{"id":11,"date":"2015-08-24T14:11:35","date_gmt":"2015-08-24T14:11:35","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/hopyan\/?page_id=11"},"modified":"2025-09-08T15:37:27","modified_gmt":"2025-09-08T15:37:27","slug":"publications","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/hopyan\/publications\/","title":{"rendered":"Papers"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_empty_space][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<ul>\n<li><a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2504185122\" target=\"_blank\" rel=\"noopener\">A thermodynamic perspective on mammalian neural crest ingression<\/a>.<br \/>\nPasiliao CC, Thomas EC, Yung T, Zhu M, Tao H, Sun Y, Goyal S, Hopyan S.<br \/>\n<strong>Proc Natl Acad Sci U S A<\/strong>. (2025) Sep 9;122(36):e2504185122.<span class=\"docsum-authors full-authors\"><span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adt7274?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed\" target=\"_blank\" rel=\"noopener\">Tissue stiffness mapping by light sheet elastography<\/a>.<br \/>\nZhu M, Zhang K, Thomas EC, Xu R, Ciruna B, Hopyan S, Sun Y.<br \/>\n<strong>Science Advances<\/strong>. (2025) Mar 14;11(11):eadt7274.<span class=\"docsum-authors full-authors\"><span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adl6366\" target=\"_blank\" rel=\"noopener\">A fibronectin gradient remodels mixed-phase mesoderm<\/a>.<br \/>\nZhu M, Gu B, Thomas EC, Huang Y, Kim YK, Tao H, Yung TM, Chen X, Zhang K, Woolaver EK, Nevin MR, Huang X, Winklbauer R, Rossant J, Sun Y, Hopyan S.<br \/>\n<strong>Science Advances<\/strong>. (2024) Jul 19;10(29):eadl6366.<span class=\"docsum-authors full-authors\"><span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38814743\/\" target=\"_blank\" rel=\"noopener\">Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion<\/a>.<br \/>\nPolsani N, Yung T, Thomas E, Phung-Rojas M, Gupta I, Denker J, Lau K, Feng X, Ibarra B, Hopyan S, Atit RP.<br \/>\n<strong>Development<\/strong>. (2024) Jun 15;151(12):dev202596.<span class=\"docsum-authors full-authors\"><span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37803831\/\" target=\"_blank\" rel=\"noopener\">Shape driven confluent rigidity transition in curved biological tissues.<\/a><br \/>\n<span class=\"docsum-authors full-authors\">Thomas E, Hopyan S.<br \/>\n<strong>Biophysical Journal.<\/strong> (2023) Nov 7;122(21):4264-4273.<span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37639585\/\" target=\"_blank\" rel=\"noopener\">Indentation induces instantaneous nuclear stiffening and unfolding of nuclear envelop wrinkles.<\/a><br \/>\n<span class=\"docsum-authors full-authors\">Tang W, Chen X, Wang X, Zhu M, Shan G, Wang T, Dou W, Wang J, Law J, Gong Z, Hopyan S, Huang X, Sun Y.<br \/>\n<span lang=\"EN-US\"><strong>Proceedings of the National Academy of Sciences, USA.<\/strong><\/span> (2023) doi: 10.1073\/pnas.2307356120.<span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36350289\/\" target=\"_blank\" rel=\"noopener\">Transgenic force sensors and software to measure force transmission across the mammalian nuclear envelope in vivo.<\/a><br \/>\n<span class=\"docsum-authors full-authors\">Fenelon KD, Thomas E, Samani M, Zhu M, Tao H, Sun Y, McNeill H, Hopyan S.<br \/>\n<strong>Biology Open.<\/strong> (2022) Sep 5;120(36):e2307356120. <span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36137018\/\" target=\"_blank\" rel=\"noopener\">Pitx2 patterns an accelerator-brake mechanical feedback through latent TGF\u03b2 to rotate the gut.<\/a><br \/>\n<span class=\"docsum-authors full-authors\">Sanketi BD, Zuela-Sopilniak N, Bundschuh E, Gopal S, Hu S, Long J, Lammerding J, Hopyan S, Kurpios NA.<br \/>\n<strong>Science.<\/strong> (2022) Sep 23;377(6613):eabl3921.<span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35252804\/\" target=\"_blank\" rel=\"noopener\">Patterning the embryonic pulmonary mesenchyme.<\/a><br \/>\n<span class=\"docsum-authors full-authors\">Goodwin K, Jaslove JM, Tao H, Zhu M, Hopyan S, Nelson CM.<br \/>\n<strong>iScience.<\/strong>\u00a0(2022) doi: 10.1016\/j.isci.2022.103838.<span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35042406\/\" target=\"_blank\" rel=\"noopener\">Live imaging YAP signalling in mouse embryo development.<\/a><br \/>\n<span class=\"docsum-authors full-authors\">Gu B, Bradshaw B, Zhu M, Sun Y, Hopyan S, Rossant J.<br \/>\n<strong>Open Biology.<\/strong>\u00a0(2022) Jan;12(1):210335.<span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphy.2021.670571\/full\" target=\"_blank\" rel=\"noopener\">Existing and potential applications of elastography for measuring the viscoelasticity of biological tissues<span class=\"x_x_Apple-converted-space\">\u00a0<\/span><i>in vivo<\/i><\/a>.<br \/>\nZhang K, Zhu M, Thomas E,\u00a0<span class=\"markxo6yifrgi\" data-markjs=\"true\" data-ogac=\"\" data-ogab=\"\" data-ogsc=\"\" data-ogsb=\"\">Hopyan<\/span> S, Sun Y.<br \/>\n<strong><span lang=\"EN-US\">Frontiers in Physics. <\/span><\/strong><span lang=\"EN-US\">(2021)\u00a0<\/span><span lang=\"EN-US\">doi:10.3389\/fphy.2021.670571<\/span><span lang=\"EN-US\">.<span class=\"docsum-authors full-authors\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32907847\/\" target=\"_blank\" rel=\"noopener\">IRX3\/5 regulate mitotic chromatid segregation and limb bud shape<\/a>.<br \/>\nTao H, Lambert JP, Yung TM, Zhu M, Hahn NA, Li D, Lau K, Sturgeon K, Puviindran V, Zhang X, Gong W, Chen XX, Anderson G, Garry DJ, Henkelman RM, Sun Y, Iulianella A, Kawakami Y, Gingras AC, Hui CC, Hopyan S<b>.<br \/>\nDevelopment. (<\/b>2020) Oct 5;147(19). <span lang=\"EN-US\"><span lang=\"EN-US\"><span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32666052\/\" target=\"_blank\" rel=\"noopener\">Magnetic micromanipulation for <em>in vivo<\/em> measurement of stiffness heterogeneity and anisotropy in the mouse mandibular arch<\/a>.<br \/>\nZhu M, Zhang K, Tao H, Hopyan S, Sun Y.<br \/>\n<strong>Research<\/strong> (Wash DC). (2020) Jun 22;2020:7914074.<span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/li>\n<li><a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32155439\/\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"result_click\" data-ga-action=\"3\" data-ga-label=\"32155439\" data-full-article-url=\"from_term=sevan+hopyan+2020&amp;from_pos=3\" data-article-id=\"32155439\">Hedgehog-activated Fat4 and PCP pathways mediate mesenchymal cell clustering and villus formation in gut development.<\/a><br \/>\nRao-Bhatia A, Zhu M, Yin WC, Coquenlorge S, Zhang X, Woo J, Sun Y, Dean CH, Liu A, Hui CC, Shivdasani RA, McNeill H, Hopyan S, Kim TH.<br \/>\n<strong>Developmental Cell<\/strong>. (2020) Mar 9;52(5):647-658. <span lang=\"EN-US\"><span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/412072v1\" target=\"_blank\" rel=\"noopener noreferrer\"><span lang=\"EN-US\">Spatial mapping of tissue properties <i>in vivo <\/i>reveals a 3D stiffness gradient in the mouse limb bud<\/span><\/a><b><span lang=\"EN-US\">.<br \/>\n<\/span><\/b><span lang=\"EN-US\">Zhu M, Tao H, Samani M, Luo M, Wang X, Hopyan S, Sun Y. <\/span><span lang=\"EN-US\"><br \/>\n<strong>Proceedings of the National Academy of Sciences, USA.<\/strong>\u00a0(2020);<\/span> Mar 3;117(9):4781-4791.<span lang=\"en-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/li>\n<li><a href=\"https:\/\/robotics.sciencemag.org\/content\/4\/28\/eaav6180\" target=\"_blank\" rel=\"noopener noreferrer\">Intracellular manipulation and measurement with multipole magnetic tweezers<\/a><span lang=\"EN-US\">.<br \/>\n<\/span><span lang=\"EN-US\">Wang X, Ho C, Tsatskis Y, Law J, Zhang Z, Zhu M, Dai C, Wang F, Tan M, Hopyan S, McNeill H, Sun Y.<\/span><span lang=\"EN-US\"><span lang=\"EN-US\"><span lang=\"EN-US\"><br \/>\n<strong>Science Robotics. <\/strong>(2019) 4(28).<span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/span><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30979871\" target=\"_blank\" rel=\"noopener noreferrer\">Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch.<\/a><br \/>\nTao H, Zhu M, Lau K, Whitley OKW, Samani M, Xiao X, Chen XX, Hahn NA, Liu W, Valencia M, Wang X, Fenelon KS,\u00a0Pasiliao CC, Hu D, Wu J, Spring S, Ferguson J, Karuna EP, Henkelman RM, Dunn A, Huang H, Ho HH, Atit R, Goyal S, Sun Y, Hopyan S.<br \/>\n<strong>Nature Communications<\/strong>. 2019 Apr 12:10(1):1703.\u00a0<span lang=\"en-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30246301\" target=\"_blank\" rel=\"noopener noreferrer\">The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in human nephrogenesis and Wilms tumour development.<\/a><br \/>\nMengelbier LH, Lindell-Munther S, Jansson C, Esfandyari J, Karlsson J, Yasui H, Lau K, Bexell D, Hui CC, Hopyan S, Gisselsson D.<br \/>\n<strong>Journal of Pathology. <\/strong>(2019) Jan; 247(1):86-98. <span lang=\"EN-US\"><span lang=\"EN-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/span><\/li>\n<li class=\"title\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30509858\" target=\"_blank\" rel=\"noopener noreferrer\">Characterizing inner pressure and stiffness of trophoblast and inner cell mass of blastocysts.<\/a><br \/>\nWang X, Zhang Z, Tao H, Liu J, Hopyan S, Sun Y.<br \/>\n<strong><span class=\"jrnl\" title=\"Biophysical journal\">Biophysical Journal<\/span><\/strong>. 2018 Dec 18;115(12):2443-2450.\u00a0<span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/li>\n<\/ul>\n<div class=\"rslt\">\n<div class=\"rslt\">\n<ul>\n<li class=\"title\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29777038\" target=\"_blank\" rel=\"noopener noreferrer\">Mechanical stability of the cell nucleus &#8211; roles played by the cytoskeleton in nuclear deformation and strain recovery.<\/a><br \/>\nWang X, Liu H, Zhu M, Cao C, Xu Z, Tsatskis Y, Lau K, Kuok C, Filleter T, McNeill H, Simmons CA, Hopyan S, Sun Y.<br \/>\n<strong><span class=\"jrnl\" title=\"Journal of cell science\">Journal of Cell Science<\/span><\/strong>. 2018 Jul 4;131(13).<span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/li>\n<\/ul>\n<\/div>\n<ul>\n<li>\n<p class=\"title\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29729398\" target=\"_blank\" rel=\"noopener noreferrer\">Genetic interaction between Gli3 and Ezh2 during limb pattern formation.<\/a><br \/>\nDeimling SJ, Lau K, Hui CC, Hopyan S.<br \/>\n<strong><span class=\"jrnl\" title=\"Mechanisms of development\">Mechanisms of Development<\/span><\/strong>. 2018 Jun;151:30-36.\u00a0<span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/p>\n<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29280270\" target=\"_blank\" rel=\"noopener noreferrer\">Cell ingression: Relevance to limb development and for adaptive evolution<\/a>.<br \/>\nPasiliao C.C., Hopyan S.<br \/>\n<strong>Genesis<\/strong> 2018 Jan;56 (1).\u00a0<span lang=\"en-US\"><span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/span><\/li>\n<li>\n<p class=\"title\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28669818\" target=\"_blank\" rel=\"noopener noreferrer\">Biophysical regulation of early limb bud morphogenesis.<\/a><br \/>\nHopyan S.<br \/>\n<strong><span class=\"jrnl\" title=\"Developmental biology\">Developmental Biology<\/span><\/strong>. 2017 Sep 15;429(2):429-433.<span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/p>\n<\/li>\n<li>\n<p class=\"title\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28641117\" target=\"_blank\" rel=\"noopener noreferrer\">Structural components of nuclear integrity with gene regulatory potential.<\/a><br \/>\nFenelon KD, Hopyan S.<br \/>\n<strong><span class=\"jrnl\" title=\"Current opinion in cell biology\">Current Opinion in Cell Biology<\/span>.<\/strong> 2017 Jun 19;48:63-71.\u00a0<span lang=\"en-US\"><\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/p>\n<\/li>\n<li>\n<div align=\"justify\"><span lang=\"en-US\"><a href=\"http:\/\/www.cell.com\/biophysj\/abstract\/S0006-3495(17)30440-X\" target=\"_blank\" rel=\"noopener noreferrer\">Cell and tissue scale forces coregulate Fgfr2-dependent tetrads and rosettes in the mouse embryo.<\/a><br \/>\n<\/span><span lang=\"en-US\">Wen J, Tao H, Lau K, Simmons CA, Sun Y, Hopyan S.<\/span><\/div>\n<div align=\"justify\">\n<p><span lang=\"en-US\"><strong>Biophysical Journal.<\/strong> 2017 May 23;112 (10) 2209-2218. <\/p>\n<div class=\"hr-thin\"><\/div>\n<p><\/span><\/p>\n<\/div>\n<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28319333\" target=\"_blank\" rel=\"noopener noreferrer\">The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies.<\/a><br \/>\nTao H, Kawakami Y, Hui CC, Hopyan S.<br \/>\n<strong>Wiley Interdisciplinary Reviews: Developmental Biology.\u00a0<\/strong>\u00a02017 Jul;6(4) <\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<li>Visualization and force measurement during mouse development.<br \/>\nTao H, Hopyan S.<br \/>\n<strong>Seitai no kagaku\/Science of the living body. (2017)<\/strong>\u00a068(5):454-455.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26791356\" target=\"_blank\" rel=\"noopener noreferrer\">Tibial hemimilia associated with GLI3 truncation.<\/a><br \/>\nDeimling S, Sotiropoulos C, Lau K, Chaudhry S, Sturgeon K, Kelley S, Narayanan U, Howard A, Hui CC, Hopyan S.<br \/>\n<strong>Journal of Human Genetics<\/strong>. 2016 May;61(5):443-6.\u00a0<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25893915\" target=\"_blank\" rel=\"noopener noreferrer\">Anisotropic stress orients remodelling of mammalian limb bud ectoderm.<br \/>\n<\/a>Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JT, Wong MD, Li D, Deimling S, Ciruna B, Scott I, Simmons C, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S.<br \/>\n<strong><span class=\"jrnl\" title=\"Nature cell biology\">Nature Cell Biology<\/span><\/strong>. 2015 May;17(5):569-79.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24726283\" target=\"_blank\" rel=\"noopener noreferrer\">A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers.<\/a><br \/>\nZhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC.<br \/>\n<strong><span class=\"jrnl\" title=\"Developmental cell\">Developmental Cell<\/span><\/strong>. 2014 Apr 28;29(2):241-9.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<div class=\"rprt\">\n<div class=\"rslt\">\n<ul>\n<li class=\"title\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24726282\" target=\"_blank\" rel=\"noopener noreferrer\">Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.<\/a><br \/>\nLi D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC.<br \/>\n<strong><span class=\"jrnl\" title=\"Developmental cell\">Developmental Cell<\/span><\/strong>. 2014 Apr 28;29(2):233-40.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"rprt\">\n<div class=\"rslt\">\n<ul>\n<li class=\"title\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24673613\"><em>In situ<\/em> mechanical characterization of the cell nucleus by atomic force microscopy.<\/a><br \/>\nLiu H, Wen J, Xiao Y, Liu J, Hopyan S, Radisic M, Simmons CA, Sun Y.<br \/>\n<strong><span class=\"jrnl\" title=\"ACS nano\">ACS Nano<\/span><\/strong>. 2014 Apr 22;8(4):3821-8.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"rprt\">\n<div class=\"rslt\">\n<ul>\n<li class=\"title\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21795281\" target=\"_blank\" rel=\"noopener noreferrer\">Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.<br \/>\n<\/a>Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S.<br \/>\n<strong><span class=\"jrnl\" title=\"Development (Cambridge, England)\">Development<\/span><\/strong>. 2011 Sep;138(17):3759-67.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"rprt\">\n<div class=\"rslt\">\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21384474\" target=\"_blank\" rel=\"noopener noreferrer\">Budding behaviors: Growth of the limb as a model of morphogenesis.<br \/>\n<\/a>Hopyan S, Sharpe J, Yang Y.<br \/>\n<strong><span class=\"jrnl\" title=\"Developmental dynamics : an official publication of the American Association of Anatomists\">Developmental Dynamics<\/span><\/strong>. 2011 May;240(5):1054-62.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<ul>\n<li class=\"title\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20554720\">Oriented cell motility and division underlie early limb bud morphogenesis.<br \/>\n<\/a>Wyngaarden LA, Vogeli KM, Ciruna BG, Wells M, Hadjantonakis AK, Hopyan S.<br \/>\n<strong><span class=\"jrnl\" title=\"Development (Cambridge, England)\">Development<\/span><\/strong>. 2010 Aug 1;137(15):2551-8.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<ul>\n<li class=\"title\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18053979\" target=\"_blank\" rel=\"noopener noreferrer\">Plasticity of proximal-distal cell fate in the mammalian limb bud.<br \/>\n<\/a>Wyngaarden LA, Hopyan S.<br \/>\n<strong><span class=\"jrnl\" title=\"Developmental biology\">Developmental Biology<\/span><\/strong>. 2008 Jan 1;313(1):225-33.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"rprt\">\n<div class=\"rslt\">\n<div>\n<div class=\"rprt\">\n<div class=\"rslt\">\n<ul>\n<li class=\"title\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17328886\" target=\"_blank\" rel=\"noopener noreferrer\">PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms.<br \/>\n<\/a>Mau E, Whetstone H, Yu C, Hopyan S, Wunder JS, Alman BA.<br \/>\n<strong><span class=\"jrnl\" title=\"Developmental biology\">Developmental Biology<\/span><\/strong>. 2007 May 1;305(1):28-39.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"rprt\">\n<div class=\"rslt\">\n<ul>\n<li class=\"title\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16400033\">Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation.<br \/>\n<\/a>Tiet TD, Hopyan S, Nadesan P, Gokgoz N, Poon R, Lin AC, Yan T, Andrulis IL, Alman BA, Wunder JS.<br \/>\n<strong><span class=\"jrnl\" title=\"The American journal of pathology\">American Journal of Pathology<\/span><\/strong>. 2006 Jan;168(1):321-30.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"rprt\">\n<div class=\"rslt\">\n<ul>\n<li class=\"title\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15834844\" target=\"_blank\" rel=\"noopener noreferrer\">Dysregulation of hedgehog signalling predisposes to synovial chondromatosis.<br \/>\n<\/a>Hopyan S, Nadesan P, Yu C, Wunder J, Alman BA.<br \/>\n<strong><span class=\"jrnl\" title=\"The Journal of pathology\">Journal of Pathology<\/span><\/strong>. 2005 Jun;206(2):143-50.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"rprt\">\n<div class=\"rslt\">\n<ul>\n<li class=\"title\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11850620\" target=\"_blank\" rel=\"noopener noreferrer\">A mutant PTH\/PTHrP type I receptor in enchondromatosis.<br \/>\n<\/a>Hopyan S, Gokgoz N, Poon R, Gensure RC, Yu C, Cole WG, Bell RS, J\u00fcppner H, Andrulis IL, Wunder JS, Alman BA.<br \/>\n<strong><span class=\"jrnl\" title=\"Nature genetics\">Nature Genetics<\/span><\/strong>. 2002 Mar;30(3):306-10.<\/p>\n<div class=\"hr-thin\"><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_empty_space][vc_column_text css_animation=&#8221;fadeIn&#8221;] A thermodynamic perspective on mammalian neural crest ingression. Pasiliao CC, Thomas EC, Yung T, Zhu M, Tao H, Sun Y, Goyal S, Hopyan S. Proc Natl Acad Sci U S A. (2025) Sep 9;122(36):e2504185122. Tissue stiffness mapping by light sheet elastography. Zhu M, Zhang K, Thomas EC, Xu R, Ciruna B, Hopyan S,&hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Papers - Hopyan Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/hopyan\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Papers\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_empty_space][vc_column_text css_animation=&#8221;fadeIn&#8221;] A thermodynamic perspective on mammalian neural crest ingression. Pasiliao CC, Thomas EC, Yung T, Zhu M, Tao H, Sun Y, Goyal S, Hopyan S. Proc Natl Acad Sci U S A. (2025) Sep 9;122(36):e2504185122. Tissue stiffness mapping by light sheet elastography. 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Pasiliao CC, Thomas EC, Yung T, Zhu M, Tao H, Sun Y, Goyal S, Hopyan S. Proc Natl Acad Sci U S A. (2025) Sep 9;122(36):e2504185122. Tissue stiffness mapping by light sheet elastography. 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