{"id":254,"date":"2017-09-22T19:03:42","date_gmt":"2017-09-22T19:03:42","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/?page_id=254"},"modified":"2025-05-20T10:05:40","modified_gmt":"2025-05-20T14:05:40","slug":"lifestyle-outcomes","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/lifestyle-outcomes\/","title":{"rendered":"Lifestyle Outcomes"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_empty_space height=&#8221;25px&#8221;]<div class=\"dt-fancy-separator h2-size\" style=\"width: 100%;\"><div class=\"dt-fancy-title\" style=\"color: #0068b3;\"><span class=\"separator-holder separator-left\" style=\"border-color: #767a83;\"><\/span>ACTIVE TEENS WITH MULTIPLE SCLEROSIS (ATOMIC)<span class=\"separator-holder separator-right\" style=\"border-color: #767a83;\"><\/span><\/div><\/div>[vc_empty_space height=&#8221;25px&#8221;]<div class=\"dt-fancy-separator h4-size style-disabled\" style=\"width: 100%;\"><div class=\"dt-fancy-title\"><span class=\"separator-holder separator-left\"><\/span>Full Title: Physical Activity, Quality of Life, and Disease Outcomes in Youth with Multiple Sclerosis: The Atomic (Active Teens Multiple Sclerosis) Physical Activity Research Program<span class=\"separator-holder separator-right\"><\/span><\/div><\/div>[vc_empty_space height=&#8221;25px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-ce08d818600f7dd35086376248a74353.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-ce08d818600f7dd35086376248a74353.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-ce08d818600f7dd35086376248a74353 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-ce08d818600f7dd35086376248a74353 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-ce08d818600f7dd35086376248a74353 alignnone caption-on  vc_custom_1621012866150 enable-bg-rollover dt-icon-bg-off\" ><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20500%20749&#39;%2F%3E\" data-src=\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/wp-content\/uploads\/sites\/64\/2021\/05\/clique-images-hSB2HmJYaTo-unsplash-scaled-500x749.jpg\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/wp-content\/uploads\/sites\/64\/2021\/05\/clique-images-hSB2HmJYaTo-unsplash-scaled-500x749.jpg 500w, https:\/\/lab.research.sickkids.ca\/neuroinflamm\/wp-content\/uploads\/sites\/64\/2021\/05\/clique-images-hSB2HmJYaTo-unsplash-scaled-1000x1498.jpg 1000w\" loading=\"eager\" sizes=\"(max-width: 500px) 100vw, 500px\" width=\"500\" height=\"749\"  data-dt-location=\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/lifestyle-outcomes\/clique-images-hsb2hmjyato-unsplash\/\" style=\"--ratio: 500 \/ 749;\" alt=\"Running up stairs\" \/><\/div><\/div><div class=\"shortcode-single-caption\">Photo by <a href=\"https:\/\/unsplash.com\/@cliqueimages?utm_source=unsplash&amp;utm_medium=referral&amp;utm_content=creditCopyText\">Clique Images<\/a> on <a href=\"https:\/\/unsplash.com\/s\/photos\/physical-activity?utm_source=unsplash&amp;utm_medium=referral&amp;utm_content=creditCopyText\">Unsplash<\/a><\/div><\/div>[\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_column_text]<\/p>\n<h4 style=\"text-align: center\">Increased physical activity (PA) has the potential to improve brain tissue integrity, mental health outcomes, and quality of life in youth with multiple sclerosis (MS). We have demonstrated associations between lower levels of PA and higher levels of depressive symptoms and fatigue in these youth over time. Furthermore, we have demonstrated an association between higher levels of PA and lower levels of disease activity in youth with MS. Finally, extensive work in adults with MS supports the role of PA in reducing disease activity and symptoms, resulting in improved quality of life in adults with MS. Importantly, our preliminary work shows that youth with MS have very low levels of PA. Increasing PA, therefore, has the potential to have both disease-modifying and psychosocial benefits in youth with MS. Other research has shown that group-based exercise classes while increasing PA at the time of the intervention, do not lead to sustained increases in levels of everyday living PA. Any intervention oriented towards sustained increases in PA must address barriers and facilitators to behaviour change.<\/h4>\n<h4 style=\"text-align: center\">We have developed a user-driven app to address these issues: through it, we will be able to deliver MS-specific PA information via a mobile app platform, overcoming the barriers of patient engagement and distance. We propose to test the feasibility of implementing a mobile app-based physical activity intervention in youth with MS and to examine the extent to which the intervention can change physical activity levels in this population. Secondary and exploratory outcomes will be to evaluate improvement in regional brain volumes, mood, and quality of life in youth with MS.<\/h4>\n<h4 style=\"text-align: center\"><\/h4>\n<h4 style=\"text-align: center\">For more information and participation, please contact <a style=\"color: #0068b3;text-decoration: underline\" href=\"mailto:yeh.team@sickkids.ca\">Jesse Joynt<\/a>.<\/h4>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column]<div class=\"dt-fancy-separator h4-size style-disabled\" style=\"width: 100%;\"><div class=\"dt-fancy-title\" style=\"color: #0068b3;\"><span class=\"separator-holder separator-left\"><\/span>ADDITIONAL INFORMATION ABOUT THIS STUDY CAN BE FOUND AT<span class=\"separator-holder separator-right\"><\/span><\/div><\/div>[vc_empty_space height=&#8221;10px&#8221;]\n\t\t\t<div class=\"ult_dual_button  ult-adjust-bottom-margin to-center  dual_button\"  data-response=\"on\" id=\"ult_btn_3298514231\">\n\n\t\t\t<div id=\"dualbtn-4405\" class=\"ulitmate_dual_buttons ult-dual-btn3 ult_main_dualbtn \" data-bcolor=\"#333333\"data-bhcolor=\"\">\n\n\t\t\t<div class=\"ult_dualbutton-wrapper btn-inline place-template bt1 \"><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04782466\" title=\"clinicaltrials.gov\" target=\"_blank\" rel=\"noopener\"  class=\"ult_ivan_button round-square with-icon icon-before with-text place-template ult_dual1\" style=\";margin-right:px;;background-color:#ffffff !important;; border-color:#333333;border-style:;border-width:0px;border-radius:px;width:180px;;\">\n\t\t\t<span class=\"ult-dual-btn-1 Style 2\" style=\"\"  data-bgcolor=\"#ffffff\" data-bghovercolor=\"rgba(0,104,179,0.18)\" data-icon_color=\"#333333\" data-icon_hover_color=\"#333333\" data-textcolor=\"#767a83\" data-texthovercolor=\"#0068b3\" data-iconbgcolor=\"transperent\" data-iconbghovercolor=\"transperent\" data-iconborder=\"transperent\" data-iconhoverborder=\"transperent\" >\n\t\t\t<span class=\"icon-simple icon-left1 ult_btn1span ult-dual-btn-no-icon\"  style=\";padding-left:0px; \"><\/span>\n\t\t\t<span class=\"text-btn ult-dual-button-title ult-responsive\"  data-ultimate-target='#dualbtn-4405 .ult-dual-button-title'  data-responsive-json-new='{\"font-size\":\"desktop:20px;\",\"line-height\":\"desktop:15px;\"}'  style=\"font-weight:normal;color:#767a83;\">clinicaltrials.gov<\/span>\n\n\t\t\t<\/span>\n\t\t\t<\/a><span class=\"middle-text\" style=\"line-height: 1.8em;color:#ffffff;background-color:#0068b3;border-width:0px;\">\n\t\t\t<span class=\"middle-inner\"  >and<\/span>\n\t\t\t<\/span>\n\n\t\t\t<\/div>\n\n\t\t\t<div class=\"ult_dualbutton-wrapper btn-inline place-template btn2 \"><a href=\"https:\/\/research4kids.research.sickkids.ca\/trialdescription\/333\" title=\"research4kids\" target=\"_blank\" rel=\"noopener\"  class=\"ult_ivan_button round-square with-icon icon-after with-text place-template ult_dual2\"  style=\";background-color:#ffffff !important;;margin-left:px;;border-color:#333333;border-style:;border-width:0px;border-radius:px;width:180px;\">\n\t\t\t<span class=\"ult-dual-btn-2 Style 2\"  data-bgcolor=\"#ffffff\" data-bghovercolor=\"rgba(0,104,179,0.18)\" data-icon_color=\"#333333\" data-icon_hover_color=\"#333333\" data-textcolor=\"#767a83\" data-texthovercolor=\"#0068b3\" data-iconbgcolor=\"transperent\" data-iconbghovercolor=\"transperent\" data-iconborder=\"transperent\" data-iconhoverborder=\"transperent\" >\n\t\t\t<span class=\"text-btn ult-dual-button-title\" style=\"font-weight:normal;color:#767a83;\">research4kids<\/span>\n\n\t\t\t<span class=\"icon-simple icon-right2 ult_btn1span ult-dual-btn-no-icon\"  style=\";padding-left:0px; \"><\/span>\n\t\t\t<\/span>\n\t\t\t<\/a><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column]<div class=\"dt-fancy-separator h2-size\" style=\"width: 100%;\"><div class=\"dt-fancy-title\" style=\"color: #0068b3;\"><span class=\"separator-holder separator-left\" style=\"border-color: #767a83;\"><\/span>PEACH STUDY<span class=\"separator-holder separator-right\" style=\"border-color: #767a83;\"><\/span><\/div><\/div>[vc_empty_space height=&#8221;25px&#8221;]<div class=\"dt-fancy-separator h4-size style-disabled\" style=\"width: 100%;\"><div class=\"dt-fancy-title\"><span class=\"separator-holder separator-left\"><\/span> Participation, Environment, And Key Clinical and Health Outcomes in Children with Multiple Sclerosis (PEACH)<span class=\"separator-holder separator-right\"><\/span><\/div><\/div>[vc_empty_space height=&#8221;25px&#8221;][vc_row_inner][vc_column_inner width=&#8221;2\/3&#8243; css=&#8221;.vc_custom_1621012894276{padding-top: 20px !important;}&#8221;][vc_column_text]<\/p>\n<p>We are currently conducting and recruiting for a new study looking at the relationship between participation in home, school and community activities, and mental health in children and youth with multiple sclerosis (MS). We hope to use this information to better understand how neuroinflammatory disease can affect a child\u2019s mental health and ability to participate in activities at home, school and in the community. Over the course of the study, we hope to also identify what other factors affect their ability to participate in these activities.<\/p>\n<p>We are looking for youth aged 5 to 17 years old with Multiple Sclerosis (MS) and youth with acquired monophasic demyelination syndrome (mono-ADS).<\/p>\n<p>For more information and participation, please contact: <a href=\"Paul.yoo@sickkids.ca\">Paul Yoo<\/a><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-7aea026e9ad197639de3b19314c71347.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-7aea026e9ad197639de3b19314c71347.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-7aea026e9ad197639de3b19314c71347 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-7aea026e9ad197639de3b19314c71347 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-7aea026e9ad197639de3b19314c71347 alignnone caption-on  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:500px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20500%20222&#39;%2F%3E\" data-src=\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/wp-content\/uploads\/sites\/64\/2021\/05\/gender-6188940_1920-500x222.jpg\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/wp-content\/uploads\/sites\/64\/2021\/05\/gender-6188940_1920-500x222.jpg 500w, https:\/\/lab.research.sickkids.ca\/neuroinflamm\/wp-content\/uploads\/sites\/64\/2021\/05\/gender-6188940_1920-1000x444.jpg 1000w\" loading=\"eager\" sizes=\"(max-width: 500px) 100vw, 500px\" width=\"500\" height=\"222\"  data-dt-location=\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/lifestyle-outcomes\/gender-6188940_1920\/\" style=\"--ratio: 500 \/ 222;\" alt=\"\" \/><\/div><\/div><div class=\"shortcode-single-caption\">Image by <a href=\"https:\/\/pixabay.com\/users\/geralt-9301\/?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=6188940\">Gerd Altmann<\/a> from <a href=\"https:\/\/pixabay.com\/?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=6188940\">Pixabay<\/a>\n<\/div><\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;25px&#8221;][\/vc_column][\/vc_row][vc_row full_width_row=&#8221;true&#8221;][vc_column css=&#8221;.vc_custom_1621011666224{padding-right: 195px !important;padding-left: 195px !important;background-color: #f2f2f2 !important;}&#8221;][vc_column_text css=&#8221;.vc_custom_1621011030672{padding-left: 25px !important;}&#8221;]<\/p>\n<h3 style=\"color: #0068b3;text-align: left\">COMPLETED STUDIES<\/h3>\n<p>[\/vc_column_text][vc_toggle title=&#8221;Physical Activity, Depression, and Fatigue in Paediatric MS&#8221;]<\/p>\n<h5 style=\"color: #db58a7\">Full Title: Benefits of Moderate- to Vigorous Physical Activity on Depression and Fatigue in Pediatric MS<\/h5>\n<p>Cross-sectional studies have demonstrated an association between higher levels of moderate to vigorous physical activity (MVPA) and less fatigue and depression among children with multiple sclerosis (MS) and monophasic demyelinating disorders (mono-ADS). While inferences of causality are not possible with cross-sectional studies, time-varying relationships can be examined with longitudinal studies.<\/p>\n<p>The objectives of this study are to examine the relationship between MVPA and symptoms of fatigue and depression among youth with demyelinating conditions over time. Standardized fatigue, depression, and MVPA questionnaires are collected at each visit from youth with MS and mono-ADS attending a Neuroinflammatory Clinic (2013-2017). The associations of MVPA with fatigue and depression will be examined over time, controlling for age and time from disease onset, sex, relapse rate, depression, and disability. <a href=\"https:\/\/www.jpeds.com\/article\/S0022-3476(19)30128-3\/abstract\">Read our publication<\/a>[\/vc_toggle][vc_toggle title=&#8221;Sleep, Physical Activity and MS Symptoms in Paediatric MS&#8221;]<\/p>\n<h5 style=\"color: #db58a7\">Full Title: Sleep, Physical Activity and MS Symptoms in Paediatric MS<\/h5>\n<p>Most youth with multiple sclerosis (MS) experience symptoms such as depression and fatigue. In addition, cognitive issues, especially with attention and memory occur frequently. However, little is known about interventions that might work to improve these symptoms. In other work, we have shown that higher levels of physical activity are associated with lower levels of depression and fatigue. Others have shown that sleep may reduce fatigue and depression while improving attention and memory in the adult MS population and other pediatric populations. Importantly, sleep problems are frequently encountered in youth with MS and were seen in 60% of surveyed youth with MS in our preliminary work. Whether sleep plays an important role in symptoms in youth with MS, and the relationship between sleep and physical activity in youth with MS is unknown and may differ from the relationship seen in otherwise healthy individuals due to consequences of the disease process. Describing and identifying problems and disturbances with sleep, and examining their relationship to physical activity and MS-related symptoms is the first step towards developing effective interventions for these problems.<strong><br \/>\n<\/strong><\/p>\n<p>Our preliminary findings suggest that sleep problems occur in over half of youth with MS. However, it is not clear how these sleep problems might affect these youth. Furthermore, there has been no research to date using objective measures to document the rate of sleep problems in this population. Modifying sleep habits may also have an effect on physical activity levels in these youth. Finding ways to increase physical activity levels is important, as we have shown that increased physical activity is related to improved disease symptom status. This research will address these issues. Our goal is to understand sleep problems in youth with MS. We will also study how sleep habits, physical activity, and disease symptoms are related to one another in these youth. We will do this by evaluating the sleep habits using questionnaires and an objective measure of sleep activity, a wrist-based activity monitor (ActiWatch). In addition, we will measure physical activity in all participants objectively using a wearable activity monitor (accelerometry). Finally, we will assess levels of disease activity, fatigue and depression in order to understand how these disease symptoms are related to sleep and physical activity.[\/vc_toggle][vc_toggle title=&#8221;Physical Activity Barriers and Facilitators&#8221;]This study\u2019s objective is to better understand the levels of physical activity youth with neuroinflammatory disorders engage in and how fit they are. This research study \u00a0is designed to learn about the amount and type of physical activities that are done by youth with neuroinflammation and also by healthy youth. We would like to know how fit these youth are and would like to ask about things that get in the way of taking part in physical activity.\u00a0 We also want to know what helps youth to take part in physical activity.\u00a0 Finally, we hope that this research helps us give better advice on the best ways to be physically active in youth with neuroinflammation.[\/vc_toggle][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;25px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;150px&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_empty_space height=&#8221;25px&#8221;][vc_empty_space height=&#8221;25px&#8221;][vc_empty_space height=&#8221;25px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_column_text] Increased physical activity (PA) has the potential to improve brain tissue integrity, mental health outcomes, and quality of life in youth with multiple sclerosis (MS). We have demonstrated associations between lower levels of PA and higher levels of depressive symptoms and fatigue in these youth over time. Furthermore, we&hellip;<\/p>\n","protected":false},"author":119,"featured_media":0,"parent":263,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-254","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Lifestyle Outcomes - Paediatric Neuroinflammatory Disorders Program<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/lifestyle-outcomes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lifestyle Outcomes\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_empty_space height=&#8221;25px&#8221;][vc_empty_space height=&#8221;25px&#8221;][vc_empty_space height=&#8221;25px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_column_text] Increased physical activity (PA) has the potential to improve brain tissue integrity, mental health outcomes, and quality of life in youth with multiple sclerosis (MS). We have demonstrated associations between lower levels of PA and higher levels of depressive symptoms and fatigue in these youth over time. Furthermore, we&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/lifestyle-outcomes\/\" \/>\n<meta property=\"og:site_name\" content=\"Paediatric Neuroinflammatory Disorders Program\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-20T14:05:40+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/lifestyle-outcomes\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/lifestyle-outcomes\/\",\"name\":\"Lifestyle Outcomes - Paediatric Neuroinflammatory Disorders Program\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/#website\"},\"datePublished\":\"2017-09-22T19:03:42+00:00\",\"dateModified\":\"2025-05-20T14:05:40+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/lifestyle-outcomes\/#breadcrumb\"},\"inLanguage\":\"en-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/lifestyle-outcomes\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/lifestyle-outcomes\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research\",\"item\":\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Lifestyle Outcomes\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/#website\",\"url\":\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/\",\"name\":\"Paediatric Neuroinflammatory Disorders Program\",\"description\":\"Paediatric Neuroinflammatory Disorders Program\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-CA\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Lifestyle Outcomes - Paediatric Neuroinflammatory Disorders Program","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lab.research.sickkids.ca\/neuroinflamm\/research\/lifestyle-outcomes\/","og_locale":"en_US","og_type":"article","og_title":"Lifestyle Outcomes","og_description":"[vc_row][vc_column][vc_empty_space height=&#8221;25px&#8221;][vc_empty_space height=&#8221;25px&#8221;][vc_empty_space height=&#8221;25px&#8221;][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_column_text] Increased physical activity (PA) has the potential to improve brain tissue integrity, mental health outcomes, and quality of life in youth with multiple sclerosis (MS). We have demonstrated associations between lower levels of PA and higher levels of depressive symptoms and fatigue in these youth over time. 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