{"id":58,"date":"2015-08-04T16:53:04","date_gmt":"2015-08-04T16:53:04","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/huang\/?page_id=58"},"modified":"2026-03-24T18:02:08","modified_gmt":"2026-03-24T18:02:08","slug":"home-2","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/huang\/","title":{"rendered":"Home"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row type=&#8221;5&#8243; css=&#8221;.vc_custom_1463592882802{margin-bottom: 0px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;]<div class=\"gap\" style=\"line-height: 45px; height: 45px;\"><\/div>[vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h2 style=\"text-align: center\"><strong><span style=\"color: #000000\">Xi Huang Lab<br \/>\n<\/span><\/strong><\/h2>\n<p>&nbsp;<\/p>\n<h6 style=\"text-align: center\"><a class=\"dt-single-image\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2018\/10\/Huang.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-567 size-medium\" src=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2018\/10\/Huang-249x300.jpg\" alt=\"\" width=\"249\" height=\"300\" srcset=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2018\/10\/Huang-249x300.jpg 249w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2018\/10\/Huang-768x925.jpg 768w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2018\/10\/Huang-850x1024.jpg 850w\" sizes=\"auto, (max-width: 249px) 100vw, 249px\" \/><\/a><\/h6>\n<p style=\"text-align: center\"><span style=\"color: #333333\">calligraphy by Daming Huang<\/span><\/p>\n<p style=\"text-align: center\"><span style=\"color: #3366ff\">We do curiosity-driven and serendipitous science to <\/span><\/p>\n<p style=\"text-align: center\"><span style=\"color: #3366ff\">decode mechano-electrical-chemical signaling\u00a0in cancer<\/span><\/p>\n<p>[\/vc_column_text][vc_column_text][\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243; offset=&#8221;vc_hidden-xs&#8221;]<div class=\"gap\" style=\"line-height: 45px; height: 45px;\"><\/div>[rev_slider_vc alias=&#8221;mainslider&#8221;][\/vc_column][\/vc_row][vc_row parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; min_height=&#8221;750&#8243;][vc_column width=&#8221;5\/6&#8243;]<div class=\"gap\" style=\"line-height: 60px; height: 60px;\"><\/div>[vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h4 style=\"text-align: left\"><span style=\"color: #000000\"><strong>Research<\/strong><\/span><\/h4>\n<p>[\/vc_column_text]<div class=\"gap\" style=\"line-height: 30px; height: 30px;\"><\/div>[vc_column_text css_animation=&#8221;fadeIn&#8221;]<span lang=\"EN-US\" style=\"color: #000000\">We study physical properties and mechano-electrical-chemical signaling in cancer. While extensive research has informed genetics and biochemical mechanisms in tumorigenesis, how mechanical and electrical signaling regulate cancer is less defined. Ion channels govern cell behaviors by perceiving physicochemical cues (mechanical force, membrane voltage, temperature, pH etc.) to control ion flux across membranes. We ask the following questions: <\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><span style=\"color: #333333\">At the system level, what are the <strong>mutational landscape and functional alterations of ion channels<\/strong> in cancer?<\/span><\/li>\n<li><span style=\"color: #333333\">At the tissue level, how do ion channels regulate <strong>tumor initiation, progression, metastasis, and drug resistance<\/strong> in genetically tractable animal models?\u00a0<\/span><\/li>\n<li><span style=\"color: #333333\">At the cellular level, how do ion channels <strong>perceive physicochemical cues<\/strong>\u00a0to control cancer cell state?<\/span><\/li>\n<li><span style=\"color: #333333\">At the molecular level, how do different ion channels form a <strong>functional network<\/strong> to regulate cancer cell behaviors?<\/span><\/li>\n<li><span style=\"color: #333333\">Can we use ion channel-targeting <strong>drugs<\/strong> to treat cancer?<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000\">Using multi-disciplinary approaches in multi-omics, bioinformatics, <em>Drosophila<\/em> and mouse genetics, xenograft modeling, advanced imaging, electrophysiology, and bioengineering, we discover disease mechanisms and therapeutic vulnerabilities at the interface of cancer biology, neuroscience, and mechanobiology.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\"><span style=\"color: #3366ff\">Richard Feynmann \u2014 Study hard what interests you the most in the most undisciplined, irreverent and original manner possible<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h4><div class=\"gap\" style=\"line-height: 15px; height: 15px;\"><\/div><\/h4>\n<h4><span style=\"color: #000000\"><strong>Funding partners<\/strong><\/span><\/h4>\n<p>[\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row margin_bottom=&#8221;30&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221;][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;351&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;http:\/\/www.sickkidsfoundation.com&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;35&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;http:\/\/www.sickkids.ca\/gfcc\/&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;403&#8243; img_size=&#8221;full&#8221; 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img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/www.concernfoundation.org&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;411&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;http:\/\/www.meaganswalk.com&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;402&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;http:\/\/www.sickkids.ca\/Brainchild\/&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;413&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;http:\/\/www.rare-diseases-catalyst-network.ca&#8221;][\/vc_column][\/vc_row][vc_row margin_bottom=&#8221;30&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221;][vc_column width=&#8221;1\/6&#8243;][vc_empty_space height=&#8221;25px&#8221;][vc_single_image image=&#8221;787&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/www.utoronto.ca&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;432&#8243; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/oicr.on.ca&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;425&#8243; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;http:\/\/cdmrp.army.mil\/default&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_empty_space height=&#8221;20px&#8221;][vc_single_image image=&#8221;473&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;http:\/\/www.chairs-chaires.gc.ca\/chairholders-titulaires\/profile-eng.aspx?profileId=4370&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_empty_space height=&#8221;26px&#8221;][vc_single_image image=&#8221;594&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;http:\/\/www.sontagfoundation.org&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_empty_space height=&#8221;64px&#8221;][vc_single_image image=&#8221;847&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/www.ontario.ca\/page\/early-researcher-awards&#8221;][\/vc_column][\/vc_row][vc_row margin_bottom=&#8221;30&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221;][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;1002&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/www.pablove.org&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;1005&#8243; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/rallyfoundation.org&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;1000&#8243; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/www.braintumour.ca&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;1003&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/hopperbelmont.org&#8221;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;1288&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/charlieteofoundation.org.au&#8221;][\/vc_column][\/vc_row][vc_row type=&#8221;3&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-60&#8243; margin_bottom=&#8221;20&#8243; padding_top=&#8221;125&#8243; padding_bottom=&#8221;60&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; anchor=&#8221;People&#8221; css=&#8221;.vc_custom_1458741518961{margin-bottom: 20px !important;}&#8221;][vc_column][vc_empty_space height=&#8221;10px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h4><span style=\"color: #000000\"><strong>People<\/strong><\/span><\/h4>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;3&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-40&#8243; margin_bottom=&#8221;20&#8243; padding_top=&#8221;10&#8243; padding_bottom=&#8221;60&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; min_height=&#8221;230&#8243; anchor=&#8221;Research&#8221;][vc_column][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h6><span style=\"color: #000000\"><strong><span style=\"color: #333333\"><a class=\"dt-pswp-item\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/12\/Screenshot-2022-12-10-at-12.00.21-AM.jpg\" data-dt-img-description=\"\" data-large_image_width=\"1706\" data-large_image_height=\"1843\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1057 size-medium alignleft\" src=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/12\/Screenshot-2022-12-10-at-12.00.21-AM-272x300.jpg\" alt=\"\" width=\"272\" height=\"300\" srcset=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/12\/Screenshot-2022-12-10-at-12.00.21-AM-272x300.jpg 272w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/12\/Screenshot-2022-12-10-at-12.00.21-AM-929x1024.jpg 929w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/12\/Screenshot-2022-12-10-at-12.00.21-AM-768x846.jpg 768w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/12\/Screenshot-2022-12-10-at-12.00.21-AM-1394x1536.jpg 1394w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/12\/Screenshot-2022-12-10-at-12.00.21-AM.jpg 1414w\" sizes=\"auto, (max-width: 272px) 100vw, 272px\" \/><\/a><\/span><\/strong><\/span><\/h6>\n<h6><\/h6>\n<h6 style=\"text-align: left\"><span style=\"color: #000000\"><strong><span style=\"color: #333333\">Xi Huang, PhD<\/span><\/strong><\/span><\/h6>\n<p><span style=\"color: #333333\">Canada Research Chair in\u00a0Cancer Biophysics<\/span><\/p>\n<p><span style=\"color: #333333\">Senior Scientist &#8211; Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children<\/span><\/p>\n<p><span style=\"color: #333333\">Senior Scientist &#8211; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children<\/span><\/p>\n<p><span style=\"color: #333333\">Associate Professor &#8211; Department of Molecular Genetics, University of Toronto<\/span><\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:xi.huang@sickkids.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;3&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-40&#8243; margin_bottom=&#8221;20&#8243; padding_top=&#8221;10&#8243; padding_bottom=&#8221;60&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; min_height=&#8221;230&#8243; anchor=&#8221;Research&#8221;][vc_column][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h6><span style=\"color: #000000\"><strong><span style=\"color: #333333\"><a href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2023\/01\/Nalma-1-scaled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1076 size-medium alignleft\" src=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2023\/01\/Nalma-1-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2023\/01\/Nalma-1-300x225.jpg 300w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2023\/01\/Nalma-1-1024x768.jpg 1024w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2023\/01\/Nalma-1-768x576.jpg 768w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2023\/01\/Nalma-1-1536x1151.jpg 1536w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2023\/01\/Nalma-1-2048x1535.jpg 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>Nalma Uy<\/span><\/strong><\/span><\/h6>\n<p><span style=\"color: #333333\">Administrative Assistant to Dr. Xi Huang<\/span><\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:nalma.uy@sickkids.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;3&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-60&#8243; margin_bottom=&#8221;20&#8243; padding_top=&#8221;30&#8243; padding_bottom=&#8221;60&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; anchor=&#8221;People&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h6><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1028 size-medium\" src=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/11\/Zaleena-Akheralie-300x225.jpg\" alt=\"Graduate student Zaleena Akheralie\" width=\"300\" height=\"225\" srcset=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/11\/Zaleena-Akheralie-300x225.jpg 300w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/11\/Zaleena-Akheralie.jpg 768w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Zaleena Akheralie, B.Sc.<\/strong><\/h6>\n<p><span style=\"color: #333333\">PhD Student<\/span><\/p>\n<p><span style=\"color: #333333\">Department of Molecular Genetics, University of Toronto<\/span><\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:zaleena.akheralie@sickkids.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>\n<p>&nbsp;<\/p>\n<p><strong><div class=\"gap\" style=\"line-height: 18px; height: 18px;\"><\/div>Education:<\/strong><\/p>\n<p>B.Sc. &#8211; Specialist in Molecular Biology and minor in Chemistry,\u00a0University of Toronto<\/p>\n<ul>\n<li>Garron Family Cancer Centre Travel Award, The Hospital for Sick Children (2025)<\/li>\n<li>Travel Award, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children (2025)<\/li>\n<li>Ontario Graduate Scholarship (2025-2026)<\/li>\n<li>Henry and Berenice Kaufmann Foundation Trainee Award in Brain Cancer Research, Brain Canada Foundation (2024)<\/li>\n<li>Collaborative Specialization in Developmental Biology\u00a0Graduate Student Grant Proposal Award, University of Toronto (2024)<\/li>\n<li>Restracomp Scholarship, The Hospital for Sick Children (2024)<\/li>\n<li>Research Training Centre (RTC) Travel Award, The Hospital for Sick Children (2023-2024)<\/li>\n<\/ul>\n<p style=\"text-align: left\"><div class=\"gap\" style=\"line-height: 15px; height: 15px;\"><\/div>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h6><span style=\"color: #333333\"><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1026 size-medium\" src=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/11\/Julia-Carrillo-Garcia-300x225.jpg\" alt=\"Postdoctoral Fellow Julia Carrillo Garc\u00eda\" width=\"300\" height=\"225\" srcset=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/11\/Julia-Carrillo-Garcia-300x225.jpg 300w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/11\/Julia-Carrillo-Garcia-1024x768.jpg 1024w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/11\/Julia-Carrillo-Garcia-768x576.jpg 768w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/11\/Julia-Carrillo-Garcia-1536x1152.jpg 1536w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/11\/Julia-Carrillo-Garcia-2048x1536.jpg 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/strong><\/span><strong>Julia Carrillo-Garcia, PhD<\/strong><\/h6>\n<p><span style=\"color: #333333\">Postdoctoral Fellow<br \/>\n<\/span><\/p>\n<p>Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children<\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:julia.carrillogarcia@sickkids.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>\n<p><strong><div class=\"gap\" style=\"line-height: 12px; height: 12px;\"><\/div>Education:<\/strong><\/p>\n<p>PhD &#8211; Biomedicine, Pompeu Fabra University<\/p>\n<ul>\n<li>Poster Award, Society of Chinese Bioscientists in America (SCBA) &#8211; Toronto Chapter (2026)<\/li>\n<li>Garron Family Cancer Centre Travel Award, The Hospital for Sick Children (2025)<\/li>\n<li>Travel Award, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children (2025)<\/li>\n<li>Restracomp Fellowship, The Hospital for Sick Children (2023-2025)<\/li>\n<\/ul>\n<div class=\"gap\" style=\"line-height: 15px; height: 15px;\"><\/div>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;3&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-60&#8243; margin_bottom=&#8221;20&#8243; padding_top=&#8221;30&#8243; padding_bottom=&#8221;60&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; anchor=&#8221;People&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h6><span style=\"color: #333333\"><strong><a class=\"dt-pswp-item\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/03\/Jade-scaled.jpg\" data-dt-img-description=\"\" data-large_image_width=\"2560\" data-large_image_height=\"1920\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-936 alignleft\" src=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/03\/Jade-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/03\/Jade-300x225.jpg 300w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/03\/Jade-1024x768.jpg 1024w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/03\/Jade-768x576.jpg 768w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/03\/Jade-1536x1152.jpg 1536w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2022\/03\/Jade-2048x1536.jpg 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>Jade Chan, PhD<\/strong><\/span><\/h6>\n<p><span style=\"color: #333333\">Postdoctoral Fellow<br \/>\n<\/span><\/p>\n<p>Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children<\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:jade.chan@sickkids.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>\n<p><strong><div class=\"gap\" style=\"line-height: 12px; height: 12px;\"><\/div>Education:<\/strong><\/p>\n<p>PhD &#8211; Molecular Genetics, University of Toronto<\/p>\n<p>B.Sc. &#8211; Co-operative Program, Major: Honours Psychology, Minor: Biology, University of Waterloo<\/p>\n<ul>\n<li>Research Training Centre (RTC) Travel Award, The Hospital for Sick Children (2026)<\/li>\n<li>Travel Award, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children (2025)<\/li>\n<li>Ontario Graduate Scholarship (2023-2024)<\/li>\n<li>School of Graduate Studies (SGS) Conference Grant, University of Toronto (2023)<\/li>\n<li>Restracomp Scholarship, The Hospital for Sick Children (2020-2024)<\/li>\n<\/ul>\n<div class=\"gap\" style=\"line-height: 15px; height: 15px;\"><\/div>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h6><span style=\"color: #333333\"><strong><a class=\"dt-pswp-item\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/11\/Junsheng-Chen-scaled-e1732643010593.jpg\" data-dt-img-description=\"\" data-large_image_width=\"2560\" data-large_image_height=\"1920\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1397 size-medium\" src=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/11\/Junsheng-Chen-scaled-e1732643460569-300x229.jpg\" alt=\"\" width=\"300\" height=\"229\" srcset=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/11\/Junsheng-Chen-scaled-e1732643460569-300x229.jpg 300w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/11\/Junsheng-Chen-scaled-e1732643460569-1024x783.jpg 1024w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/11\/Junsheng-Chen-scaled-e1732643460569-768x587.jpg 768w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/11\/Junsheng-Chen-scaled-e1732643460569.jpg 1233w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>Junsheng Chen, MD PhD<\/strong><\/span><\/h6>\n<p>Postdoctoral Fellow<\/p>\n<p>Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children<\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:junsheng.chen@sickkids.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>\n<p><strong><div class=\"gap\" style=\"line-height: 12px; height: 12px;\"><\/div>Education:<\/strong><\/p>\n<p>PhD &#8211; Cell Biology, University of Alberta<\/p>\n<ul>\n<li>Restracomp Fellowship, The Hospital for Sick Children (2026-2028)<\/li>\n<\/ul>\n<div class=\"gap\" style=\"line-height: 15px; height: 15px;\"><\/div>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;3&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-60&#8243; margin_bottom=&#8221;20&#8243; padding_top=&#8221;30&#8243; padding_bottom=&#8221;60&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; anchor=&#8221;People&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h6><span style=\"color: #333333\"><strong><a href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/12\/Nathan-Ng-scaled.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1486 size-medium\" src=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/12\/Nathan-Ng-scaled-e1765839548728-300x250.jpeg\" alt=\"\" width=\"300\" height=\"250\" srcset=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/12\/Nathan-Ng-scaled-e1765839548728-300x250.jpeg 300w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/12\/Nathan-Ng-scaled-e1765839548728-1024x853.jpeg 1024w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/12\/Nathan-Ng-scaled-e1765839548728-768x640.jpeg 768w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/12\/Nathan-Ng-scaled-e1765839548728-1536x1280.jpeg 1536w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/12\/Nathan-Ng-scaled-e1765839548728.jpeg 1750w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/strong><\/span><strong>Nathan Ng, B.Sc.<\/strong><\/h6>\n<p><span style=\"color: #333333\">M.Sc. Student<br \/>\n<\/span><\/p>\n<p style=\"font-weight: 400\"><span style=\"color: #333333\">Department of Molecular Genetics, University of Toronto<\/span><\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:nathann.ng@mail.utoronto.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>\n<p><strong><div class=\"gap\" style=\"line-height: 12px; height: 12px;\"><\/div>Education:<\/strong><\/p>\n<p style=\"font-weight: 400\">B.Sc. \u2013 Specialist in Pharmacology, University of Toronto<\/p>\n<div class=\"gap\" style=\"line-height: 15px; height: 15px;\"><\/div>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h6><span style=\"color: #333333\"><strong><a href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/10\/Qi.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1391 size-medium\" src=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/10\/Qi-e1765839690272-300x249.jpg\" alt=\"\" width=\"300\" height=\"249\" srcset=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/10\/Qi-e1765839690272-300x249.jpg 300w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/10\/Qi-e1765839690272-768x637.jpg 768w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/10\/Qi-e1765839690272.jpg 1000w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/strong><\/span><strong>Qi Yang, MD<\/strong><\/h6>\n<p><span style=\"color: #333333\">Postdoctoral Fellow<br \/>\n<\/span><\/p>\n<p>Developmental, Stem Cell and Cancer Biology Program, The Hospital for Sick Children<\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:qi.yang@sickkids.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>\n<p><strong><div class=\"gap\" style=\"line-height: 12px; height: 12px;\"><\/div>Education:<\/strong><\/p>\n<p>MD &#8211; Neurosurgery, Xiangya Hospital, Central South University<\/p>\n<ul>\n<li>Restracomp Fellowship, The Hospital for Sick Children (2025-2027)<\/li>\n<\/ul>\n<div class=\"gap\" style=\"line-height: 15px; height: 15px;\"><\/div>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<p><a href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/12\/Lab-photo-Liam.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1485 size-medium\" src=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/12\/Lab-photo-Liam-e1766077841604-300x245.jpg\" alt=\"\" width=\"300\" height=\"245\" srcset=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/12\/Lab-photo-Liam-e1766077841604-300x245.jpg 300w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/12\/Lab-photo-Liam-e1766077841604.jpg 678w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<h6><strong> Liam Zhang, B.Sc.<\/strong><\/h6>\n<p><span style=\"color: #333333\">PhD Student<br \/>\nDepartment of Molecular Genetics, University of Toronto<\/span><\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:lichoe.zhang@mail.utoronto.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>\n<p><strong><div class=\"gap\" style=\"line-height: 12px; height: 12px;\"><\/div>Education:<\/strong><\/p>\n<p>B.Sc. &#8211; Cell &amp; Molecular Biology, Human Biology, Immunology, University of Toronto<\/p>\n<div class=\"gap\" style=\"line-height: 15px; height: 15px;\"><\/div>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h6 style=\"text-align: left\"><span style=\"color: #333333\"><strong><a class=\"dt-pswp-item\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/09\/Robert-Du-Yang-Zhang-1.png\" data-dt-img-description=\"\" data-large_image_width=\"1812\" data-large_image_height=\"1924\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1387 size-medium\" src=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/09\/Robert-Du-Yang-Zhang-1-e1765839636965-300x251.png\" alt=\"\" width=\"300\" height=\"251\" srcset=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/09\/Robert-Du-Yang-Zhang-1-e1765839636965-300x251.png 300w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/09\/Robert-Du-Yang-Zhang-1-e1765839636965-1024x857.png 1024w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/09\/Robert-Du-Yang-Zhang-1-e1765839636965-768x643.png 768w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/09\/Robert-Du-Yang-Zhang-1-e1765839636965-1536x1286.png 1536w, https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/09\/Robert-Du-Yang-Zhang-1-e1765839636965.png 1754w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/strong><\/span><span style=\"color: #333333\"><strong>Robert Du Yang Zhang<\/strong><\/span><\/h6>\n<p><span style=\"color: #333333\">B.Sc. Student<\/span><\/p>\n<p><span style=\"color: #333333\">Cell &amp; Molecular Biology, Immunology, <\/span><span style=\"color: #333333\">University of Toronto<\/span><\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:robertdy.zhang@mail.utoronto.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Undergraduate Research Opportunity Program (UROP) Award, University of Toronto (2025)<\/li>\n<li>Lunenfeld Summer Student Scholarship, The Hospital for Sick Children (2025)<\/li>\n<li>Garron Family Cancer Centre Summer Student Award, The Hospital for Sick Children (2025)<\/li>\n<\/ul>\n<div class=\"gap\" style=\"line-height: 15px; height: 15px;\"><\/div>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;3&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-60&#8243; margin_bottom=&#8221;20&#8243; padding_top=&#8221;30&#8243; padding_bottom=&#8221;60&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; anchor=&#8221;People&#8221;][vc_column][vc_column_text]\n<table id=\"tablepress-2\" class=\"tablepress tablepress-id-2 tablepress-responsive\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">Name<\/th><th class=\"column-2\">Trainee Status<\/th><th class=\"column-3\">Achievements<\/th><th class=\"column-4\">Current Position<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">Jade Chan<\/td><td class=\"column-2\">PhD student (2018-2025)<\/td><td class=\"column-3\">\u2022\tTravel Award, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children (2025)<br \/>\n\u2022\tOntario Graduate Scholarship (2023-2024)<br \/>\n\u2022\tSchool of Graduate Studies (SGS) Conference Grant, University of Toronto (2023)<br \/>\n\u2022\tRestracomp Scholarship, The Hospital for Sick Children (2020-2024)<\/td><td class=\"column-4\">Postdoctoral Fellow, The Hospital for Sick Children<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">Hyun-Kee Min<\/td><td class=\"column-2\">PhD student (2017-2025)<\/td><td class=\"column-3\">\u2022\tPublication Award, Society of Chinese Bioscientists in America (SCBA) - Toronto Chapter (2025)<br \/>\n\u2022\tStudent Work Placement Program, BioTalent Canada (2025)<br \/>\n\u2022\tResearch Training Centre (RTC) Travel Award, The Hospital for Sick Children (2024)<br \/>\n\u2022\tSchool of Graduate Studies Conference Grant, University of Toronto (2023)<br \/>\n\u2022\tRestracomp Scholarship, The Hospital for Sick Children (2022)<br \/>\n\u2022\tOntario Graduate Scholarship (2021-2022)<br \/>\n<\/td><td class=\"column-4\">Health Economics and Outcomes Research Associate, Eversana<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">Anders Erickson<\/td><td class=\"column-2\">MD\/PhD student (2024-2025)<\/td><td class=\"column-3\">\u2022\tCanada Graduate Scholarship in Honour of Nelson Mandela (2023-2025)<br \/>\n\u2022\tRestracomp Scholarship, The Hospital for Sick Children (2023-2025)<br \/>\n\u2022\tMr. Robert and Ms. Francine Ruggles Innovation Award (2023-2024)<br \/>\n\u2022\t1st Prize Oral Presentation, Laboratory Medicine and Pathobiology Research Conference, University of Toronto (2023)<br \/>\n\u2022\tMD Program Research Conference Bursary (2022)<br \/>\n\u2022\tR.O. Torrance Bursary (2021 &amp; 2022)<br \/>\n\u2022\tOntario Graduate Scholarship (2021-2022)<br \/>\n\u2022\t1st Prize McMurrich E-Poster Competition, Department of Surgery \u201cGallie Day\u201d, University of Toronto (2021)<\/td><td class=\"column-4\">Medical Student, University of Toronto<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">Shahrzad Bahrampour<\/td><td class=\"column-2\">Postdoctoral Fellow (2019-2024)<\/td><td class=\"column-3\">\u2022\tPowered by Pablove Research Grant, Pablove Foundation (2023)<br \/>\n\u2022\tTravel Award, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children (2023)<br \/>\n\u2022\tBest Presentation Award, Garron Family Cancer Centre Cancer Research Day, The Hospital for Sick Children (2023)<br \/>\n\u2022\tRestracomp Fellowship, The Hospital for Sick Children (2022-2024)<br \/>\n\u2022\tInternational Postdoc Grant, Swedish Research Council (2018-2022)<br \/>\n\u2022\tBest Poster Presentation Prize, Canadian Drosophila Research Conference (2019)<\/td><td class=\"column-4\">Staff Scientist, Western University<\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\">Namal Abeysundara<\/td><td class=\"column-2\">Postdoctoral Fellow (2018-2024)<\/td><td class=\"column-3\">\u2022\tExceptional Trainee Award, The Hospital for Sick Children (2023)<br \/>\n\u2022\tRestracomp Fellowship, The Hospital for Sick Children (2022-2023)<br \/>\n\u2022\tRally Foundation for Childhood Cancer Research Postdoctoral Fellow Grant (2019-2021)<\/td><td class=\"column-4\">Specialist, Advanced Therapeutics Manufacturing Facility, University of British Columbia<\/td>\n<\/tr>\n<tr class=\"row-7\">\n\t<td class=\"column-1\">Deekshitha Jetta<\/td><td class=\"column-2\">Postdoctoral Fellow (2022-2023)<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">Research Scientist, Apollo Hospitals<\/td>\n<\/tr>\n<tr class=\"row-8\">\n\t<td class=\"column-1\">Ali Momin<\/td><td class=\"column-2\">PhD student (2017-2023)<\/td><td class=\"column-3\">\u2022\tRestracomp Scholarship, The Hospital for Sick Children (2021-2023)<br \/>\n\u2022\tOntario Graduate Scholarship (2021-2022)<br \/>\n\u2022\tGarron Family Cancer Centre Trainee Travel Award (2021)<br \/>\n\u2022\tOntario Graduate Scholarship (2020-2021)<br \/>\n\u2022\tSchool of Graduate Studies Conference Grant, University of Toronto (2019)<\/td><td class=\"column-4\">Consultant, Boston Consulting Group<\/td>\n<\/tr>\n<tr class=\"row-9\">\n\t<td class=\"column-1\">Xian Wang<\/td><td class=\"column-2\">Postdoctoral Fellow (2020-2023)<\/td><td class=\"column-3\">\u2022\tInspiration Award, Hopper-Belmont Foundation (2021)<br \/>\n\u2022\tDunn with Cancer Research Fellowship, Brain Tumour Foundation of Canada (2021-2023)<br \/>\n\u2022\tLap-Chee Tsui Fellowship, The Hospital for Sick Children (2021-2023)<\/td><td class=\"column-4\">Assistant Professor, Queen's University<\/td>\n<\/tr>\n<tr class=\"row-10\">\n\t<td class=\"column-1\">Xin Chen<\/td><td class=\"column-2\">Postdoctoral Fellow (2015-2022)<\/td><td class=\"column-3\">\u2022\tWinner of Abstract Competition, Cancer Neuroscience Meeting, MD Anderson Cancer Center (2022)<br \/>\n\u2022\tGarron Family Cancer Centre Travel Award (2022)<br \/>\n\u2022\tRestracomp Fellowship, The Hospital for Sick Children (2019-2021)<br \/>\n\u2022\tDr. Choong-Chin Liew Best Paper Award Honorable Mention, Society of Chinese Bioscientists in America (SCBA) - Toronto Chapter (2018)<\/td><td class=\"column-4\">Principal Investigator, Shanghai Jiaotong University<\/td>\n<\/tr>\n<tr class=\"row-11\">\n\t<td class=\"column-1\">Jerry Fan<\/td><td class=\"column-2\">PhD Student (2015-2022)<\/td><td class=\"column-3\">\u2022\tGarron Family Cancer Centre Travel Award (2022)<br \/>\n\u2022\tRestracomp Scholarship, The Hospital for Sick Children (2018-2020)<br \/>\n\u2022\tAmerican Brain Tumor Association Stipend (2018)<br \/>\n\u2022\tGarron Family Cancer Centre Travel Award (2018)<\/td><td class=\"column-4\">Senior Scientist, Precision Molecular Oncology, Bayer<\/td>\n<\/tr>\n<tr class=\"row-12\">\n\t<td class=\"column-1\">Weifan Dong<\/td><td class=\"column-2\">PhD Student (2015-2022)<\/td><td class=\"column-3\">\u2022\tCAN-CIHR-INMHA Brain Star Award, Canadian Association for Neuroscience (CAN) and Canadian Institutes of Health\u2019s Institute of Neurosciences, Mental Health and Addiction (CIHR-INMHA) (2023)<br \/>\n\u2022\tPublication Award, Society of Chinese Bioscientists in America (SCBA) - Toronto Chapter (2023)<br \/>\n\u2022\tGarron Family Cancer Centre Travel Award (2022)<br \/>\n\u2022\tBest Poster Award, Program in Developmental, Stem Cell &amp; Cancer Biology Retreat, The Hospital for Sick Children (2017)<\/td><td class=\"column-4\">Postdoctoral Fellow, University of Pennsylvania<\/td>\n<\/tr>\n<tr class=\"row-13\">\n\t<td class=\"column-1\">Kamilia Talipova<\/td><td class=\"column-2\">Research Technician (2021-2022)<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">Graduate Student, University of Toronto<\/td>\n<\/tr>\n<tr class=\"row-14\">\n\t<td class=\"column-1\">Siyi Wanggou<\/td><td class=\"column-2\">Postdoctoral Fellow (2020-2021)<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">Associate Professor, Neurosurgeon, Deputy Chief Physician, Xiangya Hospital, Central South University<\/td>\n<\/tr>\n<tr class=\"row-15\">\n\t<td class=\"column-1\">Rochelle McAdam<\/td><td class=\"column-2\">PhD Student (2015-2020)<\/td><td class=\"column-3\">\u2022\tOntario Graduate Scholarship (2019-2020)<br \/>\n\u2022\tDalton Whitebread Scholarship (2017-2018)<br \/>\n\u2022\tRestracomp Scholarship, The Hospital for Sick Children (2017-2020)<br \/>\n\u2022\tAmerican Brain Tumor Association Stipend (2016)<br \/>\n\u2022\tCold Spring Harbour Helmsley Charitable Trust Scholarship (2016)<\/td><td class=\"column-4\">Resident Physician, Western University<\/td>\n<\/tr>\n<tr class=\"row-16\">\n\t<td class=\"column-1\">Michelle Francisco<\/td><td class=\"column-2\">Research Project Coordinator (2015-2020)<\/td><td class=\"column-3\"><\/td><td class=\"column-4\">Medical Excellence and Operations Manager, Astellas Pharma<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-2 from cache -->[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;5&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-25&#8243; margin_bottom=&#8221;140&#8243; padding_top=&#8221;100&#8243; padding_bottom=&#8221;70&#8243; bg_cover=&#8221;true&#8221; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; min_height=&#8221;400&#8243; anchor=&#8221;Publications&#8221; css=&#8221;.vc_custom_1463592830102{margin-bottom: 140px !important;}&#8221;][vc_column][vc_empty_space][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h4><span style=\"color: #000000\"><strong>Publications<\/strong><\/span><\/h4>\n<p>[\/vc_column_text][vc_empty_space][vc_row_inner][vc_column_inner width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;1447&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/39862856\/&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;1405&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/37697045\/&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;1138&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/36323321\/&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;1155&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/33752907\/&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;1143&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/30344046\/&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;1\/6&#8243;][vc_single_image image=&#8221;1158&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/22855790\/&#8221;][\/vc_column_inner][\/vc_row_inner][vc_empty_space][vc_row_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_video link=&#8221;https:\/\/www.youtube.com\/watch?v=CDR0BikjA2M&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_video link=&#8221;https:\/\/www.youtube.com\/watch?v=ewpEt47cdac&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_video link=&#8221;https:\/\/www.youtube.com\/watch?v=YQMnEfMQIww&#8221;][\/vc_column_inner][\/vc_row_inner][vc_empty_space][vc_column_text]<\/p>\n<h5><\/h5>\n<h5><strong>BY TOPICS (SELECTED PUBLICATIONS)<\/strong><\/h5>\n<p>&nbsp;<\/p>\n<h5><strong>Ion channel regulation of tumor cell-fluid interaction<\/strong><\/h5>\n<ul>\n<li>Min HK*, Zhao H*, Bahcheli A, Pan P, Chan J, Chen J, Low E, Zhou Y, Wang X, Bajic S, Peng R, Wanggou S, Yang Q, Zhang RDY, Wang L, Ren X, Qi H, Shi Y, Hayes MN, Ciruna B, Reimand J, Liu X, Huang X (2025) Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis. <strong><em>Nature Biomedical Engineering <\/em><\/strong>doi.org\/10.1038\/s41551-025-01487-5 (* contributed equally) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40897897\/\">PMID: 40897897<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2026\/03\/Fluid-shear-stress-activates-a-targetable-mechano-metastatic.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p style=\"font-weight: 400;padding-left: 40px\"><em>Media coverage:<\/em><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">How brain fluid movement drives cancer spread and ways to fight back<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.sickkids.ca\/en\/news\/archive\/2025\/sickkids-scientists-discover-how-brain-fluid-movement-drives-cancer-spread-and-ways-to-fight-back\/\">SickKids News<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.eurekalert.org\/news-releases\/1097148\">EurekAlert!<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/medicalxpress.com\/news\/2025-09-brain-fluid-dynamics-cancer-ways.html\">Medical Express<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/ecancer.org\/en\/news\/26985-scientists-discover-how-brain-fluid-movement-drives-cancer-spread-and-ways-to-fight-back\">ecancer<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/healthmedicinet.com\/hmn-2025-how-brain-fluid-dynamics-cancer-ways\/\">Health Medicine Network<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Researchers uncover how brain fluid dynamics fuel cancer spread and reveal new strategies to combat it<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/bioengineer.org\/researchers-uncover-how-brain-fluid-dynamics-fuel-cancer-spread-and-reveal-new-strategies-to-combat-it\/\">Bioengineer.org<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/scienmag.com\/researchers-uncover-how-brain-fluid-dynamics-fuel-cancer-spread-and-reveal-new-strategies-to-combat-it\/\">Scienmag<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Cerebrospinal Fluid Dynamics Impact Medulloblastoma Spread<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.lifetechnology.com\/blogs\/life-technology-medical-news\/cerebrospinal-fluid-dynamics-impact-medulloblastoma-spread\">Life Technology<sup>TM<\/sup><\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">How fluid motion in the brain accelerates medulloblastoma spread<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/moleculargenetics.utoronto.ca\/news\/new-study-huang-lab-reveals-how-fluid-motion-brain-accelerates-medulloblastoma-spread\">MoGen Communications<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<h5><strong>Ion channel regulation of tumor cell-neuron interaction<\/strong><\/h5>\n<ul>\n<li>Dong W, Fekete A, Chen X, Liu H, Beilhartz GL, Chen X, Bahrampour S, Xiong Y, Yang Q, Zhao H, Kong T, Morioka MS, Jung G, Kim JE, Schramek D, Dirks PB, Song Y, Kim TH, He Y, Wanggou S, Li X, Melnyk RA, Wang LY, Huang X (2023) A designer peptide against the EAG2-Kv\u03b22 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma. <strong><em>Nature Cancer<\/em><\/strong> 4, 1418\u20131436 (<strong>Cover Article<\/strong>) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37697045\/\">PMID: 37697045<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/DesignerPeptide.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p style=\"font-weight: 400;padding-left: 40px\"><em>Editorial highlights<\/em><em>:<\/em><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Editorial: <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.nature.com\/articles\/s43018-023-00664-2\">The never-abating excitement for targeted therapies<\/a><\/span>. <em>Nature Cancer<\/em> 4, 1397-1398<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">News &amp; Views: <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.nature.com\/articles\/s43018-023-00640-w\">Targeting network circuitry in glioma<\/a><\/span>. <em>Nature Cancer<\/em> 4, 1406\u20131407<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Behind the paper: <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/cancercommunity.nature.com\/posts\/a-designer-peptide-against-the-eag2-kv-2-potassium-channel-targets-the-interaction-of-cancer-cells-and-neurons-to-treat-glioblastoma\">Nature Cancer Community<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><em>Media coverage<\/em><em>:<\/em><\/p>\n<p style=\"padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.youtube.com\/watch?v=CDR0BikjA2M\">Video abstract<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Discovery of protein-protein interaction lays foundation for future glioblastoma therapy<\/p>\n<p style=\"padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.sickkids.ca\/en\/news\/archive\/2023\/discovery-of-protein-protein-interaction-lays-foundation-for-future-glioblastoma-therapy\/\">SickKids News<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.eurekalert.org\/news-releases\/1001029\">EurekAlert!<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/bioengineer.org\/discovery-of-protein-protein-interaction-lays-foundation-for-future-glioblastoma-therapy\/\">Bioengineer.org<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.technologynetworks.com\/tn\/news\/potential-brain-cancer-therapy-uncovered-by-protein-interaction-discovery-378696\">Technology Networks<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.news-medical.net\/news\/20230911\/Study-reveals-a-new-potential-treatment-approach-for-glioblastoma.aspx\">News Medical<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.thedailyscience.org\/new-designer-peptide-shows-promise-in-treating-glioblastoma.html\">The Daily Science<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/press-news.org\/179093-discovery-of-protein-protein-interaction-lays-foundation-for-future-glioblastoma-therapy.html\">Press-News.org<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/medicalxpress.com\/news\/2023-09-discovery-protein-protein-interaction-lays-foundation.html\">Medical Xpress<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.nouvelles-du-monde.com\/therapie-potentielle-contre-le-cancer-du-cerveau-decouverte-grace-a-la-decouverte-des-interactions-proteiques\/\">Nouvelles Du Monde<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/futur-en-seine.paris\/un-traitement-potentiel-pour-le-cancer-du-cerveau-decouvert-grace-a-la-decouverte-dinteractions-proteiques\/\">Futur en Seine<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Designer Peptide Targeting Protein-Protein Interaction Could Become Glioblastoma Treatment <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.insideprecisionmedicine.com\/topics\/oncology\/designer-peptide-targeting-protein-protein-interaction-could-become-glioblastoma-treatment\/\">Inside Precision Medicine<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Cracking the cancer-neuroscience connection <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.drugdiscoverynews.com\/cracking-the-cancer-neuroscience-connection-15882\">Drug Discovery News<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Researchers pave the way for new glioblastoma treatment <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/moleculargenetics.utoronto.ca\/news\/mogen-researchers-xi-huang-lab-pave-way-new-glioblastoma-treatment\">Department of Molecular Genetics, University of Toronto<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">First-in-class\u591a\u80bd\u5206\u5b50\u901a\u8fc7\u6291\u5236\u80bf\u7624-\u795e\u7ecf\u5143\u4e92\u4f5c\u6cbb\u7597\u8111\u80f6\u8d28\u7624 <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA3MzQyNjY1MQ==&amp;mid=2652710214&amp;idx=5&amp;sn=51898a86a2c08289d9a89f5a7e501b8d&amp;chksm=84e6b6f2b3913fe42589d3e057707a7145b91c276a60759ca437501866de721c3957d4103a43&amp;scene=0&amp;xtrack=1\">BioArt<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">SickKids\u79d1\u7814\u7a81\u7834\uff1a\u52a9\u529b\u7814\u53d1\u8111\u764c\u65b0\u7597\u6cd5 <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/mp.weixin.qq.com\/s\/yUpStTvc39bMAbQ_Y4BFsw\">SickKids\u75c5\u7ae5\u533b\u9662\u57fa\u91d1\u4f1a<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<h5><strong>Ion channel regulation of tumor cell-blood vessel interaction<\/strong><\/h5>\n<ul>\n<li>Chen X*, Momin A*, Wanggou S*, Wang X, Min HK, Dou W, Gong Z, Chan J, Dong W, Fan JJ, Xiong Y, Talipova K, Zhao H, Chen YX, Veerasammy K, Fekete A, Kumar SA, Liu H, Yang Q, Son JE, Dou Z, Hu M, Pardis P, Juraschka K, Donovan L, Zhang J, Ramaswamy V, Selvadurai H, Dirks PB, Taylor MD, Wang LY, Hui CC, Abzalimov R, He Y, Sun Y, Li X<sup>#<\/sup>, Huang X<sup>#,\u00a7<\/sup>\u00a0(2023) Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity. <strong><em>Neuron<\/em> <\/strong>111:30-48 (<strong>Cover Article<\/strong>)\u00a0(* contributed equally,\u00a0<sup>#<\/sup>\u00a0corresponding author,\u00a0<sup>\u00a7\u00a0<\/sup>lead contact) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36323321\/\">PMID: 36323321<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Xin-Chen-2-2023.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p style=\"font-weight: 400;padding-left: 40px\"><em>Editorial highlights<\/em><em>:<\/em><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Preview:\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(22)01081-9?dgcid=raven_jbs_etoc_email\">Breaking down the barrier to medulloblastoma treatment: Piezo2 knockout disrupts the BTB and increases vascular permeability<\/a><\/span>. <em>Neuron<\/em> 111(1):3-5<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><em>Media coverage<\/em><em>:<\/em><em>\u00a0<\/em><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">New research rethinks the blood-tumour barrier and identifies novel path to brain cancer treatment<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.sickkids.ca\/en\/news\/archive\/2022\/new-research-rethinks-the-blood-tumour-barrier-and-identifies-novel-path-to-brain-cancer-treatment\/\">SickKids News<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.eurekalert.org\/news-releases\/969793\">EurekAlert!<\/a>,\u00a0<a style=\"color: #3366ff\" href=\"https:\/\/medicalxpress.com\/news\/2022-11-rethinks-blood-tumor-barrier-path-brain.html\">Medical Xpress<\/a>,\u00a0<a style=\"color: #3366ff\" href=\"https:\/\/www.news-medical.net\/news\/20221101\/New-research-lays-the-foundation-for-more-effectively-treating-pediatric-brain-tumor.aspx\">News-Medical<\/a>,\u00a0<a style=\"color: #3366ff\" href=\"https:\/\/www.technologynetworks.com\/cancer-research\/news\/bloodtumor-barrier-discovery-could-advance-brain-cancer-treatment-367202\">Technology Networks<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Breaking through the blood-tumour barrier to better treat brain cancer <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/oicr.on.ca\/breaking-through-the-blood-tumour-barrier-to-better-treat-brain-cancer\/\">OICR News<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Study provides path for overcoming blood-tumor barrier in treating medulloblastoma\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.scienceboard.net\/index.aspx?sec=ser&amp;sub=def&amp;pag=dis&amp;ItemID=4946\">The Science Advisory Board<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Touch receptor plays a role in blood-tumor barrier\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.bioworld.com\/articles\/691204-touch-receptor-plays-role-in-blood-tumor-barrier\">BioWorld<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">\u673a\u68b0\u654f\u611f\u6027\u80bf\u7624\u7ec6\u80de\u6784\u6210\u7684\u5168\u65b0\u8840-\u80bf\u7624\u5c4f\u969c\u963b\u788d\u8111\u80bf\u7624\u5316\u7597\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/mp.weixin.qq.com\/s\/VKvMsfLB-vwMho8SwKXc9w?from=citexs\">BioArt<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<h5><strong>Ion channel regulation of tumor cell-extracellular matrix interaction<\/strong><\/h5>\n<ul>\n<li>Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan J, Yin WC, Min HK, Hu M, Draghici D, Dou W, Li F, Coutinho FJ, Whetstone H, Kushida MM, Dirks PB, Song Y, Hui CC, Sun Y, Wang LY, Li X, Huang X (2018) A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression. <strong><em>Neuron<\/em><\/strong> 100(4):799-815.e7.<span style=\"color: #3366ff\"> <a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30344046\/\">PMID: 30344046<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Xin-Chen-2018.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p style=\"padding-left: 40px\"><em>Editorial highlights<\/em><em>:<\/em><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Video abstract: <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.youtube.com\/watch?v=YQMnEfMQIww&amp;themeRefresh=1\">how brain tumors stiffen and grow<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Preview:\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(18)31002-X\">Unlocking the dangers of a stiffening brain<\/a> <\/span><em>Neuron<\/em> 100(4):763-765<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/f1000.com\/prime\/734273220\">F1000Prime Recommended<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.cell.com\/bestof\">Best of Neuron 2018-2019<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><em>Media coverage<\/em><em>:<\/em><em>\u00a0<\/em><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">May the force not be with you\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.sickkids.ca\/AboutSickKids\/Newsroom\/Past-News\/2018\/brain-tumour-cells-hijack-ion-channels.html\">SickKids News<\/a>,\u00a0<a style=\"color: #3366ff\" href=\"https:\/\/www.cancerstemcellnews.com\/issue\/volume-7-42-oct-24\/\">Cancer Stem Cell News<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Researchers find a new way to address the challenge of brain tumour \u201cstiffness\u201d\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/news.oicr.on.ca\/2018\/10\/researchers-find-a-new-way-to-address-the-challenge-of-brain-tumour-stiffness\/\">OICR News<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">\u8c03\u8282\u80bf\u7624\u7ec4\u7ec7\u673a\u68b0\u7279\u6027\u6216\u53ef\u6210\u4e3a\u80bf\u7624\u6cbb\u7597\u65b0\u65b9\u5f0f\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA3MzQyNjY1MQ==&amp;mid=2652463528&amp;idx=1&amp;sn=9a3d048c72fe8e1018f75b28731cc311&amp;chksm=84e2f21cb3957b0a2baf16e8785c31665ebc9d505f2d78d30fe8a7a3a4260453c3468c4be586&amp;scene=21#wechat_redirect\">BioArt<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<h5><strong>Ion channel regulation of tumor cell-intrinsic properties<\/strong><\/h5>\n<ul>\n<li>Fan JJ*, Erickson AW*, Carrillo-Garcia J*, Wang X*, Skowron P*, Wang X, Chen X, Shan G, Dou W, Bahrampour S, Xiong Y, Dong W, Abeysundara N, Francisco MA, Pusong RJ, Wang W, Li M, Ying E, Su\u00e1rez RA, Farooq H, Holgado BL, Wu X, Daniels C, Dupuy AJ, Cadi\u00f1anos J, Bradley A, Bagchi A, Moriarity BS, Largaespada DA, Morrissy AS, Ramaswamy V, Mack SC, Garzia L, Dirks PB, Li X, Wanggou S, Egan S, Sun Y, Taylor MD<sup>#<\/sup>, Huang X<sup>#<\/sup> (2025) A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance. <strong><em>Developmental Cell <\/em><\/strong><span lang=\"EN-US\">60 (11), 1532-1549 <\/span>(<strong>Cover Article<\/strong>) (* contributed equally, <sup>#<\/sup> corresponding author)\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39862856\/\">PMID:39862856<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/05\/A-forward-genetic-screen-identifies-potassium-channel-essentiality-in-SHH-medulloblastoma-maintenance.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p style=\"font-weight: 400;padding-left: 40px\"><em>Editorial highlight<\/em>:<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Preview: <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.cell.com\/developmental-cell\/abstract\/S1534-5807(25)00254-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1534580725002540%3Fshowall%3Dtrue\">Taking the \u201clazy\u201d way identifies KCNB2 as a regulator of SHH-MB maintenance<\/a>.<\/span> <em>Developmental Cell<\/em> 60 (11), 1517-1518<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><em>Media coverage:<\/em><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Targeting potassium channel shows promise for treating brain tumours<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.sickkids.ca\/en\/news\/archive\/2025\/targeting-potassium-channel-shows-promise-for-treating-brain-tumours\/\">SickKids News<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.sciencedaily.com\/releases\/2025\/01\/250124151010.htm\">ScienceDaily<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.eurekalert.org\/news-releases\/1071620\">EurekAlert!<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/medicalxpress.com\/news\/2025-01-potassium-channel-brain-tumors-children.html\">Medical Express<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.technologynetworks.com\/cancer-research\/news\/blocking-potassium-channels-could-halt-medulloblastoma-growth-395395\">Technology Networks<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.news-medical.net\/news\/20250124\/Breakthrough-gene-discovery-offers-new-hope-for-medulloblastoma-therapy.aspx\">News-Medical<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.insideprecisionmedicine.com\/topics\/oncology\/newly-discovered-medulloblastoma-tumor-driver-gene-could-lead-to-more-effective-treatments\/\">Inside Precision Medicine<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">The Role of KCNB2 in SHH Medulloblastoma: A Path to Targeted Cancer Therapy<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/medicineinnovates.com\/role-kcnb2-shh-medulloblastoma-path-targeted-cancer-therapy\/\">Medicine Innovates<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Exploring Potassium Channel Inhibition: A Promising Avenue for Brain Tumor Therapeutics <a href=\"https:\/\/bioengineer.org\/exploring-potassium-channel-inhibition-a-promising-avenue-for-brain-tumor-therapeutics\/#google_vignette\"><span style=\"color: #3366ff\">Bioengineer.org<\/span><\/a><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">\u201cLazy Piggy\u201d genetic tool identifies tumour weakness in medulloblastoma <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/moleculargenetics.utoronto.ca\/news\/huang-labs-study-pediatric-brain-cancer-lands-developmental-cell-cover\">MoGen Communications<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">\u6b63\u5411\u9057\u4f20\u5b66\u7b5b\u9009\u63ed\u793a\u94be\u79bb\u5b50\u901a\u9053\u7ef4\u6301\u9ad3\u6bcd\u7ec6\u80de\u7624\u751f\u957f\u673a\u5236 <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.163.com\/dy\/article\/JMO4OLCO0532BT7X.html\">BioArt<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Bahcheli AT*, Min HK*, Bayati M, Zhao H, Fortuna A, Dong W, Dzneladze I, Chan J, Chen X, Guevara-Hoyer K, Dirks PB, Huang X<sup>#<\/sup>, Reimand J<sup>#<\/sup> (2024) Pan-cancer ion transport signature reveals functional regulators of glioblastoma aggression. <strong><em>The<\/em><\/strong> <strong><em>EMBO Journal <\/em><\/strong>43: 196\u2013224 (* contributed equally, <sup>#<\/sup>corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38177502\/\"><span class=\"id-label\"><span style=\"color: #3366ff\">PMID: <\/span><\/span><span style=\"color: #3366ff\">38177502<\/span><\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Alexander-T-Bahcheli-2024.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p style=\"padding-left: 40px\"><em>Media coverage:<\/em><\/p>\n<p style=\"padding-left: 40px\">AI helps find new leads for brain cancer drug discovery <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/oicr.on.ca\/ai-helps-find-new-leads-for-brain-cancer-drug-discovery\/\">OICR News<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Francisco MA, Wanggou S, Fan JJ, Dong W, Chen X, Momin A, Abeysundara N, Min HK, Chan J, McAdam R, Sia M, Pusong RJ, Liu S, Patel N, Ramaswamy V, Kijima N, Wang LY, Song Y, Kafri R, Taylor MD, Li X<sup>#<\/sup>, Huang X<sup># <\/sup>(2020) Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth. <strong><em>Journal of Experimental Medicine<\/em><\/strong> 217(5):e20190971. (<sup>#<\/sup> corresponding author)<span style=\"color: #3366ff\"> <a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32097463\/\">PMID: 32097463<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Michelle-A.-2020.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p style=\"padding-left: 40px\"><em>Media coverage:<\/em><\/p>\n<p style=\"padding-left: 40px\">Study shows common cell protein could be targeted to treat childhood brain cancers\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/news.oicr.on.ca\/2020\/02\/study-shows-common-cell-protein-could-be-targeted-to-treat-childhood-brain-cancers\/\">OICR News<\/a><\/span><\/p>\n<p style=\"padding-left: 40px\">\u6c2f\u79bb\u5b50\u901a\u9053CLIC1\u5728\u9ad3\u6bcd\u7ec6\u80de\u7624\u7684\u81f4\u75c5\u4f5c\u7528\u673a\u5236\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA3MzQyNjY1MQ==&amp;mid=2652481834&amp;idx=8&amp;sn=d2f744a8b128863fef803fd2d2a8f531&amp;chksm=84e23a9eb395b3881a1535fc30841b8d10e087ddc50503f09fefcb1f70f578b7951ea6dc7b3b&amp;scene=21#wechat_redirect\">BioArt<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X*, He Y*, Dubuc AM*, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens S, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN<sup>#<\/sup>, Jan LY<sup>#<\/sup> (2015) EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. <strong><em>Nature Neuroscience<\/em><\/strong> 18(9): 1236-46. (* contributed equally,\u00a0<sup>#<\/sup> corresponding author)<span style=\"color: #3366ff\"> <a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26258683\/\">PMID: 26258683<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Xi-Huang-2015.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p style=\"padding-left: 40px\"><em>Editorial highlights<\/em>:<\/p>\n<p style=\"padding-left: 40px\">Channeling brain cancer.<em> Science Signaling<\/em>\u00a0(2015): 8 (392), ec245<\/p>\n<p style=\"padding-left: 40px\">Therapy: Reinventing the wheel.<em> Nature Reviews Cancer <\/em>(2015): 15, 514<\/p>\n<p style=\"padding-left: 40px\">EAG2 potassium channel: A new regulator of malignancy and therapeutic target in medulloblastoma. <em>Neuro-Oncology<\/em> (2015): 17(12), 1547<\/p>\n<p style=\"padding-left: 40px\">Voltage spikes driving medulloblastoma. <em>Cancer Research<\/em> (2015): 75, 4439<\/p>\n<p style=\"padding-left: 40px\">Targeting ion channels in cancer. <em>Lab Animal <\/em>(2015):\u00a044, 370<\/p>\n<p style=\"padding-left: 40px\"><em>Media coverage<\/em><em>:\u00a0<\/em><\/p>\n<p style=\"padding-left: 40px\">Common class of \u201cchannel blocking\u201d drugs may find a role in cancer therapy <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.sciencedaily.com\/releases\/2015\/08\/150811092140.htm\">ScienceDaily<\/a>, <a style=\"color: #3366ff\" href=\"http:\/\/www.eurekalert.org\/pub_releases\/2015-08\/uoc--cco081015.php\">EurekAlert!<\/a>,\u00a0<a style=\"color: #3366ff\" href=\"http:\/\/www.neuroscientistnews.com\/clinical-updates\/common-class-channel-blocking-drugs-may-find-role-cancer-therapy\">Neuroscientist News<\/a>, <a style=\"color: #3366ff\" href=\"http:\/\/www.newswise.com\/articles\/common-class-of-channel-blocking-drugs-may-find-a-role-in-cancer-therapy\">Newswise<\/a>, <a style=\"color: #3366ff\" href=\"http:\/\/www.healthcanal.com\/cancers\/66011-common-class-of-%E2%80%98channel-blocking%E2%80%99-drugs-may-find-a-role-in-cancer-therapy.html\">HealthCanal<\/a>,\u00a0<a style=\"color: #3366ff\" href=\"https:\/\/www.ucsf.edu\/news\/2015\/08\/131261\/common-class-%E2%80%98channel-blocking%E2%80%99-drugs-may-find-role-cancer-therapy\">UCSF\u00a0News Center<\/a><\/span><\/p>\n<p style=\"padding-left: 40px\">Potassium Channel Blockers Show Promise as Treatment for Brain Tumors <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.oncotherapynetwork.com\/central-nervous-system-cancer-targets\/potassium-channel-blockers-show-promise-treatment-brain-tumors\">OncoTherapy Network<\/a><\/span><\/p>\n<p style=\"padding-left: 40px\">Targeting an Ion Channel to Treat Common Pediatric Brain Tumor <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/news.feinberg.northwestern.edu\/2015\/09\/targeting-an-ion-channel-to-treat-most-common-pediatric-brain-tumor\/\">Northwestern University News Center<\/a><\/span><\/p>\n<p style=\"padding-left: 40px\">Ion Channels May Play a Role in a New Generation of Cancer Therapies <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.icagen.com\/blog\/detail\/917\/ion-channels-may-play-a-role-in-a-new-generation-of-cancer\">Icagen<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY (2012) Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. <strong><em>Genes &amp; Development<\/em><\/strong> 26(16): 1780-96. (<strong>Cover Article<\/strong>) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22855790\/\">PMID: 22855790<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/GD2012.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p style=\"padding-left: 40px\"><em>Editorial highlights<\/em>:<\/p>\n<p style=\"padding-left: 40px\">Medulloblastoma: Pump up the volume. <em>Nature Reviews Cancer<\/em>, 12, 583<\/p>\n<p style=\"padding-left: 40px\">Targeting ion channels. <em>Nature Structural &amp; Molecular Biology<\/em>, 19, 867<\/p>\n<p style=\"padding-left: 40px\">Ion Channel Activity Promotes Mitotic Entry and Tumor Cell Growth. <em>Cancer Discovery<\/em>, 2, 763<\/p>\n<p>&nbsp;<\/p>\n<h5><strong>New tools for studying ionic signaling, measuring cell mechanics, and treating brain cancer<\/strong><\/h5>\n<ul>\n<li>Wang X, Gong Z, Wang T, Law J, Chen X, Wanggou S, Wang J, Ying B, Francisco MA, Dong W, Yi X, Fan JJ, Angers S, Dirks PB, Li X, Liu X, Huang X<sup>#<\/sup>, Sun Y<sup>#<\/sup> (2023) Mechanical nanosurgery of chemoresistant glioblastoma. <strong><em>Science Advances<\/em><\/strong> 9, eade5321 (<sup>#<\/sup> corresponding author)<span style=\"color: #3366ff\"> <a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36989359\/\">PMID: 36989359<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Xian-Wang-2023-1.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p style=\"font-weight: 400;padding-left: 40px\"><em>Editorial highlights<\/em><em>:<\/em><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Nanotubes disrupt brain tumours.\u00a0<em>Nature Reviews Neurology<\/em> (2023) 19, 323<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Mechanical nanosurgery for glioblastoma. <em>Nature Reviews Materials<\/em> (2023) 8, 307<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><em>Media coverage<\/em><em>:<\/em><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Video abstract: <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.youtube.com\/watch?v=ewpEt47cdac\">Mechanical Nanosurgery: Using Precision Magnetics To Destroy Tumor Cells From Within<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Precision magnetics could be game-changer for therapy-resistant brain cancers<\/p>\n<p style=\"font-weight: 400;padding-left: 40px\"><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.sickkids.ca\/en\/news\/archive\/2023\/precision-magnetics-could-be-gamechanger-for-therapy-resistant-brain-cancers\/\">SickKids News<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/oicr.on.ca\/precision-magnetics-could-be-game-changer-for-therapy-resistant-brain-cancers\/\">OICR News<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.eurekalert.org\/news-releases\/985597\">EurekAlert!<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.technologynetworks.com\/tn\/news\/precision-magnetics-could-potentially-treat-aggressive-brain-cancer-372004\">Technology Networks<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/www.newswise.com\/articles\/precision-magnetics-could-be-game-changer-for-therapy-resistant-brain-cancers?ta=home\">Newswise<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/mobile.hospimedica.com\/critical-care\/articles\/294796822\/mechanical-nanosurgery-uses-nanotechnology-and-precision-magnetics-to-destroy-therapy-resistant-brain-cancers.html\">HospiMedica<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/scitechdaily.com\/nano-warriors-how-mechanical-nanosurgery-is-tackling-aggressive-brain-tumors\/\">SciTechDaily<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/headtopics.com\/us\/mechanical-nanosurgery-how-precision-magnetics-is-tackling-aggressive-brain-tumors-37812945\">Head Topics<\/a>, <\/span><a href=\"https:\/\/oncologynews.com.au\/latest-news\/precision-magnetics-could-be-game-changer-for-therapy-resistant-glioblastoma\/\"><span style=\"color: #3366ff\">OncologyNews,<\/span><\/a>\u00a0<a href=\"https:\/\/www.nanowerk.com\/nanotechnology-news2\/newsid=62784.php\"><span style=\"color: #3366ff\">Nanowerk<\/span><\/a><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Robotic nano-surgery shown effective at treating aggressive brain cancer in mice <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.utoronto.ca\/news\/robotic-nano-surgery-shown-be-effective-treating-brain-cancer-pre-clinical-models?utm_source=MedEmail+2022&amp;utm_campaign=23d0bd0904-MedEmail_2019_2020_Vol29_Iss2_COPY_01&amp;utm_medium=email&amp;utm_term=0_f51fac87dd-23d0bd0904-91884013\">University of Toronto News<\/a>, <a style=\"color: #3366ff\" href=\"https:\/\/news.engineering.utoronto.ca\/robotic-nano-surgery-shown-effective-at-treating-aggressive-brain-cancer-in-mice\/\">University of Toronto Engineering News<\/a><a style=\"color: #3366ff\" href=\"https:\/\/www.biomedwire.com\/mechanical-nanosurgery-could-revolutionize-brain-cancer-treatment\/\">, BioMedWire<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Nanotubes shred tumors in mice <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.drugdiscoverynews.com\/nanotubes-shred-tumors-in-mice-15717\">Drug Discovery News<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Robotic nano-surgery shown to be effective at treating brain cancer in pre-clinical models<span style=\"color: #3366ff\"> <a style=\"color: #3366ff\" href=\"https:\/\/educationnewscanada.com\/article\/education\/level\/university\/1\/1016402\/robotic-nano-surgery-shown-to-be-effective-at-treating-brain-cancer-in-pre-clinical-models.html\">Education News Canada<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Nano-robotic scalpel swarm shreds brain cancer cells from the inside <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/newatlas.com\/medical\/nano-robotic-scalpel-brain-cancer\/\">News Atlas <\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Robotic nano-surgery kills GBM cancer cells in mice\u2019s brains <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/techinformed.com\/robotic-nano-surgery-kills-gbm-cancer-cells\/\">Tech Informed<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Mechanical nanosurgery attacks aggressive brain cancer <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/physicsworld.com\/a\/mechanical-nanosurgery-attacks-aggressive-brain-cancer\/\">Physics World<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Tiny robots, giant steps: how nanotechnology could improve cancer and fertility treatment <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.theguardian.com\/whats-possible-ask-toronto\/2023\/sep\/29\/tiny-robots-giant-steps-how-nanotechnology-could-improve-cancer-and-fertility-treatment\">The Guardian<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">Talk science to me with Dan Riskin (begins at 4:40)<span style=\"color: #3366ff\"> <a style=\"color: #3366ff\" href=\"https:\/\/www.iheartradio.ca\/580-cfra\/audio-podcasts\/vks-talk-science-to-me-with-dan-riskin-1.19511563?mode=Article\">iHeartRadio<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">\u78c1\u77f3\u3068\u9244\u7c89\u3067\u30b0\u30ea\u30aa\u30d6\u30e9\u30b9\u30c8\u30fc\u30de\u3092\u9664\u53bb\u3059\u308b <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/aasj.jp\/news\/watch\/21874\">All About Science Japan<\/a><\/span><\/p>\n<p style=\"font-weight: 400;padding-left: 40px\">\u5229\u7528\u78c1\u63a7\u78b3\u7eb3\u7c73\u7ba1\u6cbb\u7597\u8010\u836f\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624 <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/news.bioon.com\/article\/e3c9e65378a7.html\">bioon<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Tang W, Chen X, Wang X, Zhu M, Shan G, Wang T, Dou W, Wang J, Law J, Gong Z, Hopyan S<sup>#<\/sup>, Huang X<sup>#<\/sup>, Sun Y<sup>#<\/sup> (2023) Indentation induces instantaneous nuclear stiffening and unfolding of nuclear envelop wrinkles. <b><i>Proceedings of the National Academy of Sciences<\/i><\/b><strong><em>\u00a0<\/em><\/strong>120(36):e2307356120 (<sup>#<\/sup> corresponding author) <a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37639585\/\">PMID: 37639585<\/a> <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Wentian-Tang-2023.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Wang X*, Wang T*, Chen X, Law J, Shan G, Tang W, Gong Z, Pan P, Liu X, Yu J, Ru C<sup>#<\/sup>, Huang X<sup>#<\/sup>, Sun Y<sup># <\/sup>(2022) Microrobotic swarms for intracellular measurement with enhanced signal-to-noise ratio. <strong><em>ACS Nano<\/em><\/strong>16(7):10824\u201310839 (<sup>#<\/sup> corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35786860\/\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 35786860<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Xian-Wang-2-2022.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h5><strong>Reviews of ion channel functions in cancer<\/strong><\/h5>\n<ul>\n<li>Momin A*<sup>,<\/sup><sup>#<\/sup>, Bahrampour S*, Min HK*, Chen X*, Wang X, Sun Y, Huang X<sup>#<\/sup> (2021) Channeling force in the brain: mechanosensitive ion channels choreograph mechanics and malignancies. <strong><em>Trends in Pharmacological Sciences<\/em><\/strong> 42(5):367-384. (<strong>Cover Article<\/strong>) (* contributed equally,\u00a0<sup>#<\/sup> corresponding author)\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33752907\/\">PMID: 33752907<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Ali-Momin-2021.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Fan JJ<sup>#<\/sup> and Huang X<sup>#<\/sup> (2020) Ion channels in cancer: orchestrators of electrical signaling and cellular crosstalk. <strong><em>Reviews of<\/em><\/strong><strong><em> Physiology, Biochemistry and Pharmacology<\/em><\/strong> (<sup>#<\/sup> corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32894333\/\">PMID: 32894333<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Jerry-J-Fan-2020.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X<sup>#<\/sup> and Jan LY<sup>#<\/sup> (2014) Targeting potassium channels in cancer. <strong><em>Journal of Cell Biology<\/em><\/strong> 206(2): 151-62. (<sup>#<\/sup> corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25049269\/\">PMID: 25049269<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Xi-Huang-8-2014.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h5><strong>BY YEARS (ALL PUBLICATIONS)<\/strong><\/h5>\n<h5><strong>The Hospital for Sick Children \/ University of Toronto<\/strong><\/h5>\n<h5><strong>2025<\/strong><\/h5>\n<div>\n<ul>\n<li style=\"font-weight: 400\">Jung G*, Liang Z*, Jain P*, Deutsch H*, Li F, Rathi K, Sun Z, Chen X, Straka J, Kazerooni AF, Sun Y, Koptyra MP, Sanchez-maldonado S, Familiar A, Waanders AJ, Nabavizadeh A, Huang X, Resnick AC<sup>#<\/sup>, Song Y<sup>#<\/sup> (2025) Pediatric low-grade glioma genetic models reveal dysregulation of repulsive guidance signaling and upregulation of GPR180. <strong><em>npj Precision Oncology<\/em><\/strong> 9:344 (* contributed equally, <sup>#<\/sup> corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41219403\/\">PMID: 41219403<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li style=\"font-weight: 400\">Zheng J*<sup>,<\/sup><sup>#<\/sup>, Yang Q*, Liu H*, Zhao H*, Wang S*, Liu Y, Wu X, Ding Y, Ying H, Ye Y, Huang X, Ye L, Zheng R, Lin H, Li M, Wang T, Zhao Z, Xu M, Duan Y, Guo H, Yuan Z, Haycock P, Davey Smith G, Martin RM, Ning G, Hu F<sup>#<\/sup>, Wang W<sup>#<\/sup>, Gaunt TR<sup>#<\/sup>, Lu J<sup>#<\/sup>, Bi Y<sup>#<\/sup> (2025) Integrating\u00a0single-cell transcriptome-wide\u00a0Mendelian randomization and differentially expressed gene analyses to prioritize\u00a0dynamic\u00a0immune-related drug targets for cancers. <strong><em>Advanced Science<\/em> <\/strong>doi: 10.1002\/advs.202507451<strong>\u00a0<\/strong>(* contributed equally, <sup>#<\/sup> corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41216857\/\">PMID: 41216857<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X<sup><span lang=\"EN-US\">#<\/span><\/sup>, <span lang=\"EN-US\">Taylor MD<sup># <\/sup><\/span>(2025) Glutamate promotes glioma growth via a non-excitable, receptor tyrosine kinase-mediated mechanism. <b><i>Neuron <\/i><\/b>113(21):<span class=\"meta-panelpages\"><span class=\"meta-panelpages\"><span class=\"meta-panelpages\">3493-3495 <span style=\"color: #3366ff\"><span style=\"color: #000000\">(<sup># <\/sup>corresponding author) <\/span><\/span><\/span><\/span><\/span><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41197605\/\">PMID: 41197605<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2026\/03\/Glutamate-promotes-glioma-growth-via-a-non-excitable-receptor-tyrosine-kinase-mediated-mechanism.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<\/div>\n<p>&nbsp;<\/p>\n<ul>\n<li>Min HK*, Zhao H*, Bahcheli A, Pan P, Chan J, Chen J, Low E, Zhou Y, Wang X, Bajic S, Peng R, Wanggou S, Yang Q, Zhang RDY, Wang L, Ren X, Qi H, Shi Y, Hayes MN, Ciruna B, Reimand J, Liu X, Huang X (2025) Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis. <strong><em>Nature Biomedical Engineering<\/em><\/strong> doi.org\/10.1038\/s41551-025-01487-5 (* contributed equally) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40897897\/\">PMID: 40897897<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2026\/03\/Fluid-shear-stress-activates-a-targetable-mechano-metastatic.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>N\u00f6r C*, Kharas K*, Rasnitsyn A, Vladoiu M, Cho NW, Young JS, N\u00f6r F, Mankahla N, Haapasalo J, Nordfors K, Rapic S, Skowron P, Su\u00e1rez RA, Bahcheli AT, Ocsenas O, Chen X, Bahrampour S, Momin A, Sundaresan L, Ong W, Hendrikse LD, Abeysundara N, Juraschka K, Ly M, Pallota JG, Douglas T, Huang N, Wang H, Mak E, Qin L, Liu J, Shen L, Luu B, Manno A, Kumar S, Donovan LK, Fong V, Richman C, Daniels C, Garzia L, Rich JN, Hawkins C, Wu X, DaCosta R, Reimand J, Huang X, Ramaswamy V<sup>#<\/sup>, Raleigh D<sup>#<\/sup>, Taylor MD<sup>#<\/sup> (2025) Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process. <strong><strong><em>Developmental Cell <\/em><\/strong><\/strong>60(21):2880-2896 (* contributed equally, <sup>#<\/sup> corresponding author)<span style=\"color: #3366ff\"> <a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40609543\/\">PMID: 40609543<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Wu X*, Xu P*, Zhang Z, Yang Q, Huang X, Pan P, Liu X (2025) Ultrasoft iontronics: stretchable diodes enabled by ionically conductive bottlebrush elastomers. <strong><em>Advanced Functional Materials <\/em><\/strong>(* contributed equally) <span style=\"color: #3366ff\"><a class=\"epub-doi\" style=\"color: #3366ff\" href=\"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adfm.202503859\" aria-label=\"Digital Object Identifier for Ultrasoft Iontronics: Stretchable Diodes Enabled by Ionically Conductive Bottlebrush Elastomers link\">doi.org\/10.1002\/adfm.202503859<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Abeysundara N* Rasnitsyn A*, Fong V*, Bahcheli A, Ommeren RV, Juraschka K, Vladoiu M, Ong W, Livingston B, de Antonellis P, Ly M, Holgado BL, Sirbu O, Bahrampour S, Min N, Fan JJ, Nor C, Visvanathan A, Zhang J, Wang H, Qin L, Huang N, Pallotta J, Douglas T, Mak E, Su H, Ng K, Zhang KY, Daniels C, Lucas C-H G, Eberhart CG, Liu H, Jiang T, Notta F, Ramaswamy V, Reimand J, Gallo M, Rich JN, Wu X, Huang X, Taylor MD (2025) Metastatic medulloblastoma remodels the local leptomeningeal microenvironment\u00a0to promote further metastatic colonization and growth. <strong><em>Nature Cell Biology <\/em><\/strong>27, 863\u2013874\u00a0(* contributed equally) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40263572\/\">PMID:\u00a040263572<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Yang Y*, Hao C*, Jiao T*, Yang Z*, Li H*, Zhang Y, Zhang W, Doherty M, Sun C, Yang T, Li J, Wu J, Zhang M, Wang Y, Xie D, Wang T, Wang N, Huang X, Li C, Gonzalez FJ, Wei J<sup>#<\/sup>, Xie C<sup>#<\/sup>, Zeng C<sup>#<\/sup>, Lei G<sup>#<\/sup> (2025) Osteoarthritis treatment via GLP-1 mediated 1 gut-joint axis by targeting intestinal FXR signaling. <strong><em>Science<\/em><\/strong> 388, eadt0548 (* contributed equally, <sup>#<\/sup> corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40179178\/\">PMID: 40179178<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Desai K, Wanggou S, Luis E, Whetstone H, Yu C, Vanner RJ, Selvadurai HJ, Lee L, Vijay J, Jaramillo J, Fan JJ, Guilhamon P, Kushida M, Li X, Stein G, Kesari S, Simons BD, Huang X, Dirks PB (2025) OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma. <strong><em>Nature Communications<\/em><\/strong> 16:1092 <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39904987\/\">PMID:\u00a039904987<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Fan JJ*, Erickson AW*, Carrillo-Garcia J*, Wang X*, Skowron P*, Wang X, Chen X, Shan G, Dou W, Bahrampour S, Xiong Y, Dong W, Abeysundara N, Francisco MA, Pusong RJ, Wang W, Li M, Ying E, Su\u00e1rez RA, Farooq H, Holgado BL, Wu X, Daniels C, Dupuy AJ, Cadi\u00f1anos J, Bradley A, Bagchi A, Moriarity BS, Largaespada DA, Morrissy AS, Ramaswamy V, Mack SC, Garzia L, Dirks PB, Li X, Wanggou S, Egan S, Sun Y, Taylor MD<sup>#<\/sup>, Huang X<sup>#<\/sup> (2025) A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance. <strong><em>Developmental Cell <\/em><\/strong><span lang=\"EN-US\">60 (11), 1532-1549 <\/span>(* contributed equally, <sup>#<\/sup> corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39862856\/\">PMID:39862856<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2025\/05\/A-forward-genetic-screen-identifies-potassium-channel-essentiality-in-SHH-medulloblastoma-maintenance.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<h5><strong>\u00a02024<\/strong><\/h5>\n<ul>\n<li>Baghdadi MB<sup>#<\/sup>, Houtekamer RM, Perrin L, Rao-Bhatia A, Whelen M, Decker L, Bergert M, P\u00e9rez-Gonz\u00e0lez C, Bouras R, Gropplero G, Loe AKH, Afkhami-Poostchi A, Chen X, Huang X, Descroix S, Wrana JL, Diz-Mu\u00f1oz A, Gloerich M, Ayyaz A, Matic Vignjevic D*<sup>,<\/sup><sup>#<\/sup>, Kim TH*<sup>,<\/sup><sup>#<\/sup> (2024) PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance. <strong><em>Science<\/em><\/strong> 386(6725):eadj7615 (* contributed equally,<sup> # <\/sup>corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39607940\/\">PMID:39607940<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Zhu M, Gu B, Thomas EC, Huang Y, Kim Y-K, Tao H, Yung TM, Chen X, Zhang K, Woolaver EK, Nevin MR, Huang X, Winklbauer R, Rossant J, Sun Y<sup>#<\/sup>, Hopyan S<sup>#<\/sup> (2024) A fibronectin gradient remodels mixed phase mesoderm. <strong><em>Science Advances<\/em><\/strong> 10, eadl6366 (<sup>#<\/sup> corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39028807\/\">PMID:39028807<\/a>\u00a0<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Bahcheli AT*, Min HK*, Bayati M, Zhao H, Fortuna A, Dong W, Dzneladze I, Chan J, Chen X, Guevara-Hoyer K, Dirks PB, Huang X<sup>#<\/sup>, Reimand J<sup>#<\/sup> (2024) Pan-cancer ion transport signature reveals functional regulators of glioblastoma aggression. <strong><em>The<\/em><\/strong> <strong><em>EMBO Journal <\/em><\/strong>43: 196\u2013224 (* contributed equally, <sup>#<\/sup>corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38177502\/\"><span class=\"id-label\"><span style=\"color: #3366ff\">PMID: <\/span><\/span><span style=\"color: #3366ff\">38177502<\/span><\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Alexander-T-Bahcheli-2024.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<h5><strong>2023<\/strong><\/h5>\n<ul>\n<li>Dong W, Fekete A, Chen X, Liu H, Beilhartz GL, Chen X, Bahrampour S, Xiong Y, Yang Q, Zhao H, Kong T, Morioka MS, Jung G, Kim JE, Schramek D, Dirks PB, Song Y, Kim TH, He Y, Wanggou S, Li X, Melnyk RA, Wang LY, Huang X (2023) A designer peptide against the EAG2-Kv\u03b22 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma. <strong><em>Nature Cancer<\/em><\/strong> 4, 1418-1436 <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37697045\/\">PMID: 37697045<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/DesignerPeptide.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Tang W, Chen X, Wang X, Zhu M, Shan G, Wang T, Dou W, Wang J, Law J, Gong Z, Hopyan S<sup>#<\/sup>, Huang X<sup>#<\/sup>, Sun Y<sup>#<\/sup> (2023) Indentation induces instantaneous nuclear stiffening and unfolding of nuclear envelop wrinkles. <b><i>Proceedings of the National Academy of Sciences<\/i><\/b><strong><em>\u00a0<\/em><\/strong>120(36):e2307356120 (<sup>#<\/sup> corresponding author) <a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37639585\/\">PMID: 37639585<\/a> <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Wentian-Tang-2023.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Dave BM, Chen X, McCready F, Charton CS, Morley RM, Tailor JK, Ellis J, Huang X, Dirks PB (2023) Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis. <strong><em>Development<\/em><\/strong> 150 (13): dev201534. <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37381820\/\">PMID: 37381820<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Wang X, Gong Z, Wang T, Law J, Chen X, Wanggou S, Wang J, Ying B, Francisco MA, Dong W, Yi X, Fan JJ, Angers S, Dirks PB, Li X, Liu X, Huang X<sup>#<\/sup>, Sun Y<sup>#<\/sup> (2023) Mechanical nanosurgery of chemoresistant glioblastoma. <strong><em>Science Advances<\/em><\/strong> 9, eade5321\u00a0(<sup>#<\/sup>\u00a0corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36989359\/\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 36989358<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Xian-Wang-2023-1.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Dou W, Abdelkader D, Chen X, Wang T, Malhi M, Gong Z, Mirshafiei F, Zhu M, Shan G, Huang X, Maynes J, Sun Y (2023) Ultrathin and flexible bioelectronic arrays for functional measurement of iPSC-cardiomyocytes under cardiotropic drug administration and controlled microenvironments.<strong> <em>Nano Letters<\/em><\/strong> 23, 6, 2321\u20132331<span style=\"color: #000000\">\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36893018\/\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 36893018<\/a><\/span><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Xu P, Wang S, Lin A, Min N, Zhou Z, Dou W, Sun Y, Huang X, Tran H<sup>#<\/sup>, Liu X<sup>#<\/sup> (2023) Conductive SWCNT\/PDMS bottlebrush elastomers for ultrasoft electronics. <strong><em>Nature Communications<\/em><\/strong> 14(1):623 (<sup>#<\/sup>\u00a0corresponding author)<span style=\"color: #3366ff\"> <a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36739447\/\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 36739447<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Chen X*, Momin A*, Wanggou S*, Wang X, Min HK, Dou W, Gong Z, Chan J, Dong W, Fan JJ, Xiong Y, Talipova K, Zhao H, Chen YX, Veerasammy K, Fekete A, Kumar SA, Liu H, Yang Q, Son JE, Dou Z, Hu M, Pardis P, Juraschka K, Donovan LK, Zhang J, Ramaswamy V, Selvadurai HJ, Dirks PB, Taylor MD, Wang LY, Hui CC, Abzalimov R, He Y, Sun Y, Li X<sup>#<\/sup>, Huang X<sup>#,\u00a7<\/sup>\u00a0(2023) Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity. <strong><em>Neuron\u00a0<\/em><\/strong>111(1):30-48 (* contributed equally,\u00a0<sup>#<\/sup>\u00a0corresponding author,\u00a0<sup>\u00a7\u00a0<\/sup>lead contact) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36323321\/\">PMID: 36323321<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Xin-Chen-2-2023.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<h5><strong>2022<\/strong><\/h5>\n<ul>\n<li>Hendrikse LD*, Haldipur P*, Saulnier O*, Millman J, Sjoboen AH, Erickson A, Ong W, Gordon V, L C-M, Mercier AL, Shokouhian M, Su\u00e1rez RA, Ly M, Borlase S, Scott DS, Vladoiu MC, Farooq H, Sirbu O, Nakashima T, Nambu S, Funakoshi Y, Bahcheli A, Diaz-Mejia J, Golser J, Bach K, Phuong-Bao T, Skowron P, Wang E, Kumar S, Balin P, Visvanathan A, Lee JJY, Ayoub R, Chen X, Chen X, Mungall KL, Luu B, B\u00e9rub\u00e9 P, Wang YC, Pfister SM, Delattre O, Kim S-K, Bourdeaut F, Doz FP, Masliah-Planchon J, Grajkowska WA, Loukides J, Dirks PB, F\u00e8vre-Montange M, Jouvet A, French PJ, Kros JM, Zitterbart K, Bailey SD, Eberhart CG, Rao AAN, Giannini C, Olson JM, Garami M, Hauser P, Phillips JJ, Ra YS, de Torres C, Mora J, Li KKW, Ng H-K, Poon WS, Pollack IF, L\u00f3pez-Aguilar E, Gillespie GY, Van Meter TE, Shofuda T, Vibhakar R, Thompson RC, Cooper MK, Rubin JB, Kumabe T, Jung S, Lach B, Ferrucci V, Antonellis PD, Zollo M, Robinson S, Stearns DS, Van Meir EG, Porrati P, Finocchiaro G, Massimino M, Carlotti CG, Faria CC, Roussel MF, Boop F, Chan JA, Aldinger KA, Razavi F, Silvestri E, McLendon RE, Thompson EM, Ansari M, Garre ML, de Le\u00f3n FCP, Aguilar PE, Conti MPPD, Morrissy AS, Cavalli FMG, Wu X, Daniels C, Rich JN, Jones SJM, Moore RA, Marra MA, Huang X, Reimand J, Ellison DW, Sorensen PHB, Wechsler-Reya RJ, Weiss WA, Pugh TJ, Garzia L, Kleinman CL, Stein LD, Jabado N, Malkin D, Ayrault O, Doble B, Ramaswamy V, Werbowetski-Ogilvie TE<sup>#<\/sup>, Suzuki H<sup>#<\/sup>, Millen KJ<sup>#<\/sup>, Taylor MD<sup>#\u00a0<\/sup>(2022) Failure of human rhombic lip differentiation constitutes medulloblastoma.\u00a0<strong><em>Nature\u00a0<\/em><\/strong>(* contributed equally,\u00a0<sup>#\u00a0<\/sup>corresponding author) 609(7929): 1021-2018 <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36131014\/\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 36131014<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Law J*, Wang X*, Luo M, Xin L, Du X, Dou W, Wang T, Shan G, Wang Y, Song P<sup>#<\/sup>, Huang X, Yu J<sup>#<\/sup>, Sun Y<sup>#\u00a0<\/sup>(2022) Microrobotic swarms for selective embolization. <strong><em>Science Advances<\/em> <\/strong>22;8(29):eabm5752 (<sup>#<\/sup>\u00a0corresponding author)\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35857830\/\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 35857830<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Wang X*, Wang T*, Chen X, Law J, Shan G, Tang W, Gong Z, Pan P, Liu X, Yu J, Ru C<sup>#<\/sup>, Huang X<sup>#<\/sup>, Sun Y<sup>#\u00a0<\/sup>(2022) Microrobotic swarms for intracellular measurement with enhanced signal-to-noise ratio.\u00a0<strong><em>ACS Nano <\/em><\/strong>16(7):10824-10839\u00a0(* contributed equally,\u00a0<sup>#<\/sup>\u00a0corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35786860\/\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 35786860<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Xian-Wang-2-2022.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Yang Q, Jiang N, Zou H, Fan X, Liu T, Huang X, Wanggou S, Li X (2022) Alterations in 3D chromatin organization contribute to tumorigenesis of EGFR-amplified glioblastoma. <strong><em>Computational and<\/em><\/strong> <strong><em>Structural Biotechnology Journal<\/em><\/strong> 20:1967-1978 <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35521558\/\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 35521558<\/a><\/span><\/li>\n<\/ul>\n<h5><strong>2021<\/strong><\/h5>\n<ul>\n<li>Son JE<sup>#<\/sup>, Dou Z, Wanggou S, Chan J, Mo R, Li X, Huang X, Kim K, Michaud JL, Hui CC<sup>#<\/sup> (2021) Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency. <strong><em>Science Advances<\/em><\/strong> 7(44):eabh4503\u00a0(<sup>#<\/sup>\u00a0corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34705510\/\">PMID:\u00a034705510<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Zhang Z, Dai C, Shan G, Chen X, Liu H, Abdalla K, Kuznyetsova I, Moskovstev S, Huang X, Librach C, Jarvi K, Sun Y (2021) Quantitative selection of single human sperm with high DNA integrity for intracytoplasmic sperm injection. <strong><em>Fertility and Sterility<\/em><\/strong> 116(5):1308-1318. <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34266663\/\">PMID:\u00a034266663<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Son JE*, Dou Z*, Kim K, Wanggou S, Cha VSB, Mo R, Zhang X, Ketela T, Chen X, Li X, Huang X, Hui CC (2021) Expression of Irx3 and Irx5 in Ins2-Cre+ cells regulates hypothalamic postnatal neurogenesis and leptin response. <strong><em>Nature Metabolism<\/em><\/strong> 3(5):701-713\u00a0(* contributed equally) <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33859429\/\"><span style=\"color: #3366ff\">PMID:\u00a033859429<\/span><\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Pryszlak M*, Wiggans M*, Chen X, Jaramillo JE, Burns SE, Richards LM, Pugh TJ, Kaplan DR, Huang X, Dirks PD, Pearson BJ (2021) The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. <strong><em>Cell Reports<\/em><\/strong> 34(13):108903\u00a0(* contributed equally)\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33789112\/\">PMID:\u00a033789112<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Momin A*<sup>,<\/sup><sup>#<\/sup>, Bahrampour S*, Min HK*, Chen X*, Wang X, Sun Y, Huang X<sup>#<\/sup>\u00a0(2021) Channeling force in the brain: mechanosensitive ion channels choreograph mechanics and malignancies. <strong><em>Trends in Pharmacological Sciences\u00a0<\/em><\/strong>42(5):367-384 (* contributed equally,\u00a0<sup>#<\/sup> corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33752907\/\">PMID:\u00a033752907<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Ali-Momin-2021.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Shahzad U, Taccone M, Kumar S, Okura H, Krumholtz S, Ishida J, Mine C, Gouveia K, Edgar J, Smith C, Hayes M, Huang X, Derry BW, Taylor MD, and Rutka JT (2021) Modeling human brain tumours in flies, worms, and zebrafish: From proof of principle to novel therapeutic targets. <strong><em>Neuro-Oncology<\/em><\/strong>\u00a023(5):718-731. <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33378446\/\">PMID:\u00a033378446<\/a><\/span><\/li>\n<\/ul>\n<h5><strong>2020<\/strong><\/h5>\n<ul>\n<li>Fan JJ<sup>#<\/sup> and Huang X<sup>#,\u00a7<\/sup> (2020) Ion channels in cancer: orchestrators of electrical signaling and cellular crosstalk. <em><strong>Reviews of Physiology, Biochemistry and Pharmacology<\/strong>\u00a0<\/em>(<sup>#<\/sup> corresponding author) <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32894333\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #3366ff\">PMID: 32894333<\/span><\/a> <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Jerry-J-Fan-2020.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Francisco MA, Wanggou S, Fan JJ, Dong W, Chen X, Momin A, Abeysundara N, Min HK, Chan J, McAdam R, Sia M, Pusong RJ, Liu S, Patel N, Ramaswamy V, Kijima N, Wang LY, Song Y, Kafri R, Taylor MD, Li X<sup>#<\/sup>, Huang X<sup>#,\u00a7<\/sup> (2020) Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth. <strong><em>Journal of Experimental Medicine<\/em><\/strong>\u00a0<span lang=\"EN-US\">217.5: e20190971\u00a0<\/span>(<sup>#<\/sup> corresponding author) <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32097463\"><span style=\"color: #3366ff\">PMID: 32097463<\/span><\/a><span style=\"color: #3366ff\"> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Michelle-A.-2020.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<h5><strong>2019<\/strong><\/h5>\n<ul>\n<li>Pigott BJ, Peters CJ, He Y, Huang X, Younger S, Jan LY, Jan YN (2019) Paralytic, the <em>Drosophila<\/em> voltage-gated sodium channel, regulates proliferation of neural progenitors. <strong><em>Genes &amp; Development<\/em><\/strong>\u00a01;33(23-24):1739-1750. <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31753914\">PMID: 31753914<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Suzuki H*, Kumar SA*, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Jouvet A, F\u00e8vre-Montange M, Garr\u00e8 ML, Nageswara Rao AA, Giannini C, Kros JM, French PJ, Jabado N, Ng HK, Poon WS, Eberhart CG, Pollack IF, Olson JM, Weiss WA, Kumabe T, L\u00f3pez-Aguilar E, Lach B, Massimino M, Van Meir EG, Rubin JB, Vibhakar R, Chambless LB, Kijima N, Klekner A, Bogn\u00e1r L, Chan JA, Faria CC, Ragoussis J, Pfister SM, Goldenberg A, Wechsler-Reya RJ, Bailey SD, Garzia L, Morrissy AS, Marra MA, Huang X, Malkin D, Ayrault O, Ramaswamy V, Puente XS, Calarco JA, Stein L, Taylor MD (2019) Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. <strong><em>Nature<\/em><\/strong>\u00a0574(7780):707-711 (* contributed equally)\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Recurrent+noncoding+U1+snRNA+mutations+drive+cryptic+splicing+in+SHH+medulloblastoma\">PMID: 31664194<\/a><\/span><\/li>\n<\/ul>\n<h5><strong>2018<\/strong><\/h5>\n<ul>\n<li>Wang YA, Li XL, Mo YZ, Fan CM, Tang L, Xiong F, Guo C, Xiang B, Zhou M, Ma J, Huang X, Wu X, Li Y, Li GY, Zeng ZY, Xiong W (2018) Effects of tumor metabolic microenvironment on regulatory T cells. <strong><em>Molecular Cancer<\/em><\/strong>\u00a017(1):168. <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30477520\">PMID: 30477520<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan JJ, Yin WC, Min HK, Hu M, Draghici D, Dou W, Li F, Coutinho FJ, Whetstone H, Kushida MM, Dirks PB, Song Y, Hui CC, Sun Y, Wang LY, Li X, and Huang X (2018) A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression. <strong><em>Neuron<\/em><\/strong>\u00a0100(4):799-815.e7. <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30344046\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 30344046<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Xin-Chen-2018.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Frattini V, Pagnotta SM, Tala, Fan JJ, Russo MV, Lee SB, Garofano L, Zhang J, Shi P, Lewis G, Sanson H, Frederick V, Cerulo L, Rolland DCM, Mall R, Mokhtari K, Elenitoba-Johnson KSJ, Sanson M, Huang X, Ceccarelli M, Lasorella A, Iavarone A (2018) A metabolic function of FGFR3-TACC3 gene fusions in cancer. <strong><em>Nature<\/em><\/strong>\u00a0553,\u00a0222\u2013227.\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29323298\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 29323298<\/a><\/span><\/li>\n<\/ul>\n<h5><strong>2017<\/strong><\/h5>\n<ul>\n<li>Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O\u2019Connor M, Lan X, Whetstone H, Coutinho FC, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai, H, Atwal G, Kushida M, Clarke ID, Voisin V, Cusimano MD, Bernstein M, Das S, Bader G, Arrowsmith CH, Angers S, Huang X, Lupien M, Dirks PB (2017) ASCL1 reorganizes chromatin to direct neuronal fate and suppress tumorigenicity. <strong><em>Cell Stem Cell<\/em><\/strong>\u00a021(2):209-224.e7.<span style=\"color: #3366ff\"> <a style=\"color: #3366ff\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28712938\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 28712938<\/a><\/span><\/li>\n<\/ul>\n<h5><strong>2016<\/strong><\/h5>\n<ul>\n<li>Agnihotri S, Golbourn B, Huang X, Remke M, Younger S, Cairns RA, Chalil A, Smith CA, Krumholtz SL, MacKenzie D, Rakopoulos P, Ramaswamy V, Taccone MS, Mischel PS, Fuller GN, Hawkins C, Stanford WL, Taylor MD, Zadeh G, Rutka JT (2016) PINK1 is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma.\u00a0<strong><em>Cancer\u00a0<\/em><\/strong><b><i>Research<\/i><\/b>\u00a076(16):4708-19.\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PINK1+is+a+Negative+Regulator+of+Growth+and+the+Warburg+Effect+in+Glioblastoma\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 2732564<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Morrissy AS*, Garzia L*, Shih DJH, Zuyderduyn S,\u00a0Huang X, Skowron P, Remke M, Cavalli FMG, Ramaswamy V, Lindsay P, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall KL, Yusanne M, Tse K, Zeng T, Shumansky K, Roth AJL, Shah S, Farooq H, Kijima N, Holgado BL, Lee JJY, Matan-Lithwick S, Liu J, Mack SC, Manno A, Michaelraj KA, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson YY, Wu X, Pugh T, Ally A, Bilenky M, Butterfied YSN, Carlsen R, Cheng Y, Chuah E, Corbett RD, Dhalla N, He A, Lee D, Li HI, Long W, Mayo M, Plettner P, Qian JQ, Schein JE, Tam A, Wong T, Birol I, Zhao Y, Faria CC, Pimentel J, Bendel AE, Fults DW, Walter AW, Kumabe T, Tominaga T, Collins VP, Cho YJ, Hoffman C, Lyden D, Wisoff J, Garvin JH, Stearns DS, Massimi L, Schuller U, Sterba J, Zitterbart K, Puget S, Ayrault O, Dunn SE, Tirapelli DPC, Carlotti CG, Wheeler H, Hallahan AR, Ingram W, MacDonald TJ, Olson JJ, Van Meir EG, Lee JY, Wang KC, Kim SK, Cho BK, Pietsch T, Fleischack G, Tippelt S, Ra YS, Bailey S, Lindsay JC, Clifford SC, Eberhart CG, Cooper MK, Packer R, Massimino M, Garre ML, Bartels U, Tabori U, Hawkins C, Dirks P, Bouffet E, Rutka JT, Wechsler-Reya RJ, Weiss WA, Collier LS, Dupuy AJ, Korshunov A, Jones DTW, Kool M, Northcott PA, Pfister SM, Largaespada DA, Mungall AJ, Moore RA, Jabado N, Bader GD, Jones JM, Malkin D, Marra MA<sup>#<\/sup>. Taylor MD<sup>#<\/sup>\u00a0(2016) Divergent Clonal Selection Drives Medulloblastoma at Recurrence.\u00a0<strong><em>Nature<\/em><\/strong>\u00a0529, 351\u2013357 (* contributed equally,\u00a0<sup>#<\/sup> corresponding author). <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+26760213\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 26760213<\/a><\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h5><strong>2010 &#8211; 2015 (University of California, San Francisco)<\/strong><\/h5>\n<ul>\n<li>Huang X*, He Y*, Dubuc AM*, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens S, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN<sup>#<\/sup>, Jan LY<sup>#<\/sup>\u00a0(2015) EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. <strong><em>Nature<\/em>\u00a0<em>Neuroscience<\/em><\/strong>\u00a018(9): 1236-46. (* contributed equally,\u00a0<sup>#<\/sup> corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=26258683\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 26258683<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/Xi-Huang-2015.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Song Y, Sretavan D, Salegio E, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN (2015) Regulation of axon regeneration by the RNA repair and splicing pathway.\u00a0<strong><em>Nature<\/em>\u00a0<\/strong><em><strong>Neuroscience<\/strong>\u00a0<\/em>18(6): 817-25.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+25961792\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #3366ff\">PMID: 25961792<\/span><\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD (2014) Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.\u00a0<strong><em>Nature Medicine<\/em><\/strong>\u00a0(12): 1394-1396.\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+25401693\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 25401693<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X<sup>#<\/sup> and Jan LY<sup>#<\/sup>\u00a0(2014) Targeting potassium channels in cancer. <strong><em>Journal of Cell Biology<\/em><\/strong>\u00a0206(2): 151-62. (<sup>#<\/sup> corresponding author) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=25049269\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 25049269<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Xi-Huang-8-2014.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY (2012) Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. <strong><em>Genes &amp; Development<\/em><\/strong>\u00a015; 26(16): 1780-96. (<strong>Cover Article<\/strong>) <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+22855790\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 22855790<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/GD2012.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Cheng FY*, Huang X*, Sarangi A, Ketova T, Cooper MK, Litingtung Y, Chiang C (2012) Widespread contribution of Gdf7 lineage to cerebellar cell types and implications for Hedgehog-driven medulloblastoma formation\u00a0<strong><em>PLoS ONE<\/em><\/strong>\u00a07(4): e35541. (* contributed equally)\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+22539980\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #3366ff\">PMID: 22539980<\/span><\/a> <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Frances-Y-Cheng-2012.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<h5><strong>2004 &#8211; 2010 (Vanderbilt University)<\/strong><\/h5>\n<ul>\n<li>Huang X, Liu J, Ketova T, Fleming JT, Grover VK, Cooper MK, Litingtung Y, Chiang C (2010) Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. <b><i>Proceedings of the National Academy of Sciences<\/i><\/b><em>\u00a0<\/em>107(18): 8422-7.\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+20400693\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 20400693<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Xi-Huang-9-2009.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X, Sarangi A, Ketova T, Litingtung Y, Cooper MK, Chiang C (2010) Intracranial orthotopic allografting of medulloblastoma cells in immunocompromised mice. <strong><em>Journal of Visualized Experiments<\/em><\/strong>\u00a0(44). pii: 2153.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+20972404\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #3366ff\">PMID: 20972404<\/span><\/a> <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Xi-Huang-4-2010.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X, Ketova T, Litingtung Y, Chiang C (2010) Isolation, enrichment and maintenance of medulloblastoma stem cells. <strong><em>Journal of Visualized Experiments<\/em><\/strong>\u00a0(43). pii: 2086.\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+20834221\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 20834221<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Xi-Huang-5-2010.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, Chiang C (2009) Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. <em><strong>Development<\/strong><\/em>\u00a0136(15): 2535-43.\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+19570847\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 19570847<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Xi-Huang-7-2009.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p style=\"padding-left: 30px\"><em>Editorial highlight<\/em><em>:<\/em><\/p>\n<p style=\"padding-left: 30px\">Shh, choroid plexus growth in progress.\u00a0<em>Development.<\/em>\u00a0(2009) 136: e1502<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Oh S*, Huang X*, Liu J, Litingtung Y, Chiang C (2009) Shh and Gli3 activities are required for timely generation of motor neuron progenitors.\u00a0<strong><em>Developmental Biology<\/em><\/strong>\u00a0331(2): 261-9. (* contributed equally)\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+19433083\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 19433083<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/06\/SaeOck-Oh-2009-1.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X*, Goudy SL*, Ketova T, Litingtung Y, Chiang C (2008) Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. <strong><em>Developmental Dynamics<\/em><\/strong>\u00a0237(10): 3079-87 (* contributed equally)\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+18816854\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 18816854<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Xi-Huang-3-2008.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Fogel JL, Chiang C, Huang X, Agarwala S (2008) Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedgehog signaling.\u00a0<strong><em>Developmental Dynamics<\/em><\/strong>\u00a0237(5): 1359-72.\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+18429041\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 18429041<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X, Litingtung Y, Chiang C (2007) Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord. <strong><em>Development<\/em><\/strong>\u00a0134(11): 2095-10\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+17507410\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 17507410<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Xi-Huang-6-2007.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Huang X, Litingtung Y, Chiang C (2007) Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly. <em><strong>Human Molecular Genetics<\/strong>\u00a0<\/em>16(12): 1454-68.\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+17468181\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 17468181<\/a> <a style=\"color: #3366ff\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2024\/05\/Xi-Huang-2-2007.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Oh S, Huang X, Chiang C (2005) Specific requirements of sonic hedgehog signaling during oligodendrocyte development.\u00a0<strong><em>Developmental Dynamics<\/em><\/strong>\u00a0234(3): 489-96.\u00a0<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=PMID%3A+15880651\" target=\"_blank\" rel=\"noopener noreferrer\">PMID: 15880651<\/a><\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;3&#8243; 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font-size:20px;\" class=\"slick-next default\"><i class=\"ultsl-arrow-right4\"><\/i><\/button>',prevArrow: '<button type=\"button\" role=\"button\" aria-label=\"Previous\" style=\"color:#333333; font-size:20px;\" class=\"slick-prev default\"><i class=\"ultsl-arrow-left4\"><\/i><\/button>',slidesToScroll:3,slidesToShow:3,swipe: true,draggable: true,touchMove: true,pauseOnHover: true,pauseOnFocus: false,responsive: [\n\t\t\t\t\t\t\t{\n\t\t\t\t\t\t\t  breakpoint: 1026,\n\t\t\t\t\t\t\t  settings: {\n\t\t\t\t\t\t\t\tslidesToShow: 3,\n\t\t\t\t\t\t\t\tslidesToScroll: 3,  \n\t\t\t\t\t\t\t  }\n\t\t\t\t\t\t\t},\n\t\t\t\t\t\t\t{\n\t\t\t\t\t\t\t  breakpoint: 1025,\n\t\t\t\t\t\t\t  settings: {\n\t\t\t\t\t\t\t\tslidesToShow: 3,\n\t\t\t\t\t\t\t\tslidesToScroll: 3\n\t\t\t\t\t\t\t  }\n\t\t\t\t\t\t\t},\n\t\t\t\t\t\t\t{\n\t\t\t\t\t\t\t  breakpoint: 760,\n\t\t\t\t\t\t\t  settings: {\n\t\t\t\t\t\t\t\tslidesToShow: 2,\n\t\t\t\t\t\t\t\tslidesToScroll: 2\n\t\t\t\t\t\t\t  }\n\t\t\t\t\t\t\t}\n\t\t\t\t\t\t],pauseOnDotsHover: true,customPaging: function(slider, i) {\n                   return '<i type=\"button\" style= \"color:#333333;\" class=\"ultsl-record\" data-role=\"none\"><\/i>';\n                },});\n\t\t\t\t\t}\n\t\t\t\t});\n\t\t\t<\/script>\n\t\t\t[\/vc_column][\/vc_row][vc_row type=&#8221;5&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-40&#8243; margin_bottom=&#8221;20&#8243; padding_top=&#8221;125&#8243; padding_bottom=&#8221;40&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; anchor=&#8221;Join&#8221; min_height=&#8221;300&#8243; css=&#8221;.vc_custom_1458741564366{margin-bottom: 20px !important;}&#8221;][vc_column width=&#8221;2\/3&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h4><span style=\"color: #000000\"><strong>Be part of our team<\/strong><\/span><\/h4>\n<p>[\/vc_column_text][vc_empty_space height=&#8221;45px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<span style=\"color: #333333\">We always wish to hear from talented candidates who are interested in joining our lab.<\/span><\/p>\n<p><span style=\"color: #3366ff\"><strong>There are two priorities in the Huang lab:<\/strong><\/span><\/p>\n<p><span style=\"color: #3366ff\"><strong>1. Performing mechanistic studies to discover the unknown functions of ion channels during development and tumourigenesis<\/strong><\/span><\/p>\n<p><span style=\"color: #3366ff\"><strong>2. Realizing the best potential and fostering the career development of all lab members<\/strong><\/span><\/p>\n<p><span style=\"color: #333333\">Before every lab member joins, both scientific and career goals will be discussed with the PI, and a plan to achieve these goals will be laid out. Both postdoctoral fellows and graduate students will be able to choose from a number of projects depending on his\/her interests, and they are encouraged to test their own ideas and develop new directions.<\/span><\/p>\n<p><span style=\"color: #333333\">Postdoctoral fellows are expected to independently lead projects with input from the PI and other lab members. While graduate students will initially work closely with the PI and senior members in the lab, they will also be fostered to develop independence and become the pilots of their projects.<\/span><\/p>\n<p><span style=\"color: #333333\">Besides the general lab duties, lab manager and research assistants are also encouraged to take on scientific projects depending on his\/her interests and talents. Everyone is expected to work smart and do the best science, and the PI will make every effort to develop a collegial lab environment and promote the professional growth of all lab members.\u00a0<\/span>[\/vc_column_text]<blockquote class=\"text-big fadeIn animate-element shortcode-blockquote\"><h5><span style=\"color: #0046ad\"><strong><em>The lab succeeds when its members succeed!<\/em><\/strong><\/span><\/h5>\n<\/blockquote>[\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_empty_space height=&#8221;128px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1466178520841{padding-top: 20px !important;padding-right: 25px !important;padding-bottom: 20px !important;padding-left: 25px !important;background-color: #cee8ea !important;}&#8221;]Prospective<strong> postdoctoral fellows <\/strong>can apply directly by sending their CV and cover letter outlining their research interests to Dr. Huang<\/p>\n<p>&nbsp;<\/p>\n<p>Individuals interested in joining the lab as a<strong> graduate student<\/strong> must be admitted to the graduate program in the <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.moleculargenetics.utoronto.ca\" target=\"_blank\" rel=\"noopener noreferrer\">Department of Molecular Genetics<\/a><\/span> at the <span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.utoronto.ca\" target=\"_blank\" rel=\"noopener noreferrer\">University of Toronto<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Undergraduate students<\/strong> can join the lab as long as they are enrolled in any department at a recognized university[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;5&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-30&#8243; margin_bottom=&#8221;20&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; min_height=&#8221;30&#8243;][vc_column][vc_column_text][\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;4&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-10&#8243; margin_bottom=&#8221;10&#8243; padding_top=&#8221;90&#8243; padding_bottom=&#8221;25&#8243; parallax_content=&#8221;parallax_content_value&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; min_height=&#8221;30&#8243; anchor=&#8221;Contact&#8221; css=&#8221;.vc_custom_1458741578977{margin-bottom: 10px !important;}&#8221;][vc_column][vc_empty_space height=&#8221;30px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h4><span style=\"color: #000000\"><strong>Contact information<\/strong><\/span><\/h4>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;4&#8243; animation=&#8221;fadeIn&#8221; margin_top=&#8221;-10&#8243; margin_bottom=&#8221;20&#8243; padding_top=&#8221;30&#8243; padding_bottom=&#8221;40&#8243; parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; min_height=&#8221;300&#8243; anchor=&#8221;Contact&#8221;][vc_column width=&#8221;1\/3&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h6>Dr. Xi Huang<\/h6>\n<p>Senior Scientist<\/p>\n<p>&nbsp;<\/p>\n<p>Peter Gilgan Centre for Research and Learning<\/p>\n<p>686 Bay Street, Room 16.9704<\/p>\n<p>Toronto, ON M5G 0A4<\/p>\n<p><strong>Office:<\/strong> (416) 813-7654 Ext: 309526<\/p>\n<p><strong>Main Lab: <\/strong>16.9420 (Ext: 309527)<\/p>\n<p><strong>Fly Lab:<\/strong> 15.9400 (Ext: 309528)<\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:xi.huang@sickkids.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>\n<div class=\"gap\" style=\"line-height: 25px; height: 25px;\"><\/div>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h6>Ms. Nalma Uy<\/h6>\n<p>Administrative Assistant to Dr. Xi Huang<\/p>\n<p>&nbsp;<\/p>\n<p>Peter Gilgan Centre for Research and Learning<\/p>\n<p>686 Bay Street, 16.9801-U1<\/p>\n<p>Toronto, ON M5G 0A4<\/p>\n<p>(416) 813-7654 Ext: 309120<\/p>\n<p>&nbsp;<\/p>\n<div class=\"soc-ico\"><a title=\"Mail page opens in new window\" href=\"mailto:nalma.uy@sickkids.ca\" target=\"_top\" class=\"mail\"><span class=\"soc-font-icon\"><\/span><span class=\"screen-reader-text\">Mail page opens in new window<\/span><\/a><\/div>\n<div class=\"gap\" style=\"line-height: 25px; height: 25px;\"><\/div>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_gmaps link=&#8221;#E-8_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&#8221; size=&#8221;350&#8243;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;5&#8243; css=&#8221;.vc_custom_1463592882802{margin-bottom: 0px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;] Xi Huang Lab &nbsp; calligraphy by Daming Huang We do curiosity-driven and serendipitous science to decode mechano-electrical-chemical signaling\u00a0in cancer [\/vc_column_text][vc_column_text][\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243; offset=&#8221;vc_hidden-xs&#8221;][rev_slider_vc alias=&#8221;mainslider&#8221;][\/vc_column][\/vc_row][vc_row parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; min_height=&#8221;750&#8243;][vc_column width=&#8221;5\/6&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;] Research [\/vc_column_text][vc_column_text css_animation=&#8221;fadeIn&#8221;]We study physical properties and mechano-electrical-chemical signaling in cancer. While extensive research has informed genetics and biochemical mechanisms&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-microsite.php","meta":{"footnotes":""},"class_list":["post-58","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Home - Huang Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/huang\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Home\" \/>\n<meta property=\"og:description\" content=\"[vc_row type=&#8221;5&#8243; css=&#8221;.vc_custom_1463592882802{margin-bottom: 0px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;] Xi Huang Lab &nbsp; calligraphy by Daming Huang We do curiosity-driven and serendipitous science to decode mechano-electrical-chemical signaling\u00a0in cancer [\/vc_column_text][vc_column_text][\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243; offset=&#8221;vc_hidden-xs&#8221;][rev_slider_vc alias=&#8221;mainslider&#8221;][\/vc_column][\/vc_row][vc_row parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; min_height=&#8221;750&#8243;][vc_column width=&#8221;5\/6&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;] Research [\/vc_column_text][vc_column_text css_animation=&#8221;fadeIn&#8221;]We study physical properties and mechano-electrical-chemical signaling in cancer. While extensive research has informed genetics and biochemical mechanisms&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/huang\/\" \/>\n<meta property=\"og:site_name\" content=\"Huang Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-24T18:02:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2018\/10\/Huang.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2304\" \/>\n\t<meta property=\"og:image:height\" content=\"2776\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"34 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/huang\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/huang\/\",\"name\":\"Home - Huang Lab\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/huang\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/huang\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/huang\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2018\/10\/Huang-249x300.jpg\",\"datePublished\":\"2015-08-04T16:53:04+00:00\",\"dateModified\":\"2026-03-24T18:02:08+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/huang\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lab.research.sickkids.ca\/huang\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/huang\/#primaryimage\",\"url\":\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2018\/10\/Huang.jpg\",\"contentUrl\":\"https:\/\/lab.research.sickkids.ca\/huang\/wp-content\/uploads\/sites\/9\/2018\/10\/Huang.jpg\",\"width\":2304,\"height\":2776,\"caption\":\"Huang in Chinese.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/huang\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lab.research.sickkids.ca\/huang\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Home\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/huang\/#website\",\"url\":\"https:\/\/lab.research.sickkids.ca\/huang\/\",\"name\":\"Huang Lab\",\"description\":\"Ion channels in brain development and tumourigenesis\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lab.research.sickkids.ca\/huang\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Home - Huang Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lab.research.sickkids.ca\/huang\/","og_locale":"en_US","og_type":"article","og_title":"Home","og_description":"[vc_row type=&#8221;5&#8243; css=&#8221;.vc_custom_1463592882802{margin-bottom: 0px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;] Xi Huang Lab &nbsp; calligraphy by Daming Huang We do curiosity-driven and serendipitous science to decode mechano-electrical-chemical signaling\u00a0in cancer [\/vc_column_text][vc_column_text][\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243; offset=&#8221;vc_hidden-xs&#8221;][rev_slider_vc alias=&#8221;mainslider&#8221;][\/vc_column][\/vc_row][vc_row parallax_content=&#8221;off&#8221; fadeout_row=&#8221;fadeout_row_value&#8221; min_height=&#8221;750&#8243;][vc_column width=&#8221;5\/6&#8243;][vc_column_text css_animation=&#8221;fadeIn&#8221;] Research [\/vc_column_text][vc_column_text css_animation=&#8221;fadeIn&#8221;]We study physical properties and mechano-electrical-chemical signaling in cancer. 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