{"id":7,"date":"2016-05-19T17:18:05","date_gmt":"2016-05-19T17:18:05","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/kim\/?page_id=7"},"modified":"2020-10-05T16:23:49","modified_gmt":"2020-10-05T16:23:49","slug":"home","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/kim\/","title":{"rendered":"Research"},"content":{"rendered":"

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Our research group investigates the mechanisms of gut stem cell niches in development and disease:<\/h2><\/div><\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”2\/3″][vc_row_inner css=”.vc_custom_1465318366728{padding-right: 100px !important;padding-left: 100px !important;}”][vc_column_inner][vc_empty_space height=”50px”][vc_column_text css_animation=”fadeIn”]<\/p>\n
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    How are different organs and cell types generated from stem cells?<\/h2>\n<\/li>\n<\/ul>\n

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      How do the environment and surrounding tissues interact with stem cells to maintain homeostasis?<\/h2>\n<\/li>\n<\/ul>\n

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        How is normal developmental and stem cell homeostasis altered in\u00a0cancer and inflammation?<\/h2>\n<\/li>\n<\/ul>\n

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        • To address these questions, we apply a combined approach of mouse genetics, stem cell organoid culture, epigenomics and genomics. In humans, the average gut length is about ten metres, and the gut epithelium self-renews rapidly by the activity of stem cells throughout life. These stem cells differentiate into distinct cell types for food digestion (stomach) and absorption (intestine). Since it is a common target of diseases such as cancer, peptic ulcers, and inflammatory bowel disease, we use the gut as a model system.<\/li><\/ul><\/div>