{"id":1579,"date":"2025-11-17T17:39:07","date_gmt":"2025-11-17T17:39:07","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/knight\/?p=1579"},"modified":"2025-11-17T17:42:38","modified_gmt":"2025-11-17T17:42:38","slug":"the-impact-of-childhood-onset-systemic-inflammatory-diseases-on-the-developing-brain-an-exploratory-study-of-children-with-juvenile-myositis-and-systemic-lupus-erythematosus","status":"publish","type":"post","link":"https:\/\/lab.research.sickkids.ca\/knight\/the-impact-of-childhood-onset-systemic-inflammatory-diseases-on-the-developing-brain-an-exploratory-study-of-children-with-juvenile-myositis-and-systemic-lupus-erythematosus\/","title":{"rendered":"The Impact of Childhood-onset Systemic Inflammatory Diseases on the Developing Brain: An Exploratory Study of Children with Juvenile Myositis and Systemic Lupus Erythematosus"},"content":{"rendered":"<p><strong>Principal Investigator: <\/strong><span data-contrast=\"none\">Andrea Knight, MD, MSCE<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\"><strong>Funded by:<\/strong> Cure JM, Lupus Research Alliance and US Department of Defense<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\"><strong>Study Goals:<\/strong> To characterize cognitive and psychiatric function in children with JM, compared to patients with cSLE and healthy controls.\u00a0To characterize neuroimaging metrics in children with JM, compared to patients with cSLE and healthy controls.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559685&quot;:0}\">\u00a0<\/span><\/p>\n<p><strong>Description: <\/strong><span data-contrast=\"none\">This is a cross-sectional exploratory study that will examine cognitive and psychiatric function and investigate brain injury and structural brain changes in a cohort of 15 adolescents with Juvenile Myositis (JM). This data will compare data from childhood-onset systemic lupus erythematosus (cSLE) patients and healthy controls. We will utilize advanced neuroimaging as well as evaluate cognitive and psychiatric function.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\"><strong>Impact:<\/strong> The biological changes that underlie effects of chronic autoimmune diseases such as JM and cSLE on the developing brain are poorly characterized. While emerging literature suggests that systemic inflammation may potentiate brain inflammation and neuropsychiatric dysfunction, other potential factors contributing to neuropsychiatric dysfunction include pain, fatigue, medications, and the stress of chronic disease. Through this study, we hope to address these gaps in knowledge.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Principal Investigator: Andrea Knight, MD, MSCE\u00a0 Funded by: Cure JM, Lupus Research Alliance and US Department of Defense\u00a0 Study Goals: To characterize cognitive and psychiatric function in children with JM, compared to patients with cSLE and healthy controls.\u00a0To characterize neuroimaging metrics in children with JM, compared to patients with cSLE and healthy controls.\u00a0 Description: This  [&#8230;]<\/p>\n","protected":false},"author":503,"featured_media":1595,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,13],"tags":[],"class_list":["post-1579","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-current","category-studies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>The Impact of Childhood-onset Systemic Inflammatory Diseases on the Developing Brain: An Exploratory Study of Children with Juvenile Myositis and Systemic Lupus Erythematosus - Knight Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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