{"id":1307,"date":"2023-12-20T18:23:01","date_gmt":"2023-12-20T18:23:01","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/knight\/?p=1307"},"modified":"2025-11-12T19:54:31","modified_gmt":"2025-11-12T19:54:31","slug":"a-prospective-study-of-multi-level-biomarkers-for-pediatric-neuropsychiatric-lupus","status":"publish","type":"post","link":"https:\/\/lab.research.sickkids.ca\/knight\/a-prospective-study-of-multi-level-biomarkers-for-pediatric-neuropsychiatric-lupus\/","title":{"rendered":"A Prospective Study of Multi-level Biomarkers for Paediatric Neuropsychiatric Lupus"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p><b>Principal Investigator:<\/b> Andrea Knight, MD, MSCE<\/p>\n<p><strong>Funded by: <\/strong>Lupus Research Alliance<\/p>\n<p><strong>Study Goals:<\/strong> The goal of this study is to examine in youth with Childhood-onset Systemic Lupus Erythematosus (cSLE) the association between affective function (measured via longitudinal assessment of depression, anxiety and psychosis spectrum) and i) multimodal imaging metrics, ii) cognitive function, and iii) serum biomarkers.<\/p>\n<p><strong>Description:<\/strong> This longitudinal study recruits cSLE patients and healthy controls (age, ethnicity and sex-matched to cSLE subjects) who undergo two study visits, consisting of MRI, neurocognitive and psychiatric assessments, brief electronic survey (for covariate collection) and a blood sample collection, and medical record review.<\/p>\n<p><strong>Impact:<\/strong> This study aims to add to the knowledge of the impact of cSLE on the developing brain by examining the relationship between affective functioning in cSLE, measured by longitudinal psychiatric assessment (of depression, anxiety and psychosis spectrum), to multi-level measures. The resulting data will lead to further study of the utility of noninvasive biomarkers for predicting and managing paediatric NPSLE. Integrating multi-level biomarkers in cSLE may elucidate the mechanisms underlying inflammatory disease in NPSLE, critically impacting research and clinical care.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":442,"featured_media":1317,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16,13],"tags":[],"class_list":["post-1307","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-previous","category-studies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>A Prospective Study of Multi-level Biomarkers for Paediatric Neuropsychiatric Lupus - Knight Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/knight\/a-prospective-study-of-multi-level-biomarkers-for-pediatric-neuropsychiatric-lupus\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Prospective Study of Multi-level Biomarkers for Paediatric Neuropsychiatric Lupus\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/knight\/a-prospective-study-of-multi-level-biomarkers-for-pediatric-neuropsychiatric-lupus\/\" \/>\n<meta property=\"og:site_name\" content=\"Knight Lab\" \/>\n<meta property=\"article:published_time\" content=\"2023-12-20T18:23:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-12T19:54:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lab.research.sickkids.ca\/knight\/wp-content\/uploads\/sites\/145\/2023\/12\/biomarkers-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1705\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"lboulard\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"lboulard\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/a-prospective-study-of-multi-level-biomarkers-for-pediatric-neuropsychiatric-lupus\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/a-prospective-study-of-multi-level-biomarkers-for-pediatric-neuropsychiatric-lupus\/\"},\"author\":{\"name\":\"lboulard\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/#\/schema\/person\/4bb06f2c1da7610a8ade221b18388888\"},\"headline\":\"A Prospective Study of Multi-level Biomarkers for Paediatric Neuropsychiatric Lupus\",\"datePublished\":\"2023-12-20T18:23:01+00:00\",\"dateModified\":\"2025-11-12T19:54:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/a-prospective-study-of-multi-level-biomarkers-for-pediatric-neuropsychiatric-lupus\/\"},\"wordCount\":328,\"image\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/a-prospective-study-of-multi-level-biomarkers-for-pediatric-neuropsychiatric-lupus\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/lab.research.sickkids.ca\/knight\/wp-content\/uploads\/sites\/145\/2023\/12\/biomarkers-scaled.jpg\",\"articleSection\":[\"Previous\",\"Studies\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/a-prospective-study-of-multi-level-biomarkers-for-pediatric-neuropsychiatric-lupus\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/knight\/a-prospective-study-of-multi-level-biomarkers-for-pediatric-neuropsychiatric-lupus\/\",\"name\":\"A Prospective Study of Multi-level Biomarkers for Paediatric Neuropsychiatric Lupus - 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