Dr. David Kaplan
David Kaplan, PhD, is a molecular and cellular neurobiologist focused on cell signalling. He is a Senior Scientist at The Hospital for Sick Children (SickKids) Research Institute and Professor in the Department of Molecular Genetics at the University of Toronto. A native New Yorker, he obtained his bachelor of arts from Clark University, his PhD from Harvard University, and completed his postdoctoral training at the University of California, San Francisco. He was formerly a laboratory head at the National Cancer Institute in Maryland, Head of the Brain Tumor Research Centre at McGill University, Head of the Cancer Research Program at SickKids Research Institute in Toronto, and science chair of Brain Canada.
Among his honours are the Canada Research Chair (Tier I) in Cancer and Neuroscience, Barbara Turnbull Award for Spinal Cord Injury Research from the CIHR and Neuroscience Canada, William Feindel Chair in Neurooncology at the Montreal Neurological Institute/McGill University, and the Harold E. Johns Award for ‘Most Outstanding Applicant for a Canadian Cancer Society Research Scientist Award’ from the National Cancer Institute of Canada.
David shares a lab with his wife, Freda Miller, working on how stem cells build and maintain the brain, and discovering drugs that mobilize our stem cells to enhance and repair the aging or injured brain and skin, and to treat childhood cancers and adult brain tumors. He is best known for co-discovering, as a graduate student, the signalling protein PI3-kinase (Cell 1987), and discovering the Trk/Nerve Growth Factor receptor when his lab was at the NIH (Nature, Science 1990). He has published almost 200 research papers with over 40,000 citations. David, with Freda, founded the biotechnology companies Aegera Therapeutics and Reveille Inc. to bring their research discoveries in the cancer, nerve degeneration and stem cell fields to the clinic. David moved to Canada 20 years ago, attracted to the promised land of collaboration, great trainees, and perfect weather.