{"id":899,"date":"2023-06-13T13:26:17","date_gmt":"2023-06-13T13:26:17","guid":{"rendered":"\/?page_id=899"},"modified":"2023-12-01T13:45:27","modified_gmt":"2023-12-01T13:45:27","slug":"research","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/ivakine\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

Research<\/h1><\/div>
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A deeper look into our methodologies and techniques<\/p>\n<\/div><\/div><\/div><\/div><\/div>

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The overarching focus of the Ivakine Lab can be boiled down to two main ideas: 1) understanding the functionality of genetic variants, at scale, through saturation genome editing; and 2) developing novel CRISPR-based and small molecule-based therapeutics to generate precision therapies for rare genetic disorders \u2014 with a focus on neurodegenerative and neurodevelopmental conditions. We are using cutting edge genome editing tools and delivery vehicles to generate and correct disease-causing mutations in cell and animal models.<\/p>\n<\/blockquote>\n<\/div><\/div><\/div><\/div><\/div>

Development of novel therapeutic approaches for the
\nnext generation of precision medicines<\/h2><\/div>
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\"immunohistochemistry<\/a><\/span><\/div><\/div><\/div>

Genetic diseases manifest in various ways, some affecting the brain, muscles and several other organs. Disease-causing mutations function similarly. Our lab focuses on a variety of these mutations, including:<\/p>\n