{"id":1304,"date":"2023-12-20T18:17:23","date_gmt":"2023-12-20T18:17:23","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/knight\/?p=1304"},"modified":"2024-01-09T15:49:48","modified_gmt":"2024-01-09T15:49:48","slug":"the-impact-of-childhood-onset-lupus-on-the-developing-brain","status":"publish","type":"post","link":"https:\/\/lab.research.sickkids.ca\/knight\/the-impact-of-childhood-onset-lupus-on-the-developing-brain\/","title":{"rendered":"The Impact of Childhood-Onset Lupus on the Developing Brain"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p><strong>Principal investigator:<\/strong> Andrea Knight, MD, MSCE<\/p>\n<p><strong>Funded by: <\/strong>United States of America Department of Defense Lupus Research Program<\/p>\n<p><strong>Study Goals:<\/strong> To quantify the effect of Childhood-onset Systemic Lupus Erythematosus (cSLE) on brain structure, function and development. To determine the association of neuroimaging measures with cognitive test performance in cSLE. To determine the relative contribution of cSLE disease-related factors for predicting changes in brain structure, function, and development.<\/p>\n<p><strong>Description:<\/strong> This longitudinal study will examine the impact of cSLE on the developing brain in adolescents with new-onset disease, compared to age, sex, and ethnicity-matched healthy controls over 2 study visits. We use several measures to get comprehensive information, including cognitive and psychiatric assessment, advanced magnetic resonance imaging (MRI), and blood samples for future research. <a href=\"https:\/\/research4kids.research.sickkids.ca\/trialdescription\/347\" target=\"_blank\" rel=\"noopener\">Read more about the study.<\/a><\/p>\n<p><strong>Impact:<\/strong> The brain continues to develop throughout adolescence. This research study is being done to explore the effects of SLE on the emotional and cognitive functions of the brain, to better understand why some patients with SLE experience depression, anxiety, and trouble with memory and concentration. This research will help us understand how SLE affects the developing brain by comparing results on these outcome measures between youth with a new diagnosis of SLE and healthy individuals.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":442,"featured_media":1318,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,13],"tags":[],"class_list":["post-1304","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-current","category-studies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>The Impact of Childhood-Onset Lupus on the Developing Brain - Knight Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/knight\/the-impact-of-childhood-onset-lupus-on-the-developing-brain\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Impact of Childhood-Onset Lupus on the Developing Brain\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/knight\/the-impact-of-childhood-onset-lupus-on-the-developing-brain\/\" \/>\n<meta property=\"og:site_name\" content=\"Knight Lab\" \/>\n<meta property=\"article:published_time\" content=\"2023-12-20T18:17:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-09T15:49:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lab.research.sickkids.ca\/knight\/wp-content\/uploads\/sites\/145\/2023\/12\/brain-development-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1440\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"lboulard\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"lboulard\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/the-impact-of-childhood-onset-lupus-on-the-developing-brain\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/the-impact-of-childhood-onset-lupus-on-the-developing-brain\/\"},\"author\":{\"name\":\"lboulard\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/#\/schema\/person\/4bb06f2c1da7610a8ade221b18388888\"},\"headline\":\"The Impact of Childhood-Onset Lupus on the Developing Brain\",\"datePublished\":\"2023-12-20T18:17:23+00:00\",\"dateModified\":\"2024-01-09T15:49:48+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/the-impact-of-childhood-onset-lupus-on-the-developing-brain\/\"},\"wordCount\":324,\"image\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/the-impact-of-childhood-onset-lupus-on-the-developing-brain\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/lab.research.sickkids.ca\/knight\/wp-content\/uploads\/sites\/145\/2023\/12\/brain-development-scaled.jpg\",\"articleSection\":[\"Current\",\"Studies\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/knight\/the-impact-of-childhood-onset-lupus-on-the-developing-brain\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/knight\/the-impact-of-childhood-onset-lupus-on-the-developing-brain\/\",\"name\":\"The Impact of Childhood-Onset Lupus on the Developing Brain - 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