2012 Publications

PMID | 22262731

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice. Uribe V, Wong BK, Graham RK, Cusack CL, Skotte NH, Pouladi MA, Xie Y, Feinberg K, Ou Y, Ouyang Y, Deng Y, Franciosi S, Bissada N, Spreeuw A, Zhang W, Ehrnhoefer DE, Vaid K, Miller FD, Deshmukh M, Howland D, Hayden MR. Hum Mol Genet. 2012 May 1;21(9):1954-67.

PMID | 22770240

Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Wang J, Gallagher D, DeVito LM, Cancino GI, Tsui D, He L, Keller GM, Frankland PW, Kaplan DRMiller FD. Cell Stem Cell. 2012 Jul 6;11(1):23-35

PMID | 22902294

An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells. Vessey JP, Amadei G, Burns SE, Kiebler MA, Kaplan DRMiller FD. Cell Stem Cell. 2012 Oct 5;11(4):517-28

PMID | 22704501

Mobilizing endogenous stem cells for repair and regeneration: are we there yet? Miller FDKaplan DR. Cell Stem Cell. 2012 Jun 14;10(6):650-2.

2011 Publications

PMID | 21259316

Endogenous microglia regulate development of embryonic cortical precursor cells.  Antony J.M., Paquin A., Nutt S.L., Kaplan D.R., and Miller F.D. (2011) J. Neurosci. Res. 89, 286-298.

PMID | 21884984

Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis. Raj B, O’Hanlon D, Vessey JP, Pan Q, Ray D, Buckley NJ, Miller FD, Blencowe BJ. Mol Cell. 2011 Sep 2;43(5):843-50.

PMID | 21884984

Directed differentiation of skin-derived precursors into functional vascular smooth muscle cells. Steinbach SK, El-Mounayri O, DaCosta RS, Frontini MJ, Nong Z, Maeda A, Pickering JG, Miller FD, Husain M. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2938-48.

PMID | 21208905

Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition. Castelo-Branco P, Zhang C, Lipman T, Fujitani M, Hansford L, Clarke I, Harley CB, Tressler R, Malkin D, Walker E, Kaplan DR, Dirks P, Tabori U. Clin Cancer Res. 2011 Jan 1;17(1):111-21.

PMID | 21303981

Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. Grinshtein N, Datti A, Fujitani M, Uehling D, Prakesch M, Isaac M, Irwin MS, Wrana JL, Al-Awar R, Kaplan DR. Cancer Res. 2011 Feb 15;71(4):1385-95.

PMID | 21965674

Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins. Chung J, Grant RI, Kaplan DR, Irwin MS. J Biol Chem. 2011 Nov 25;286(47):40671-80.

2010 Publications

PMID | 20152182

CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain. Wang J, Weaver IC, Gauthier-Fisher A, Wang H, He L, Yeomans J, Wondisford F, Kaplan DR, Miller FD. Dev Cell. 2010 Jan 19;18(1):114-25.

PMID | 20348920

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain. Park KJ, Grosso CA, Aubert I, Kaplan DR, Miller FD. Nat Neurosci. 2010 May;13(5):559-66.

PMID | 20194434

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, Itie-Youten A, Wakeham A, Arsenian-Henriksson M, Melino G, Kaplan DR, Miller FD, Mak TW. Genes Dev. 2010 Mar 15;24(6):549-60.

PMID | 20579725
PMID | 20584617

p75NTR is an obligate signalling receptor required for cues that cause sympathetic neuron growth cone collapse. Naska S., Lin D.C., Miller F.D., and Kaplan D.R. (2010) Mol. Cell. Neurosci. 45, 108-120.

PMID | 20721990

Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. Smith KM, Datti A, Fujitani M, Grinshtein N, Zhang L, Morozova O, Blakely KM, Rotenberg SA, Hansford LM, Miller FD, Yeger H, Irwin MS, Moffat J, Marra MA, Baruchel S, Wrana JL, Kaplan DR. EMBO Mol Med. 2010 Sep;2(9):371-84.

PMID | 20832397

Coffin-Lowry syndrome: a role for RSK2 in mammalian neurogenesis. Dugani CB, Paquin A, Kaplan DR, Miller FD. Dev Biol. 2010 Nov 15;347(2):348-59.

PMID | 20848654

Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins. Jinno H, Morozova O, Jones KL, Biernaskie JA, Paris M, Hosokawa R, Rudnicki MA, Chai Y, Rossi F, Marra MA, Miller FD. Stem Cells. 2010 Nov;28(11):2027-40.

PMID | 21074438

TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors. Fujitani M, Cancino GI, Dugani CB, Weaver IC, Gauthier-Fisher A, Paquin A, Mak TW, Wojtowicz MJ, Miller FD, Kaplan DR. Curr Biol. 2010 Nov 23;20(22):2058-65.

PMID | 20651058

System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma. Morozova O, Vojvodic M, Grinshtein N, Hansford LM, Blakely KM, Maslova A, Hirst M, Cezard T, Morin RD, Moore R, Smith KM, Miller F, Taylor P, Thiessen N, Varhol R, Zhao Y, Jones S, Moffat J, Kislinger T, Moran MF, Kaplan DR, Marra MA. Clin Cancer Res. 2010 Sep 15;16(18):4572-82.

PMID | 20829881

SATB2 augments ΔNp63α in head and neck squamous cell carcinoma. Chung J, Lau J, Cheng LS, Grant RI, Robinson F, Ketela T, Reis PP, Roche O, Kamel-Reid S, Moffat J, Ohh M, Perez-Ordonez B, Kaplan DR, Irwin MS. EMBO Rep. 2010 Oct;11(10):777-83.

PMID | 21246933

White matter repair: skin-derived precursors as a source of myelinating cells. Biernaskie J, Miller FD. Can J Neurol Sci. 2010 Sep;37 Suppl 2:S34-41.

HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells. Pietras A, Hansford LM, Johnsson AS, Bridges E, Sjölund J, Gisselsson D, Rehn M, Beckman S, Noguera R, Navarro S, Cammenga J, Fredlund E, Kaplan DR, Påhlman S. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16805-10.

CCM2 mediates death signaling by the TrkA receptor tyrosine kinase. Harel L, Costa B, Tcherpakov M, Zapatka M, Oberthuer A, Hansford LM, Vojvodic M, Levy Z, Chen ZY, Lee FS, Avigad S, Yaniv I, Shi L, Eils R, Fischer M, Brors B, Kaplan DR, Fainzilber M. Neuron. 2009 Sep 10;63(5):585-91.

p63 antagonizes p53 to promote the survival of embryonic neural precursor cells. Dugani CB, Paquin A, Fujitani M, Kaplan DR, Miller FD. J Neurosci. 2009 May 20;29(20):6710-21.

Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells. Gauthier-Fisher A, Lin DC, Greeve M, Kaplan DR, Rottapel R, Miller FD. Nat Neurosci. 2009 Jun;12(6):735-44.

In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model. Zhang L, Smith KM, Chong AL, Stempak D, Yeger H, Marrano P, Thorner PS, Irwin MS, Kaplan DR, Baruchel S. Neoplasia. 2009 May;11(5):426-35.

Costello syndrome H-Ras alleles regulate cortical development. Paquin A, Hordo C, Kaplan DR, Miller FD. Dev Biol. 2009 Jun 15;330(2):440-51.

Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair. Lavoie JF, Biernaskie JA, Chen Y, Bagli D, Alman B, Kaplan DR, Miller FD. Stem Cells Dev. 2009 Jul-Aug;18(6):893-906.

SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells. Biernaskie J, Paris M, Morozova O, Fagan BM, Marra M, Pevny L, Miller FD. Cell Stem Cell. 2009 Dec 4;5(6):610-23.

TAp63 prevents premature aging by promoting adult stem cell maintenance. Su X, Paris M, Gi YJ, Tsai KY, Cho MS, Lin YL, Biernaskie JA, Sinha S, Prives C, Pevny LH, Miller FD, Flores ER. Cell Stem Cell. 2009 Jul 2;5(1):64-75.

Home at last: neural stem cell niches defined. Miller FD, Gauthier-Fisher A. Cell Stem Cell. 2009 Jun 5;4(6):507-10.

Isolation, expansion, and differentiation of mouse skin-derived precursors. Fernandes KJ, Miller FD. Methods Mol Biol. 2009;482:159-70.

p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer’s disease. Wetzel MK, Naska S, Laliberté CL, Rymar VV, Fujitani M, Biernaskie JA, Cole CJ, Lerch JP, Spring S, Wang SH, Frankland PW, Henkelman RM, Josselyn SA, Sadikot AF, Miller FD, Kaplan DR. Neuron. 2008 Sep 11;59(5):708-21.

Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype. Bisson N, Tremblay M, Robinson F, Kaplan DR, Trusko SP, Moss T. Cell Cycle. 2008 Apr 1;7(7):909-16.

Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Singh KK, Park KJ, Hong EJ, Kramer BM, Greenberg ME, Kaplan DR, Miller FD. Nat Neurosci. 2008 Jun;11(6):649-58.

Rap1 is involved in the signal transduction of myelin-associated glycoprotein. Taniguchi J, Fujitani M, Endo M, Kubo T, Fujitani M, Miller FDKaplan DR, Yamashita T. Cell Death Differ. 2008 Feb;15(2):408-19.

Regenerating your senses: multiple roles for neurogenesis in the adult brain. Frankland PW, Miller FD. Nat Neurosci. 2008 Oct;11(10):1124-6.

Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential. Fernandes KJ, Toma JG, Miller FD. Philos Trans R Soc Lond B Biol Sci. 2008 Jan 12;363(1489):185-98. Review.

Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. Hansford LM, McKee AE, Zhang L, George RE, Gerstle JT, Thorner PS, Smith KM, Look AT, Yeger H, Miller FD, Irwin MS, Thiele CJ, Kaplan DR. Cancer Res. 2007 Dec 1;67(23):11234-43.

Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development. Bartkowska K, Paquin A, Gauthier AS, Kaplan DR, Miller FD. Development. 2007 Dec;134(24):4369-80.

Developing with BDNF: a moving experience. Kaplan DR, Miller FD. Neuron. 2007 Jul 5;55(1):1-2.

Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome. Gauthier AS, Furstoss O, Araki T, Chan R, Neel BG, Kaplan DRMiller FD. Neuron. 2007 Apr 19;54(2):245- 62.

AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Quevedo C, Kaplan DR, Derry WB. Curr Biol. 2007 Feb 6;17(3):286-92.

To die or not to die: neurons and p63. Miller FDKaplan DR. Cell Cycle. 2007 Feb 1;6(3):312-7. Epub 2007 Feb 3. Review.

Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma. Lau L, Hansford LM, Cheng LS, Hang M, Baruchel S, Kaplan DR, Irwin MS. Oncogene. 2007 Mar 22;26(13):1920-31. Epub 2006 Sep 18.

Riding the waves: neural and nonneural origins for mesenchymal stem cells. Miller FD. Cell Stem Cell. 2007 Aug 16;1(2):129-30.

Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury. Biernaskie J, Sparling JS, Liu J, Shannon CP, Plemel JR, Xie Y, Miller FD, Tetzlaff W. J Neurosci. 2007 Sep 5;27(36):9545-59.

Timing is everything: making neurons versus glia in the developing cortex. Miller FD, Gauthier AS. Neuron. 2007 May 3;54(3):357-69. Review.

An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth. Naska S, Park KJ, Hannigan GE, Dedhar S, Miller FD, Kaplan DR. J Neurosci. 2006 Dec 20;26(51):13344-56

APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Lin DC, Quevedo C, Brewer NE, Bell A, Testa JR, Grimes ML, Miller FD, Kaplan DR. Mol Cell Biol. 2006 Dec;26(23):8928-41. Epub 2006 Sep 25

The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons. Hibbert AP, Kramer BM, Miller FD, Kaplan DR. Mol Cell Neurosci. 2006 Aug;32(4):387-402. Epub 2006 Jul 14.

The p53 family in nervous system development and disease. Jacobs WB, Kaplan DR, Miller FD. J Neurochem. 2006 Jun;97(6):1571-84. Review.

Analysis of the neurogenic potential of multipotent skin-derived precursors. Fernandes KJ, Kobayashi NR, Gallagher CJ, Barnabé-Heider F, Aumont A, Kaplan DR, Miller FD. Exp Neurol. 2006 Sep;201(1):32-48. Epub 2006 May 5.

When a motor goes bad: a kinesin regulates neuronal survival. Kaplan DR, Miller FD. Cell. 2006 Apr 21;125(2):224-6.

Isolation of skin-derived precursors (SKPs) and differentiation and enrichment of their Schwann cell progeny. Biernaskie JA, McKenzie IA, Toma JG, Miller FD. Nat Protoc. 2006;1(6):2803-12.

Skin-derived precursors generate myelinating Schwann cells for the injured and dysmyelinated nervous system. McKenzie IA, Biernaskie J, Toma JG, Midha R, Miller FD. J Neurosci. 2006 Jun 14;26(24):6651-60.

Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins. Volosin M, Song W, Almeida RD, Kaplan DR, Hempstead BL, Friedman WJ. J Neurosci. 2006 Jul 19;26(29):7756-66.

p63 is an essential proapoptotic protein during neural development. Jacobs WB, Govoni G, Ho D, Atwal JK, Barnabe-Heider F, Keyes WM, Mills AA, Miller FD, Kaplan DR. Neuron. 2005 Dec 8;48(5):743-56.

Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1. Barnabé-Heider F, Wasylnka JA, Fernandes KJ, Porsche C, Sendtner M, Kaplan DR, Miller FD. Neuron. 2005 Oct 20;48(2):253-65.

TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism. Lavoie JF, Lesauteur L, Kohn J, Wong J, Furtoss O, Thiele CJ, Miller FD, Kaplan DR. J Biol Chem. 2005 Aug 12;280(32):29199-207. Epub 2005 Jun 16.

Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. Torkin R, Lavoie JF, Kaplan DR, Yeger H. Mol Cancer Ther. 2005 Jan;4(1):1-11.

CCAAT/enhancer-binding protein phosphorylation biases cortical precursors to generate neurons rather than astrocytes in vivo. Paquin A, Barnabé-Heider F, Kageyama R, Miller FD. J Neurosci. 2005 Nov 16;25(46):10747-58.

A transcriptional role for C/EBP beta in the neuronal response to axonal injury. Nadeau S, Hein P, Fernandes KJ, Peterson AC, Miller FD. Mol Cell Neurosci. 2005 Aug;29(4):525-35.

Isolation and characterization of multipotent skin-derived precursors from human skin. Toma JG, McKenzie IA, Bagli D, Miller FD. Stem Cells. 2005 Jun-Jul;23(6):727-37

Activity regulates positive and negative neurotrophin-derived signals to determine axon competition. Singh KK, Miller FD. Neuron. 2005 Mar 24;45(6):837-45.

Role for Runx1 in the proliferation and neuronal differentiation of selected progenitor cells in the mammalian nervous system. Theriault FM, Nuthall HN, Dong Z, Lo R, Barnabe-Heider F, Miller FD, Stifani S. J Neurosci. 2005 Feb 23;25(8):2050-61.

A dermal niche for multipotent adult skin-derived precursor cells. Fernandes KJ, McKenzie IA, Mill P, Smith KM, Akhavan M, Barnabé-Heider F, Biernaskie J, Junek A, Kobayashi NR, Toma JG, Kaplan DR, Labosky PA, Rafuse V, Hui CC, Miller FD. Nat Cell Biol. 2004 Nov;6(11):1082-93. Erratum in: Nat Cell Biol. 2005 May;7(5):531.

The invulnerability of adult neurons: a critical role for p73. Walsh GS, Orike N, Kaplan DR, Miller FD. J Neurosci. 2004 Oct 27;24(43):9638-47.

Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. Lee AF, Ho DK, Zanassi P, Walsh GS, Kaplan DR, Miller FD. J Neurosci. 2004 Oct 13;24(41):9174-84.

Neuronal MEK is important for normal fear conditioning in mice. Shalin SC, Zirrgiebel U, Honsa KJ, Julien JP, Miller FD, Kaplan DR, Sweatt JD. J Neurosci Res. 2004 Mar 15;75(6):760-70.

Neurobiology: a move to sort life from death. Kaplan DR, Miller FD. Nature. 2004 Feb 26;427(6977):798-9. No abstract available.

Neuronal survival and p73/p63/p53: a family affair. Jacobs WB, Walsh GS, Miller FD. Neuroscientist. 2004 Oct;10(5):443-55. Review.

SRC regulates actin dynamics and invasion of malignant glial cells in three dimensions. Angers-Loustau A, Hering R, Werbowetski TE, Kaplan DR, Del Maestro RF. Mol Cancer Res. 2004 Nov;2(11):595-605.

ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. Subramaniam S, Zirrgiebel U, von Bohlen Und Halbach O, Strelau J, Laliberté C, Kaplan DR, Unsicker K., J Cell Biol. 2004 May 10;165(3):357-69. Epub 2004 May 3.

SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase. Marsh HN, Dubreuil CI, Quevedo C, Lee A, Majdan M, Walsh GS, Hausdorff S, Said FA, Zoueva O, Kozlowski M, Siminovitch K, Neel BG, Miller FD, Kaplan DR. J Cell Biol. 2003 Dec 8;163(5):999-1010.

Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse. Atwal JK, Singh KK, Tessier-Lavigne M, Miller FD, Kaplan DR. J Neurosci. 2003 Aug 20;23(20):7602-9.

Signaling mechanisms underlying dendrite formation. Miller FD, Kaplan DR. Curr Opin Neurobiol. 2003 Jun;13(3):391-8. Review.

Axon growth inhibition: signals from the p75 neurotrophin receptor. Kaplan DR, Miller FD. Nat Neurosci. 2003 May;6(5):435-6. No abstract available.

TrkB receptor signaling regulates developmental death dynamics, but not final number, of retinal ganglion cells. Pollock GS, Robichon R, Boyd KA, Kerkel KA, Kramer M, Lyles J, Ambalavanar R, Khan A, Kaplan DR, Williams RW, Frost DO. J Neurosci. 2003 Nov 5;23(31):10137-45.

Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1. Nguyen MD, Boudreau M, Kriz J, Couillard-Després S, Kaplan DR, Julien JP. J Neurosci. 2003 Mar 15;23(6):2131-40.

Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways. Barnabé-Heider F, Miller FD. J Neurosci. 2003 Jun 15;23(12):5149-60.

Neurobiology. TRK makes the retrograde. Miller FD, Kaplan DR. Science. 2002 Feb 22;295(5559):1471-3

N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. Wartiovaara K, Barnabe-Heider F, Miller FD, Kaplan DR. J Neurosci. 2002 Feb 1;22(3):815-24.

Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3′-kinase pathway. Jaboin J, Kim CJ, Kaplan DR, Thiele CJ. Cancer Res. 2002 Nov 15;62(22):6756-63.

The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism. Makris C, Voisin L, Giasson E, Tudan C, Kaplan DR, Meloche S. Oncogene. 2002 Nov 7;21(51):7891-6.

Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes. Senger DL, Tudan C, Guiot MC, Mazzoni IE, Molenkamp G, LeBlanc R, Antel J, Olivier A, Snipes GJ, Kaplan DR. Cancer Res. 2002 Apr 1;62(7):2131-40.

An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis. Ménard C, Hein P, Paquin A, Savelson A, Yang XM, Lederfein D, Barnabé-Heider F, Mir AA, Sterneck E, Peterson AC, Johnson PF, Vinson C, Miller FD. Neuron. 2002 Nov 14;36(4):597-610.

p73 is required for survival and maintenance of CNS neurons. Pozniak CD, Barnabé-Heider F, Rymar VV, Lee AF, Sadikot AF, Miller FD. J Neurosci. 2002 Nov 15;22(22):9800-9.

Signaling mechanisms underlying reversible, activity-dependent dendrite formation. Vaillant AR, Zanassi P, Walsh GS, Aumont A, Alonso A, Miller FD. Neuron. 2002 Jun 13;34(6):985-98.

Thyroid hormone-dependent regulation of Talpha1 alpha-tubulin during brain development. Lorenzo PI, Ménard C, Miller FD, Bernal J. Mol Cell Neurosci. 2002 Mar;19(3):333-43.