{"id":702,"date":"2019-07-18T07:48:55","date_gmt":"2019-07-18T11:48:55","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/parekh\/?page_id=702"},"modified":"2019-07-29T11:29:25","modified_gmt":"2019-07-29T15:29:25","slug":"find","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/parekh\/research\/find\/","title":{"rendered":"FIND"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_custom_heading text=&#8221;Family History of Nephropathy and Diabetes&#8221; font_container=&#8221;tag:h2|font_size:20|text_align:left|line_height:1&#8243; google_fonts=&#8221;font_family:Arimo%3Aregular%2Citalic%2C700%2C700italic|font_style:700%20bold%20regular%3A700%3Anormal&#8221;][vc_separator][vc_column_text]<strong>Overview<\/strong>: Family Investigation of Nephropathy and Diabetes (FIND) was a multicentre observational study of multi-ethnic participants recruited from 11 centres across the USA between 1999 and 2004. Data were collected until 2007. A genome-wide association study (GWAS) was conducted to identify genetic determinants of diabetic kidney disease.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Objectives<\/strong>: The primary aim of the FIND study was to identify genes responsible for diabetic nephropathy and whether these genes exhibit linkage relationships to nephropathy. A secondary aim was to use environmental data as a guide for determining possible risk factor effects on genetic susceptibility to diabetic nephropathy. As part of FIND, a biobank was created to store biological samples collected from participants for use in future studies related to diabetes and kidney diseases.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Progress<\/strong>: Data collection for the FIND study was completed in 2007. With these data, several genes associated with diabetic nephropathy, albuminuria, and GFR were identified. Notably, MYH9 was found to be associated with nondiabetic end-stage renal disease in African Americans.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_row_inner][vc_column_inner][vc_single_image image=&#8221;274&#8243; img_size=&#8221;medium&#8221; style=&#8221;vc_box_shadow&#8221;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_custom_heading text=&#8221;A comprehensive list of publications from the FIND study.&#8221; font_container=&#8221;tag:h2|font_size:20|text_align:center|color:%23ffffff|line_height:1&#8243; google_fonts=&#8221;font_family:Arimo%3Aregular%2Citalic%2C700%2C700italic|font_style:700%20bold%20regular%3A700%3Anormal&#8221; css=&#8221;.vc_custom_1564414208974{padding-top: 10px !important;padding-bottom: 10px !important;background-color: #000000 !important;}&#8221; link=&#8221;url:https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F%3Fterm%3DFamily%2520Investigation%2520of%2520Nephropathy%2520and%2520Diabetes%2520Research%2520Group%255BCorporate%2520Author%255D||target:%20_blank&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_custom_heading text=&#8221;Family History of Nephropathy and Diabetes&#8221; font_container=&#8221;tag:h2|font_size:20|text_align:left|line_height:1&#8243; google_fonts=&#8221;font_family:Arimo%3Aregular%2Citalic%2C700%2C700italic|font_style:700%20bold%20regular%3A700%3Anormal&#8221;][vc_separator][vc_column_text]Overview: Family Investigation of Nephropathy and Diabetes (FIND) was a multicentre observational study of multi-ethnic participants recruited from 11 centres across the USA between 1999 and 2004. Data were collected until 2007. A genome-wide association study (GWAS) was conducted to identify genetic determinants of diabetic kidney&hellip;<\/p>\n","protected":false},"author":82,"featured_media":0,"parent":14,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-702","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>FIND - The Parekh Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/parekh\/research\/find\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FIND\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_custom_heading text=&#8221;Family History of Nephropathy and Diabetes&#8221; font_container=&#8221;tag:h2|font_size:20|text_align:left|line_height:1&#8243; google_fonts=&#8221;font_family:Arimo%3Aregular%2Citalic%2C700%2C700italic|font_style:700%20bold%20regular%3A700%3Anormal&#8221;][vc_separator][vc_column_text]Overview: Family Investigation of Nephropathy and Diabetes (FIND) was a multicentre observational study of multi-ethnic participants recruited from 11 centres across the USA between 1999 and 2004. Data were collected until 2007. A genome-wide association study (GWAS) was conducted to identify genetic determinants of diabetic kidney&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/parekh\/research\/find\/\" \/>\n<meta property=\"og:site_name\" content=\"The Parekh Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2019-07-29T15:29:25+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/parekh\/research\/find\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/parekh\/research\/find\/\",\"name\":\"FIND - The Parekh Lab\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/parekh\/#website\"},\"datePublished\":\"2019-07-18T11:48:55+00:00\",\"dateModified\":\"2019-07-29T15:29:25+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/parekh\/research\/find\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lab.research.sickkids.ca\/parekh\/research\/find\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/parekh\/research\/find\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lab.research.sickkids.ca\/parekh\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Projects\",\"item\":\"https:\/\/lab.research.sickkids.ca\/parekh\/research\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"FIND\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/parekh\/#website\",\"url\":\"https:\/\/lab.research.sickkids.ca\/parekh\/\",\"name\":\"The Parekh Lab\",\"description\":\"Working to give children with kidney disease a brighter future.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lab.research.sickkids.ca\/parekh\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"FIND - The Parekh Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lab.research.sickkids.ca\/parekh\/research\/find\/","og_locale":"en_US","og_type":"article","og_title":"FIND","og_description":"[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_custom_heading text=&#8221;Family History of Nephropathy and Diabetes&#8221; font_container=&#8221;tag:h2|font_size:20|text_align:left|line_height:1&#8243; google_fonts=&#8221;font_family:Arimo%3Aregular%2Citalic%2C700%2C700italic|font_style:700%20bold%20regular%3A700%3Anormal&#8221;][vc_separator][vc_column_text]Overview: Family Investigation of Nephropathy and Diabetes (FIND) was a multicentre observational study of multi-ethnic participants recruited from 11 centres across the USA between 1999 and 2004. 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