{"id":9,"date":"2015-08-24T14:10:54","date_gmt":"2015-08-24T14:10:54","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/hopyan\/?page_id=9"},"modified":"2025-12-10T20:25:25","modified_gmt":"2025-12-10T20:25:25","slug":"hopyan-lab-research","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/hopyan\/hopyan-lab-research\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;3\/4&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<h2><span style=\"color: #000000\">Tissue shape<\/span><\/h2>\n<p>Early organ primordial such as the limb buds and pharyngeal arches are composed of mesodermal corer that are surrounded by ectoderm. \u00a0Our aim is to define the physical basis by which these structures morph by combining live imaging, physical measurements, and genetics in the mouse embryo. \u00a0A current focus of the lab is how physical property gradients of stiffness and membrane potential morph the limb bud and heart by orienting cellular movements and extracellular matrix remodelling.<\/p>\n<p>Some of the tools we have generated for this purpose include transgenic sensors of vinculin tension, ATP\/ADP ratio, and membrane potential, magnetic tweezer and light sheet elastography systems to measure viscoelasticity, and endogenous reporters of fibronectin and YAP.[\/vc_column_text][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][vc_column width=&#8221;1\/4&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;3\/4&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<h2><span style=\"color: #000000\">Mechanotransduction<\/span><\/h2>\n<p>Forces that shape tissues during development are are least partially transmitted to nuclei. \u00a0We ask whether nuclear stresses modify gene regulation during development with a focus on the limb bud. \u00a0Tools we have generated for this purpose include transgenic sensors of nuclear membrane tension and devices to manipulate forces upon the limb bud.[\/vc_column_text][vc_row_inner][vc_column_inner width=&#8221;2\/3&#8243;][vc_empty_space][\/vc_column_inner][\/vc_row_inner][vc_empty_space height=&#8221;50px&#8221;][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][vc_column width=&#8221;1\/4&#8243;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;2\/3&#8243;][\/vc_column][vc_column width=&#8221;1\/3&#8243;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;3\/4&#8243;][vc_column_text css=&#8221;&#8221;] Tissue shape Early organ primordial such as the limb buds and pharyngeal arches are composed of mesodermal corer that are surrounded by ectoderm. \u00a0Our aim is to define the physical basis by which these structures morph by combining live imaging, physical measurements, and genetics in the mouse embryo. \u00a0A current focus of&hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - 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