We use population-based cancer registries and health administrative databases (e.g., OHIP claims, hospitalizations) in Ontario to study a wide variety of long-term outcomes in survivors of childhood and AYA cancers, and in their family members. Selected examples include:<\/p>\n<\/div>
Adverse mental health outcomes in a population-based cohort of survivors of childhood cancer<\/a> (Nathan et al. Cancer <\/em>2018)<\/p>\n Incidence and Predictors of Mental Health Outcomes Among Survivors of Adolescent and Young Adult Cancer: A Population-Based Study Using the IMPACT Cohort<\/a> (De et al. J Clin Oncol<\/em> 2021)<\/p>\n Long-Term Mental Health Outcomes in Mothers and Siblings of Children With Cancer: A Population-Based, Matched Cohort Study<\/a> (Van Warmerdam et al. J Clin Oncol<\/em> 2020)<\/p>\n<\/div><\/div><\/div> Obstetrical and Perinatal Outcomes in Female Survivors of Childhood and Adolescent Cancer: A Population-Based Cohort Study<\/a> (Zgardau et al., J Natl Cancer Inst<\/em> 2022)<\/p>\n<\/div><\/div><\/div> Outcomes after solid organ transplantation in survivors of childhood, adolescent and young adult cancer: A population-based study.<\/a> (Nathan et al. J Natl Cancer Inst <\/span><\/em>2025)<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div> We conduct economic evaluations of various interventions and develop simulation models to support health system planning. This has included:<\/p>\n<\/div><\/div><\/div> Development of a policy model for pediatric acute lymphoblastic leukemia to facilitate economic evaluation<\/a>\u00a0 (Pechlivanoglou et al. J Natl Cancer Inst <\/em>2025)<\/p>\n<\/div><\/div><\/div> Cost-utility of nelarabine for the first-line treatment of newly diagnosed pediatric T-cell acute lymphoblastic leukemia in Canada. <\/a>(Shoukry et al. Pediatr Blood Cancer<\/em><\/span>\u00a0<\/em>2024)<\/span><\/p>\n<\/div><\/div><\/div> Health care utilisation and costs associated with different treatment protocols for newly diagnosed childhood acute lymphoblastic leukaemia: A population-based study in Ontario, Canada<\/a> (Gupta et al. Eur J Cancer<\/em> 2021)<\/p>\n Resource Utilization and Costs in Adolescents Treated for Cancer in Pediatric vs Adult Institutions<\/a> (Nathan et al. J Natl Cancer Inst<\/em> 2019)<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div> We seek opportunities to create novel data linkages that become permanent resources. These resources allow researchers to study a broad range of clinical and policy-relevant research questions.<\/p>\n A key example is the Initiative to Maximize Progress in Adolescent and Young Adult Cancer Therapy (IMPACT) cohort. IMPACT is housed at ICES and contains detailed chart-derived diagnostic and treatment information for AYAs aged 15\u201321 who were diagnosed with leukemia, lymphoma, sarcoma, or testicular cancer in Ontario. Some studies using IMPACT have included:<\/p>\n<\/div><\/div><\/div> The Initiative to Maximize Progress in Adolescent and Young Adult Cancer Therapy (IMPACT) Cohort Study: a population-based cohort of young Canadians with cancer<\/a>. (Baxter et al.\u00a0BMC Cancer<\/em>\u00a02014)<\/p>\n<\/div><\/div><\/div> The effect of adopting pediatric protocols in adolescents and young adults with acute lymphoblastic leukemia in pediatric vs adult centers: An IMPACT Cohort study<\/a> (Gupta et al. Cancer Med<\/em> 2019)<\/p>\n<\/i><\/i><\/span>Obstetrical and perinatal outcomes among female survivors<\/span><\/a><\/h3><\/div>
<\/i><\/i><\/span>Solid organ transplantation among survivors<\/span><\/a><\/h3><\/div>
Health economics<\/h2>\n<\/div>
<\/i><\/i><\/span>A policy model for pediatric acute lymphoblastic leukemia<\/span><\/a><\/h3><\/div>
<\/i><\/i><\/span>Nelarabine for newly diagnosed T-cell acute lymphoblastic leukemia<\/span><\/a><\/h3><\/div>
<\/i><\/i><\/span>Costs of treatment and health-care utilization<\/span><\/a><\/h3><\/div>
Data creation and linkage<\/h2>\n<\/div>
<\/i><\/i><\/span>The IMPACT cohort: Data resource profile<\/span><\/a><\/h3><\/div>
<\/i><\/i><\/span>Outcomes by locus of care<\/span><\/a><\/h3><\/div>