{"id":75,"date":"2016-01-21T14:59:35","date_gmt":"2016-01-21T19:59:35","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/kahr\/?page_id=75"},"modified":"2024-04-25T08:36:01","modified_gmt":"2024-04-25T12:36:01","slug":"gallery","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/kahr\/gallery\/","title":{"rendered":"Gallery"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]Platelets are small cells that come from some of the largest, megakaryocytes.<\/strong><\/p>\n

Working at both ends of the cell size scale, our work relies heavily on state-of-the-art imaging techniques.<\/strong><\/p>\n

 <\/p>\n

Several images from our lab have featured on journal and book covers, and won awards:<\/strong><\/p>\n

 <\/p>\n

Blood<\/em>, November 2013, an NBEAL2-knockout mouse megakaryocyte:<\/strong><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

Cover of the recent Platelets and Megakaryocytes volume of Methods in Molecular Biology<\/em>, <\/strong><\/p>\n

where we have a chapter on advanced fluorescence microscopy imaging methods:<\/strong><\/p>\n

\"\"<\/a><\/p>\n

A better look at that cover image, deconstructed:<\/strong><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

Blood<\/em>, July 2015, showing a 3D render of a megakaryocyte:<\/strong><\/p>\n

\"\"<\/a><\/p>\n

ATVB<\/em>, October 2018, showing a megakaryocyte taking up green fluorescent fibrinogen:<\/strong><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

Winning image on the cover of Platelets<\/em> for 2018, showing a proplatelet-forming megakaryocyte:<\/a><\/strong><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

Molecular Cancer Research<\/em>, November 2019, showing platelets adhering to cancer cells.<\/strong><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

Blood<\/em>, August 6 2020, showing NBEAL2 and SEC22B in a megakaryocyte.<\/strong><\/p>\n

\"\"<\/a><\/strong><\/p>\n

 <\/p>\n

Other images:<\/strong><\/p>\n

When megakaryocytes reach the final stage of maturity, they extend long proplatelets into the bloodstream that contain microtubules (magenta) that give rise to the cytoskeletal rings of platelets.<\/strong><\/p>\n

\"Mouse<\/a><\/p>\n

 <\/p>\n

Multipanel SIM image of a platelet-forming mouse megakaryocyte<\/strong><\/p>\n

\"Proplatelet-mass\"<\/a><\/p>\n

 <\/p>\n

The end results are platelets containing structures that include a tubulin cytoskeletal ring, myosin matrix, secretory alpha granules and surface membrane:<\/strong><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n

Platelets may be small, but they are complicated. Other aspects of their anatomy include an actin matrix, granule contents and a calcium store system:<\/strong><\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_column_text]Platelets are small cells that come from some of the largest, megakaryocytes. Working at both ends of the cell size scale, our work relies heavily on state-of-the-art imaging techniques.   Several images from our lab have featured on journal and book covers, and won awards:   Blood, November 2013, an NBEAL2-knockout mouse megakaryocyte:   Cover…<\/p>\n","protected":false},"author":53,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-75","page","type-page","status-publish","hentry","description-off"],"yoast_head":"\nGallery - Kahr Lab | SickKids<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/kahr\/gallery\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gallery\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text]Platelets are small cells that come from some of the largest, megakaryocytes. 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