{"id":1587,"date":"2025-11-17T18:03:46","date_gmt":"2025-11-17T18:03:46","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/knight\/?p=1587"},"modified":"2025-11-21T18:35:00","modified_gmt":"2025-11-21T18:35:00","slug":"a-multisite-observational-study-to-examine-the-effects-of-childhood-onset-sle-on-cognitive-functions-over-time-using-the-pedanam-tool-for-cognitive-and-behavioral-assessments","status":"publish","type":"post","link":"https:\/\/lab.research.sickkids.ca\/knight\/a-multisite-observational-study-to-examine-the-effects-of-childhood-onset-sle-on-cognitive-functions-over-time-using-the-pedanam-tool-for-cognitive-and-behavioral-assessments\/","title":{"rendered":"A Multisite, Observational Study to Examine the Effects of Childhood-Onset SLE on Cognitive Functions Over Time, using the pedANAM Tool for Cognitive and Behavioral Assessments"},"content":{"rendered":"<p><strong>Principal Investigator: <\/strong><span data-contrast=\"none\">Andrea Knight, MD, MSCE<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\"><strong>Co-Principal Investigators:<\/strong> Ekemini Ogbu, MD, MSc, FAAP\u00a0<\/span> <span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\"><strong>Funded by:<\/strong> Department of Defense<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\"><strong>Study Goals:<\/strong> To determine the longitudinal outcome of Neuropsychiatric SLE (NPSLE) and the trajectories of cognitive functions in pediatric SLE patients. To compare the longitudinal outcomes of children without NPSLE, including disease activity damage index, medication adherence and quality of life.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\"><strong>Description:<\/strong> Participants from the CARRA registry with a diagnosis of SLE will be invited to join this study.\u00a0 Participants will complete computer-based survey (pedANAM) each year, for up to five years.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\"><strong>Impact:<\/strong> This study is being done to find out how pediatric systemic lupus erythematosus (pSLE) affects thinking abilities and cognitive functions over time. Through this study, we hope to learn about the long-term effects of lupus on cognition.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Principal Investigator: Andrea Knight, MD, MSCE\u00a0 Co-Principal Investigators: Ekemini Ogbu, MD, MSc, FAAP\u00a0 \u00a0 Funded by: Department of Defense\u00a0 Study Goals: To determine the longitudinal outcome of Neuropsychiatric SLE (NPSLE) and the trajectories of cognitive functions in pediatric SLE patients. To compare the longitudinal outcomes of children without NPSLE, including disease activity damage index, medication  [&#8230;]<\/p>\n","protected":false},"author":503,"featured_media":1605,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,13],"tags":[],"class_list":["post-1587","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-current","category-studies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>A Multisite, Observational Study to Examine the Effects of Childhood-Onset SLE on Cognitive Functions Over Time, using the pedANAM Tool for Cognitive and Behavioral Assessments - Knight Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/knight\/a-multisite-observational-study-to-examine-the-effects-of-childhood-onset-sle-on-cognitive-functions-over-time-using-the-pedanam-tool-for-cognitive-and-behavioral-assessments\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Multisite, Observational Study to Examine the Effects of Childhood-Onset SLE on Cognitive Functions Over Time, using the pedANAM Tool for Cognitive and Behavioral Assessments\" \/>\n<meta property=\"og:description\" content=\"Principal Investigator: Andrea Knight, MD, MSCE\u00a0 Co-Principal Investigators: Ekemini Ogbu, MD, MSc, FAAP\u00a0 \u00a0 Funded by: Department of Defense\u00a0 Study Goals: To determine the longitudinal outcome of Neuropsychiatric SLE (NPSLE) and the trajectories of cognitive functions in pediatric SLE patients. 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