{"id":1260,"date":"2023-12-18T14:04:45","date_gmt":"2023-12-18T14:04:45","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/knight\/?p=1260"},"modified":"2024-01-09T15:53:12","modified_gmt":"2024-01-09T15:53:12","slug":"inflammation-brain-injury-and-trajectories-of-cognitive-function-in-childhood-onset-lupus","status":"publish","type":"post","link":"https:\/\/lab.research.sickkids.ca\/knight\/inflammation-brain-injury-and-trajectories-of-cognitive-function-in-childhood-onset-lupus\/","title":{"rendered":"Inflammation, Brain Injury and Trajectories of Cognitive Function in Childhood-Onset Lupus"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1216.8px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p><strong>Principal Investigator:<\/strong> Andrea Knight, MD, MSCE<\/p>\n<p><strong>Funded by:<\/strong> Lupus Research Alliance<\/p>\n<p><strong>Study Goals: <\/strong>To examine trajectories of cognitive function, and investigate correlates to systemic IFN-mediated inflammation, brain injury and structural brain changes in adolescents with Childhood-onset Systemic Lupus Erythematosus (cSLE).<\/p>\n<p><strong>Description: <\/strong>We are currently recruiting adolescents with cSLE and healthy controls. Building on our work from &#8220;A Prospective Study of Multi-level Biomarkers for Pediatric Neuropsychiatric Lupus&#8221; and &#8220;The Impact of Childhood-Onset Lupus on the Developing Brain&#8221;, this study will follow participants over a three-year time period, utilizing advanced neuroimaging to characterize brain structure and function over time.<\/p>\n<p><strong>Impact: <\/strong>This study will leverage and expand upon ongoing studies to focus on understanding trajectories of executive function and structural brain changes in adolescents over a period of critical brain maturation, and investigate the inflammatory mechanisms underlying associated brain injury, studying sNFL as a potential novel marker in cSLE.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":353,"featured_media":1320,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,13],"tags":[],"class_list":["post-1260","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-current","category-studies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - 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