Publications

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J. Cell Press. 2015 Dec 3;163(6):1515-26.
Graphical abstract of "High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities"
Graphical abstract of publication entitled "High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities"

Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9-Cas12a platform.

Gonatopoulos-Pournatzis T, Aregger M, Brown KR, Farhangmehr S, Braunschweig U, Ward HN, Ha KCH, Weiss A, Billman M, Durbic T, Myers CL, Blencowe BJ, Moffat J. Nature Biotechnology. 2020 May;38(5):638-648.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

Aregger M, Lawson KA, Billmann M, Costanzo M, Tong AHY, Chan K, Rahman M, Brown KR, Ross C, Usaj M, Nedyalkova L, Sizova O, Habsid A, Pawling J, Lin ZY, Abdouni H, Wong CJ, Weiss A, Mero P, Dennis JW, Gingras AC, Myers CL, Andrews BJ, Boone C, Moffat J. Nat Metabolism. 2020 Jun; 2(6):499-513.

Image of publication entitled "Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism"
Image of publication entitled "Functional genomic landscape of cancer-intrinsic evasion of killing by T cells"

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

Lawson KA, Sousa CM, Zhang X, Kim E, Akthar R, Caumanns JJ, Yao Y, Mikolajewicz N, Abou Zid A, Fan ZP, Hui S, Krall JA, Simons DM, Slater CJ, De Jesus V, Tang L, Singh R, Goldford JE, Martin S, Huang Q, Francis EA, Habsid A, Climie R, Tieu D, Wei J, Li R, Tong AHY, Aregger M, Chan KS, Han H, Wang X, Mero P, Brumell JH, Finelli A, Ailles L, Bader G, Smolen GA, Kingsbury GA, Hart T, Kung C, Moffat J. Nature, 2020 Oct; 586(7827):120-126.

Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux

Masud, S. N., Chandrashekhar, M., Aregger, M., Tan, G., Zhang, X., Mero, P., Pirman, D. A., Zaslaver, O., Smolen, G. A., Lin, Z.-Y., Wong, C. J., Boone, C., Gingras, A.-C., Montenegro-Burke, J. R., & Moffat, J. Nature Chemical Biology, 2022 Dec; 18(12): 1370–1379.

Image of publication entitled "Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux"

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Marcotte R, Brown KR, Suarez F, Sayad A, Karamboulas K, Krzyzanowski PM, Sircoulomb F, Medrano M, Fedyshyn Y, Koh JLY, van Dyk D, Fedyshyn B, Luhova M, Brito GC, Vizeacoumar FJ, Vizeacoumar FS, Datti A, Kasimer D, Buzina A, Mero P, Misquitta C, Normand J, Haider M, Ketela T, Wrana JL, Rottapel R, Neel BG, Moffat J. Cancer Discovery. 2012 Feb;2(2):172-189.