{"id":657,"date":"2014-11-24T19:21:25","date_gmt":"2014-11-24T19:21:25","guid":{"rendered":"http:\/\/lab-dev.research.sickkids.ca\/justice-lab2\/?page_id=7"},"modified":"2023-01-31T20:17:34","modified_gmt":"2023-01-31T20:17:34","slug":"home","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/justice\/","title":{"rendered":"Home"},"content":{"rendered":"

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Dr. Justice has retired and is now Senior Scientist Emeritus, so this website is no longer active.\u00a0 The lab is no longer taking new graduate or undergraduate students. \u00a0For more information, please contact Julie Ruston at\u00a0julie.ruston@sickkids.ca<\/a><\/h3>\n

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Research in the Justice lab merges mouse modeling with clinical genetics to inform epigenetic disease mechanisms and develop treatment strategies. To understand complex human diseases, model organisms are established to confirm causes, study molecular and cellular mechanisms and develop preventative and therapeutic interventions. Throughout her career, Justice has used mutagenesis screens in mouse models to uncover transcriptional mechanisms in disease, developing and exploiting genomic strategies for gene identification. Now, her program has converged on epigenetics, a field that studies how changes in DNA and its associated proteins can affect inheritance of traits through multiple generations, and regulate wide-spread gene expression and genome stability. Genetic tricks are used to ask questions about mammalian gene function and genome organization. Mouse models are used to identify pathways for disease pathology that may identify therapeutic targets.<\/p>\n

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<\/div>[\/vc_column][\/vc_row][vc_row margin_top=”0″ margin_bottom=”0″ bg_type=”no_bg”][vc_column width=”1\/2″][vc_single_image image=”682″ img_size=”900×300″ onclick=”custom_link” link=”https:\/\/lab.research.sickkids.ca\/justice\/research\/rett-project\/”][\/vc_column][vc_column width=”1\/2″][vc_single_image image=”681″ img_size=”900×300″ onclick=”custom_link” link=”https:\/\/lab.research.sickkids.ca\/justice\/research\/cancer-project\/”][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_column_text] Dr. Justice has retired and is now Senior Scientist Emeritus, so this website is no longer active.\u00a0 The lab is no longer taking new graduate or undergraduate students. \u00a0For more information, please contact Julie Ruston at\u00a0julie.ruston@sickkids.ca [\/vc_column_text][vc_single_image image=”650″ img_size=”1250×352″ alignment=”center” style=”vc_box_border”][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1435686077307{padding-right: 40px !important;padding-left: 40px !important;}”] Research in the Justice lab merges mouse modeling…<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-657","page","type-page","status-publish","hentry","description-off"],"yoast_head":"\nHome - Justice Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/justice\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Home\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text] Dr. Justice has retired and is now Senior Scientist Emeritus, so this website is no longer active.\u00a0 The lab is no longer taking new graduate or undergraduate students. \u00a0For more information, please contact Julie Ruston at\u00a0julie.ruston@sickkids.ca [\/vc_column_text][vc_single_image image=”650″ img_size=”1250×352″ alignment=”center” style=”vc_box_border”][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=”.vc_custom_1435686077307{padding-right: 40px !important;padding-left: 40px !important;}”] Research in the Justice lab merges mouse modeling…\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/justice\/\" \/>\n<meta property=\"og:site_name\" content=\"Justice Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-31T20:17:34+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/justice\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/justice\/\",\"name\":\"Home - 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