Our Team

Jason Moffat

Senior Scientist, Program Head Genetics and Genome Biology,
The Hospital for Sick Children

Professor Molecular Genetics, IBME,
University of Toronto

Jason Moffat is a Senior Scientist and Program Head for the Genetics and Genome Biology program at The Hospital for Sick Children. He is also a Full Professor in the Department of Molecular Genetics, Faculty of Medicine at the University of Toronto, and cross-appointed to the Institute of Biomedical Engineering in the Faculties of Medicine and Engineering.

The Moffat Lab focuses on developing and applying genome-scale genetic perturbation technologies and analytical approaches to explore genotype-phenotype relationships in human and mouse cells to find therapeutic targets for cancer. His lab generated the first gold standard sets of essential and non-essential human genes for functional genomics efforts. The Moffat Lab has also catalogued essential gene sets for human embryonic stem cells as well as cancer intrinsic evasion to cytotoxic T lymphocytes. More recently, his lab has also been examining genetic and chemical-genetic interactions important for cell fitness and establishing properties of genetic interactions in a human cell model.