{"id":9,"date":"2016-05-19T17:18:56","date_gmt":"2016-05-19T17:18:56","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/kim\/?page_id=9"},"modified":"2025-04-04T01:20:03","modified_gmt":"2025-04-04T01:20:03","slug":"publications","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/kim\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;]<div id=\"highlight-box-wrap-2622\"  data-ultimate-target='#highlight-box-wrap-2622'  data-responsive-json-new='{\"font-size\":\"desktop:32px;\",\"line-height\":\"\"}'  class=\"ultimate-call-to-action ult-adjust-bottom-margin  ctaction-text-center ult-responsive\" style=\"font-weight:normal;color:#ffffff;background:#000000;padding-top:20px;padding-bottom:20px;padding-left:20px;padding-right:20px;\"  data-background=\"#000000\"  data-background-hover=\"#000000\"  data-override=\"0\" ><div class=\"uvc-ctaction-data uvc-ctaction-data-no-effect ult-responsive\">Journal Articles<\/div><\/div>[\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;1\/4&#8243;][\/vc_column_inner][\/vc_row_inner]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><strong><a id=\"anchor-852e1b0a-8f8c-d664-c59f-092feedc5e45\" title=\"Original URL: https:\/\/www.cell.com\/cell-stem-cell\/abstract\/S1934-5909(25)00082-7. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.cell.com%2Fcell-stem-cell%2Fabstract%2FS1934-5909(25)00082-7&amp;data=05%7C02%7Cnalma.uy%40sickkids.ca%7C402dc08281ec44796b7e08dd72d92c75%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638792999268848530%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=yCo7fCDGnhjDR2ASDa7gGRfmrc6hceOzfyXmKmPft1U%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-linkindex=\"0\" data-olk-copy-source=\"MessageBody\">A robust ingredient makes human gut stem cell niches on a dish.<\/a><\/strong><br \/>\nChoi C and Kim T-H.<br \/>\n<strong>Cell Stem Cell<\/strong> (2025) April 03;32(4):501-503.<\/li>\n<li><a href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.science.org%2Fdoi%2F10.1126%2Fscience.adj7615&amp;data=05%7C02%7Cnalma.uy%40sickkids.ca%7C1ddc9e0bb3eb46a9e60b08dd13bdf50a%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638688428752598213%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=pmzGgXfsudx0MG3FaioVrhfTlm%2BgViDh2Kr8m%2BXp%2BdI%3D&amp;reserved=0\"><strong>PIEZO-dependent mechano-sensing is essential for intestinal stem cell fate decision and maintenance.<\/strong><\/a><br \/>\nBaghdadi MB<sup>#<\/sup>, Houtekamer RM, Perrin L, Rao-Bhatia A, Whelen M, Decker L, Bergert M, P\u00e9rez-Gonz\u00e0lez C, Bouras R, Gropplero G, Loe AKH, Afkhami-Poostchi A, Chen X, Huang X, Descroix S. Wrana JL, Diz-Munoz A, Gloerich M, Ayyaz A, Vignjevic DM<sup>#<\/sup>, Kim T-H<sup>#<\/sup>\u00a0(<sup>#\u00a0<\/sup>co-corresponding authors).<br \/>\n<strong>Science<\/strong><em>\u00a0<\/em>(2024) Nov29;386(6725):eadj7615.<br \/>\n(Featured in\u00a0<a href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.sickkids.ca%2Fen%2Fnews%2Farchive%2F2024%2Fcritical-relationship-between-stem-cells-and-mechanical-signals-unveiled%2F&amp;data=05%7C02%7Cnalma.uy%40sickkids.ca%7C1ddc9e0bb3eb46a9e60b08dd13bdf50a%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638688428752624840%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=LHzCNfj6SaJOUm5R%2F8Ux0f9PQqpet5VNJvHBC%2Fc9tCg%3D&amp;reserved=0\">SickKids news<\/a><u>,<\/u>\u00a0<a href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.sciencedaily.com%2Freleases%2F2024%2F12%2F241202123642.htm&amp;data=05%7C02%7Cnalma.uy%40sickkids.ca%7C1ddc9e0bb3eb46a9e60b08dd13bdf50a%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638688428752640455%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=xf9kvfd0LitSn84vXfjAkpTT0cPDksqt3IWPdON%2F3E8%3D&amp;reserved=0\">ScienceDaily<\/a>,\u00a0<a href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.eurekalert.org%2Fnews-releases%2F1066597&amp;data=05%7C02%7Cnalma.uy%40sickkids.ca%7C1ddc9e0bb3eb46a9e60b08dd13bdf50a%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638688428752658551%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=wP4qlFZwA8fuPCu2TroH0ncW5A2eRZPFqJzgmv7Yhnc%3D&amp;reserved=0\">EurekAlert!<\/a>,\u00a0<a href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fmedicalxpress.com%2Fnews%2F2024-12-reveals-stem-cells-environmental-implications.html&amp;data=05%7C02%7Cnalma.uy%40sickkids.ca%7C1ddc9e0bb3eb46a9e60b08dd13bdf50a%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638688428752678087%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=8Vm8pWuYWkG%2BL3Hn6qTSf%2Bgb2IgQNv6GCM6bHfBAHbM%3D&amp;reserved=0\">MedicalPress<\/a>,\u00a0<a href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.news-medical.net%2Fnews%2F20241202%2FStudy-reveals-how-stem-cells-sense-and-respond-to-their-environment.aspx&amp;data=05%7C02%7Cnalma.uy%40sickkids.ca%7C1ddc9e0bb3eb46a9e60b08dd13bdf50a%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638688428752693789%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=p7yK646PivAk5JizRtzhJBd2UFYayc2e8f8qTMBSdD0%3D&amp;reserved=0\">NewsMedical <\/a>and selected by\u00a0<a title=\"Original URL: https:\/\/www.bloomburton.com\/canada-in-science-november-2024\/. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.bloomburton.com%2Fcanada-in-science-november-2024%2F&amp;data=05%7C02%7Cnalma.uy%40sickkids.ca%7C0b72e8209b5646df6b7008dd212433e1%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638703161547730512%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=LRNOZu65ylxH%2BCmtaqAXG1%2BojXB5bLGE4uFoyrxuuok%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"0\">Canada in Science for November 2024<\/a>)<\/li>\n<li><u><a title=\"Original URL: https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(23)01509-7. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.cell.com%2Fcell-reports%2Ffulltext%2FS2211-1247(23)01509-7&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716556918534%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=hxiK4tRgNBbfgzwnP4LsJV5r9TmDccrjNi%2BZYh3QEBs%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"0\"><strong>YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration<\/strong><\/a><strong>.<\/strong><br \/>\n<\/u>Loe AKH*, Rao-Bhatia A*, Wei Z*\u00a0, Kim JE, Guan B, Qin Y, Hog M, Kwak H, Liu X, Zhang L, Wrana JL, Guo H<sup>#<\/sup>, Kim T-H<sup>#<\/sup>. (* equal contribution, <span lang=\"EN-US\"><sup># <\/sup>co-corresponding authors).<\/span><br \/>\n<b>Cell Reports (<\/b>2023) Dec 26;42(12) 113497.<br \/>\n(Featured in\u00a0<u><a title=\"Original URL: https:\/\/mp.weixin.qq.com\/s\/RbEnOUZntE1C7beq6CXMTA?poc_token=HEeKcGWj20j0p-OWajo0aBWA-U_Uqf39CGSpJkZy. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fmp.weixin.qq.com%2Fs%2FRbEnOUZntE1C7beq6CXMTA%3Fpoc_token%3DHEeKcGWj20j0p-OWajo0aBWA-U_Uqf39CGSpJkZy&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716556918534%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=omJmwtTZgAqFJ6bh%2FGQUn%2BZcgXbNK442RLbgsNmIhK0%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"1\">BioMedArt<\/a><\/u>)<\/li>\n<li><u><strong><a title=\"Original URL: https:\/\/www.nature.com\/articles\/s43018-023-00626-8. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs43018-023-00626-8&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716556918534%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=INRRRqT0LNNpqJDVBzPjRMTCxkqEzvbiPji1itSwrS8%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"2\">A designer peptide against the EAG2-Kv\u03b22 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma.<\/a><\/strong><br \/>\n<\/u>Dong W, Fekete A, Chen X, Liu H, Beilhartz GL, Chen X, Bahrampour S, Xiong Y, Yang Q, Zhao H, Kong T, Morioka MS, Jung G, Kim JE, Schramek D, Dirks PB, Song Y, Kim T-H, He Y, Wanggou S, Li X, Melnyk RA, Wang LY, Huang X.<br \/>\n<b>Nature Cancer<\/b> (2023) 4;1418-1436.<br \/>\n(Cover Article, previewed by Nature Cancer, Featured in <a title=\"Original URL: https:\/\/www.sickkids.ca\/en\/news\/archive\/2023\/discovery-of-protein-protein-interaction-lays-foundation-for-future-glioblastoma-therapy\/. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.sickkids.ca%2Fen%2Fnews%2Farchive%2F2023%2Fdiscovery-of-protein-protein-interaction-lays-foundation-for-future-glioblastoma-therapy%2F&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716556918534%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=fVp3l2lY6irBK5QC6axoACgJz2LzWFh00BQhNbqEkiM%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"3\">SickKids News<\/a>,\u00a0<a title=\"Original URL: https:\/\/www.eurekalert.org\/news-releases\/1001029. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.eurekalert.org%2Fnews-releases%2F1001029&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716557074753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=x9tESwdXzgeHAErB0s2WFdBpI7ibZHoyWWwQlHCoyM4%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"4\">EurekAlert!<\/a>,\u00a0<a title=\"Original URL: https:\/\/bioengineer.org\/discovery-of-protein-protein-interaction-lays-foundation-for-future-glioblastoma-therapy\/. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbioengineer.org%2Fdiscovery-of-protein-protein-interaction-lays-foundation-for-future-glioblastoma-therapy%2F&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716557074753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=Xtw1p1RuNCbWCrGM%2Bz1Nj7O6vxG4mV5HPhnT%2FIhJjVI%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"5\">Bioengineer.org<\/a>,\u00a0<a title=\"Original URL: https:\/\/www.technologynetworks.com\/tn\/news\/potential-brain-cancer-therapy-uncovered-by-protein-interaction-discovery-378696. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.technologynetworks.com%2Ftn%2Fnews%2Fpotential-brain-cancer-therapy-uncovered-by-protein-interaction-discovery-378696&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716557074753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=s012%2BFldeM%2BVxrGEhF8kmDa71LAbdog7tSexMZKcwQk%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"6\">Technology Networks<\/a>,\u00a0<a title=\"Original URL: https:\/\/www.news-medical.net\/news\/20230911\/Study-reveals-a-new-potential-treatment-approach-for-glioblastoma.aspx. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.news-medical.net%2Fnews%2F20230911%2FStudy-reveals-a-new-potential-treatment-approach-for-glioblastoma.aspx&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716557074753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=AN4THY5a%2BhRvzhxOKiMH%2BM6gnE7HAM2jHe6R%2F1gSsus%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"7\">News Medical<\/a>,\u00a0<a title=\"Original URL: https:\/\/www.thedailyscience.org\/new-designer-peptide-shows-promise-in-treating-glioblastoma.html. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.thedailyscience.org%2Fnew-designer-peptide-shows-promise-in-treating-glioblastoma.html&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716557074753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=UZRE69VND7%2BOmjFgVGWelVK5KK9%2BeCO4pZKTjUZAcE4%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"8\">The Daily Science<\/a>,\u00a0<a title=\"Original URL: https:\/\/press-news.org\/179093-discovery-of-protein-protein-interaction-lays-foundation-for-future-glioblastoma-therapy.html. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fpress-news.org%2F179093-discovery-of-protein-protein-interaction-lays-foundation-for-future-glioblastoma-therapy.html&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716557074753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=azUUKEQlLjk5wbeKjLAv9DxHZUvTOgAFX1x1ZKO7rOE%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"9\">Press-News.org<\/a>,\u00a0<a title=\"Original URL: https:\/\/medicalxpress.com\/news\/2023-09-discovery-protein-protein-interaction-lays-foundation.html. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fmedicalxpress.com%2Fnews%2F2023-09-discovery-protein-protein-interaction-lays-foundation.html&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716557074753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=9AKDuVdm7tZ31FhEVUDrdiBbHLcoUgffdKggTH7WbFA%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"10\">Medical Xpress<\/a>,\u00a0<a title=\"Original URL: https:\/\/www.nouvelles-du-monde.com\/therapie-potentielle-contre-le-cancer-du-cerveau-decouverte-grace-a-la-decouverte-des-interactions-proteiques\/. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.nouvelles-du-monde.com%2Ftherapie-potentielle-contre-le-cancer-du-cerveau-decouverte-grace-a-la-decouverte-des-interactions-proteiques%2F&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716557074753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=jd6ZlLM%2B%2BTrjxFf%2BLjoNXsNJ0uZqBDf%2Fohad4RgwGVw%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"11\">Nouvelles Du Monde<\/a>,\u00a0<a title=\"Original URL: https:\/\/futur-en-seine.paris\/un-traitement-potentiel-pour-le-cancer-du-cerveau-decouvert-grace-a-la-decouverte-dinteractions-proteiques\/. Click or tap if you trust this link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Ffutur-en-seine.paris%2Fun-traitement-potentiel-pour-le-cancer-du-cerveau-decouvert-grace-a-la-decouverte-dinteractions-proteiques%2F&amp;data=05%7C01%7Cnalma.uy%40sickkids.ca%7C9d1bf6c78bf1441db0b808dbf66c2515%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638374716557074753%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=OSByl9ylG%2F%2FoeQvWYOavc90B%2F%2BE7DNMsTeKYQOwGuY0%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"Verified\" data-linkindex=\"12\">Futur en Seine<\/a>)<\/li>\n<li>\n<p class=\"x_MsoNormal\"><u><strong><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-36228-2\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-safelink=\"true\" data-linkindex=\"1\">Epigenetic control of cellular crosstalk defines gastrointestinal organ fate and function.<\/a><\/strong><br \/>\n<\/u>Smith RJ*, Liang M*, Loe AKH, Yung T, Kim JE, Hudson M, Wilson MD, Kim T-H (* equal contribution).<br \/>\n<b>Nature Communications<\/b> (2023) Jan 30;S41467-023-36338-2.<\/p>\n<\/li>\n<li><span lang=\"EN-US\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36653445\/\" target=\"_blank\" rel=\"noopener\"><strong>Chromatin and noncoding RNA-mediated mechanisms of gastric tumorigenesis.<\/strong> <\/a><br \/>\n<\/span><span lang=\"EN-US\">Loe AKH*, Zhu L*, Kim T-H (* equal contribution).<br \/>\n<\/span><strong><span lang=\"EN-US\">Experimental <\/span><span lang=\"EN-US\">&amp;<\/span><span lang=\"EN-US\"> Molecular Medicine<\/span><\/strong><span lang=\"EN-US\"> (2023) Jan;55(1):22-31. <\/span><\/li>\n<li><span lang=\"EN-US\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36658046\/\" target=\"_blank\" rel=\"noopener\"><strong>The multiple roles of enteric glial cells in intestinal homeostasis and regeneration.<\/strong><\/a><br \/>\nBaghdadi MB<sup>#<\/sup>, Kim T-H<sup>#<\/sup>(<sup># <\/sup>co-corresponding authors).<br \/>\n<\/span><strong><span lang=\"EN-US\">Seminars in Cell <\/span><span lang=\"EN-US\">&amp;<\/span><span lang=\"EN-US\"> Developmental Biology<\/span><\/strong><span lang=\"EN-US\">\u00a0(2023) Jan 17;S1084-9521(23)00005-8.<\/span><\/li>\n<li><span lang=\"EN-US\"><strong><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1074761322005933?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-safelink=\"true\" data-linkindex=\"0\">Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development.<\/a><\/strong><br \/>\n<\/span><span lang=\"EN-US\"><span class=\"markbp6cxwyy6\" data-markjs=\"true\" data-ogac=\"\" data-ogab=\"\" data-ogsc=\"\" data-ogsb=\"\">Kim<\/span> JE, Fei L, Horne R, Lee D, Loe AK, Miyake H, Ayar E, <span class=\"markbp6cxwyy6\" data-markjs=\"true\" data-ogac=\"\" data-ogab=\"\" data-ogsc=\"\" data-ogsb=\"\">Kim<\/span> DK, Surette MG, Philpott DJ, Sherman P, Guo G, Pierro A, <span class=\"markbp6cxwyy6\" data-markjs=\"true\" data-ogac=\"\" data-ogab=\"\" data-ogsc=\"\" data-ogsb=\"\">Kim<\/span>T-H.<br \/>\n<\/span><span lang=\"EN-US\"><strong>Immunity<\/strong>\u00a0(2022)<\/span><span lang=\"EN-US\"><br \/>\n<\/span><span lang=\"EN-US\">(Featured in\u00a0<a href=\"https:\/\/www.sickkids.ca\/en\/news\/archive\/2022\/study-uncovers-relationship-between-stem-cell-development-and-gut-microbes-in-newborn-health\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-safelink=\"true\" data-linkindex=\"0\">SickKids news<\/a>, previewed by\u00a0<a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(22)00595-7\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-safelink=\"true\" data-linkindex=\"1\">Immunity<\/a>, and selected by <a href=\"https:\/\/www.bloomburton.com\/canada-in-science-december-2022\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-safelink=\"true\" data-linkindex=\"2\">2022 December\u2019s Top Science in Canada<\/a>)<\/span><\/li>\n<li><u><span lang=\"EN-US\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-022-30624-w\" target=\"_blank\" rel=\"noopener\"><strong>Single cell chromatin profiling of the primitive gut tube reveals regulatory dynamics underlying lineage fate decisions.<\/strong><\/a><br \/>\n<\/span><\/u>Smith RJ*, Zhang H*, Hu SS*, Yung T, Francis F, Lee L, Onaitis MW, Dirks PB, Zhang C<sup>#<\/sup>, Kim T-H<sup>#<\/sup> (* equal contribution; <sup># <\/sup>co-corresponding authors).<br \/>\n<strong>Nature Communications<\/strong> (2022) May 26;13(1):2965.<br \/>\n(Featured in <a name=\"x__GoBack\"><\/a><u><a href=\"https:\/\/healthcommunity.nature.com\/posts\/defining-the-chromatin-and-transcriptional-regulation-of-organ-specification-237a57f2-2bfd-4a7e-b5cf-751bd3b1e20e\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-linkindex=\"0\">Nature Portfolio Health Community<\/a>, <a href=\"https:\/\/www.cbs19news.com\/story\/47156936\/uva-scientists-make-exciting-discovery-that-could-help-them-better-understand-and-treat-cancer\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-linkindex=\"0\">CBS19 news<\/a>, <a href=\"https:\/\/newsroom.uvahealth.com\/2022\/08\/24\/organ-development-discovery-to-boost-battle-against-cancer\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-linkindex=\"1\">UVA Health system news room<\/a>, <a href=\"http:\/\/ct.moreover.com\/?a=48565780799&amp;p=1pl&amp;v=1&amp;x=nqVgqaYciosgXJS-szKAHA\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-linkindex=\"3\">Bioengineer.org<\/a>, <a href=\"https:\/\/www.eurekalert.org\/news-releases\/962757\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-linkindex=\"4\">EurekAlert!<\/a>, <a href=\"https:\/\/scienmag.com\/organ-development-discovery-could-boost-battle-against-cancer\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-linkindex=\"5\">ScienMag<\/a>, <a href=\"https:\/\/vervetimes.com\/organ-development-discovery-could-boost-battle-against-cancer\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-linkindex=\"6\">Verve times<\/a>, <a href=\"https:\/\/phys.org\/news\/2022-08-organ-development-discovery-boost-cancer.html\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-linkindex=\"7\">Phys.org<\/a>, and <a href=\"https:\/\/swifttelecast.com\/organ-development-discovery-could-boost-battle-against-cancer\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-auth=\"NotApplicable\" data-linkindex=\"8\">Swift Telecast<\/a>)<\/u><\/li>\n<li><strong><a href=\"https:\/\/star-protocols.cell.com\/protocols\/1614\" target=\"_blank\" rel=\"noopener\">Analysis of mouse intestinal organoid culture with conditioned media isolated from mucosal enteric glial cells.<\/a><\/strong><br \/>\nBaghdadi MB and Kim T-H.<br \/>\n<strong>STAR Protocols<\/strong> (2022) 10.1016\/jxpro.2022.101351<\/li>\n<li class=\"x_MsoNormal\">\n<div><a href=\"https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(21)00416-1\" target=\"_blank\" rel=\"noopener\"><strong>Enteric glial cell heterogeneity regulates intestinal stem cell niches.<\/strong><\/a><\/div>\n<p>Baghdadi MB, Ayyaz A, Coquenlorge S, Chu B, Kumar S, Streutker C, Wrana JL and Kim T-H.<br \/>\n<strong>Cell Stem Cell<\/strong><span class=\"apple-converted-space\">\u00a0<\/span>(2022) Jan 6;29(1):86-100.<br \/>\n(Featured in UofT Molecular Genetics news, \u201c<a href=\"https:\/\/moleculargenetics.utoronto.ca\/news\/sickkids-research-team-discovers-role-gut-brain-cells-inflammatory-bowel-disease\" target=\"_blank\" rel=\"noopener\">the role of gut brain cells in IBD<\/a>\u201d, recommended by <i>Faculty Opinions<\/i>, and previewed by <a href=\"https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(21)00487-2\" target=\"_blank\" rel=\"noopener\">Cell Stem Cell<\/a>)<\/li>\n<li><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\"><a href=\"https:\/\/rupress.org\/jem\/article-abstract\/218\/6\/e20200219\/211950\/\" target=\"_blank\" rel=\"noopener\"><strong>Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy.<\/strong><\/a><br \/>\nLoe<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\"> AK<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">H<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">*<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">, Francis R<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">*<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">, <\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">Seo<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\"> J, <\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">Lutao<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\"> D, Wang Y, <\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">Kim JE, Hakim SW, Kim J<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">E<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">, He HH, Guo H<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun Superscript SCXW6426439 BCX4\" data-fontsize=\"11.5\">#<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">, Kim T-H<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun Superscript SCXW6426439 BCX4\" data-fontsize=\"11.5\">#<\/span><\/span> <span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">(* equal contribution; <\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun Superscript SCXW6426439 BCX4\" data-fontsize=\"11.5\">#<\/span><\/span> <span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\">co-corresponding authors).<\/span><\/span><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW6426439 BCX4\"><br \/>\n<\/span><\/span><strong><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW6426439 BCX4\">Journal of Experimental Medicine<\/span><\/span><\/strong><span class=\"TextRun SCXW6426439 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW6426439 BCX4\"> (2021) Jun 7; 218(6).<br \/>\n(Featured in <a href=\"http:\/\/www.ebiotrade.com\/newsf\/2021-4\/2021415162334673.htm\" target=\"_blank\" rel=\"noopener\">Ebiotrade<\/a>)<\/span><\/span><\/li>\n<li><strong><span lang=\"EN-US\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0962892420302452?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">Mesenchymal niches for digestive organ development, homeostasis and disease<\/a>.<\/span><\/strong><u><span lang=\"EN-US\"><br \/>\n<\/span><\/u><span lang=\"EN-US\">Loe AK*, Rao-Bhatia A*, Kim JE*, Kim T-H<b> <\/b>(* equal contribution).<br \/>\n<\/span><b><span lang=\"EN-US\">Trends in Cell Biology<\/span><\/b><span lang=\"EN-US\"> <span class=\"TextRun Highlight BCX4 SCXW162276068\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun BCX4 SCXW162276068\">(202<\/span><\/span><span class=\"TextRun Highlight BCX4 SCXW162276068\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun BCX4 SCXW162276068\">1<\/span><\/span><span class=\"TextRun Highlight BCX4 SCXW162276068\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun BCX4 SCXW162276068\">)<\/span><\/span><span class=\"TextRun Highlight BCX4 SCXW162276068\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun BCX4 SCXW162276068\"> Mar;31(3):152-165<\/span><\/span>.<\/span><\/li>\n<li><strong><a href=\"https:\/\/www.cell.com\/developmental-cell\/fulltext\/S1534-5807(20)30099-X\" target=\"_blank\" rel=\"noopener noreferrer\">Fat4-Dchs1<i> <\/i>and planar cell polarity pathways activated by Hedgehog mediate mesenchymal clustering and villus formation during mammalian gut development<\/a><span lang=\"EN-US\">.<br \/>\n<\/span><\/strong><span lang=\"EN-US\">Rao-Bhatia A, Zhu M, Yin WC, <\/span><span lang=\"EN-US\">Coquenlorge-Gallon S, Zhang X, Woo JH, Dean CH, Liu A, Hui CC, Shivdasani RA, McNeill H, Hopyan S, Kim T-H.<br \/>\n<\/span><strong><span lang=\"EN-US\">Developmental Cell<\/span><\/strong><span lang=\"EN-US\">\u00a0(2020) March 9,\u00a052(5):647-658.<br \/>\n<span class=\"TextRun Highlight SCXW196966491 BCX4\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW196966491 BCX4\">(Featured in SickKids news, &#8220;<a href=\"https:\/\/www.sickkids.ca\/en\/news\/archive\/2020\/intestinal-intelligence-understanding-how-tiny-gut-projections-arise-could-inform-new-treatments\/\" target=\"_blank\" rel=\"noopener noreferrer\">Intestinal intelligence<\/a>&#8221; <span class=\"TextRun Highlight SCXW170842984 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW170842984 BCX4\">and recommended by <em>Faculty Opinions<\/em><\/span><\/span><span class=\"TextRun Highlight SCXW170842984 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW170842984 BCX4\">)<\/span><\/span><span class=\"EOP SCXW170842984 BCX4\" data-ccp-props=\"{}\">\u00a0<\/span><\/span><\/span><\/span><span lang=\"EN-US\"><br \/>\n<\/span><\/li>\n<li><strong><span lang=\"EN-US\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-14058-5\" target=\"_blank\" rel=\"noopener noreferrer\">Single cell and genetic analyses reveal conserved cell populations and signaling mechanisms of gastrointestinal stromal niches<\/a>.<br \/>\n<\/span><\/strong><span lang=\"EN-US\">Kim JE, Fei L, Yin WC, Coquenlorge-Gallon S, Rao-Bhatia A, Zhang X, Shi SSW, Lee JH, Hahn NA, Rizvi W, Kim KH, Sung HK, Hui CC, Guo G,\u00a0Kim T-H.<br \/>\n<\/span><span lang=\"EN-US\"><strong>Nature Communications<\/strong> (2020) 11, 334.\u00a0<\/span><\/li>\n<li><strong><a href=\"https:\/\/advances.sciencemag.org\/content\/5\/12\/eaax8898\" target=\"_blank\" rel=\"noopener noreferrer\">Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer<\/a>.<\/strong><br \/>\nFrancis R<strong>*<\/strong>, Guo H<strong>*<\/strong>, Ahmed M, Yung T, Dirks PB, He HH<sup>#<\/sup>, Kim T-H<sup>#<\/sup> (<strong>*<\/strong>equal contribution; <strong><sup>#<\/sup><\/strong> co-corresponding authors).<br \/>\n<strong>Science Advances<\/strong>\u00a0(2019)\u00a0Dec 11;Vol 5 no. 12, eaax8898.<br \/>\n(Featured in University Health Network news, \u201c<a href=\"http:\/\/www.uhnresearch.ca\/news\/cancers-gut-reaction\" target=\"_blank\" rel=\"noopener noreferrer\">Cancer\u2019s gut reaction<\/a>&#8220;)<\/li>\n<li><strong><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-12624-5\" target=\"_blank\" rel=\"noopener noreferrer\">Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals<\/a>.<\/strong><br \/>\nYung T<strong>*<\/strong>, Poon F<strong>*<\/strong>, Liang M, Coquenlorge S, McGaugh EC, Hui CC, Wilson MD, Nostro MC<strong><sup>#<\/sup><\/strong>, Kim T-H<strong><sup>#<\/sup><\/strong>. (<strong>*<\/strong> equal contribution; <b><sup>#<\/sup><\/b> co-corresponding authors)<br \/>\n<strong><span class=\"jrnl\" title=\"Nature communications\">Nature Communications\u00a0<\/span><\/strong>(2019) Oct 11;10(1):4647.<br \/>\n(Featured in Editors\u2019 Highlights, University Health Network News &#8220;<a href=\"https:\/\/www.uhn.ca\/corporate\/News\/Pages\/Making_cells_to_treat_diabetes.aspx\" target=\"_blank\" rel=\"noopener noreferrer\">Making cells to treat diabetes<\/a>&#8221; and recommended by Faculty of 1000)<\/li>\n<li><span lang=\"EN-US\"><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31167144\" target=\"_blank\" rel=\"noopener noreferrer\">GLI2 modulated by SUFU and SPOP induces intestinal stem cell niche signals in development and tumorigenesis.<\/a>\u00a0<\/strong><br \/>\n<\/span><span lang=\"EN-US\">Coquenlorge-Gallon S<\/span><b><span lang=\"EN-US\">*<\/span><\/b><span lang=\"DE\">, Yin WC<\/span><b><span lang=\"EN-US\">*<\/span><\/b><span lang=\"EN-US\">, Yung T, Pan J, Zhang X, Mo R<\/span>, Belik J<span lang=\"DE\">, Hui CC<\/span><span lang=\"NL\">,\u00a0Kim T-H<b>\u00a0<\/b>(<\/span><span lang=\"EN-US\"><b>*\u00a0<\/b>equal contribution)<\/span>.<br \/>\n<b>Cell Reports\u00a0<\/b>(2019) Jun 4;27(10):3006-3018.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28644919\" target=\"_blank\" rel=\"noopener noreferrer\"><u><strong>Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity and niches.<\/strong><br \/>\n<\/u><\/a>Smith RJ, Rao-Bhatia A, Kim T-H.<br \/>\n<b>WIREs Developmental Biology\u00a0<\/b>(2017) Sep;6(5).<br \/>\n(Cover article and featured in Advanced Science news)<\/li>\n<li><strong><a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(19)30627-8\" target=\"_blank\" rel=\"noopener noreferrer\">Single-cell transcript profiles reveal multilineage priming in early progenitors derived from Lgr5<sup>+<\/sup>\u00a0intestinal stem cells<\/a>.<\/strong><br \/>\nKim T-H*, Saadatpour A*, Guo G, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC#, Shivdasani RA.#\u00a0(* equal contribution).<br \/>\n<strong>Cell Reports<\/strong>\u00a0(2016)\u00a0Aug 23;16(8):2053-60.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26884394\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Stomach development, stem cells and disease.<\/strong><\/a><br \/>\nKim T-H# and Shivdasani RA# (# co-corresponding authors)<br \/>\n<strong>Development\u00a0<\/strong>(2016) 143: 554-565.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Broadly+permissive+intestinal+chromatin+underlies+lateral+inhibition+and+cell+plasticity\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity.<\/strong><\/a><br \/>\nKim T-H, Li F, Ferreiro-Neira I, Ho L-L, Luyten A, Nalapareddy K, Liu XS, Verzi M, Shivdasani RA.<br \/>\n<strong>Nature<\/strong>\u00a0(2014) 506(7489):511-5.<br \/>\n(Recommended by Faculty of 1000)<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Intestinal+stem+cell+niche%3A+Famished+Paneth+cells%2C+gluttonous+stem+cells.\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Intestinal stem cell niche: Famished Paneth cells, gluttonous stem cells.<\/strong><\/a><br \/>\nKim T-H, Shivdasani RA.<br \/>\n<strong>Current Biology<\/strong>\u00a0(2012) 22(14):R579-80.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Intact+function+of+Lgr5-expressing+stem+cells+in+the+absence+of+Paneth+cells.\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Intact function of Lgr5-expressing stem cells in the absence of Paneth cells.<\/strong><\/a><br \/>\nKim T-H, Escudero S, Shivdasani RA.<br \/>\n<strong>Proceedings of the National Academy of Science-USA<\/strong>\u00a0(2012) 109(10):3932-7.<\/li>\n<li><strong><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Phactr4+regulates+directional+migration+of+Enteric+Neural+Crest+through+PP1%2C+integrin+signaling+and+cofilin+activity\" target=\"_blank\" rel=\"noopener noreferrer\">Phactr4 regulates directional migration of Enteric Neural Crest through PP1, integrin signaling and cofilin activity<\/a>.<\/strong>\u00a0(* equal contribution)<br \/>\nZhang Y*, Kim T-H*, Niswander L.<br \/>\n<strong>Genes &amp; Development<\/strong>\u00a0(2012) 26(1):69-81.<br \/>\n(Cover Article, featured in perspectives Genes &amp; Development 2012;26(1):1-5,\u00a0highlighted in Nature Cell Biology 2012;14:130, and recommended by Faculty of 1000)<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Endodermal+Hedgehog+signals+modulate+Notch+pathway+activity+in+the+developing+digestive+tract+mesenchyme\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.<\/strong><\/a> (* equal contribution)<br \/>\nKim T-H*, Kim B-M*, Mao J, Rowan S, Shivdasani RA.<br \/>\n<strong>Development\u00a0<\/strong>(2011) 138(15):3225-33.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Notch+signaling+in+stomach+epithelial+stem+cell+homeostasis.+Journal+of+Experimental+Medicine\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Notch signaling in stomach epithelial stem cell homeostasis.<\/strong><\/a><br \/>\nKim T-H, Shivdasani RA.<br \/>\n<strong>Journal of Experimental Medicine<\/strong>\u00a0(2011) 208(4):677-88.<br \/>\n(Cover article)<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=)+Genetic+evidence+that+intestinal+Notch+functions+vary+regionally+and+operate+through+a+common+mechanism+of+Math1+repression\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression.<\/strong><\/a><br \/>\nKim T-H, Shivdasani RA.<br \/>\n<strong>Journal of Biological Chemistry\u00a0<\/strong>(2011) 286:11427-33.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Phactr4+regulates+neural+tube+closure+by+controlling+PP1%2C+Rb+phosphorylation+and+cell+cycle+progression\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Phactr4 regulates neural tube closure by controlling PP1, Rb phosphorylation and cell cycle progression.<\/strong><\/a><br \/>\nKim T-H, Goodman J, Anderson K, Niswander L.<br \/>\n<strong>Developmental Cell\u00a0<\/strong>(2007) 13:87-102.<\/li>\n<\/ul>\n<\/div>[\/vc_column][\/vc_row][vc_row][vc_column][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][vc_empty_space]<div id=\"highlight-box-wrap-1267\"  data-ultimate-target='#highlight-box-wrap-1267'  data-responsive-json-new='{\"font-size\":\"desktop:32px;\",\"line-height\":\"\"}'  class=\"ultimate-call-to-action ult-adjust-bottom-margin  ctaction-text-center ult-responsive\" style=\"font-weight:normal;color:#ffffff;background:#000000;padding-top:20px;padding-bottom:20px;padding-left:20px;padding-right:20px;\"  data-background=\"#000000\"  data-background-hover=\"#000000\"  data-override=\"0\" ><div class=\"uvc-ctaction-data uvc-ctaction-data-no-effect ult-responsive\">Book Chapters<\/div><\/div>[\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;1\/4&#8243;][\/vc_column_inner][\/vc_row_inner]<div class=\"standard-arrow list-divider bullet-top\"><h3><\/h3>\n<ul>\n<li><b><span data-contrast=\"auto\">Animal models of congenital gastrointestinal maladies<\/span><\/b><b><span data-contrast=\"auto\">, <\/span><\/b><b><span data-contrast=\"auto\">Animal Models of Human Birth Defects<\/span><\/b><b><span data-contrast=\"auto\">. Advance in Experimental Medicine and Biology<\/span><\/b><b><span data-contrast=\"auto\">.<\/span><\/b><i><span data-contrast=\"auto\">\u00a0<\/span><\/i><span data-ccp-props=\"{&quot;469777462&quot;:[220,720],&quot;469777927&quot;:[0,0],&quot;469777928&quot;:[1,1]}\"><br \/>\n<\/span><span data-contrast=\"auto\">Smith RJ, Francis R, Kim JE, Kim T-H.<\/span><span data-contrast=\"auto\"> In: <\/span><span data-contrast=\"auto\">Aimin<\/span><span data-contrast=\"auto\"> Liu ed.<\/span> <span data-contrast=\"auto\">(<\/span><span data-contrast=\"auto\">2020<\/span><span data-contrast=\"auto\">)<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;469777462&quot;:[220,720],&quot;469777927&quot;:[0,0],&quot;469777928&quot;:[1,1]}\"><br \/>\n<\/span><span data-contrast=\"auto\">Springer Nature, U<\/span><span data-contrast=\"auto\">nited Kingdom: pp. <\/span><span data-contrast=\"auto\">87-107<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;469777462&quot;:[220,720],&quot;469777927&quot;:[0,0],&quot;469777928&quot;:[1,1]}\">\u00a0<\/span><\/li>\n<li><strong>The Alimentary Canal. The Atlas of Mouse Development<\/strong> (Kaufman)-supplement.\n<div>San Roman AK, Kim T-H,\u00a0Shivdasani RA.\u00a0In: Baldock R, Bard J, Davidson D, Morriss-Kay G, eds. (2016)<\/div>\n<div>Elsevier, Netherlands; Ch. 5, pp. 77-84.<\/div>\n<\/li>\n<li><strong>Basic science of Stomach Development. Translational Gastroenterology: Organogenesis to Disease.<\/strong>\n<div>Kim T-H, Shivdasani RA. In: Gumucio DL, Samuelson LC, Spence JR, eds. (2014)<\/div>\n<div>Wiley Blackwell, United States: pp. 43-56.<\/div>\n<\/li>\n<\/ul>\n<\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;1\/4&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_row_inner][vc_column_inner width=&#8221;1\/4&#8243;][vc_empty_space][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;1\/4&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - 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