{"id":82,"date":"2019-01-28T18:00:24","date_gmt":"2019-01-28T18:00:24","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/mcglade\/?page_id=82"},"modified":"2022-12-05T17:12:13","modified_gmt":"2022-12-05T17:12:13","slug":"publications","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/mcglade\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_custom_heading text=&#8221;Publications&#8221; font_container=&#8221;tag:h1|text_align:center&#8221; google_fonts=&#8221;font_family:Lato%3A100%2C100italic%2C300%2C300italic%2Cregular%2Citalic%2C700%2C700italic%2C900%2C900italic|font_style:400%20regular%3A400%3Anormal&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_tta_accordion style=&#8221;modern&#8221; spacing=&#8221;1&#8243; gap=&#8221;1&#8243; c_icon=&#8221;chevron&#8221; active_section=&#8221;0&#8243; collapsible_all=&#8221;true&#8221;][vc_tta_section title=&#8221;2022&#8243; tab_id=&#8221;1586182361383-60dabca5-20f7&#8243;][vc_column_text]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41388-022-02225-w\" target=\"_blank\" rel=\"noopener\">Numb exon 9 inclusion regulates Integrin\u03b25 surface expression and promotes breast cancer metastasis.<\/a> Zhang, Y., Dho, S. E., Othman, K., Simpson, C. D., Lapierre, J., Bondoc, A.,<strong> McGlade, C. J.<\/strong> (2022).\u00a0 <i>Oncogene<\/i>,\u00a0<i>41<\/i>(14), 2079\u20132094.<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;2021&#8243; tab_id=&#8221;1663612162722-189976a2-5b1e&#8221;][vc_column_text]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022283621000747?via%3Dihub\" target=\"_blank\" rel=\"noopener\">SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function.<\/a> Wybenga-Groot, L. E., Tench, A. J., Simpson, C. D., Germain, J. S., Raught, B., Moran, M. F., <strong>McGlade, C. J.<\/strong> (2021).<i>Journal of molecular biology<\/i>,\u00a0<i>433<\/i>(8), 166880.<\/li>\n<li><a href=\"https:\/\/scripts.iucr.org\/cgi-bin\/paper?S2053230X21000911\" target=\"_blank\" rel=\"noopener\">Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL-SLAP2 crystal complex.<\/a> Wybenga-Groot, L. E., &amp; McGlade, C. J. (2021).\u00a0 <i>Acta crystallographica. Section F, Structural biology communications<\/i>,\u00a0<i>77<\/i>(Pt 2), 37\u201346.<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;2019&#8243; tab_id=&#8221;1663611740926-452b9803-2ec3&#8243;][vc_column_text]<\/p>\n<ul>\n<li class=\"citation-text\"><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2019.01020\/full\" target=\"_blank\" rel=\"noopener\">SLAP Is a Negative Regulator of Fc\u03b5RI Receptor-Mediated Signaling and Allergic Response<\/a>. Sharma, N., Ponce, M., Kaul, S., Pan, Z., Berry, D. M., Eiwegger, T., <strong>McGlade, C.J.<\/strong> (2019).<i>Frontiers in immunology<\/i>,\u00a0<i>10<\/i>, 1020.<\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41598-019-48902-x\" target=\"_blank\" rel=\"noopener\">Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.<\/a> Dho, S. E., Silva-Gagliardi, N., Morgese, F., Coyaud, E., Lamoureux, E., Berry, D. M., Raught, B., <strong>McGlade, C. J<\/strong>. (2019). <i>Scientific reports<\/i>,\u00a0<i>9<\/i>(1), 12471.<\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2472555222068204?via%3Dihub\" target=\"_blank\" rel=\"noopener\">Screening of Chemical Libraries Using a Yeast Model of Retinal Disease.<\/a>\u00a0 Scott, B. M., Wybenga-Groot, L. E., <strong>McGlade, C. J<\/strong>., Heon, E., Peisajovich, S. G., Chang, B. (2019). <i>SLAS discovery : advancing life sciences R &amp; D<\/i>,\u00a0<i>24<\/i>(10), 969\u2013977.<\/li>\n<\/ul>\n<div class=\"citation-actions\"><\/div>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;2018&#8243; tab_id=&#8221;1550697307199-599cc30c-6192&#8243;][vc_column_text]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30295974\" target=\"_blank\" rel=\"noopener\">E3 ubiquitin ligases LNX1 and LNX2 localize at neuronal gap junctions formed by connexin36 in rodent brain and molecularly interact with connexin36.<\/a> Lynn, B.D., Li, X., Hormuzdi, S.G., <u>Griffiths, E.K.<\/u>, <strong>McGlade, C.J.<\/strong> and J.I. Nagy. (2018) <em>. <\/em>European Journal of Neuroscience<strong>. <\/strong>Nov;48(9):3062-3081<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28981589\" target=\"_blank\" rel=\"noopener\">Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases.<\/a> Sapir, T., Levy, T., Kozer, N., Shin, I., Zamor, V., Haffner-Krausz, R., <strong>McGlade, C.J<\/strong>., Reiner, O. (2018). Cereb Cortex. Sep 1; 28(9):3115-3128<\/li>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0898656818301748\" target=\"_blank\" rel=\"noopener\">Tie2 signalling through Erk1\/2 regulates TLR4 driven inflammation<\/a>. Smith T.L., Van Slyke, P., Jones, N., Dumont, D.J., and <strong>McGlade, C.J.<\/strong> (2018). Cell Signal. Aug 2:51:211-221. Doi 10.1016\/j.cell sig.<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;2017&#8243; tab_id=&#8221;1550697307199-8f8994a5-5699&#8243;][vc_column_text]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28067668\" target=\"_blank\" rel=\"noopener\">Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation<\/a>. Hirai, M., <strong>McGlade, C. J<\/strong>. and Chen, J., and S. Evans. (2017) .\u00a0<strong>J Clin Invest.<\/strong>\u00a0 Feb 1;127(2):569-582. doi: 10.1172\/JCI91081. <em>Collaborator<\/em><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;2016&#8243; tab_id=&#8221;1550697311714-980e33a7-25cb&#8221;][vc_column_text]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27870829\" target=\"_blank\" rel=\"noopener\">Mouse Crumbs2 promotes the gastrulation epithelial-to-mesenchymal transition<\/a>. Ramkumar, N., Omelchenko, T., <u>Silva-Gagliardi, N.F.<\/u>, <strong>McGlade, C.J.,<\/strong> Winjholds, J., and K.V. Anderson. (2016). Nature Cell Biology,Dec;18(12):1281-1291.\u00a0<em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27960086\" target=\"_blank\" rel=\"noopener\">Integrated genomic and epi-genomic analysis identify subgroup specific therapeutic targets and CNS rhabdoid tumours<\/a>. Torchia, J, D. Picard D, K. C. Ho, L.-L. Cousin, C. E. Hawkins, D. A. Khuong Quang, T. S. Y. Chan, L. Letourneau, P. Hu, B. J. Golbourn, D. M. A. Gendoo, M. Barszczyk, M Sin-Chan P, M. Dzamba, A. M. Mezlini, M. Warmuth-Metz, M. Bourgey, S. Morrissy, Y.-S. Ra, C. P. Dunham, S. Yip, H.-k. Ng, J.-Q. Lu, S. Albrecht, J. Pimentel, J. Chan, C. C. Faria, L. Roque, B. Baskin, D. Birks, N. Foreman, D. Strother, A. Klekner, G. Miklos, P. Hauser, T. Hortob\u00e1gyi, B. Wilson, J. Hukin, A.-S. Caret, T. Van Meter, S.-H. Chiou, E. Hwang, H. Nakamura, H. Toledano, I. Fried, D. Fults, T. Wataya, C. Fryer, D. Eisenstat, K. Scheineman, D. Johnston, S. Zelcer, A. Fleming, N. Sirachainan, M. A. Barakzai, E. Kienha, A. Erdreich-Epstein, M. D. Krieger, J. Xu, G. D. Bader, <strong>C. J. McGlade<\/strong>, G. Bourque, A. Montpetit, D. Stephens, U. Sch\u00fcller, T. Tihan, T. Nicolaides, J. Phillips, S. Rutkowski, T. Pietsch, S.-K. Kim, J. T. Rutka, M. D. Taylor, P. Dirks, A Judkins, M. Brudno, E. Bouffet, J. Majewski, N. Jabado and A.Huang. Cancer Cell. (2016) Dec 12;30(6):891-908.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27041567\" target=\"_blank\" rel=\"noopener\">Oncogenic signaling through ERK regulates alternative splicing of Numb<\/a>. Rajendran, D. Zhang-Y, Berry, D.M. and <strong>C J. McGlad.\u00a0<\/strong>(2016). Oncogene,\u00a029;35(39):5202-13.<em>\u00a0<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27013196\" target=\"_blank\" rel=\"noopener\">Myc associated transforming protein JPO2 cooperates with LEDGF\/p75 to modulate AKT signaling<\/a>. Chan T., Hawkins, C.E.,<u> Krieger, J.R.<\/u>, <strong>McGlade<\/strong>, C.J. and A. Huang. (2016) .Cancer Research,\u00a06(9):2802-2812.<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;2015&#8243; tab_id=&#8221;1550697319138-8932df75-6d37&#8243;][vc_column_text]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26496195\" target=\"_blank\" rel=\"noopener\">Protein O-glucosyltransferase 1 (Poglut1) is required for the activity of Crumbs2 during mouse gastrulation.<\/a> Ramkumar, N., Lee, J.D., Harvey, B.M., <u>Silva-Gagliardi, N.F<\/u>., <strong>McGlade, C.J.,<\/strong> Haltiwanger, R.S., and K. V. Anderson. (2015). PLoS Genetics. 11(10):e1005551.\u00a0 <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25587033\" target=\"_blank\" rel=\"noopener\">Tyrosine phosphorylation of the Lyn SH2 domain modulates its binding affinity and specificity<\/a>. Jin, L., <u>Wybenga-Groot, L.E.,<\/u> Tong, J., Taylor, P., <strong>McGlade, C.J<\/strong>., Minden, M., Trudel, S., and M.F. Moran. (2015). 14(3):695-706. Mol Cell Proteomics. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25446260\" target=\"_blank\" rel=\"noopener\">The SLAP adaptor proteins and regulation of receptor tyrosine kinase signaling<\/a><strong>.\u00a0<\/strong><u>Wybenga-Groot, L.E.<\/u> and <strong>C.J., McGlade.\u00a0<\/strong>(2015).\u00a0Cellular Signaling 27(2):267-274. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25403733\" target=\"_blank\" rel=\"noopener\">Comprehensive Phosphorylation Site Analysis of the Endocytic Adaptor Protein Numb<\/a>. <u>Krieger, J.R.,<\/u> Taylor, P., Moran, M.F. and <strong>C.J. McGlade.\u00a0<\/strong>(2015). Proteomics. 15(2-3):434-446. <em>Senior Responsible Author<\/em><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;2014&#8243; tab_id=&#8221;1550697317934-1b7779ef-cfa1&#8243;][vc_column_text]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24815189\" target=\"_blank\" rel=\"noopener\">Structural basis of Rad53 kinase activation by dimerization and activation segment exchange<\/a>. <u>Wybenga-Groot, L.E.,<\/u> Ho, C.S., Sweeney, F.D., Ceccarelli, D.F., <strong>McGlade, C.J.<\/strong>, Durocher, D., and F. Sicheri. (2014). Cell Signal 26(9):1825-1836.<em>, <\/em><em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24275455\" target=\"_blank\" rel=\"noopener\">The E3 ubiquitin ligase RNF126 ubiquitinates GGA3 and regulates the endosomal sorting of the CI-MPR.<\/a>\u00a0<u>Smith C. J.<\/u> and <strong>C. J. McGlade.\u00a0<\/strong>(2014). Exp Cell Res<strong>.<\/strong> \u00a0320(2):219-232. <em>Senior Responsible Author <\/em><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;2013&#8243; tab_id=&#8221;1550697316764-8361928b-505c&#8221;][vc_column_text]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24018043\" target=\"_blank\" rel=\"noopener\">Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through beta-sheet formation<\/a>.<u> Wybenga-Groot. L.E.<\/u> and <strong>C. J. McGlade<\/strong> (2013). Cell Signal. Dec;25(12):2702-2708. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23399893\" target=\"_blank\" rel=\"noopener\">Gads (Grb2-related Adaptor Downstream of Shc) is Required for BCR-ABL mediated Lymphoid Leukemia.\u00a0<\/a>Gillis, L., <u>Berry, D.M.,<\/u> Minden, M.D., <strong>McGlade, C.J.<\/strong> and D.L. Barber (2013)Leukemia. 27(8):1666-1676. [Epub 2013 Feb 12.] <em>Co-Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23418353\" target=\"_blank\" rel=\"noopener\">The ubiquitin ligases RNF126 and RabRING7 regulate endosomal sorting of the Epidermal Growth Factor Receptor<\/a>. <u>Smith, C.J., Berry, D.M<\/u>., and <strong>C.J. McGlade.\u00a0<\/strong>(2013). J Cell Sci. 126:1366-1380. [Epub 2013 Feb 15.] <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23211419\" target=\"_blank\" rel=\"noopener\">Identification and SRM Quantification of Endocytosis Factors Associated with Numb Isoforms<\/a>.<em>\u00a0<\/em><u>Krieger, J.R.,<\/u> Taylor, Gajadar, A.S., Guha, A., P. Moran, M.F. and <strong>C.J. McGlade<\/strong>.(2013).\u00a0Mol. Cell. Proteomics<em>. <\/em>Feb;12(2):499-514. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23032369\" target=\"_blank\" rel=\"noopener\">Divergent lymphocyte signalling revealed by a powerful new tool for analysis of time lapse microscopy.<\/a> Pham K., Shimoni, R.,. Ludford-Menting, M.J., Nowell C.J., Lobachevsky, L., Bomzon, Z., Gu, M, Speed, T.P., <strong>McGlade, C.J<\/strong>., Russell, S.M. (2013) .Immunol Cell Biol. Jan;91(1):70-81. <em>Collaborator<\/em><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;2011&#8243; tab_id=&#8221;1550697315594-8b800dd2-0b76&#8243;][vc_column_text]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22087225\" target=\"_blank\" rel=\"noopener\">Biochemical and Computational analysis of the LNX1 interaction network<\/a>. <u>Wolting, C.D., Griffiths, E.K., Sarao, R. Prevost, B., Wybenga-Groot, L.,<\/u> and <strong>C.J. McGlade<\/strong>.\u00a0(2011).\u00a0 PLoS One 6(11):e26248.<em> Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21356309\" target=\"_blank\" rel=\"noopener\">Numb Regulates Notch1, but not Notch3, During Myogenesis<\/a>. Beres BJ, George R, Lougher EJ, Barton M, Verrelli BC, <strong>McGlade CJ<\/strong>, Rawls JA, Wilson-Rawls J. (2011) Mech Dev. 2011 128(5-6):247-257. <em>Collaborator<\/em><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21464220\" target=\"_blank\" rel=\"noopener\">A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas.<\/a> Agnihotri S, Wolf A, Munoz DM, <u>Smith CJ<\/u>, Gajadhar A, Restrepo A, Clarke ID, Fuller GN, Kesari S, Dirks PB, <strong>McGlade CJ<\/strong>, Stanford WL, Aldape K, Mischel PS, Hawkins C, Guha A. (2011). J Exp. Med. 2011 Apr 11;208(4):689-702. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21147098\" target=\"_blank\" rel=\"noopener\">Numb is a negative regulator of HGF dependent cell scattering and Rac1 activation<\/a>.<u> Lau, K.<\/u>, and <strong>C.J. McGlade.\u00a0<\/strong>(2011). Exp. Cell Res. 2011 15;317(4):539-551. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21041478\" target=\"_blank\" rel=\"noopener\">Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer<\/a>. Mesquitta-Ali, C.M., Cheng, E., Shai, O., Liu, N., <strong>McGlade, C.J<\/strong>., Tsao, M.S., and B.J. Blencowe. (2011). Mol Cell Biol. 2011 Jan;31(1):138-150. <em>Collaborator<\/em><\/li>\n<li>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21220694\" target=\"_blank\" rel=\"noopener\">The SLAP adaptor proteins regulate GM-CSF Receptor signaling and dendritic cell maturation<\/a>.\u00a0<u>Liontos LM<\/u>, Dissanayake D, Ohashi PS, Weiss A, Dragone LL, and <strong>CJ. McGlade.<\/strong> (2011). J Immunol. 15;186(4):1923-1933.<em> Senior Responsible Author<\/em><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;Past Publications&#8221; tab_id=&#8221;1550781882518-2b397160-bace&#8221;][vc_column_text]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19567869\" target=\"_blank\" rel=\"noopener\">Numb regulates post-endocytic trafficking and degradation of Notch1<\/a>.\u00a0<u>McGill, M.A<\/u>. <u>Dho, S.E.,<\/u> Weinmaster, G., and <strong>C.J. McGlade<\/strong>. (2009).\u00a0J. Biol. Chem 284(39):26427-26438. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/nature08067\" target=\"_blank\" rel=\"noopener\">Yurt, Coracle, NeurexinIV and the Na(+), K(+)-ATPase form a novel group of epithelial polarity proteins<\/a>. Laprise, P., <u>Lau, K.,<\/u> Harris, K.P., <u>Silva-Gagliardi, N.,<\/u> Paul, S.M., Beronja, S., Beitel, G.J., <strong>McGlade, C.J<\/strong>., and U. Tepass. (2009) Y Nature. 459(7250):1141-1145. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2710801\/\" target=\"_blank\" rel=\"noopener\">Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2<\/a>. Hughes CE, Auger JM, <strong>McGlade J<\/strong>, Eble JA, Pearce AC, Watson SP. (2008) . J Thromb Haemost. 2008 Dec;6(12):2152-2159 <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17988153\" target=\"_blank\" rel=\"noopener\">Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenillin complex in culture cells.<\/a> Pardossi-Piquard, R., Chen, F., <u>Silva-Gagliardi,<\/u> N.F., Szego, M., McInnes, R., <strong>McGlade, C.J<\/strong>., St George-Hyslop, P., and P.E. Fraser. (2007) . Biochemistry 48:13704-13710. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17353186\" target=\"_blank\" rel=\"noopener\">SLAP-2 mediates c-Cbl dependent down regulation of Colony Stimulating Factor-1 Receptor signaling<\/a>. <u>Pakuts, B. Debonneville, C., Liontos, L.M., Loreto, M.P<\/u>., and <strong>C.J. McGlade<\/strong> (2007) .\u00a0<strong> J. Biol. Chem<\/strong>. 282:17953-17963<em>. Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17507402\" target=\"_blank\" rel=\"noopener\">The FERM protein Epb4.1l5 is required for organization of the neural plate and the epithelial-mesenchymal transition at the primitive streak of the mouse<\/a>. Lee, J.D., <u>Silva-Gagliardi, N.F<\/u>., Tepass, U., <strong>McGlade, C..J<\/strong>., and K.V. Anderson. (2007) . Development. 134(11):2007-2016. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.cell.com\/current-biology\/fulltext\/S0960-9822(02)01038-2?script=true\" target=\"_blank\" rel=\"noopener\">TCR signaling requires a high affinity interaction between Gads C-SH3 domain and the SLAP-76 RXXK motif<\/a>. Seet, B.T., <u>Berry, D.M<\/u>., Maltzman, J., Shabason, J., Raina, M., Koretzky, G.A., <strong>McGlade, C.J<\/strong>., and T. Pawson. (2007). EMBO J 26:678-689. <em>Collaborato<\/em>r<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17203073\" target=\"_blank\" rel=\"noopener\">aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb<\/a>. <u>Smith, CA., Lau, K.,<\/u> Rahmani, Z., <u>Dho, SE,<\/u> Brothers, G., She, Y., Bonneil, E., Thibault, P., <u>Berry, DM<\/u>, Le Borgne<sup>. <\/sup>R., Shweisguth, F., and <strong>C.J. McGlade.<\/strong>(2007). EMBO J. Jan 24;26(2):468-80. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16998530\" target=\"_blank\" rel=\"noopener\">PTP1B and TC-PTP: Novel roles in immune cell signaling<\/a>. <u>Simoncic, PD<\/u>. <strong>McGlade, CJ<\/strong>., and ML. Tremblay (2006) PTP1B and TC-PTP:\u00a0 Can J Physiol. Pharm. 2006 Jul;84(7):667-75 <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-7-338\" target=\"_blank\" rel=\"noopener\">Cluster analysis of protein array results via similarity of gene ontology annotation<\/a>. <u>Wolting<\/u>, C., <strong>McGlade, CJ<\/strong>., and D. Tritchler. (2006) BMC Bioinformatics, 7:338\u00a0<em>Co-author (CW supervisor)<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1593178\/\" target=\"_blank\" rel=\"noopener\">Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane<\/a>. <u>Dho, S.E.,<\/u> Siderovski, D.P., Trejo, J., and <strong>C. J. McGlade<\/strong> (2006) Mol Biol. Cell Sep;17(9):4142-55 <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16950127\" target=\"_blank\" rel=\"noopener\">The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size.<\/a> Laprise, P. Beronja, S., <u>Silva-Gagliardi, N.,<\/u> Pellikka, M., Jensen, A., <strong>McGlade, C.J<\/strong>. and U. Tepass. (2006). Dev. Cell, 11(3):363-374. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16705167\" target=\"_blank\" rel=\"noopener\">T-cell Protein Tyrosine Phosphatase (Tcptp) is a negative regulator of CSF-1 signaling and mononuclear\u00a0 phagocyte development<\/a>. <u>Simoncic, D.P<\/u>., Bourdeau, A., Lee-Loy, A., Rohrschneider, L.R., Tremblay, M.L., Stanley, E.R. and <strong>C.J. McGlade<\/strong>. (2006)\u00a0\u00a0Mol. Cell Biol.\u00a0 26:4149-4160. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16122940\" target=\"_blank\" rel=\"noopener\">LNX1 is a perisynaptic Schwann cell specific E3 ubiquitin ligase that interacts with ErbB2<\/a>. Young, P., <u>Nie, J<\/u>., Wang, X., <strong>McGlade, CJ<\/strong>., Rich, MM., G. Feng. (2005)\u00a0 Mol. Cell. Neuroscience, 30(2):238-248. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15381729\" target=\"_blank\" rel=\"noopener\">The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades<\/a>. Zhu, Y.X., <u>Benn, S.<\/u>, Li, Z.H., Wei, E., Masih-Khan, E., Trieu, Y., Bali, M., <strong>McGlade, C.J<\/strong>., Claudio, J.O., and A.K. Stewart. (2004)\u00a0 J. Exp. Med. 200(6):737-747.<em> Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15155807\" target=\"_blank\" rel=\"noopener\">The cell fate determinant Numb interacts with EHD\/Rme-1 family proteins and has a role in endocytic recycling<\/a>. <u>Smith, C.A., Dho, S.E<\/u>., and <strong>C.J. McGlade<\/strong>. (2004).\u00a0 Mol. Biol<em>. <\/em>Cell.15: 3698-3708.<em>\u00a0 Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14990566\" target=\"_blank\" rel=\"noopener\">A novel PTB-PDZ domain interaction mediates isoform-specific ubiquitylation of mammalian Numb<\/a><strong><em>.\u00a0<\/em><\/strong><u>J. Nie,<\/u> S.C. Li and <strong>C. J. McGlade<\/strong>. (2004). J. Biol. Chem. 279:20807-20815. <em>\u00a0Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12682059\" target=\"_blank\" rel=\"noopener\">Mammalian Numb proteins inhibit Notch nuclear activity and promote Notch ubiquitination<\/a><strong>.\u00a0<\/strong><u>McGill, M.A.<\/u> and <strong>McGlade C.J<\/strong>. (2003). J. Biol<em>.<\/em> Chem. 278:23196-203. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12654726\" target=\"_blank\" rel=\"noopener\">Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity<\/a>. Salmena, L., Lemmers, B.,\u00a0 Hakem, A.,\u00a0 Matysiak-Zablocki, E., Murakami, K., Au, P-Y.B., <u>Berry, DM<\/u>.,\u00a0\u00a0 Tamblyn, L., Shehabeldin,\u00a0 A.,\u00a0 Migon, E.,\u00a0 Wakeham, A.,\u00a0 Bouchard,\u00a0 D., Yeh, W-C.,\u00a0 <strong>McGlade,\u00a0 C.J<\/strong>., Ohashi, P.S., and R. Hakem (2003). Genes Dev. 17(7):883-95. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12640133\" target=\"_blank\" rel=\"noopener\">Gads\/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells<\/a>. Yamasaki, S., Sakuma, Ritsuko, M., Shina-Suzuki, R., <u>Berry, D.<\/u> Nishida, K., Hirano, T., <strong>McGlade, CJ<\/strong> and Saito, T. (2003) . Mol. Cell. Biol<em>. <\/em>23:2515-29.<em> Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12606711\" target=\"_blank\" rel=\"noopener\">Integrin cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling<\/a>. Calderwood, DA, Fujioka, Y, de Pereda, JM, Garcia-Alvarez, B, Nakamoto, T, Margolis, B, <strong>McGlade, CJ<\/strong>, Liddington, RC and MH Ginsberg. (2003). Proc. Natl. Acad. Sci. USA. 100:2272-2277. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12620234\" target=\"_blank\" rel=\"noopener\">Structural Basis for Specific Binding of the Gads SH3 Domain to an RxxK Motif-Containing SLP-76 Peptide<\/a>. A Novel Mode of Peptide Recognition. Liu, Q., <u>Berry, D<\/u>., Nash P., Pawson, T., <strong>McGlade, CJ<\/strong>., Li, S-C. (2003)\u00a0 Molecular Cell. 11:471-481.<em> Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12500307\" target=\"_blank\" rel=\"noopener\">Involvement of numb in vertebrate retinal development: Evidence for multiple roles of numb in neural differentiation and maturation<\/a>. Dooley CM, James J, <strong>McGlade C.J<\/strong>., Ahmad I. (2003) J Neurobiol. 54:313-325 <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/1206114\" target=\"_blank\" rel=\"noopener\">Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform<\/a>.\u00a0<u>Loreto, M.P.<\/u>,<strong> McGlade, C.J. <\/strong>(2003) , SLAP-2-v. Oncogene.\u00a0 22: 266-273. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12356870\" target=\"_blank\" rel=\"noopener\">T cell receptor ligation induces the formation of signaling assemblies whose composition is dynamically regulated<\/a>. Bunnell, S., Hong, D., Kardon, J., Yamazaki, T., <strong>McGlade, C.J<\/strong>., Barr, V., and Samelson, L. (2002) . <strong>J. Cell. Biol.<\/strong> 158:1263-1275. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.cell.com\/abstract\/S0960-9822(02)01038-2\" target=\"_blank\" rel=\"noopener\">A novel, high affinity SH3-binding motif confers specificity for the interaction between Gads and SLP-76 in T-cell signaling<\/a>. <u>Berry, D.M<\/u>., Nash, P., <u>Liu, S. K-W<\/u>., Pawson, T., and <strong>McGlade, C.J<\/strong>. (2002)\u00a0 Curr Biol. 12:1336-1340. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/academic.oup.com\/neuro-oncology\/article\/4\/4\/242\/1239271\" target=\"_blank\" rel=\"noopener\">PI 3\u2019 Kinase and MEK1\/2 Differentially Regulate Expression of Vascular Endothelial Growth Factor in Human Malignant Astrocytoma Cell Lines<\/a>. <u>Woods, S.A<\/u>., <strong>McGlade, C.J<\/strong>., Guha, A. (2002)\u00a0 Neuro-oncol. 4:<strong>(<\/strong>4) 242-252. <em>Co-Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12024036\" target=\"_blank\" rel=\"noopener\">Functional cooperation between c-Cbl and Src-like adaptor protein SLAP-2 in the negative regulation of TCR signaling<\/a>. <u>Loreto, M.P., Berry, D.M.<\/u> and <strong>McGlade, C.J<\/strong>. (2002) Mol. Cell. Biol.<strong>,<\/strong> 22:4241-4255. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12011466\" target=\"_blank\" rel=\"noopener\">The gamma-secretase-generated intracellular domain of b-amyloid precursor protein binds to Numb and inhibits Notch signaling<\/a>. Roncarati, R., Sestan, N., Scheinfeld, M.H., Berechid, B.E., Lopez, P.A., Meucci, O., <strong>McGlade, C.J<\/strong>. Rakic, P., and D\u2019Adamio, L. (2002) Proc. Natl. Acad. Sci. 99:7107-7102. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11970899\" target=\"_blank\" rel=\"noopener\">Attenuation of leptin action and regulation of obesity by PTP1B<\/a>. Cheng. A., Uetani, N., <u>Simoncic, P.D<\/u>., Chaubet, V.P., Lee-Loy, A., <strong>McGlade, C.J<\/strong>., Kennedy, B.P., and Tremblay, M.L. (2002) Dev. Cell 2:497- 503. <em>Collaborator<\/em><\/li>\n<li><a href=\"http:\/\/www.jimmunol.org\/content\/168\/7\/3173\" target=\"_blank\" rel=\"noopener\">Transgenic expression of Numb in the thymus inhibits Notch signalling but does not alter T cell fate specification<\/a><em>.\u00a0<\/em><u>French M.B.<\/u>, Koch U. <u>McGill M.A., Dho S.E.<\/u>, Guidos C.J., and <strong>C.J. McGlade<\/strong>. (2002) <em>\u00a0<\/em>J. Immunol. 68:3173-80. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11850625\" target=\"_blank\" rel=\"noopener\">Crumbs, the Drosophila homologue of human CRB1\/RP12, is essential for photoreceptor morphogenesis<\/a>. Pellikka, M, Tanentzapf,G, Pinto, M, <u>Smith, CA<\/u>, <strong>McGlade, CJ<\/strong>, Ready, DF, and Tepass, U (2002) Nature 416:143-149. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11909529\" target=\"_blank\" rel=\"noopener\">The T-cell Protein Tyrosine Phosphatase is a negative regulator of Janus Family Kinases 1 and 3<\/a>. <u>Simoncic, D.P<\/u>., Barber, D.L., Tremblay, M.L. and <strong>C.J. McGlade<\/strong>. (2002)\u00a0 Curr. Biol. 19:446-53. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11782429\" target=\"_blank\" rel=\"noopener\">LNX functions as a RING-type E3 that targets the cell fate determinant Numb for ubiquitin-dependent degradation<\/a>. <u>Nie, J., McGill, M.A., Dermer, M., Dho, S.E., Wolting, C.D<\/u>., and <strong>C.J McGlade<\/strong>. (2002) EMBO J, 21: 93-102. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11607830\" target=\"_blank\" rel=\"noopener\">The role of Gads in hematopoietic cell signalling<\/a>. Oncogene, <u>Liu, S. K.-W., Berry, D.M.<\/u>, and <strong>McGlade, C.J<\/strong>. (2001)\u00a0 20:6284-6290. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11696324\" target=\"_blank\" rel=\"noopener\"><em>Neuralized <\/em>functions as an E3 ubiquitin ligase during <em>Drosophila<\/em> development<\/a>. Yeh, E., <u>Dermer, M.<\/u>, Zhou, L., Commisso, C. <strong>McGlade, C.J<\/strong>., Boulianne, G.L. (2001). Curr. Biol. 11:1675-1679. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11536050\" target=\"_blank\" rel=\"noopener\">HACS1 encodes a novel SH3-SAM adaptor differentially expressed in normal and malignant hematopoietic cells<\/a><em>.\u00a0<\/em>Claudio, J.O., Zhu, Y.X. <u>Benn, S.J., Shukla, H.<\/u>, <strong>McGlade, C.J<\/strong>., Falcioni, N. Stewart, A.K. (2001) \u00a0Oncogene 20:5373-5377. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/1204218\" target=\"_blank\" rel=\"noopener\">Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor.<\/a> <u>Berry, D.M., Benn, S.J<\/u>., Cheng, A., <strong>McGlade, C.J<\/strong>. (2001) Oncogene. 20:1203-1211. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11239162\" target=\"_blank\" rel=\"noopener\">Requirement for the SLP-76 adaptor Gads in T cell development<\/a>. Yoder, J., Pham, C., Matsubayashi, Y., <u>Liu, S.K<\/u>., <strong>McGlade, C.J<\/strong>., and A. Cheng. (2001) Science 291:1987-1991. <em>Co-Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11076972\">Apical, lateral and basal polarization cues contribute to the development of the follicular epithelium during <em>Drosophila<\/em> oogenesis<\/a>. Tanentzapf, G., <u>Smith, C.<\/u>, <strong>McGlade, C.J<\/strong>. and U. Tepass. (2000). J. Cell Biol. 151:891-904 <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10942756\" target=\"_blank\" rel=\"noopener\">Interaction of LAT with multiple adapter proteins in\u00a0 platelets\u00a0 activated by the GPVI selective ligand, convulxin<\/a>. Asazuma, N., J. I. Wilde, O. Berlanga, M. Leduc, A. Leo, E. Schweighoffer, V. Tybulewicz, C. Bon, <u>S.K. Liu<\/u>, <strong>C.J. McGlade<\/strong>, B. Schraven and S. P. Watson. (2000). J Biol Chem. 275:33427-33434 <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/m\/pubmed\/10903746\/\" target=\"_blank\" rel=\"noopener\">The Hematopoietic specific adaptor protein Gads is implicated in coupling HPK1 to the T-cell receptor<\/a>. <u>Liu, S.K., Smith, C.A.<\/u>, Kiefer, F. and <strong>C.J.McGlade<\/strong>. (2000). J. Imm. 165:1417-1426. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10811803\" target=\"_blank\" rel=\"noopener\">The association of Grb2, Gads and PLC-g with phosphorylated LAT tyrosine residues: the effect of tyrosine mutations on TCR-mediated signalling<\/a>. Zhang, W., Trible, R.P., Zhu, M., <u>Liu, S.K.,<\/u> <strong>McGlade, C.J<\/strong>., and L.E. Samelson. (2000)\u00a0 J. Biol. Chem. 275:23355-23361. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10551880\" target=\"_blank\" rel=\"noopener\">Differential expression and subcellular localization of mammalian Numb protein isoforms<\/a>. <u>Dho, S.E., French M.B., Woods S.A.<\/u>, and <strong>J.McGlade.<\/strong> (1999). J. Biol. Chem<em>.<\/em> 274: 33097-33104. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10086341\" target=\"_blank\" rel=\"noopener\">Cloning and characterization of mPAL, a unique Shc binding protein expressed in proliferating cells<\/a>. <u>Schmandt, R, Liu, S.K.,<\/u> and <strong>C.J. McGlade<\/strong> (1999). Oncogene 18:1867-1880. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10021361\" target=\"_blank\" rel=\"noopener\">The hematopoietic-specific adaptor protein, Gads functions in T cell receptor signaling through interactions with SLP-76 and LAT.<\/a> <u>Liu S. K.<\/u>, N. Fang, <u>D. Bouchard<\/u>, G. A. Koretzky, and <strong>C. J. McGlade<\/strong> (1999).\u00a0\u00a0Curr. Biol. 9: 78-88. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9872323\" target=\"_blank\" rel=\"noopener\">Gads is a novel SH2 and SH3 domain containing adaptor protein that binds to tyrosine phosphorylated Shc<\/a>. <u>Liu, S.K.<\/u> and <strong>C.J. McGlade<\/strong>. (1998).\u00a0 Oncogene 17:3073-3082.<em> Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9846878\" target=\"_blank\" rel=\"noopener\">Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity<\/a>. Li, S.-C., C. Zwahlen, S.J.F. Vincent, <strong>C.J. McGlade<\/strong>, L.E. Kay, T. Pawson, and J.D. Forman-Kay. (1998)\u00a0 Nature Structure 5:1075-1083. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9535908\" target=\"_blank\" rel=\"noopener\">The mNumb PTB(PI) Domain: Characterization of Binding Specificity and Identification of a Numb Binding Protein<\/a>. <u>Dho, S., Jacob, S., French, M., C., Wolting<\/u>, Rohrschneider, L., and <strong>C.J. McGlade<\/strong>.(1998) (1998) J. Biol. Chem. 273:9179-9187. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9585435\" target=\"_blank\" rel=\"noopener\">Cloning and chromosomal localization of TIC, a new member of the bHLH\/PAS family of transcription factors<\/a>. <u>Wolting, C.<\/u> and <strong>C.J. McGlade<\/strong>.(1998). Mammalian Genome. 9:463-468. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/j.1460-2075.1996.tb00874.x\" target=\"_blank\" rel=\"noopener\">Requirement of phospholipase Cg , the tyrosine phosphorylation of SYP, the adapter proteins Shc and Nck for PDGF- induced DNA synthesis: evidence for the existence of Ras dependent and Ras-independent pathways<\/a>. Roche, S., <strong>J. McGlade<\/strong>, M. Jones, G.P. Gish, T. Pawson and S.A. Courtneidge. (1996)\u00a0 EMBO J. 15:4940-4948. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8805372\" target=\"_blank\" rel=\"noopener\">Mammalian NUMB is a novel signaling adapter protein that specifies neuronal cell fates<\/a>. Verdi, J., <u>R. Schmandt<\/u>, A. Bashirullah, <u>S. Jacob<\/u>, R. Salvino, C. Craig, H. Lipshitz, and <strong>C.J. McGlade<\/strong><u>.<\/u> (1996). Curr. Biol. 6:1134-1145. <em>Senior Responsible Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8646773\" target=\"_blank\" rel=\"noopener\">Drosophila Photoreceptor Axon Guidance and Targeting Requires the Dreadlocks SH2\/SH3 Adapter Protein.<\/a> Garrity, Y. Rao, I. Salecker, <strong>J. McGlade<\/strong>, T. Pawson, and S.L. Zipursky. (1996). Cell 85:639-650. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8665844\" target=\"_blank\" rel=\"noopener\">NEDD4 WW domains bind to the proline rich regions in the \u00df and g subunits of the epithelial sodium channel (ENaC) deleted in Liddle&#8217;s syndrome<\/a>. Staub, O., S. Dho, P. Henry, J. Correa, T. Ishikawa, <strong>J. McGlade<\/strong>, and D. Rotin. (1996)\u00a0 EMBO J. 15:2371-2380. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.researchgate.net\/publication\/296605496_Phosphotyrosine-independent_binding_of_SHC_to_the_NPLH_sequence_of_murine_protein-tyrosine_phosphatase-PEST_-_Evidence_for_extended_phosphotyrosine_binding_phosphotyrosine_interaction_domain_recogniti\" target=\"_blank\" rel=\"noopener\">Phosphotyrosine Independent binding of SHC to the NPLH Sequence of MPTP-PEST: Evidence for extended PTB\/PI Domain Recognition Specificity<\/a>. Charest, A., J. Wagner, <u>S. Jacob, <\/u><strong>C.J. McGlade<\/strong>, and M.L. Tremblay. (1996)\u00a0 J. Biol. Chem. 271:8424-8429. <em>Co-Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7651398\" target=\"_blank\" rel=\"noopener\">A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase<\/a>. Lai, K-M. V., J.P. Olivier, G.D. Gish, M. Henkemeyer, <strong>J. McGlade<\/strong>, and T. Pawson. (1995)\u00a0 Mol. Cell. Biol. 9:4810-4819. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8084588\" target=\"_blank\" rel=\"noopener\">Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins<\/a>. Salcini, A.E., <strong>J. McGlade<\/strong>, G. Pelicci, I. Nicoletti, T. Pawson and P.G. Pelicci. (1994)\u00a0\u00a0Oncogene. 9:2827-2836. <em>Co-Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7909355\" target=\"_blank\" rel=\"noopener\">Analysis of the role of Shc and Grb-2 proteins in signal transduction by the v-ErbB protein<\/a>. Meyer, S., K. LaBudda<strong>, J. McGlade<\/strong>, M.J. Hayman. (1994)\u00a0 Mol. Cell. Biol. 14:3253-3262. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8195171\" target=\"_blank\" rel=\"noopener\">Direct interaction between Shc and the PDGFb-receptor<\/a>. Yokote, K., S. Mori, K. Hansen, <strong>J. McGlade<\/strong>, T. Pawson, C.-H. Heldin, and L. Claesson-Welsh. (1994)\u00a0 J. Biol. Chem. 269:15337-15343. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7511210\" target=\"_blank\" rel=\"noopener\">Specific motifs recognized by the SH2 domains of csk, 3BP2, fes\/fps, Grb-2, SHPTP1, SHC, Syk and vav<\/a>. Songyang, Z., S.E. Shoelson, <strong>J. McGlade<\/strong>, P.Olivier, T. Pawson, R.X. Bustelo, H. Hanafusa, T. Yi, R. Ren, D. Baltimore, S. Ratnofsky, R.A. Feldman, and L.C. Cantley. (1994)\u00a0 Mol. Cell Biol. 14: 2777-2785. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8290264\" target=\"_blank\" rel=\"noopener\">Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase<\/a>. Crowe, A., <strong>J. McGlade<\/strong>, T. Pawson, and M. J. Hayman.(1994)\u00a0 Oncogene.9:537-544. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8134103\" target=\"_blank\" rel=\"noopener\">Immunolocaliation of the Nuk receptor tyrosine kinase suggests a role in segmental patterning of the brain and axonogenesis<\/a>. Henkemeyer, M., L.E.M. Marengere, <strong>J. McGlade<\/strong>, J. P. Olivier, R. A. Conlon, D. Holmyard, K. Letwin, and T. Pawson. (1994)\u00a0 Oncogene.9: 1001-1014. <em>Co-Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8103930\" target=\"_blank\" rel=\"noopener\">Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways<\/a>. Pawson, T., P. Olivier, M. Rozakis-Adcock, <strong>J. McGlade<\/strong>, and M. Henkemeyer. (1993)\u00a0 Phil. Trans. R. Soc. London B 340: 279-285. <em>Co-Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8344248\" target=\"_blank\" rel=\"noopener\">The amino-terminal region of GAP regulates cytoskeletal structure and cell adhesion<\/a>. <strong>McGlade, C.<\/strong>J., B. Brunkhorst, G. Mbamalu, D. Anderson, J. Settleman, S. Dedhar, M. Rozakis-Adcock, L.B. Chen and T. Pawson. (1993) EMBO J. 12:3073-3081. <em>Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8101647\" target=\"_blank\" rel=\"noopener\">Shc products are substrates of erbB-2 kinase<\/a>. Segatto, O., G. Pelicci, S. Giuli, G. Degiesi, P.P. Di Fiore, <strong>J. McGlade<\/strong>, T. Pawson, and P.G. Pelicci. (1993)\u00a0 Oncogene, 8:2105-2112. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7681824\" target=\"_blank\" rel=\"noopener\">Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse<\/a>. Ruff-Jamison, S., <strong>J. McGlade<\/strong>, K. Chen, T. Pawson, and S.Cohen. (1993)\u00a0 J. Biol. <strong>Chem<\/strong>. 268:7610-7612. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8449939\" target=\"_blank\" rel=\"noopener\">Insulin-induced phosphorylation of the 46 and 52 kDa Shc proteins<\/a>. Pronk, G.J., <strong>J. McGlade<\/strong>, T. Pawson, and J.L. Bos. (1993)\u00a0 J. Biol. Chem. 268:5748-5753. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1465135\" target=\"_blank\" rel=\"noopener\">Association of the Shc and Grb2\/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases.<\/a>\u00a0Rozakis-Adcock, M., <strong>J. McGlade<\/strong>, G. Mbamalu, G. Pelicci, R. Daly, W. Li, A. Batzer, P.G. Pelicci, J. Schlessinger, and T. Pawson. (1992)\u00a0 Nature 360:689-692. <em>Co-Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.pnas.org\/content\/89\/19\/8869\" target=\"_blank\" rel=\"noopener\">Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases<\/a>. <strong>McGlade, J.<\/strong>, A. Cheng, G, Pelicci, P.G. Pelicci, and T. Pawson. (1992)\u00a0 Proc. Natl. Acad. Sci. USA. 89:8869-8873. <em>Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1623525\" target=\"_blank\" rel=\"noopener\">A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signalling<\/a>. Pelicci, G., L. Lanfrancone, F. Grignani, <strong>J. McGlade<\/strong>, F. Cavallo, G. Forni, I. Nicoletti, T. Pawson and P.G. Pelicci. (1992)\u00a0Cell 70:93-104. <em>Co-Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1372092\" target=\"_blank\" rel=\"noopener\">SH2 domains of the p85a subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors<\/a>. <strong>McGlade, C.J<\/strong>., C. Ellis, M. Reedijk, D. Anderson, G. Mbamalu, A.D. Reith, G. Panayotou, P. End, A. Bernstein, A. Kazlauskas, M.D. Waterfield, and T. Pawson. (1992)\u00a0 Mol. and Cell. Biol. 12:991-997. <em>Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1828498\" target=\"_blank\" rel=\"noopener\">Individual adenovirus E1B proteins induce transformation independently but by additive pathways<\/a>. McClorey, W, <strong>C.J. McGlade<\/strong>, D. Takayesu, P.E. Branton. (1991)\u00a0 J. Gen. Virol. 72:1467-1471. <em>Co-Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2521265\" target=\"_blank\" rel=\"noopener\">Mapping of a phosphorylation site in the 176R (19kDa) early region 1B protein of human adenovirus type 5<\/a>. <strong>McGlade, C.J<\/strong>., M.L. Tremblay, and P.E. Branton. (1989) Virology 163:119-127. <em>Principle Author<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2966155\" target=\"_blank\" rel=\"noopener\">Identification of the phosphorylation sites in early region 1A proteins of adenovirus type 5 by amino acid sequencing of peptide fragments<\/a>. Tremblay, M.L., <strong>C.J. McGlade<\/strong>, G. Gerber, and P.E. Branton. (1988) J. Biol. Chem. 263:6375-6383. <em>Collaborator<\/em><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2957509\" target=\"_blank\" rel=\"noopener\">Acylation of the 176R (19-kilodalton) early region 1B protein of human adenovirus type 5<\/a><strong>. McGlade, C.J<\/strong>., M.L. Tremblay, S-P. Yee, R. Ross, and P.E. Branton. (1987)\u00a0 J. Virol. 61:3227-3234. <em>Principle Author<\/em><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;415&#8243; img_size=&#8221;full&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_custom_heading text=&#8221;Publications&#8221; font_container=&#8221;tag:h1|text_align:center&#8221; google_fonts=&#8221;font_family:Lato%3A100%2C100italic%2C300%2C300italic%2Cregular%2Citalic%2C700%2C700italic%2C900%2C900italic|font_style:400%20regular%3A400%3Anormal&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_tta_accordion style=&#8221;modern&#8221; spacing=&#8221;1&#8243; gap=&#8221;1&#8243; c_icon=&#8221;chevron&#8221; active_section=&#8221;0&#8243; collapsible_all=&#8221;true&#8221;][vc_tta_section title=&#8221;2022&#8243; tab_id=&#8221;1586182361383-60dabca5-20f7&#8243;][vc_column_text] Numb exon 9 inclusion regulates Integrin\u03b25 surface expression and promotes breast cancer metastasis. Zhang, Y., Dho, S. E., Othman, K., Simpson, C. D., Lapierre, J., Bondoc, A., McGlade, C. J. (2022).\u00a0 Oncogene,\u00a041(14), 2079\u20132094. [\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;2021&#8243; tab_id=&#8221;1663612162722-189976a2-5b1e&#8221;][vc_column_text] SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition&hellip;<\/p>\n","protected":false},"author":212,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-82","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Publications - McGlade Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/mcglade\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_custom_heading text=&#8221;Publications&#8221; font_container=&#8221;tag:h1|text_align:center&#8221; google_fonts=&#8221;font_family:Lato%3A100%2C100italic%2C300%2C300italic%2Cregular%2Citalic%2C700%2C700italic%2C900%2C900italic|font_style:400%20regular%3A400%3Anormal&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_tta_accordion style=&#8221;modern&#8221; spacing=&#8221;1&#8243; gap=&#8221;1&#8243; c_icon=&#8221;chevron&#8221; active_section=&#8221;0&#8243; collapsible_all=&#8221;true&#8221;][vc_tta_section title=&#8221;2022&#8243; tab_id=&#8221;1586182361383-60dabca5-20f7&#8243;][vc_column_text] Numb exon 9 inclusion regulates Integrin\u03b25 surface expression and promotes breast cancer metastasis. Zhang, Y., Dho, S. E., Othman, K., Simpson, C. D., Lapierre, J., Bondoc, A., McGlade, C. J. (2022).\u00a0 Oncogene,\u00a041(14), 2079\u20132094. [\/vc_column_text][\/vc_tta_section][vc_tta_section title=&#8221;2021&#8243; tab_id=&#8221;1663612162722-189976a2-5b1e&#8221;][vc_column_text] SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/mcglade\/publications\/\" \/>\n<meta property=\"og:site_name\" content=\"McGlade Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2022-12-05T17:12:13+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"21 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/mcglade\/publications\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/mcglade\/publications\/\",\"name\":\"Publications - McGlade Lab\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/mcglade\/#website\"},\"datePublished\":\"2019-01-28T18:00:24+00:00\",\"dateModified\":\"2022-12-05T17:12:13+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/mcglade\/publications\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lab.research.sickkids.ca\/mcglade\/publications\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/mcglade\/publications\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lab.research.sickkids.ca\/mcglade\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/mcglade\/#website\",\"url\":\"https:\/\/lab.research.sickkids.ca\/mcglade\/\",\"name\":\"McGlade Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lab.research.sickkids.ca\/mcglade\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Publications - McGlade Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lab.research.sickkids.ca\/mcglade\/publications\/","og_locale":"en_US","og_type":"article","og_title":"Publications","og_description":"[vc_row][vc_column][vc_custom_heading text=&#8221;Publications&#8221; font_container=&#8221;tag:h1|text_align:center&#8221; google_fonts=&#8221;font_family:Lato%3A100%2C100italic%2C300%2C300italic%2Cregular%2Citalic%2C700%2C700italic%2C900%2C900italic|font_style:400%20regular%3A400%3Anormal&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_tta_accordion style=&#8221;modern&#8221; spacing=&#8221;1&#8243; gap=&#8221;1&#8243; c_icon=&#8221;chevron&#8221; active_section=&#8221;0&#8243; collapsible_all=&#8221;true&#8221;][vc_tta_section title=&#8221;2022&#8243; tab_id=&#8221;1586182361383-60dabca5-20f7&#8243;][vc_column_text] Numb exon 9 inclusion regulates Integrin\u03b25 surface expression and promotes breast cancer metastasis. Zhang, Y., Dho, S. E., Othman, K., Simpson, C. D., Lapierre, J., Bondoc, A., McGlade, C. J. (2022).\u00a0 Oncogene,\u00a041(14), 2079\u20132094. 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