Publications

Characterization of adipose depot-specific stromal cell populations by single-cell mass cytometry. Kim YH, Lee JH, Yeung JL, Das E, Kim RY, Jiang Y, Moon JH, Jeong H, Thakkar N, Son JE, Trzaskalski N, Hui CC, Doh KO, Mulvihill EE, Kim JR, Kim KH, Sung HK. iScience. 2022 Mar 26;25(4):104166
COVID-19 and obesity: fighting two pandemics with intermittent fasting. Ealey KN, Phillips J, Sung HK. Trends Endocrinol Metab. 2021 Sep;32(9):706-720.
Thermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice. Kim YH, Lee JH, Yeung JL, Das E, Kim RY, Jiang Y, Moon JH, Jeong H, Thakkar N, Son JE, Trzaskalski N, Hui CC, Doh KO, Mulvihill EE, Kim JR, Kim KH, Sung HK. Sci Rep. 2019 Feb 21;9(1):2479.
Visualization of 3D White Adipose Tissue Structure Using Whole-mount Staining. Jiang Y, Yeung JL, Lee JH, An J, Steadman PE, Kim JR, Sung HK. J Vis Exp. 2018 Nov 17;(141)
Flow Cytometry and Lineage Tracing Study for Identification of Adipocyte Precursor Cell (APC) Populations. Lee JH, Yeganeh A, Konoeda H, Moon JH, Sung HK. Methods Mol Biol. 2018; 1752:111-121.
Adipose Tissue and Modulation of Hypertension. Das E, Moon JH, Lee JH, Thakkar N, Pausova Z, Sung HK.Curr Hypertens Rep. 2018 Sep 18;20(11):96
Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage. Kim KH, Kim YH, Son JE, Lee JH, Kim S, Choe MS, Moon JH, Zhong J, Fu K, Lenglin F, Yoo JA, Bilan PJ, Klip A, Nagy A, Kim JR, Park JG, Hussein SM, Doh KO, Hui CC, Sung HK. Cell Research 2017; 11:1309-1326.
Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Sung HK, Doh KO, Son JE, Park JG, Bae Y, Choi S, Nelson SM, Cowling R, Nagy K, Michael IP, Koh GY, Adamson SL, Pawson T, Nagy A. Cell Metab.2013 Jan 8;17(1):61-72.
Circadian rhythms in metabolic organs and the microbiota during acute fasting in mice. Pickel L, Lee JH, Maughan H, Shi IQ, Verma N, Yeung C, Guttman D, Sung HK. Circadian rhythms in metabolic organs and the microbiota during acute fasting in mice. Physiol Rep. 2022 Jul;10(14):e15393. doi: 10.14814/phy2.15393. PMID: 35851583; PMCID: PMC9295129.
Shared pathobiology identifies AMPK as a therapeutic target for obesity and autosomal dominant polycystic kidney disease. Iliuta IA, Song X, Pickel L, Haghighi A, Retnakaran R, Scholey J, Sung HK, Steinberg GR, Pei Y. Shared pathobiology identifies AMPK as a therapeutic target for obesity and autosomal dominant polycystic kidney disease. Front Mol Biosci. 2022 Aug 23;9:962933. doi: 10.3389/fmolb.2022.962933. PMID: 36106024; PMCID: PMC9467623.
Disruption of adipocyte YAP improves glucose homeostasis in mice and decreases adipose tissue fibrosis. Han DJ, Aslam R, Misra PS, Chiu F, Ojha T, Chowdhury A, Chan CK, Sung HK, Yuen DA, Luk CT. Disruption of adipocyte YAP improves glucose homeostasis in mice and decreases adipose tissue fibrosis. Mol Metab. 2022 Dec;66:101594. doi: 10.1016/j.molmet.2022.101594. Epub 2022 Sep 20. PMID: 36165813; PMCID: PMC9551211.
Gut microbiome modified by bariatric surgery improves insulin sensitivity and correlates with increased brown fat activity and energy expenditure. Yadav J, Liang T, Qin T, Nathan N, Schwenger KJP, Pickel L, Xie L, Lei H, Winer DA, Maughan H, Robertson SJ, Woo M, Lou W, Banks K, Jackson T, Okrainec A, Hota SS, Poutanen SM, Sung HK, Allard JP, Philpott DJ, Gaisano HY. Gut microbiome modified by bariatric surgery improves insulin sensitivity and correlates with increased brown fat activity and energy expenditure. Cell Rep Med. 2023 May 16;4(5):101051. doi: 10.1016/j.xcrm.2023.101051. PMID: 37196633; PMCID: PMC10213984.
Evidence of Metabolic Dysfunction in Amyotrophic Lateral Sclerosis (ALS) Patients and Animal Models. Maksimovic K, Youssef M, You J, Sung HK, Park J. Evidence of Metabolic Dysfunction in Amyotrophic Lateral Sclerosis (ALS) Patients and Animal Models. Biomolecules. 2023 May 19;13(5):863. doi: 10.3390/biom13050863. PMID: 37238732; PMCID: PMC10216611.
Adipose Tissue and Plasma Markers Associated with HbA1c Pre- and Post-bariatric Surgery: a Cross-sectional and Cohort Study. Keshavjee SH, Schwenger KJP, Yadav J, Pickel L, Ghorbani Y, Sung HK, Jung H, Lou W, Fischer SE, Jackson TD, Okrainec A, Allard JP. Adipose Tissue and Plasma Markers Associated with HbA1c Pre- and Post-bariatric Surgery: a Cross-sectional and Cohort Study. Obes Surg. 2023 Aug;33(8):2443-2451. doi: 10.1007/s11695-023-06679-z. Epub 2023 Jun 28. PMID: 37380880.
Diet and Polycystic Kidney Disease: Nutrients, Foods, Dietary Patterns, and Implications for Practice. Lambert K, Gardos R, Coolican H, Pickel L, Sung HK, Wang AY, Ong AC. Diet and Polycystic Kidney Disease: Nutrients, Foods, Dietary Patterns, and Implications for Practice. Semin Nephrol. 2023 Mar;43(2):151405. doi: 10.1016/j.semnephrol.2023.151405. Epub 2023 Aug 4. PMID: 37542985.
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts. Harding J, Vintersten-Nagy K, Yang H, Tang JK, Shutova M, Jong ED, Lee JH, Massumi M, Oussenko T, Izadifar Z, Zhang P, Rogers IM, Wheeler MB, Lye SJ, Sung HK, Li C, Izadifar M, Nagy A. Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts. Nat Biomed Eng. 2024 Apr;8(4):427-442. doi: 10.1038/s41551-023-01133-y. Epub 2023 Nov 23. PMID: 37996616; PMCID: PMC11087263.
Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalk. Knuth CM, Barayan D, Lee JH, Auger C, de Brito Monteiro L, Ricciuti Z, Metko D, Wells L, Sung HK, Screaton RA, Jeschke MG. Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalk. Cell Rep. 2024 Jan 23;43(1):113584. doi: 10.1016/j.celrep.2023.113584. Epub 2023 Dec 20. PMID: 38117653; PMCID: PMC10845122.
Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue. Ealey KN, Togo J, Lee JH, Patel Y, Kim JR, Park SY, Sung HK. Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue. Geroscience. 2024 Jun;46(3):3457-3470. doi: 10.1007/s11357-024-01093-4. Epub 2024 Feb 21. PMID: 38379117; PMCID: PMC11009208.
Inhibitory Regulation of FOXO1 in PPARδ Expression Drives Mitochondrial Dysfunction and Insulin Resistance. Park S, Cha HN, Shin MG, Park S, Kim Y, Kim MS, Shin KH, Thoudam T, Lee EJ, Wolfe RR, Dan J, Koh JH, Kim IY, Choi I, Lee IK, Sung HK, Park SY. Inhibitory Regulation of FOXO1 in PPARδ Expression Drives Mitochondrial Dysfunction and Insulin Resistance. Diabetes. 2024 Jul 1;73(7):1084-1098. doi: 10.2337/db23-0432. PMID: 38656552.
Obesity and the cerebral cortex: Underlying neurobiology in mice and humans. Patel Y, Woo A, Shi S, Ayoub R, Shin J, Botta A, Ketela T, Sung HK, Lerch J, Nieman B, Paus T, Pausova Z. Obesity and the cerebral cortex: Underlying neurobiology in mice and humans. Brain Behav Immun. 2024 Jul;119:637-647. doi: 10.1016/j.bbi.2024.04.033. Epub 2024 Apr 23. PMID: 38663773.
Intermittent fasting-a double edged sword for atherosclerosis. Togo J, Sung HK. Intermittent fasting-a double edged sword for atherosclerosis. Life Metab. 2024 Apr 25;3(3):loae015. doi: 10.1093/lifemeta/loae015. PMID: 38736615; PMCID: PMC11085033.
Lactate promotes fatty acid oxidation by the tricarboxylic acid cycle and mitochondrial respiration in muscles of obese mice. Park SY, Jung SR, Kim JY, Kim YW, Sung HK, Park SY, Doh KO, Koh JH. Lactate promotes fatty acid oxidation by the tricarboxylic acid cycle and mitochondrial respiration in muscles of obese mice. Am J Physiol Cell Physiol. 2024 Sep 1;327(3):C619-C633. doi: 10.1152/ajpcell.00060.2024. Epub 2024 Jul 9. PMID: 38981606.
Reprogramming of Energy Metabolism in Human PKD1 Polycystic Kidney Disease: A Systems Biology Analysis. Song X, Pickel L, Sung HK, Scholey J, Pei Y. Reprogramming of Energy Metabolism in Human PKD1 Polycystic Kidney Disease: A Systems Biology Analysis. Int J Mol Sci. 2024 Jun 29;25(13):7173. doi: 10.3390/ijms25137173. PMID: 39000280; PMCID: PMC11240917.
From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling. Vo N, Zhang Q, Sung HK. From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling. J Pharm Pharm Sci. 2024 Jul 22;27:13062. doi: 10.3389/jpps.2024.13062. PMID: 39104461; PMCID: PMC11298356.
The Circadian Clock of Müller Glia Is Necessary for Retinal Homeostasis and Neuronal Survival. Pickel L, Kim SJ, Hacibekiroglu S, Nagy A, Lee J, Sung HK. The Circadian Clock of Müller Glia Is Necessary for Retinal Homeostasis and Neuronal Survival. Am J Pathol. 2024 Nov;194(11):2179-2193. doi: 10.1016/j.ajpath.2024.07.017. Epub 2024 Aug 13. PMID: 39147235.
SVF MEDIATES IMMUNOMETABOLIC ALTERATIONS IN BURN-INDUCED HYPERMETABOLIC ADIPOSE TISSUE VIA MITOCHONDRIAL TRANSFER. de Brito Monteiro L, Bieerkehazhi S, Aijaz A, Knuth CM, Rix G, Lee JH, Sung HK, Farahat M, Jeschke MG. SVF MEDIATES IMMUNOMETABOLIC ALTERATIONS IN BURN-INDUCED HYPERMETABOLIC ADIPOSE TISSUE VIA MITOCHONDRIAL TRANSFER. Shock. 2025 Aug 1;64(2):226-235. doi: 10.1097/SHK.0000000000002608. Epub 2025 Apr 16. PMID: 40267513.

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