{"id":9,"date":"2016-11-01T15:39:26","date_gmt":"2016-11-01T15:39:26","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/grandi\/?page_id=9"},"modified":"2026-04-15T18:40:17","modified_gmt":"2026-04-15T18:40:17","slug":"research","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/grandi\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container hundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:0px;--awb-padding-right:0px;--awb-padding-bottom:0px;--awb-padding-left:0px;--awb-margin-top:0px;--awb-margin-bottom:0px;--awb-background-color:rgba(255,255,255,0);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-justify-content-center fusion-flex-content-wrap\" style=\"width:calc( 100% + 0px ) !important;max-width:calc( 100% + 0px ) !important;margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><header class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-padding-top:100px;--awb-padding-right:50px;--awb-padding-left:50px;--awb-bg-color:var(--awb-color1);--awb-bg-color-hover:var(--awb-color1);--awb-bg-image:linear-gradient(180deg, var(--awb-color1) 0%,rgba(255,255,255,0) 100%);--awb-bg-size:cover;--awb-box-shadow: 0px 0px ;;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:0px;--awb-margin-bottom-large:0px;--awb-spacing-left-large:0px;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:0px;--awb-spacing-left-medium:0px;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:0px;--awb-spacing-left-small:0px;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-space-between fusion-content-layout-column\"><div class=\"fusion-tabs fusion-tabs-1 classic vertical-tabs icon-position-left mobile-mode-accordion\" style=\"--awb-title-border-radius-top-left:0px;--awb-title-border-radius-top-right:0px;--awb-title-border-radius-bottom-right:0px;--awb-title-border-radius-bottom-left:0px;--awb-title-font-size:18px;--awb-title-text-transform:var(--awb-typography1-text-transform);--awb-alignment:start;--awb-inactive-color:var(--awb-custom_color_1);--awb-title-text-color:var(--awb-color6);--awb-title-active-text-color:var(--awb-color6);--awb-background-color:var(--awb-color1);--awb-border-color:var(--awb-color1);--awb-active-border-color:var(--awb-color4);--awb-title-font-family:&quot;Lato&quot;;--awb-title-font-style:normal;--awb-title-font-weight:400;\"><div class=\"nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li class=\"active\" role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-18d6221ba26571ef6a7\" aria-selected=\"true\" id=\"fusion-tab-maternalandchildhealth\" href=\"#tab-18d6221ba26571ef6a7\"><div class=\"fusion-tab-heading\">MATERNAL AND CHILD HEALTH<\/div><\/a><\/li><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-2a004a03e18526521a3\" aria-selected=\"false\" tabindex=\"-1\" id=\"fusion-tab-asaandsmm\" href=\"#tab-2a004a03e18526521a3\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-baby-carriage fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:var(--awb-color7);--icon-active-color:var(--awb-color4);\"><\/i>ASA and SMM<\/div><\/a><\/li><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-6d0c4977680746392e0\" aria-selected=\"false\" tabindex=\"-1\" id=\"fusion-tab-hypothyroidisminpregnancy\" href=\"#tab-6d0c4977680746392e0\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-baby fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:var(--awb-color7);--icon-active-color:var(--awb-color4);\"><\/i>Hypothyroidism in pregnancy <\/div><\/a><\/li><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-70bd390b8b7a925fba7\" aria-selected=\"false\" tabindex=\"-1\" id=\"fusion-tab-cvdprediction\" href=\"#tab-70bd390b8b7a925fba7\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-bezier-curve fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:#002058;--icon-active-color:var(--awb-color4);\"><\/i>CVD prediction <\/div><\/a><\/li><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-bbc31dd1018f5616f5b\" aria-selected=\"false\" tabindex=\"-1\" id=\"fusion-tab-csmmandcvd\" href=\"#tab-bbc31dd1018f5616f5b\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-ambulance fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:#002058;\"><\/i>CSMM and CVD <\/div><\/a><\/li><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-52b699bcbc11b6567b4\" aria-selected=\"false\" tabindex=\"-1\" id=\"fusion-tab-bionicproject\" href=\"#tab-52b699bcbc11b6567b4\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-female fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:#002058;\"><\/i>BIONIC Project <\/div><\/a><\/li><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-03e68973b577d563d53\" aria-selected=\"false\" tabindex=\"-1\" id=\"fusion-tab-camcco-outreach\" href=\"#tab-03e68973b577d563d53\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-hand-holding-medical fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:var(--awb-color7);\"><\/i>CAMCCO-Outreach <\/div><\/a><\/li><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-4b563070ca921b16909\" aria-selected=\"false\" tabindex=\"-1\" id=\"fusion-tab-diabetesinpregnancy\" href=\"#tab-4b563070ca921b16909\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-capsules fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:var(--awb-color7);\"><\/i>Diabetes in pregnancy<\/div><\/a><\/li><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-341d7222569fcf34aac\" aria-selected=\"false\" tabindex=\"-1\" id=\"fusion-tab-methodologicalwork\" href=\"#tab-341d7222569fcf34aac\"><div class=\"fusion-tab-heading\">METHODOLOGICAL WORK<\/div><\/a><\/li><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-27d7a539c7c1036dce4\" aria-selected=\"false\" tabindex=\"-1\" id=\"fusion-tab-targettrialemulation\" href=\"#tab-27d7a539c7c1036dce4\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-balance-scale fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:#002058;\"><\/i>Target trial emulation<\/div><\/a><\/li><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-dd79cba04fd726d3d09\" aria-selected=\"false\" tabindex=\"-1\" id=\"fusion-tab-covid-19dataconsiderations\" href=\"#tab-dd79cba04fd726d3d09\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-virus fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:#002058;\"><\/i>COVID-19 data considerations<\/div><\/a><\/li><\/ul><\/div><div class=\"tab-content\"><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li class=\"active\" role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-18d6221ba26571ef6a7\" aria-selected=\"true\" id=\"mobile-fusion-tab-maternalandchildhealth\" href=\"#tab-18d6221ba26571ef6a7\"><div class=\"fusion-tab-heading\">MATERNAL AND CHILD HEALTH<\/div><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade fusion-clearfix in active\" role=\"tabpanel\" tabindex=\"0\" aria-labelledby=\"fusion-tab-maternalandchildhealth\" id=\"tab-18d6221ba26571ef6a7\">\n<h2 data-ccp-props=\"{\"><i><\/i>\u200bMaternal and Child Health Research<\/h2>\n<p data-ccp-props=\"{\"><img decoding=\"async\" class=\"lazyload alignleft wp-image-2184\" src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-1024x683.jpeg\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-1024x683.jpeg\" alt=\"\" width=\"680\" height=\"453\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27680%27%20height%3D%27453%27%20viewBox%3D%270%200%20680%20453%27%3E%3Crect%20width%3D%27680%27%20height%3D%27453%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-200x133.jpeg 200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-300x200.jpeg 300w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-400x267.jpeg 400w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-600x400.jpeg 600w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-768x512.jpeg 768w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-800x533.jpeg 800w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-1024x683.jpeg 1024w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-1200x800.jpeg 1200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-1536x1024.jpeg 1536w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 680px) 100vw, 680px\" \/><\/p>\n<\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-2a004a03e18526521a3\" aria-selected=\"false\" tabindex=\"-1\" id=\"mobile-fusion-tab-asaandsmm\" href=\"#tab-2a004a03e18526521a3\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-baby-carriage fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:var(--awb-color7);--icon-active-color:var(--awb-color4);\"><\/i>ASA and SMM<\/div><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade fusion-clearfix\" role=\"tabpanel\" tabindex=\"0\" aria-labelledby=\"fusion-tab-asaandsmm\" id=\"tab-2a004a03e18526521a3\">\n<h2>Aspirin and severe maternal <span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">morbidities<\/span><\/h2>\n<p><a href=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill.jpg\"><img decoding=\"async\" class=\"lazyload size-medium wp-image-2608 alignleft\" src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill-300x168.jpg\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill-300x168.jpg\" alt=\"a pregnant woman taking an Aspirin\" width=\"300\" height=\"168\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27168%27%20viewBox%3D%270%200%20300%20168%27%3E%3Crect%20width%3D%27300%27%20height%3D%27168%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill-200x112.jpg 200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill-300x168.jpg 300w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill-400x224.jpg 400w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill-600x336.jpg 600w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill-768x430.jpg 768w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill-800x448.jpg 800w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill-1024x573.jpg 1024w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill-1200x672.jpg 1200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill-1536x860.jpg 1536w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/pregnant-woman-taking-a-pill.jpg 1600w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">In Canada, the number of life-threatening health conditions during pregnancy, delivery and <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">immediately after a delivery, has increased over time, affecting 14 per 1,000 deliveries. The most common severe maternal morbidities <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">(SMM) are preeclampsia, cardiac conditions and severe blood loss. <\/span><\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Aspirin <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">(ASA) has been shown to reduce the <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">chance of developing preeclampsia when given before 20 weeks of pregnancy. However, the benefit of aspirin <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">for SMM and other pregnancy complications is not clear.\u00a0<\/span>\u200b<\/p>\n<p data-ccp-props=\"{\">\u200b<span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">This population-based cohort study of Canadian women examines:<\/span>\u200b<\/p>\n<ul style=\"font-weight: 400\">\n<li data-charcodes=\"65533,0,41\" data-buautonum=\"7\" data-margin=\"360\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">The risk of SMM and adverse pregnancy outcomes between users of low-<\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">dose ASA and non-users of ASA;<\/span>\u200b<\/li>\n<li data-charcodes=\"65533,0,41\" data-buautonum=\"7\" data-margin=\"360\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">The effects of ASA use and social inequities on SMM and adverse pregnancy outcomes; and\u00a0<\/span>\u200b<\/li>\n<li data-charcodes=\"65533,0,41\" data-buautonum=\"7\" data-margin=\"360\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">The combined effect of ASA use and SARS-CoV-2 infection on SMM and adverse pregnancy outcomes.<\/span>\u200b<\/li>\n<\/ul>\n<p data-ccp-props=\"{\"><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Dr. Grandi is the Nominated Principal Investigator on this CIHR-funded project. <\/span><\/i><\/p>\n<p data-ccp-props=\"{\"><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Co-Principal Investigator: Dr. <\/span><\/i><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Joel Ray.<\/span><\/i>\u200b<\/p>\n<\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-6d0c4977680746392e0\" aria-selected=\"false\" tabindex=\"-1\" id=\"mobile-fusion-tab-hypothyroidisminpregnancy\" href=\"#tab-6d0c4977680746392e0\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-baby fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:var(--awb-color7);--icon-active-color:var(--awb-color4);\"><\/i>Hypothyroidism in pregnancy <\/div><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade fusion-clearfix\" role=\"tabpanel\" tabindex=\"0\" aria-labelledby=\"fusion-tab-hypothyroidisminpregnancy\" id=\"tab-6d0c4977680746392e0\">\n<h2>Hypothyroidism in pregnancy<\/h2>\n<p><a href=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman.jpg\"><img decoding=\"async\" class=\"lazyload alignleft wp-image-2607 size-medium\" src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman-300x168.jpg\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman-300x168.jpg\" alt=\"a doctor showing thyroid scan pictures to a pregnant woman\" width=\"300\" height=\"168\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27168%27%20viewBox%3D%270%200%20300%20168%27%3E%3Crect%20width%3D%27300%27%20height%3D%27168%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman-200x112.jpg 200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman-300x168.jpg 300w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman-400x224.jpg 400w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman-600x336.jpg 600w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman-768x430.jpg 768w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman-800x448.jpg 800w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman-1024x573.jpg 1024w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman-1200x672.jpg 1200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman-1536x860.jpg 1536w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/09\/a-doctor-showing-thyroid-scan-pictures-to-a-pregnant-woman.jpg 1600w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Hypothyroidism is one of the most common endocrine disorders during pregnancy. It is characterized by an <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">underactive thyroid and diagnosed based on high levels of thyroid stimulating hormone (TSH) with symptoms such <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">as weight gain, fatigue and dry skin. <\/span><\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Subclinical hypothyroidism (SCH) occurs in 2.0\u20132.5% of pregnancies and is <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">characterized by elevated TSH levels in the first trimester and normal thyroxine levels with no or mild symptoms of <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">hypothyroidism.\u00a0<\/span>\u200b<\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">The overall aim of this study is to determine if the use of levothyroxine (Synthroid\u00ae) during pregnancy is <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">associated with the risk of<\/span><\/p>\n<ul>\n<li data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">adverse pregnancy outcomes in women with SCH,<\/span><\/li>\n<li data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">neurodevelopmental (e.g., autism, ADHD) and cardiometabolic outcomes in children born to <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">women with SCH. <\/span>\u200b<\/li>\n<\/ul>\n<p data-ccp-props=\"{\"><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">This project is funded by the American Thyroid Association (Dr. Grandi is the Principal Investigator) and the CIHR (Dr. Grandi is a co-Investigator, with the Principle Investigator Dr. Kristian <\/span><\/i><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Filion).<\/span><\/i>\u200b<\/p>\n<\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-70bd390b8b7a925fba7\" aria-selected=\"false\" tabindex=\"-1\" id=\"mobile-fusion-tab-cvdprediction\" href=\"#tab-70bd390b8b7a925fba7\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-bezier-curve fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:#002058;--icon-active-color:var(--awb-color4);\"><\/i>CVD prediction <\/div><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade fusion-clearfix\" role=\"tabpanel\" tabindex=\"0\" aria-labelledby=\"fusion-tab-cvdprediction\" id=\"tab-70bd390b8b7a925fba7\">\n<h2><span class=\"TextRun SCXP262511830 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\"><span class=\"NormalTextRun SCXP262511830 BCX0\">Optimizing risk prediction in women with a history of pregnancy complications<\/span><\/span><\/h2>\n<p><img decoding=\"async\" class=\"lazyload alignnone size-full wp-image-2189\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271%27%20height%3D%271%27%20viewBox%3D%270%200%201%201%27%3E%3Crect%20width%3D%271%27%20height%3D%271%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM.gif\" alt=\"\" width=\"1\" height=\"1\" \/><img decoding=\"async\" class=\"lazyload wp-image-2190 alignleft\" src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-scaled.jpeg\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-scaled.jpeg\" alt=\"\" width=\"234\" height=\"156\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27234%27%20height%3D%27156%27%20viewBox%3D%270%200%20234%20156%27%3E%3Crect%20width%3D%27234%27%20height%3D%27156%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-200x133.jpeg 200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-300x200.jpeg 300w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-400x267.jpeg 400w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-600x400.jpeg 600w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-768x512.jpeg 768w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-800x534.jpeg 800w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-1024x683.jpeg 1024w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-1200x801.jpeg 1200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-1536x1025.jpeg 1536w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-SMM-scaled.jpeg 2560w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 234px) 100vw, 234px\" \/><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Over the last decade, the incidence of serious maternal complications during pregnancy has\u00a0<\/span>\u200b<span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">steadily increased. These complications, including hypertensive disorders in pregnancy, <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">gestational diabetes, preterm birth, stillbirth and placental abruption, are associated with an <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">increased risk of poor maternal and fetal outcomes in pregnancy. These complications also <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">contribute to adverse consequences for a woman\u2019s longer-term health. <\/span>\u200b<\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">This study aims to<\/span> <span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">develop and validate risk prediction models to identify recently post-partum <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">women at increased risk of developing: <\/span><\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">(1) cardiovascular disease (CVD) and cardiovascular risk <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">factors immediately after an affected pregnancy, using UK data; <\/span><\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">(2) hypertension within 5 years following an affected pregnancy, using BC data.<\/span>\u200b<\/p>\n<p data-ccp-props=\"{\"><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Dr. Grandi is a Co-Investigator and co-lead of this CIHR-funded project with Principal <\/span><\/i><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Investigator: Dr. Kristian Filion.<\/span><\/i>\u200b<\/p>\n<\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-bbc31dd1018f5616f5b\" aria-selected=\"false\" tabindex=\"-1\" id=\"mobile-fusion-tab-csmmandcvd\" href=\"#tab-bbc31dd1018f5616f5b\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-ambulance fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:#002058;\"><\/i>CSMM and CVD <\/div><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade fusion-clearfix\" role=\"tabpanel\" tabindex=\"0\" aria-labelledby=\"fusion-tab-csmmandcvd\" id=\"tab-bbc31dd1018f5616f5b\">\n<h2><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Cardiovascular severe maternal morbidities and subsequent cardiovascular diseases<\/span><\/h2>\n<p data-ccp-props=\"{\"><img decoding=\"async\" class=\"lazyload wp-image-1659 alignleft\" src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/08\/CVD_resized.jpg\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/08\/CVD_resized.jpg\" alt=\"A doctor measuring a pregnant person's blood pressure\" width=\"244\" height=\"162\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27244%27%20height%3D%27162%27%20viewBox%3D%270%200%20244%20162%27%3E%3Crect%20width%3D%27244%27%20height%3D%27162%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/08\/CVD_resized-200x133.jpg 200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/08\/CVD_resized-300x200.jpg 300w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/08\/CVD_resized-400x266.jpg 400w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/08\/CVD_resized.jpg 599w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 244px) 100vw, 244px\" \/><\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Despite improvements in maternal mortality, rates of severe maternal morbidity (SMM) have been <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">steadily rising. A subset of these indicators, defined as cardiovascular severe maternal morbidities (CSMM), <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">characterize cardiovascular complications during pregnancy. These indicators contribute to <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">increased risk of maternal morbidity and mortality following an affected pregnancy. <\/span><\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Pre-eclampsia <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">has been shown to increase the risk of long-term cardiovascular disease in women with an <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">affected pregnancy. However, the contribution of CSMM to long-term cardiovascular risk in <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">women with pre-eclampsia is unclear. Understanding how CSMM contributes to the long-term risk <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">of cardiovascular disease can improve our ability to tailor prevention strategies for at-risk women.\u00a0<\/span>\u200b<\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">The overall objective of this study is to examine the risk of cardiovascular disease, both overall <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">and by subtypes, associated with CSMM among women with pre-eclampsia. <\/span>\u200b<\/p>\n<p data-ccp-props=\"{\"><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Dr. Grandi and Dr. Malham\u00e9 are Principal Investigators on this project.<\/span><\/i><\/p>\n<p data-ccp-props=\"{\"><a href=\"https:\/\/www.healthypregnancyhub.ca\/resource\/acetaminophen-during-pregnancy-2\/\"><strong>Acetaminophen during pregnancy: What science tells us<\/strong><\/a><\/p>\n<p data-ccp-props=\"{\"><div class=\"fusion-video fusion-youtube\" style=\"--awb-max-width:600px;--awb-max-height:360px;\"><div class=\"video-shortcode\"><lite-youtube videoid=\"jonc4Oi6ViQ\" class=\"landscape\" params=\"wmode=transparent&autoplay=1&amp;mute=1&amp;enablejsapi=1\" title=\"YouTube video player 1\" data-button-label=\"Play Video\" width=\"600\" height=\"360\" data-thumbnail-size=\"auto\" data-no-cookie=\"on\"><\/lite-youtube><\/div><\/div>\u200b<\/p>\n<\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-52b699bcbc11b6567b4\" aria-selected=\"false\" tabindex=\"-1\" id=\"mobile-fusion-tab-bionicproject\" href=\"#tab-52b699bcbc11b6567b4\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-female fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:#002058;\"><\/i>BIONIC Project <\/div><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade fusion-clearfix\" role=\"tabpanel\" tabindex=\"0\" aria-labelledby=\"fusion-tab-bionicproject\" id=\"tab-52b699bcbc11b6567b4\">\n<h2><span class=\"TextRun SCXP85670295 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\"><span class=\"NormalTextRun SCXP85670295 BCX0\">The safety of biologic use in pregnancy<\/span><\/span><\/h2>\n<p data-ccp-props=\"{\"><img decoding=\"async\" class=\"lazyload alignleft wp-image-2299 size-medium\" src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/premium_photo-1702598458872-f482ce1ce74e-300x200.avif\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/premium_photo-1702598458872-f482ce1ce74e-300x200.avif\" alt=\"a doctor examining a pregnant woman\" width=\"300\" height=\"200\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27200%27%20viewBox%3D%270%200%20300%20200%27%3E%3Crect%20width%3D%27300%27%20height%3D%27200%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/premium_photo-1702598458872-f482ce1ce74e-200x134.avif 200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/premium_photo-1702598458872-f482ce1ce74e-300x200.avif 300w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/premium_photo-1702598458872-f482ce1ce74e-400x267.avif 400w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/premium_photo-1702598458872-f482ce1ce74e.avif 500w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">Immune-mediated diseases, specifically autoimmune disorders (AID) and asthma, are highly prevalent in <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">women of reproductive age and uncontrolled disease activity during pregnancy has been shown to negatively <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">influence pregnancy, and maternal and child outcomes. Over the last decade, the use of biologic medications <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">to treat AID and severe asthma has steadily risen due to its beneficial adverse effect profile. As pregnant <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">women are typically excluded from RCTs, the safety and effectiveness of biologics in this group remains <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">unknown. More importantly, there is a paucity of short- and long-term data on potential adverse outcomes in <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">children exposed in utero to these medications.&nbsp;<\/span>\u200b<\/p>\n<h3 data-ccp-props=\"{\">Overarching goal and specific objectives<\/h3>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">The main goal of this project is to conduct a <\/span>BIOlogic drug safety and effectiveness interNational pharmacoepidemiologIC study in pregnant women with AID and <span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">asthma and their children (BIONIC). Specifically, in women who continue versus discontinue biologic use in <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">pregnancy for AID and asthma, separately, we will compare the risks of: <\/span><\/p>\n<ul>\n<li data-ccp-props=\"{\"><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">Adverse outcomes in infants <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">(preterm birth, small-for-gestational age, major congenital malformations) and children (severe infections <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">from 0 to 5 years old, type 1 diabetes, juvenile AID, asthma, atopic dermatitis)<\/span><\/li>\n<li data-ccp-props=\"{\"><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">Adverse outcomes in mothers in <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">pregnancy (hypertensive disorders of pregnancy, spontaneous and induced abortions, stillbirths, serious <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">infections) and \u22641-year postpartum (serious infections)<\/span><\/li>\n<li data-ccp-props=\"{\"><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">Maternal effectiveness outcomes (asthma <\/span><span data-scheme-color=\"@000000,0,\" data-usefontface=\"true\" data-contrast=\"none\">and AID exacerbations in pregnancy)<\/span>\u200b<\/li>\n<\/ul>\n<p data-ccp-props=\"{\"><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Dr. Grandi and Dr. Longo are Principal Investigators on this project, funded by the CIHR and the <span class=\"NormalTextRun SCXW239213356 BCX8\">Canadian Foundation for Women\u2019s <\/span><span class=\"NormalTextRun SCXW239213356 BCX8\">Research<\/span><span class=\"NormalTextRun SCXW239213356 BCX8\"> .<\/span><\/span><\/i><\/p>\n<p data-ccp-props=\"{\">\u200bFor more information about the BIONIC study, please contact us at <a href=\"mailto:bionic.study@sickkids.ca\">bionic.study@sickkids.ca<\/a><\/p>\n<\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-03e68973b577d563d53\" aria-selected=\"false\" tabindex=\"-1\" id=\"mobile-fusion-tab-camcco-outreach\" href=\"#tab-03e68973b577d563d53\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-hand-holding-medical fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:var(--awb-color7);\"><\/i>CAMCCO-Outreach <\/div><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade fusion-clearfix\" role=\"tabpanel\" tabindex=\"0\" aria-labelledby=\"fusion-tab-camcco-outreach\" id=\"tab-03e68973b577d563d53\">\n<h2><span class=\"TextRun SCXP50509071 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\"><span class=\"NormalTextRun SCXP50509071 BCX0\">Safe prescribing and use of medications<\/span><\/span><\/h2>\n<p><img decoding=\"async\" class=\"lazyload wp-image-1130 alignleft\" src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/05\/Screenshot-2024-05-24-at-8.59.26\u202fPM-1.png\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/05\/Screenshot-2024-05-24-at-8.59.26\u202fPM-1.png\" alt=\"\" width=\"253\" height=\"149\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27253%27%20height%3D%27149%27%20viewBox%3D%270%200%20253%20149%27%3E%3Crect%20width%3D%27253%27%20height%3D%27149%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/05\/Screenshot-2024-05-24-at-8.59.26\u202fPM-1-200x118.png 200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/05\/Screenshot-2024-05-24-at-8.59.26\u202fPM-1-300x176.png 300w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/05\/Screenshot-2024-05-24-at-8.59.26\u202fPM-1-400x235.png 400w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/05\/Screenshot-2024-05-24-at-8.59.26\u202fPM-1-600x353.png 600w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/05\/Screenshot-2024-05-24-at-8.59.26\u202fPM-1-768x451.png 768w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/05\/Screenshot-2024-05-24-at-8.59.26\u202fPM-1-800x470.png 800w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/05\/Screenshot-2024-05-24-at-8.59.26\u202fPM-1.png 960w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 253px) 100vw, 253px\" \/><\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">The Canadian Mother-Child Cohort Outreach (CAMCCO-Outreach) mission is to advocate for the safe prescribing and use of medications <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">during pregnancy using real-world evidence, lived-experiences and community and partner <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">insights to inform the co-creation of knowledge.&nbsp;<\/span>\u200b<\/p>\n<p data-ccp-props=\"{\"><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">This initiative leverages the CAMCCO infrastructure, including the CAMCCO-Learning platform, <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">and collaborations with <\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">FirstExposure<\/span><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\"> to support knowledge dissemination to target populations.&nbsp;<\/span>\u200b<\/p>\n<p data-ccp-props=\"{\"><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Dr. Grandi is a co-Investigator on the CIHR Women\u2019s Hub grant and Member of the CAMCCO- <\/span><\/i><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Outreach Scientific Advisory Committee.&nbsp;<\/span><\/i>\u200b<\/p>\n<p><a href=\"https:\/\/www.healthypregnancyhub.ca\/resource\/acetaminophen-during-pregnancy-2\/\"><strong>Acetaminophen during pregnancy: What science tells us<\/strong><\/a><\/p>\n<div class=\"video-shortcode\"><iframe title=\"Acetaminophen During Pregnancy: What Science Tells Us\" width=\"1170\" height=\"658\" src=\"https:\/\/www.youtube.com\/embed\/jonc4Oi6ViQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-4b563070ca921b16909\" aria-selected=\"false\" tabindex=\"-1\" id=\"mobile-fusion-tab-diabetesinpregnancy\" href=\"#tab-4b563070ca921b16909\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-capsules fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:var(--awb-color7);\"><\/i>Diabetes in pregnancy<\/div><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade fusion-clearfix\" role=\"tabpanel\" tabindex=\"0\" aria-labelledby=\"fusion-tab-diabetesinpregnancy\" id=\"tab-4b563070ca921b16909\">\n<h2><span class=\"TextRun SCXP50509071 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\"><span class=\"NormalTextRun SCXP50509071 BCX0\">The safety of anti-diabetic medication use in pregnancy<\/span><\/span><\/h2>\n<p><a href=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/diabetes-pregnancy.png\"><img decoding=\"async\" class=\"lazyload alignleft wp-image-2390 size-medium\" src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/diabetes-pregnancy-300x207.png\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/diabetes-pregnancy-300x207.png\" alt=\"A pregnant woman is testing her blood glucose level using a fingerstick monitor\" width=\"300\" height=\"207\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27207%27%20viewBox%3D%270%200%20300%20207%27%3E%3Crect%20width%3D%27300%27%20height%3D%27207%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/diabetes-pregnancy-200x138.png 200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/diabetes-pregnancy-300x207.png 300w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/diabetes-pregnancy-400x276.png 400w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/diabetes-pregnancy-600x415.png 600w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/diabetes-pregnancy-768x531.png 768w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/diabetes-pregnancy-800x553.png 800w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/diabetes-pregnancy-1024x707.png 1024w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/diabetes-pregnancy.png 1061w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p data-ccp-props=\"{\">Type-2 diabetes is common among women of reproductive age. If uncontrolled, diabetes can lead to serious pregnancy complications, such as high blood pressure during pregnancy and early birth. A new class of medications for type-2 diabetes, called <em>glucagon-like peptide-1 receptor agonists (GLP-1 RA)<\/em>, has become a popular option for managing blood sugar and reducing risks like cardiovascular disease and obesity. However, we don&#8217;t yet know if GLP-1 RA is safe or effective when used before or during early pregnancy, since pregnant women are usually excluded from drug trials.<\/p>\n<p data-ccp-props=\"{\">This study will use population-based health data from Ontario and the UK to explore how often GLP-1 RA is used by women before and during early pregnancy, and whether it affects the risk of pregnancy or birth complications.<\/p>\n<p data-ccp-props=\"{\"><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Dr. Grandi is the Nominated Principal Investigator on this project. <\/span><\/i><\/p>\n<p data-ccp-props=\"{\">\u200b<i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Co-Principal Investigator: Dr. Robert Platt, Dr. <\/span><\/i><i><span data-scheme-color=\"@595959,0,18:65000,19:35000\" data-usefontface=\"true\" data-contrast=\"none\">Joel Ray.<\/span><\/i><\/p>\n<\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-341d7222569fcf34aac\" aria-selected=\"false\" tabindex=\"-1\" id=\"mobile-fusion-tab-methodologicalwork\" href=\"#tab-341d7222569fcf34aac\"><div class=\"fusion-tab-heading\">METHODOLOGICAL WORK<\/div><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade fusion-clearfix\" role=\"tabpanel\" tabindex=\"0\" aria-labelledby=\"fusion-tab-methodologicalwork\" id=\"tab-341d7222569fcf34aac\">\n<h2 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\">Methodological Research Work<\/h2>\n<p><img decoding=\"async\" class=\"lazyload alignnone size-full wp-image-2252\" src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-scaled.jpg\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-scaled.jpg\" alt=\"\" width=\"2560\" height=\"815\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272560%27%20height%3D%27815%27%20viewBox%3D%270%200%202560%20815%27%3E%3Crect%20width%3D%272560%27%20height%3D%27815%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-200x64.jpg 200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-300x95.jpg 300w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-400x127.jpg 400w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-600x191.jpg 600w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-768x244.jpg 768w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-800x255.jpg 800w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-1024x326.jpg 1024w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-1200x382.jpg 1200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-1536x489.jpg 1536w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/methods_image4_resized-scaled.jpg 2560w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><\/p>\n<p>&nbsp;<\/p>\n<\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-27d7a539c7c1036dce4\" aria-selected=\"false\" tabindex=\"-1\" id=\"mobile-fusion-tab-targettrialemulation\" href=\"#tab-27d7a539c7c1036dce4\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-balance-scale fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:#002058;\"><\/i>Target trial emulation<\/div><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade fusion-clearfix\" role=\"tabpanel\" tabindex=\"0\" aria-labelledby=\"fusion-tab-targettrialemulation\" id=\"tab-27d7a539c7c1036dce4\">\n<h2 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\">Target trial emulation in perinatal pharmacoepidemiology<\/h2>\n<p><img decoding=\"async\" class=\"lazyload alignleft wp-image-1456\" src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/baby-hands-blackwhite-FREE_pixabay-300x200.jpg\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/baby-hands-blackwhite-FREE_pixabay-300x200.jpg\" alt=\"A close-up of a baby's hand\" width=\"300\" height=\"200\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27200%27%20viewBox%3D%270%200%20300%20200%27%3E%3Crect%20width%3D%27300%27%20height%3D%27200%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/baby-hands-blackwhite-FREE_pixabay-200x133.jpg 200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/baby-hands-blackwhite-FREE_pixabay-300x200.jpg 300w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/baby-hands-blackwhite-FREE_pixabay-400x267.jpg 400w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/baby-hands-blackwhite-FREE_pixabay-600x400.jpg 600w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/baby-hands-blackwhite-FREE_pixabay-768x512.jpg 768w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/baby-hands-blackwhite-FREE_pixabay-800x533.jpg 800w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/baby-hands-blackwhite-FREE_pixabay-1024x682.jpg 1024w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/baby-hands-blackwhite-FREE_pixabay-1200x800.jpg 1200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/baby-hands-blackwhite-FREE_pixabay.jpg 1280w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>Understanding medication safety in pregnancy is important to address potential harms and to provide pregnant individuals and their providers with evidence to support decision making. Target trial emulation (TTE) has been proposed as a method to estimate effects of medications in a real-world setting. This approach is useful in the context of medication use in pregnancy given inherent challenges (e.g., detection of pregnancies, interdependence of events, etiologically relevant windows for exposure).<\/p>\n<p>We have created a working group of international leaders across academia, public sector, and industry to address aligning causal estimands with clinical and policy relevant questions regarding medication use in pregnancy using a target trial framework. The group will discuss important considerations when defining the components of the target trial touching on aspects of the complexities of this area, including etiologically relevant time windows, point versus sustained treatments, and competing events. \u200b<\/p>\n<p><i>\u200bThis effort is being co-led by Dr. Mollie Wood, Dr. Sonia Grandi, and Dr. Robert Platt.\u200b<\/i><\/p>\n<p><span class=\"TextRun Highlight SCXW146891357 BCX8\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW146891357 BCX8\">This work is funded by the International Society for Pharmacoepidemiology.<\/span><\/span><\/div><div class=\"nav fusion-mobile-tab-nav\"><ul class=\"nav-tabs\" role=\"tablist\"><li role=\"presentation\"><a class=\"tab-link\" data-toggle=\"tab\" role=\"tab\" aria-controls=\"tab-dd79cba04fd726d3d09\" aria-selected=\"false\" tabindex=\"-1\" id=\"mobile-fusion-tab-covid-19dataconsiderations\" href=\"#tab-dd79cba04fd726d3d09\"><div class=\"fusion-tab-heading\"><i class=\"fontawesome-icon fa-virus fas\" aria-hidden=\"true\" style=\"font-size:22px; --icon-color:#002058;\"><\/i>COVID-19 data considerations<\/div><\/a><\/li><\/ul><\/div><div class=\"tab-pane fade fusion-clearfix\" role=\"tabpanel\" tabindex=\"0\" aria-labelledby=\"fusion-tab-covid-19dataconsiderations\" id=\"tab-dd79cba04fd726d3d09\">\n<h2 class=\"fusion-responsive-typography-calculated\" data-fontsize=\"40\" data-lineheight=\"52px\">COVID-19 data considerations<\/h2>\n<p><img decoding=\"async\" class=\"lazyload size-full wp-image-1174 alignleft\" src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/Screenshot-2024-06-08-at-10.22.09\u202fAM.png\" data-orig-src=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/Screenshot-2024-06-08-at-10.22.09\u202fAM.png\" alt=\"Covid 19\" width=\"364\" height=\"192\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27364%27%20height%3D%27192%27%20viewBox%3D%270%200%20364%20192%27%3E%3Crect%20width%3D%27364%27%20height%3D%27192%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/Screenshot-2024-06-08-at-10.22.09\u202fAM-200x105.png 200w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/Screenshot-2024-06-08-at-10.22.09\u202fAM-300x158.png 300w, https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2024\/06\/Screenshot-2024-06-08-at-10.22.09\u202fAM.png 364w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 364px) 100vw, 364px\" \/><\/p>\n<p>The COVID-19 pandemic has had lasting impacts on the health and behavior of society. These acute and potentially chronic changes raises concerns regarding the potential heterogeneity of health outcomes and characteristics of populations prior to, during, and after the pandemic. This initiative will attempt to provide guidance on major challenges and considerations for use of data collected during the COVID-19 pandemic and offer potential methodological approaches to address data collected during this period. The working group will collate expert opinion from a variety of researchers and clinicians to inform a guidance document and future directions.\u200b<\/p>\n<p>\u200b<i>This effort is being led by Dr. Grandi in conjunction with a working group of scientists at The Hospital for Sick Children. \u200b<\/i><\/div><\/div><\/div><\/div><\/header><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":394,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Research - Sonia Grandi Lab | SickKids<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/grandi\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/grandi\/research\/\" \/>\n<meta property=\"og:site_name\" content=\"Sonia Grandi Lab | SickKids\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-15T18:40:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lab.research.sickkids.ca\/grandi\/wp-content\/uploads\/sites\/150\/2025\/06\/ResearchPage-MaternalChildHealth-1024x683.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"683\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"10 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/grandi\/research\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/grandi\/research\/\",\"name\":\"Research - 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