots of tools have been generated and we, as beneficiaries, have identified mechanisms that control nephron formation, tubule branching, and coordinated contraction of the renal pelvis and ureter. As we learn, we identify more approachable questions, the answers to which are likely to provide more understanding of normal and malformed kidney development. Some of what we have learned can now be used as a basis to translate knowledge to patients. Like the developmental biology that gave rise to our data, translation will require development of new tools and strategies.\u00a0And that is a path we are currently\u00a0following, using mouse genetics, human genetics, and kidney organoids in complementary ways to understand the significance of human genetic variants, interrogate kidney biology and pathobiology, and generate human cells and tissues for regenerative purposes.<div class=\"gap\" style=\"line-height: 5px; height: 5px;\"><\/div>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][vc_empty_space][vc_single_image image=&#8221;269&#8243; img_size=&#8221;medium&#8221; style=&#8221;vc_box_shadow&#8221; css_animation=&#8221;fadeIn&#8221; image_hovers=&#8221;false&#8221;][vc_empty_space][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_column_text css_animation=&#8221;fadeIn&#8221;] Dr. Norman Rosenblum Paediatric Nephrologist and Senior Scientist Developmental, Stem Cell &amp; Cancer Biology Program The Hospital for Sick Children Professor of Paediatrics, Physiology, and Laboratory Medicine and Pathobiology The University of Toronto Scientific Director &#8211; CIHR Institute of Nutrition, Metabolism and Diabetes Institute of Nutrition,&hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-264","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Leader - Rosenblum Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Leader\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=&#8221;1\/4&#8243;][vc_empty_space][vc_single_image image=&#8221;269&#8243; img_size=&#8221;medium&#8221; style=&#8221;vc_box_shadow&#8221; css_animation=&#8221;fadeIn&#8221; image_hovers=&#8221;false&#8221;][vc_empty_space][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_column_text css_animation=&#8221;fadeIn&#8221;] Dr. Norman Rosenblum Paediatric Nephrologist and Senior Scientist Developmental, Stem Cell &amp; Cancer Biology Program The Hospital for Sick Children Professor of Paediatrics, Physiology, and Laboratory Medicine and Pathobiology The University of Toronto Scientific Director &#8211; CIHR Institute of Nutrition, Metabolism and Diabetes Institute of Nutrition,&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/\" \/>\n<meta property=\"og:site_name\" content=\"Rosenblum Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-31T14:11:10+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/\",\"name\":\"Leader - Rosenblum Lab\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/rosenblum\/#website\"},\"datePublished\":\"2017-05-09T18:06:51+00:00\",\"dateModified\":\"2024-12-31T14:11:10+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lab.research.sickkids.ca\/rosenblum\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Leader\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/rosenblum\/#website\",\"url\":\"https:\/\/lab.research.sickkids.ca\/rosenblum\/\",\"name\":\"Rosenblum Lab\",\"description\":\"Kidney Development\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lab.research.sickkids.ca\/rosenblum\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Leader - Rosenblum Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/","og_locale":"en_US","og_type":"article","og_title":"Leader","og_description":"[vc_row][vc_column width=&#8221;1\/4&#8243;][vc_empty_space][vc_single_image image=&#8221;269&#8243; img_size=&#8221;medium&#8221; style=&#8221;vc_box_shadow&#8221; css_animation=&#8221;fadeIn&#8221; image_hovers=&#8221;false&#8221;][vc_empty_space][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_column_text css_animation=&#8221;fadeIn&#8221;] Dr. Norman Rosenblum Paediatric Nephrologist and Senior Scientist Developmental, Stem Cell &amp; Cancer Biology Program The Hospital for Sick Children Professor of Paediatrics, Physiology, and Laboratory Medicine and Pathobiology The University of Toronto Scientific Director &#8211; CIHR Institute of Nutrition, Metabolism and Diabetes Institute of Nutrition,&hellip;","og_url":"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/","og_site_name":"Rosenblum Lab","article_modified_time":"2024-12-31T14:11:10+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/","url":"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/","name":"Leader - Rosenblum Lab","isPartOf":{"@id":"https:\/\/lab.research.sickkids.ca\/rosenblum\/#website"},"datePublished":"2017-05-09T18:06:51+00:00","dateModified":"2024-12-31T14:11:10+00:00","breadcrumb":{"@id":"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/lab.research.sickkids.ca\/rosenblum\/norm-rosenblum\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/lab.research.sickkids.ca\/rosenblum\/"},{"@type":"ListItem","position":2,"name":"Leader"}]},{"@type":"WebSite","@id":"https:\/\/lab.research.sickkids.ca\/rosenblum\/#website","url":"https:\/\/lab.research.sickkids.ca\/rosenblum\/","name":"Rosenblum Lab","description":"Kidney Development","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/lab.research.sickkids.ca\/rosenblum\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/lab.research.sickkids.ca\/rosenblum\/wp-json\/wp\/v2\/pages\/264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.research.sickkids.ca\/rosenblum\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lab.research.sickkids.ca\/rosenblum\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lab.research.sickkids.ca\/rosenblum\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.research.sickkids.ca\/rosenblum\/wp-json\/wp\/v2\/comments?post=264"}],"version-history":[{"count":23,"href":"https:\/\/lab.research.sickkids.ca\/rosenblum\/wp-json\/wp\/v2\/pages\/264\/revisions"}],"predecessor-version":[{"id":935,"href":"https:\/\/lab.research.sickkids.ca\/rosenblum\/wp-json\/wp\/v2\/pages\/264\/revisions\/935"}],"wp:attachment":[{"href":"https:\/\/lab.research.sickkids.ca\/rosenblum\/wp-json\/wp\/v2\/media?parent=264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}