{"id":605,"date":"2025-02-18T17:06:49","date_gmt":"2025-02-18T17:06:49","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/heath\/?page_id=605"},"modified":"2025-04-09T18:02:57","modified_gmt":"2025-04-09T18:02:57","slug":"paediatric-rare-diseases","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/heath\/paediatric-rare-diseases\/","title":{"rendered":"PRACTICAL Platform Trial"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p>PRACTICAL is a platform trial that enables phase II and III evaluation of a range of potential interventions and strategies to improve outcomes for patients with acute hypoxemic respiratory failure (AHRF). AHRF is a common, life-threatening condition that leaves patients vulnerable to lung and diaphragm injury associated with mechanical ventilation along with other nosocomial complications of critical care. The platform enrols adult patients with AHRF to evaluate various related interventional strategies. Dr. Heath leads the statistical analysis committee for the PRACTICAL trial and the IMPaCT lab contributes to the design and analysis of different research questions within this trial.<\/p>\n<p>Learn more about\u00a0<a href=\"https:\/\/lab.research.sickkids.ca\/heath\/practical-randomised-controlled-trial\/\" target=\"_blank\" rel=\"noopener\">PRACTICAL Randomised Controlled Trial<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":253,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-605","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>PRACTICAL Platform Trial - EMBaRC Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/heath\/paediatric-rare-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PRACTICAL Platform Trial\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/heath\/paediatric-rare-diseases\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBaRC Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-09T18:02:57+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/heath\/paediatric-rare-diseases\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/heath\/paediatric-rare-diseases\/\",\"name\":\"PRACTICAL Platform Trial - 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