{"id":1313,"date":"2023-12-20T18:35:35","date_gmt":"2023-12-20T18:35:35","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/knight\/?p=1313"},"modified":"2024-01-09T15:52:51","modified_gmt":"2024-01-09T15:52:51","slug":"identifying-neuroimaging-biomarkers-of-neuropsychiatric-childhood-onset-systemic-lupus-erythematosus-ai-ml","status":"publish","type":"post","link":"https:\/\/lab.research.sickkids.ca\/knight\/identifying-neuroimaging-biomarkers-of-neuropsychiatric-childhood-onset-systemic-lupus-erythematosus-ai-ml\/","title":{"rendered":"Identifying Neuroimaging Biomarkers of Neuropsychiatric Childhood-Onset Systemic Lupus Erythematosus: AI\/ML"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p><strong>Principal Investigator:<\/strong> Andrea Knight, MD, MSCE<\/p>\n<p><b>Co-Principal Investigators<\/b>: Santiago Arciniegas, BSc, Birgit Ertl-Wagner, MD, PhD, MHBA, Matt Wagner, Farzad Khalvati, PhD, MASc, George Ibrahim, MD, PhD, FRCSC, FAANS, Linda Hiraki, MD, FRCPC, ScD, Deborah Levy, MD, MS, FRCPCS.<\/p>\n<p><strong>Study Goals:<\/strong> The goal of this study is to build an algorithm capable of classifying brain MR images of Childhood-onset Systemic Lupus Erythematosus (cSLE) patients.<\/p>\n<p><strong>Description:<\/strong> Retrospective data is collected from de-identified neuroimaging and medical chart records at SickKids. Specifically, we collect multimodal MRI scans and relevant clinical meta-data (e.g., age at time of image acquisition, sex, medical history, etc.) for each participant.<\/p>\n<p><strong>Impact:<\/strong> Conventional MRI reports fail to identify brain abnormalities in over half of NP-cSLE patients. A promising set of modern analytical tools that could be coupled with multimodal neuroimaging includes deep learning (DL) and computer vision methods. These fields have recently seen major growth and success in the automated classification of medical images. We want to incorporate deep learning methods in the study of NP-cSLE to better understand brain changes in patients with cSLE and to build a cSLE classifier.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":442,"featured_media":1321,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16,13],"tags":[],"class_list":["post-1313","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-previous","category-studies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Identifying Neuroimaging Biomarkers of Neuropsychiatric Childhood-Onset Systemic Lupus Erythematosus: AI\/ML - Knight Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/knight\/identifying-neuroimaging-biomarkers-of-neuropsychiatric-childhood-onset-systemic-lupus-erythematosus-ai-ml\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identifying Neuroimaging Biomarkers of Neuropsychiatric Childhood-Onset Systemic Lupus Erythematosus: AI\/ML\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/knight\/identifying-neuroimaging-biomarkers-of-neuropsychiatric-childhood-onset-systemic-lupus-erythematosus-ai-ml\/\" \/>\n<meta property=\"og:site_name\" content=\"Knight Lab\" \/>\n<meta property=\"article:published_time\" content=\"2023-12-20T18:35:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-09T15:52:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lab.research.sickkids.ca\/knight\/wp-content\/uploads\/sites\/145\/2023\/12\/neuroimaging-1024x683.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"683\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"lboulard\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"lboulard\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/identifying-neuroimaging-biomarkers-of-neuropsychiatric-childhood-onset-systemic-lupus-erythematosus-ai-ml\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/identifying-neuroimaging-biomarkers-of-neuropsychiatric-childhood-onset-systemic-lupus-erythematosus-ai-ml\/\"},\"author\":{\"name\":\"lboulard\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/#\/schema\/person\/4bb06f2c1da7610a8ade221b18388888\"},\"headline\":\"Identifying Neuroimaging Biomarkers of Neuropsychiatric Childhood-Onset Systemic Lupus Erythematosus: AI\/ML\",\"datePublished\":\"2023-12-20T18:35:35+00:00\",\"dateModified\":\"2024-01-09T15:52:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/identifying-neuroimaging-biomarkers-of-neuropsychiatric-childhood-onset-systemic-lupus-erythematosus-ai-ml\/\"},\"wordCount\":306,\"image\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/identifying-neuroimaging-biomarkers-of-neuropsychiatric-childhood-onset-systemic-lupus-erythematosus-ai-ml\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/lab.research.sickkids.ca\/knight\/wp-content\/uploads\/sites\/145\/2023\/12\/neuroimaging-scaled.jpg\",\"articleSection\":[\"Previous\",\"Studies\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/identifying-neuroimaging-biomarkers-of-neuropsychiatric-childhood-onset-systemic-lupus-erythematosus-ai-ml\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/knight\/identifying-neuroimaging-biomarkers-of-neuropsychiatric-childhood-onset-systemic-lupus-erythematosus-ai-ml\/\",\"name\":\"Identifying Neuroimaging Biomarkers of Neuropsychiatric Childhood-Onset Systemic Lupus Erythematosus: AI\/ML - 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