{"id":389,"date":"2023-04-17T17:34:56","date_gmt":"2023-04-17T17:34:56","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/mahant-gill\/?page_id=389"},"modified":"2025-11-14T18:14:59","modified_gmt":"2025-11-14T18:14:59","slug":"studies","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/mahant-gill\/studies\/","title":{"rendered":"Ongoing Projects"},"content":{"rendered":"

<\/i><\/i><\/span>Renal ultrasound after first febrile urinary tract infection in hospitalized children: reducing overdiagnosis and cascade effects<\/span><\/a><\/h4><\/div>
\n

Urinary tract infection (UTI) is one of the most common and costly reasons for childhood hospitalization. Based on low quality evidence, renal ultrasound is universally performed after the first febrile UTI in children at Canadian hospitals, which may result in overdiagnosis of \u2018genitourinary abnormalities\u2019 and lead to a cascade of unnecessary healthcare interventions.<\/p>\n

PIRN<\/a> is conducting a national, prospective, pragmatic, observational study across 16 hospitals to determine the utility of universal screening renal ultrasound in hospitalized children after first febrile UTI.<\/p>\n

For more information, please visit the PIRN website<\/a>.<\/p>\n

Funding Sources: Physicians\u2019 Services Incorporated (PSI) Foundation and Canadian Institutes of Health Research (CIHR) Project Grant Program<\/p>\n<\/div><\/div><\/div>

<\/i><\/i><\/span>Parenteral veRsus Enteral Fluids for infants hospitalizEd with bRonchiolitis: the PREFER shared decision making study<\/span><\/a><\/h4><\/div>
\n

Bronchiolitis is one of the most common and costly reasons for hospitalization in children. For hospitalized children who are unsafe to feed orally, there is variation in use of intravenous (IV or parenteral) or nasogastric (NG or enteral) fluids. While both are safe, little is known if parents are involved in shared decision making of selecting IV or NG fluids or informed of benefits and trade-offs is unknown.<\/p>\n

PIRN<\/a> is conducting a national, prospective, pragmatic, observational study across 15 hospitals to generate knowledge on shared decision making with parents in choosing between IV and NG fluids and on the benefits and harms of these two treatment options for hospitalized children with bronchiolitis.<\/p>\n

For more information, please visit the PIRN website<\/a>.<\/p>\n

Funding Source: CIHR Patient-Oriented Research: Early-Career Investigator Priority Announcement<\/p>\n<\/div><\/div><\/div>

<\/i><\/i><\/span>A Data-driven Approach to Identify High Priority Research Topics for Pediatric Hospital Care <\/span><\/a><\/h4><\/div>
\n

Despite extensive research on conditions managed in children\u2019s hospitals and subspeciality units, conditions managed on general pediatric units are more prevalent. There are also important health inequalities in hospital use based on characteristics (e.g. socioeconomic status).<\/p>\n

PIRN<\/a> was launched to address this gap and improve outcomes for hospitalized children. This population-based cross-sectional study of Canadian children and youth with hospital encounters will use health administrative data from the Canadian Institute for Health Information (CIHI) and Institut de la statistique du Qu\u00e9bec (ISQ) to identify conditions that are the most costly, prevalent, and with the largest health inequalities as priorities for future research in hospital pediatrics.<\/p>\n

For more information, please visit the PIRN website.<\/a><\/p>\n<\/div><\/div><\/div>

<\/i><\/i><\/span>A planning grant to explore partnerships and opportunities for the participation of Indigenous children and families in the Pediatric Inpatient Research Network<\/span><\/a><\/h4><\/div>
\n

Indigenous (First Nation, M\u00e9tis, and Inuit) compared to non-Indigenous children are more likely to be hospitalized yet many knowledge gaps exist regarding their care and outcomes in the pediatric inpatient setting.<\/p>\n

With the development of PIRN<\/a>, there is now an opportunity to advance the care and outcomes for children admitted to hospital.<\/p>\n

The current planning grant aims to develop infrastructure in PIRN to ensure meaningful, culturally-safe, partnership and participation of Indigenous children, families, and communities within this network.<\/p>\n

For more information, please visit the PIRN website<\/a>.<\/p>\n

Funding Source: Canadian Institutes of Health Research (CIHR) Planning and Dissemination Grant<\/p>\n<\/div><\/div><\/div>

<\/i><\/i><\/span>POPCORN (Pediatric Outcome Improvement through Coordination of Research Networks) <\/span><\/a><\/h4><\/div>
\n

POPCORN<\/a> unites pediatric health researchers from 16 research sites and existing national networks in pediatric research across Canada to enhance responsiveness to emerging COVID-19-related issues, including unintended consequences of preventive measures.<\/p>\n

The overall objective is to prepare Canadian child health researchers and their networks to respond rapidly and cohesively to current and future pandemic or public health issues of importance.<\/p>\n

For more information, please visit the PIRN website<\/a>.<\/p>\n<\/div><\/div><\/div>

<\/i><\/i><\/span>Care and outcomes of Canadian children hospitalized with periorbital and orbital cellulitis<\/span><\/a><\/h4><\/div>
\n

Severe orbital infections, including periorbital and orbital cellulitis, are serious infections in children. There are several important unanswered research questions regarding how hospitalized children with these infections are managed, such as which antibiotics to use, and which children need a computed tomography (CT) scan.<\/p>\n

PIRN is conducting a retrospective study across 10 hospitals to determine how care for Canadian children can be improved.<\/p>\n

For more information, please visit the PIRN website<\/a>.<\/p>\n<\/div><\/div><\/div>

<\/i><\/i><\/span>Paediatric Hospital Care Priority Setting Study <\/span><\/a><\/h4><\/div>
\n

PIRN<\/a>, in collaboration with the James Lind Alliance (JLA), conducted a CIHR-funded Priority Setting Partnership (PSP) to identify the Top 10 research questions for Inpatient General Paediatrics in Canada from the perspective of patients, caregivers, and clinicians. These priorities will guide the future research agenda for hospitalized children in Canada, and include care of special inpatient populations (eg, children with medical complexity), shared decision-making, mental health supports, and supporting Indigenous families.<\/p>\n

For more information, please visit the PIRN website<\/a>.<\/p>\n

Funding Source: CIHR Catalyst Grant in Patient Oriented Research<\/p>\n<\/div><\/div><\/div>

<\/i><\/i><\/span>Description of Canadian infants presenting with Brief Resolved Unexplained Events (BRUEs) and validation of a clinical prediction rule for risk stratification<\/span><\/a><\/h4><\/div>
\n

Infants often experience Brief Resolved Unexplained Events (BRUEs) within the first year of life. These events are concerning for caregivers, can appear to be life-threatening and pose diagnostic and management challenges for healthcare providers as they attempt to identify events likely to recur, or those caused by a serious underlying illness. Although studies have been conducted to develop clinical practice guidelines and clinical prediction rules in the United States, no studies to date have assessed the BRUE population in Canada.<\/p>\n

PIRN<\/a> will conduct a multi-site retrospective observational study of hospitalized children in Canada to identify variation in the clinical management of infants presenting with BRUEs, inform practitioners and improve outcomes.<\/p>\n

For more information, please visit the PIRN website<\/a>.<\/p>\n

Funding Sources: American Academy of Pediatrics \u2013 Resident Research Grant Program; BC Children\u2019s Hospital \u2013 BCCH Resident Research Funding; BC Children’s Hospital Research Institute (E2i) \u2013 Seeds Grant (Early Investigator) and Canadian Pediatric Society (CPS) \u2013 Hospital Pediatrics Resident Grant<\/p>\n<\/div><\/div><\/div><\/div><\/div>

<\/i><\/i><\/span>Clinical ChaRacteristics and outcomEs of hospitAlized chilDren with Acute resPiratory infecTions: the READAPT-Kids study<\/span><\/a><\/h4><\/div>
\n

After the relaxation of public health and non-pharmaceutical interventions for COVID-19, there was a significant increase in hospital admissions in children with respiratory tract infections. Little is known about the epidemiology of these cases, including the causative viral pathogens, severity of illness, and type of complications. The READAPT-Kids study aims to describe sociodemographic characteristics, clinical presentation, etiology, management, and clinical outcomes of children under the age of 18 years admitted to tertiary care pediatric hospital with severe acute respiratory infection (SARI).<\/p>\n

Funding Source: Public Health Agency of Canada (PHAC), SickKids Foundation<\/p>\n<\/div><\/div><\/div><\/div><\/div>

<\/i><\/i><\/span>iKnow to Grow: Incorporating shared decision-making into in-hospital decisions for children with medical complexity<\/span><\/a><\/h4><\/div>
\n

In this study, we will co-design a practical, and easy to implement shared decision-making (SDM) tool that can be used by HCP, and caregivers to support SDM for CMC while hospitalized in a general pediatric inpatient unit (GPIU) and will address the factors that limit SDM uptake.<\/p>\n

Funding Source: Norman Saunders Complex Care Initiative, The Hospital for Sick Children<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":391,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-389","page","type-page","status-publish","hentry"],"yoast_head":"\nOngoing Projects - Mahant Gill Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/mahant-gill\/studies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ongoing Projects\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/mahant-gill\/studies\/\" \/>\n<meta property=\"og:site_name\" content=\"Mahant Gill Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-14T18:14:59+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"11 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/mahant-gill\/studies\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/mahant-gill\/studies\/\",\"name\":\"Ongoing Projects - 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