{"id":1585,"date":"2025-11-17T18:05:34","date_gmt":"2025-11-17T18:05:34","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/knight\/?p=1585"},"modified":"2025-11-21T18:33:41","modified_gmt":"2025-11-21T18:33:41","slug":"transforming-behavioral-healthcare-to-improve-the-quality-of-life-for-individuals-with-childhood-onset-lupus","status":"publish","type":"post","link":"https:\/\/lab.research.sickkids.ca\/knight\/transforming-behavioral-healthcare-to-improve-the-quality-of-life-for-individuals-with-childhood-onset-lupus\/","title":{"rendered":"Transforming Behavioral Healthcare to Improve the Quality of Life for Individuals with Childhood-Onset Lupus"},"content":{"rendered":"<p><span data-contrast=\"none\"><strong>Co-Principal Investigators:<\/strong> Natoshia Cunningham, Ph.D.\u00a0<\/span><span data-contrast=\"auto\">and <\/span><span data-contrast=\"none\">Andrea Knight, MD, MSCE<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p><strong>Funded by: <\/strong><span data-contrast=\"none\">United States Department of Defense<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><strong>Study Goals: <\/strong><span data-contrast=\"none\">To examine the effect of TEACH on psychological\/functional outcomes and disease-related outcomes in youth with cSLE in real-world rheumatology settings versus medical TAU at post assessment (after 8 weeks).\u00a0To determine longitudinal trajectories (over 1 year) of depressive symptoms, the impact of TEACH, and the association with patient characteristics, psychological\/functional and disease-related outcomes.\u00a0To evaluate TEACH implementation outcomes using a mixed method approach.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p><strong>Description: <\/strong><span data-contrast=\"none\">This is a multi-site randomized controlled clinical trial with a type 1 effectiveness-implementation hybrid design. The primary aim is to determine the effectiveness of a cognitive behaviourial therapy intervention (TEACH) in real world settings, whereas the secondary aim is to better understand context for implementation into clinical care, for improving psychological\/functional outcomes and disease-related outcomes in people with childhood-onset systemic lupus erythematosus (cSLE). 196 eligible participants (approximately 25 participants from each of the 7 sites) will be randomized to receive either the TEACH intervention or continue medical treatment as usual (TAU) for 8 weeks. Participants will complete additional assessments online after 8-weeks, 20-weeks, 32-weeks, 44-weeks, and 56-weeks from baseline.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\"><strong>Impact:<\/strong> This study will have broad implications for SLE models of care in children and adults, and for other rheumatologic conditions. This work will improve healthcare and psychological\/functional outcomes and disease-related outcomes for patients with lupus through providing accessible and evidence-based treatments integrated into medical care.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Co-Principal Investigators: Natoshia Cunningham, Ph.D.\u00a0and Andrea Knight, MD, MSCE\u00a0 Funded by: United States Department of Defense\u00a0 Study Goals: To examine the effect of TEACH on psychological\/functional outcomes and disease-related outcomes in youth with cSLE in real-world rheumatology settings versus medical TAU at post assessment (after 8 weeks).\u00a0To determine longitudinal trajectories (over 1 year) of depressive  [&#8230;]<\/p>\n","protected":false},"author":503,"featured_media":1606,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,13],"tags":[],"class_list":["post-1585","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-current","category-studies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - 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