{"id":258,"date":"2016-06-03T14:31:27","date_gmt":"2016-06-03T14:31:27","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/guerguerian\/?page_id=258"},"modified":"2019-06-26T20:05:21","modified_gmt":"2019-06-26T20:05:21","slug":"brain-injury-critical-illness","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/guerguerian\/research\/brain-injury-critical-illness\/","title":{"rendered":"Brain injury in critical illness"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]Important decisions regarding patient treatment in the ICU or Emergency Room are often made using only physical indicators and patient history at time of admission. With a wide range of treatment options, this initial assessment plays an important role in determining\u00a0course of action.<\/p>\n<p>Access to previous medical records including vital trends prior to and post injury or medical incident are used by our lab to model and predict the incidence and severity of injury with the goal of\u00a0incorporating these algorithms into real-time diagnosis for better accuracy and treatment.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#64a0c8;box-shadow: 7px 7px 11px px #afafaf inset;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#64a0c8\" ><div id=\"ultimate-heading-64226a154bf6e3807\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-64226a154bf6e3807 uvc-8052  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"center\" style=\"text-align:center\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-64226a154bf6e3807 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;color:#ffffff;\">Quantifying brain injury on computed tomography<\/h2><\/div><\/div>\t\t<\/div><\/div>[vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Children who are admitted to the hospital with\u00a0decreased level of consciousness after a traumatic brain injury (TBI)\u00a0require urgent\u00a0medical attention. Treatment\u00a0will depend on\u00a0the type and severity of injury. Unfortunately, history and physical\u00a0findings are often unreliable in the first hours of\u00a0hospitalization, which is the critical time period in which urgent\u00a0management decisions must be made.<\/p>\n<p>We have developed a promising tool for measuring detectable evidence of TBI on routine brain scans. The tool combines features invisible to the human eye but detectable by\u00a0computer software with expert knowledge.\u00a0We want to evaluate how well our\u00a0tool can perform in a real health care setting. We believe it will\u00a0greatly improve the efficacy and quality of care provided to children after TBI.<\/p>\n<p>Lab members\u00a0involved in the study:<\/p>\n<ul>\n<li><a href=\"https:\/\/lab.research.sickkids.ca\/guerguerian\/team\/former-members\/#annacolucci\">Anna Colucci<\/a><\/li>\n<li><a href=\"https:\/\/lab.research.sickkids.ca\/guerguerian\/team\/current-members\/#!\/geraldine\">Geraldine Goco<\/a><\/li>\n<li><a href=\"https:\/\/lab.research.sickkids.ca\/guerguerian\/team\/current-members\/#!\/helena\">Helena Frndova<\/a><\/li>\n<li><a href=\"https:\/\/lab.research.sickkids.ca\/guerguerian\/team\/former-members\/#matthewvanhuyse\">Matthew Van Huyse<\/a><\/li>\n<li>Kyla McDonald<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243; css=&#8221;.vc_custom_1465826317717{border-radius: 1px !important;}&#8221;][vc_single_image image=&#8221;263&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_btn title=&#8221;QBIct web site&#8221; align=&#8221;center&#8221; i_icon_fontawesome=&#8221;fa fa-cogs&#8221; add_icon=&#8221;true&#8221; link=&#8221;url:http%3A%2F%2Fqbict.ca||target:%20_blank&#8221;][vc_empty_space]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#64a0c8;box-shadow: px px px px #f7f7f7 none;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#64a0c8\" ><div id=\"ultimate-heading-76666a154bf6e3877\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-76666a154bf6e3877 uvc-4060  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"center\" style=\"text-align:center\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-76666a154bf6e3877 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;color:#ffffff;\">Cerebral hemorrhage prediction in premature infants<\/h2><\/div><\/div>\t\t<\/div><\/div>[vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;568&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_column_text]This observational study looks to identify patterns in NIRS and non-invasive cerebral signals prior to cerebral hemorrhaging in 27 weeks preterm babies. After parental consent, infants undergo continuous cerebral monitoring using NIRS (cerebrals Sao2) and amplitude integrated EEG for first 72 hours after birth together with serial echocardiograms and head ultrasounds during this period. Understanding early predictive markers of cerebral hemorrhages will help identify infants at risk of developing hemorrhages and those who will benefit from preventative strategies. Preventing cerebral hemorrhages will ultimately improve long term neuro-developmental outcome for these infants.<\/p>\n<p>Lab members\u00a0involved in the study:<\/p>\n<ul>\n<li style=\"text-align: left\"><a href=\"https:\/\/lab.research.sickkids.ca\/guerguerian\/team\/current-members\/#!\/poorva\" target=\"_blank\" rel=\"noopener noreferrer\">Poorva Deshpande<\/a><\/li>\n<li style=\"text-align: left\"><a href=\"https:\/\/lab.research.sickkids.ca\/guerguerian\/team\/former-members\/#juliadirks\">Julia Dirks<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#64a0c8;box-shadow: 7px 7px 11px px #afafaf inset;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#64a0c8\" ><div id=\"ultimate-heading-79796a154bf6e38c2\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-79796a154bf6e38c2 uvc-8090  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"center\" style=\"text-align:center\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-79796a154bf6e38c2 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;color:#ffffff;\">RiEEG Study: Ischemia detection on electroencephalography \u2013 a retrospective study<\/h2><\/div><\/div>\t\t<\/div><\/div>[vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]RiEEG\u2019s goal is to develop a program that can monitor brain health all the time without invasive procedures at the bedside for critically ill children. Brain waves will be recorded from the child\u2019s scalp and evaluated using computer science techniques, like signal processing and machine learning. The final product is ideally an easy-to-use brain monitoring device that can analyze the brain patterns of ill children to detect changes in function in real time. This will ultimately shorten the window of time between injury and treatment.<\/p>\n<p>Lab members involved in the study:<\/p>\n<ul>\n<li><a href=\"https:\/\/lab.research.sickkids.ca\/guerguerian\/team\/current-members\/#!\/rishi\">Rishi Lalgudi Ganesan<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text]Important decisions regarding patient treatment in the ICU or Emergency Room are often made using only physical indicators and patient history at time of admission. With a wide range of treatment options, this initial assessment plays an important role in determining\u00a0course of action. Access to previous medical records including vital trends prior to and post&hellip;<\/p>\n","protected":false},"author":96,"featured_media":0,"parent":10,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-258","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Brain injury in critical illness - Guerguerian Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/guerguerian\/research\/brain-injury-critical-illness\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brain injury in critical illness\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text]Important decisions regarding patient treatment in the ICU or Emergency Room are often made using only physical indicators and patient history at time of admission. With a wide range of treatment options, this initial assessment plays an important role in determining\u00a0course of action. Access to previous medical records including vital trends prior to and post&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/guerguerian\/research\/brain-injury-critical-illness\/\" \/>\n<meta property=\"og:site_name\" content=\"Guerguerian Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2019-06-26T20:05:21+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/guerguerian\/research\/brain-injury-critical-illness\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/guerguerian\/research\/brain-injury-critical-illness\/\",\"name\":\"Brain injury in critical illness - Guerguerian Lab\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/guerguerian\/#website\"},\"datePublished\":\"2016-06-03T14:31:27+00:00\",\"dateModified\":\"2019-06-26T20:05:21+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/guerguerian\/research\/brain-injury-critical-illness\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lab.research.sickkids.ca\/guerguerian\/research\/brain-injury-critical-illness\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/guerguerian\/research\/brain-injury-critical-illness\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lab.research.sickkids.ca\/guerguerian\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Our Research\",\"item\":\"https:\/\/lab.research.sickkids.ca\/guerguerian\/research\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Brain injury in critical illness\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/guerguerian\/#website\",\"url\":\"https:\/\/lab.research.sickkids.ca\/guerguerian\/\",\"name\":\"Guerguerian Lab\",\"description\":\"Dedicated to predicting brain activity and integrating computers in neural health\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lab.research.sickkids.ca\/guerguerian\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Brain injury in critical illness - Guerguerian Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lab.research.sickkids.ca\/guerguerian\/research\/brain-injury-critical-illness\/","og_locale":"en_US","og_type":"article","og_title":"Brain injury in critical illness","og_description":"[vc_row][vc_column][vc_column_text]Important decisions regarding patient treatment in the ICU or Emergency Room are often made using only physical indicators and patient history at time of admission. 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