{"id":998,"date":"2019-09-04T16:02:43","date_gmt":"2019-09-04T16:02:43","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/guerguerian\/?page_id=998"},"modified":"2025-11-19T22:29:47","modified_gmt":"2025-11-19T22:29:47","slug":"our-research","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/guerguerian\/our-research\/","title":{"rendered":"Our Research"},"content":{"rendered":"

[vc_row full_width=”stretch_row” css=”.vc_custom_1434538871508{margin-bottom: 0px !important;}”][vc_column][vc_custom_heading text=”QBIct Study” font_container=”tag:h2|text_align:left|color:%23e37222″ use_theme_fonts=”yes”][vc_column_text]Children who are admitted to the hospital with\u00a0decreased level of consciousness after a traumatic brain injury (TBI)\u00a0require urgent\u00a0medical attention. Treatment\u00a0will depend on\u00a0the type and severity of injury. Unfortunately, history and physical\u00a0findings are often unreliable in the first hours of\u00a0hospitalization, which is the critical time period in which urgent\u00a0management decisions must be made.<\/p>\n

We have developed a promising tool for measuring detectable evidence of TBI on routine brain scans. The tool combines features invisible to the human eye but detectable by\u00a0computer software with expert knowledge.\u00a0We want to evaluate how well our\u00a0tool can perform in a real health care setting. We believe it will\u00a0greatly improve the efficacy and quality of care provided to children after TBI.<\/p>\n

Lab members involved: Anna Colucci, Geraldine Goco, Kyla McDonald, Matthew Van Huyse
\n[\/vc_column_text] <\/p>\n

[vc_row full_width=”stretch_row”][vc_column][vc_custom_heading text=”Cerebral hemorrhage prediction in premature infants” font_container=”tag:h2|text_align:left|color:%23e37222″ use_theme_fonts=”yes”][vc_column_text]This observational study looks to identify patterns in NIRS and non-invasive cerebral signals prior to cerebral hemorrhaging in 27 weeks preterm babies. After parental consent, infants undergo continuous cerebral monitoring using NIRS (cerebrals Sao2) and amplitude integrated EEG for first 72 hours after birth together with serial echocardiograms and head ultrasounds during this period. Understanding early predictive markers of cerebral hemorrhages will help identify infants at risk of developing hemorrhages and those who will benefit from preventative strategies. Preventing cerebral hemorrhages will ultimately improve long term neuro-developmental outcome for these infants.<\/p>\n

Lab members involved: Poorva Deshpande and Julia Dirks
\n[\/vc_column_text]<\/p>\n

[\/vc_column][\/vc_row][vc_row full_width=”stretch_row” css=”.vc_custom_1434538871508{margin-bottom: 0px !important;}”][vc_column][vc_custom_heading text=”RiEEG: Ischemia detection on electroencephalography” font_container=”tag:h2|text_align:left|color:%23e37222″ use_theme_fonts=”yes”][vc_column_text]RiEEG\u2019s goal is to develop a program that can monitor brain health all the time without invasive procedures at the bedside for critically ill children. Brain waves will be recorded from the child\u2019s scalp and evaluated using computer science techniques, like signal processing and machine learning. The final product is ideally an easy-to-use brain monitoring device that can analyze the brain patterns of ill children to detect changes in function in real time. This will ultimately shorten the window of time between injury and treatment.<\/p>\n

Lab member involved: Rishi Lalgudi Ganesan
\n[\/vc_column_text]<\/p>\n

[vc_empty_space height=”50″][\/vc_column][\/vc_row][vc_row][vc_column width=”1\/2″][vc_custom_heading text=”Closed Studies” font_container=”tag:h2|text_align:left|color:%23e37222″ use_theme_fonts=”yes”][vc_tta_accordion active_section=”1″ collapsible_all=”true”]<\/p>\n

[vc_tta_section title=”Edema and injury quantification” tab_id=”1566408804564-d11769e9-c816″][vc_column_text]This study examined past CT scan information and compared it to data representing the patient\u2019s function prior to and following a traumatic brain injury (TBI). It compared this data to the severity of the TBI sustained in order to determine an algorithm for predicting the child\u2019s functioning following injury. The goal of this study was to select\u00a0an analysis tool that can read CT scans and compare patterns, providing the clinicians with the ability to better assess the outcome of patient recovery.<\/p>\n

Lab members\u00a0involved in the study:\u00a0Eva Ta[\/vc_column_text][\/vc_tta_section]<\/p>\n

[vc_tta_section title=”Music Response Study” tab_id=”1566408804597-e67d4c3e-3f8b”][vc_column_text]The goal of this study is to\u00a0understand how critically ill children and neonates respond to music using multimodal physiological and cerebral monitoring.\u00a0The response to music is investigated by measuring autonomic and central nervous system activity. Brain activity is monitored using transcranial Doppler of the middle cerebral artery and near-infrared spectroscopy of the prefrontal cortex. Using these non-invasive brain monitors and additional heart rate and blood pressure monitors the physiological response to music can be investigated. This study will document the physiological and cerebral correlates of music exposure. Existing evidence suggests that music is useful as a non-invasive means of reducing stress in critically ill adults. Bed-side neuro-monitoring may provide a unique means of discerning the effect of music on neonates and children who may be non-verbal. Identifying physiological and cerebral correlates of music will inform future investigations of music as a non-invasive means of improving quality of care in paediatric ICU. This research is sponsored by CREMS<\/p>\n

Lab members\u00a0involved in the study:\u00a0Saba Moghimi,\u00a0Jessica Tomasi,\u00a0Anna Colucci[\/vc_column_text][\/vc_tta_section]<\/p>\n

[vc_tta_section title=”NIRS Usability Study” tab_id=”1566409213288-0457bf8f-da13″][vc_column_text]This study seeks to identify and repair the barriers to entry posed on near infrared spectroscopy (NIRS) equipment at the bedside in the critical care unit (CCU).\u00a0The study aims to find an answer that accommodates the multifaceted requirements of the CCU\u00a0by collaborating with representatives of each discipline in order to identify barriers from their perspectives and to develop effective and feasible solutions. Ideally, this research will ensure that the necessary equipment is always available at the bedside and that data can be recorded reliably and continuously to support clinical decision-making and patient care.<\/p>\n

Lab members\u00a0involved in the study:\u00a0Jessica Tomasi, Emily Taylor,\u00a0Calvin Lau,\u00a0Kevin Yang[\/vc_column_text][\/vc_tta_section]<\/p>\n

[vc_tta_section title=”T3 usability study” tab_id=”1566409253292-43c06358-07b6″][vc_column_text]Tracking, Trajectory, Trigger (T3) is a multi-modal monitoring software developed by Etiometry to record and visualize physiological signals and track patients\u2019 progress in the critical care unit (CCU). The program was recently launched at SickKids\u00a0as a tool for MDs, RNs and RTs. A human factors engineering approach was used to assess the user-friendliness of the software. In simulation trials,\u00a0doctors, nurses, and respiratory therapists were asked to complete tasks using the software\u00a0and provide feedback on their experience. This feedback was cycled back to Etiometry to inform iterative improvements\u00a0to the software.<\/p>\n

Lab members\u00a0involved in the study:\u00a0Ying Ling Lin,\u00a0Jessica Tomasi[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion][\/vc_column]<\/p>\n

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[vc_row full_width=”stretch_row” css=”.vc_custom_1434538871508{margin-bottom: 0px !important;}”][vc_column][vc_custom_heading text=”QBIct Study” font_container=”tag:h2|text_align:left|color:%23e37222″ use_theme_fonts=”yes”][vc_column_text]Children who are admitted to the hospital with\u00a0decreased level of consciousness after a traumatic brain injury (TBI)\u00a0require urgent\u00a0medical attention. Treatment\u00a0will depend on\u00a0the type and severity of injury. Unfortunately, history and physical\u00a0findings are often unreliable in the first hours of\u00a0hospitalization, which is the critical time period in which…<\/p>\n","protected":false},"author":23,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-998","page","type-page","status-publish","hentry","description-off"],"yoast_head":"\nOur Research - Guerguerian Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/guerguerian\/our-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Our Research\" \/>\n<meta property=\"og:description\" content=\"[vc_row full_width=”stretch_row” css=”.vc_custom_1434538871508{margin-bottom: 0px !important;}”][vc_column][vc_custom_heading text=”QBIct Study” font_container=”tag:h2|text_align:left|color:%23e37222″ use_theme_fonts=”yes”][vc_column_text]Children who are admitted to the hospital with\u00a0decreased level of consciousness after a traumatic brain injury (TBI)\u00a0require urgent\u00a0medical attention. Treatment\u00a0will depend on\u00a0the type and severity of injury. 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