{"id":7,"date":"2015-12-21T17:26:19","date_gmt":"2015-12-21T17:26:19","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/mital\/?page_id=7"},"modified":"2026-02-13T17:34:38","modified_gmt":"2026-02-13T17:34:38","slug":"mital-lab","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/mital\/","title":{"rendered":"Home"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/3&#8243; el_class=&#8221;Seema Mital, MD, FACC, FAHA, FRCP(C)&#8221;][vc_single_image image=&#8221;150&#8243; img_size=&#8221;medium&#8221; style=&#8221;vc_box_shadow_border&#8221; image_hovers=&#8221;false&#8221;][vc_column_text]<strong>Seema Mital, <\/strong>MD, FACC, FAHA, FRCP(C)<\/p>\n<p><strong>The Hospital for Sick Children<\/strong><\/p>\n<h6>Head \u2013 Cardiovascular Research<br \/>\nStaff Cardiologist \u2013 Heart Function and Transplant Program<\/h6>\n<p><strong>Research Institute<\/strong><\/p>\n<h6>Senior Scientist \u2013 Genetics &amp; Genome Biology<br \/>\nProfessor \u2013 University of Toronto, Pediatrics<\/h6>\n<p><strong>Chair Position<\/strong><\/p>\n<h6>Heart &amp; Stroke Foundation Ontario Chair in Cardiovascular Science<br \/>\nScientific Co-Lead \u2013 Ted Rogers Centre for Heart Research<\/h6>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:seema.mital@sickkids.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>\n<p><a href=\"http:\/\/www.sickkids.ca\/AboutSickKids\/Directory\/People\/M\/Seema-Mital.html\" class=\"btn-shortcode dt-btn-m btn-link title-btn-color accent-btn-hover-color default-btn-bg-color default-btn-bg-hover-color fadeIn animate-element animation-builder\" target=\"_blank\" id=\"dt-btn-1\" rel=\"noopener\"><i class=\"fa fa-chevron-circle-right\"><\/i><span>SickKids Profile<\/span><\/a>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1727875673105{margin-bottom: 0px !important;border-bottom-width: 0px !important;padding-bottom: 0px !important;}&#8221;]<\/p>\n<h4 style=\"text-align: center\"><strong>TOP SUSTAINABILITY RATING FOR THE MITAL LAB<\/strong><\/h4>\n<p>[\/vc_column_text]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-cb24af1cc8bb5eac0acf6777647c40b6.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-cb24af1cc8bb5eac0acf6777647c40b6.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-cb24af1cc8bb5eac0acf6777647c40b6 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-cb24af1cc8bb5eac0acf6777647c40b6 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-cb24af1cc8bb5eac0acf6777647c40b6 alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:275px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20275%20211&#39;%2F%3E\" data-src=\"https:\/\/lab.research.sickkids.ca\/mital\/wp-content\/uploads\/sites\/27\/2024\/10\/Screenshot-2024-10-02-091818-275x211.png\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/mital\/wp-content\/uploads\/sites\/27\/2024\/10\/Screenshot-2024-10-02-091818-275x211.png 275w, https:\/\/lab.research.sickkids.ca\/mital\/wp-content\/uploads\/sites\/27\/2024\/10\/Screenshot-2024-10-02-091818-550x422.png 550w\" loading=\"eager\" sizes=\"(max-width: 275px) 100vw, 275px\" width=\"275\" height=\"211\"  data-dt-location=\"https:\/\/lab.research.sickkids.ca\/mital\/mital-lab\/screenshot-2024-10-02-091818\/\" style=\"--ratio: 275 \/ 211;\" alt=\"\" \/><\/div><\/div><\/div>[vc_column_text css=&#8221;.vc_custom_1729888144191{margin-bottom: 0px !important;border-bottom-width: 0px !important;padding-bottom: 0px !important;}&#8221;]<\/p>\n<h4 style=\"text-align: center\"><strong>My Green Lab Team<\/strong><\/h4>\n<p>[\/vc_column_text]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-eaa86f151ec05e20b37d439b2114b614.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-eaa86f151ec05e20b37d439b2114b614.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-eaa86f151ec05e20b37d439b2114b614 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-eaa86f151ec05e20b37d439b2114b614 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-eaa86f151ec05e20b37d439b2114b614 alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:250px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20250%20187&#39;%2F%3E\" data-src=\"https:\/\/lab.research.sickkids.ca\/mital\/wp-content\/uploads\/sites\/27\/2024\/10\/IMG_0025-scaled-250x187.jpg\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/mital\/wp-content\/uploads\/sites\/27\/2024\/10\/IMG_0025-scaled-250x187.jpg 250w, https:\/\/lab.research.sickkids.ca\/mital\/wp-content\/uploads\/sites\/27\/2024\/10\/IMG_0025-scaled-500x374.jpg 500w\" loading=\"eager\" sizes=\"(max-width: 250px) 100vw, 250px\" width=\"250\" height=\"187\"  data-dt-location=\"https:\/\/lab.research.sickkids.ca\/mital\/mital-lab\/img_0025\/\" style=\"--ratio: 250 \/ 187;\" alt=\"\" \/><\/div><\/div><\/div>[\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;&#8221;]Our research focusses on genomics, pharmacogenomics and stem cell applications in childhood heart disease. In 2015, we launched the Cardiac Precision Medicine Program focussed on precision medicine approaches for childhood onset heart disease. This includes the study of DNA using next-generation sequencing, and tissue and patient-derived induced pluripotent stem cells (iPSCs) in patients with congenital cardiac malformations and cardiomyopathies.<\/p>\n<p>The goals are to identify gene defects that cause heart disease in children, identify the influence of genetic variations on disease severity and outcomes, and apply this knowledge to inform the clinical care of children with heart disease and discovery of new therapies for pediatric heart failure. An equally important goal is to study gene-environment interactions in causing heart disease. The approach to research is translational and includes clinical and basic research methodologies to answer these questions.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>We have launched several large collaborative efforts to meet these goals:<\/strong><\/p>\n<p><strong><a href=\"http:\/\/www.theheartcentrebiobank.com\" target=\"_blank\" rel=\"noopener noreferrer\">Heart Centre Biobank Registry<\/a><\/strong> \u2013 The Heart Centre Biobank is a multi-centre research network which has resulted in the establishment of the first Ontario province-wide biorepository and registry of patients with congenital and other forms of heart disease.<\/p>\n<p><strong><a href=\"http:\/\/tedrogersresearch.ca\/\" target=\"_blank\" rel=\"noopener noreferrer\">Ted Rogers Centre for Heart Research<\/a>\u00a0<\/strong>\u2013\u00a0With the goal to significantly reduce heart failure in Canada over the next decade and beyond, The Hospital for Sick Children (SickKids), University Health Network (UHN) and the University of Toronto (U of T) announced the creation of the Ted Rogers Centre for Heart Research on November 20, 2014.<\/p>\n<p><strong><a href=\"https:\/\/www.canada.ca\/en\/institutes-health-research\/news\/2022\/05\/government-of-canada-invests-in-new-pan-canadian-national-heart-failure-research-network.html\" target=\"_blank\" rel=\"noopener noreferrer\">Canadian Heart Function Alliance-<\/a><\/strong>The Canadian Heart Function Alliance (CHF Alliance) brings together an extensive network of researchers, clinicians, patients, caregivers, Indigenous elders, policy-makers and other partner organizations across the country to explore a breadth of approaches to extending the lifespan of Canadians who have heart failure.<\/p>\n<p><a href=\"https:\/\/theheartcentrebiobank.com\/proceed\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>PROCEED<\/strong><\/a> &#8211; PeRsOnalized Genomics For CongEniTal HEart Disease- <span class=\"NormalTextRun SCXW172033399 BCX0\">A international group of researchers,\u00a0<\/span><span class=\"NormalTextRun SCXW172033399 BCX0\">trainees<\/span><span class=\"NormalTextRun SCXW172033399 BCX0\">\u00a0and patient partners who together are unravelling the genomic basis of congenital heart disease to develop personalized approaches to prevention,\u00a0<\/span><span class=\"NormalTextRun SCXW172033399 BCX0\">prediction<\/span><span class=\"NormalTextRun SCXW172033399 BCX0\">\u00a0and treatment.<\/span><\/p>\n<p><a href=\"https:\/\/primacycalculator.com\/\"><strong>PRIMaCY<\/strong><\/a> &#8211; Precision Medicine in CardiomyopathY &#8211; PRIMaCY has developed an eHealth clinical decision support tool that generates an individualized 5-year risk prediction for sudden death for each patient. The primary goal is to implement the PRIMaCY tool in hospital information systems for use by physicians as a point of care tool, to evaluate the effectiveness of the tool in adherence to clinical practice guidelines, and to evaluate how it influences patient\/family counseling.<\/p>\n<p><strong>Canadian National Transplant Research Program<\/strong>\u00a0\u2013 The Canadian National Transplant Research Program (CNTRP) is a\u00a0national research network designed to increase organ and tissue donation in Canada and enhance the survival and quality of life of Canadians who receive transplants.<\/p>\n<p><strong><a href=\"https:\/\/www.fondationleducq.org\/network\/mibava-mechanistic-interrogation-of-bicuspid-aortic-valve-associated-aortopathy\/\" target=\"_blank\" rel=\"noopener noreferrer\">MIBAVA<\/a><\/strong> &#8211; Mechanistic Interrogation of Bicuspid Aortic Valve associated Aortopathy. The MIBAVA network is a research network program established to identify factors that affect the clinical outcome of patients with BAV, with particular attention to the progression of aortic aneurysm.<\/p>\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01805778\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>PCS2<\/strong><\/a> &#8211; Preventing Cardiac Sequelae in Paediatric Cancer Survivors &#8211; This is a multi-centre observational cohort study addressing the current limitations in prediction and early diagnosis of anthracycline-induced heart disease using studies based on biomarkers, genomics and cardiac imaging.[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/3&#8243; el_class=&#8221;Seema Mital, MD, FACC, FAHA, FRCP(C)&#8221;][vc_single_image image=&#8221;150&#8243; img_size=&#8221;medium&#8221; style=&#8221;vc_box_shadow_border&#8221; image_hovers=&#8221;false&#8221;][vc_column_text]Seema Mital, MD, FACC, FAHA, FRCP(C) The Hospital for Sick Children Head \u2013 Cardiovascular Research Staff Cardiologist \u2013 Heart Function and Transplant Program Research Institute Senior Scientist \u2013 Genetics &amp; Genome Biology Professor \u2013 University of Toronto, Pediatrics Chair Position Heart &amp; Stroke Foundation&hellip;<\/p>\n","protected":false},"author":45,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Home - Mital Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/mital\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Home\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=&#8221;1\/3&#8243; el_class=&#8221;Seema Mital, MD, FACC, FAHA, FRCP(C)&#8221;][vc_single_image image=&#8221;150&#8243; img_size=&#8221;medium&#8221; style=&#8221;vc_box_shadow_border&#8221; image_hovers=&#8221;false&#8221;][vc_column_text]Seema Mital, MD, FACC, FAHA, FRCP(C) The Hospital for Sick Children Head \u2013 Cardiovascular Research Staff Cardiologist \u2013 Heart Function and Transplant Program Research Institute Senior Scientist \u2013 Genetics &amp; Genome Biology Professor \u2013 University of Toronto, Pediatrics Chair Position Heart &amp; Stroke Foundation&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/mital\/\" \/>\n<meta property=\"og:site_name\" content=\"Mital Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-13T17:34:38+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/mital\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/mital\/\",\"name\":\"Home - Mital Lab\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/mital\/#website\"},\"datePublished\":\"2015-12-21T17:26:19+00:00\",\"dateModified\":\"2026-02-13T17:34:38+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/mital\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lab.research.sickkids.ca\/mital\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/mital\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lab.research.sickkids.ca\/mital\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Home\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/mital\/#website\",\"url\":\"https:\/\/lab.research.sickkids.ca\/mital\/\",\"name\":\"Mital Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lab.research.sickkids.ca\/mital\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Home - Mital Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lab.research.sickkids.ca\/mital\/","og_locale":"en_US","og_type":"article","og_title":"Home","og_description":"[vc_row][vc_column width=&#8221;1\/3&#8243; el_class=&#8221;Seema Mital, MD, FACC, FAHA, FRCP(C)&#8221;][vc_single_image image=&#8221;150&#8243; img_size=&#8221;medium&#8221; style=&#8221;vc_box_shadow_border&#8221; image_hovers=&#8221;false&#8221;][vc_column_text]Seema Mital, MD, FACC, FAHA, FRCP(C) The Hospital for Sick Children Head \u2013 Cardiovascular Research Staff Cardiologist \u2013 Heart Function and Transplant Program Research Institute Senior Scientist \u2013 Genetics &amp; Genome Biology Professor \u2013 University of Toronto, Pediatrics Chair Position Heart &amp; Stroke Foundation&hellip;","og_url":"https:\/\/lab.research.sickkids.ca\/mital\/","og_site_name":"Mital Lab","article_modified_time":"2026-02-13T17:34:38+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/lab.research.sickkids.ca\/mital\/","url":"https:\/\/lab.research.sickkids.ca\/mital\/","name":"Home - Mital Lab","isPartOf":{"@id":"https:\/\/lab.research.sickkids.ca\/mital\/#website"},"datePublished":"2015-12-21T17:26:19+00:00","dateModified":"2026-02-13T17:34:38+00:00","breadcrumb":{"@id":"https:\/\/lab.research.sickkids.ca\/mital\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/lab.research.sickkids.ca\/mital\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/lab.research.sickkids.ca\/mital\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/lab.research.sickkids.ca\/mital\/"},{"@type":"ListItem","position":2,"name":"Home"}]},{"@type":"WebSite","@id":"https:\/\/lab.research.sickkids.ca\/mital\/#website","url":"https:\/\/lab.research.sickkids.ca\/mital\/","name":"Mital Lab","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/lab.research.sickkids.ca\/mital\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/lab.research.sickkids.ca\/mital\/wp-json\/wp\/v2\/pages\/7","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.research.sickkids.ca\/mital\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lab.research.sickkids.ca\/mital\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lab.research.sickkids.ca\/mital\/wp-json\/wp\/v2\/users\/45"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.research.sickkids.ca\/mital\/wp-json\/wp\/v2\/comments?post=7"}],"version-history":[{"count":16,"href":"https:\/\/lab.research.sickkids.ca\/mital\/wp-json\/wp\/v2\/pages\/7\/revisions"}],"predecessor-version":[{"id":790,"href":"https:\/\/lab.research.sickkids.ca\/mital\/wp-json\/wp\/v2\/pages\/7\/revisions\/790"}],"wp:attachment":[{"href":"https:\/\/lab.research.sickkids.ca\/mital\/wp-json\/wp\/v2\/media?parent=7"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}