{"id":8,"date":"2018-08-14T15:48:11","date_gmt":"2018-08-14T15:48:11","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/enrich\/?page_id=8"},"modified":"2026-02-06T20:16:12","modified_gmt":"2026-02-06T20:16:12","slug":"about-us","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/enrich\/about-us\/","title":{"rendered":"About Us"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-background-position:left top;--awb-border-sizes-top:0px;--awb-border-sizes-bottom:0px;--awb-border-sizes-left:0px;--awb-border-sizes-right:0px;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:0px;--awb-padding-bottom:50px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last fusion-column-no-min-height\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1\"><h1 class=\"entry-title\" style=\"text-align: center\">EnRICH Team: Enhancing Research Impact in Child Health<\/h1>\n<\/div><div class=\"fusion-image-element fusion-image-align-center in-legacy-container\" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><div class=\"imageframe-align-center\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\" style=\"border:3px solid #f6f6f6;\"><img decoding=\"async\" width=\"1024\" height=\"676\" alt=\"EnRICH lab team summer 2021\" title=\"EnRICH Lab 2025_resized\" src=\"https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2025\/07\/EnRICH-Lab-2025_resized-1024x676.jpg\" class=\"img-responsive wp-image-1753\" srcset=\"https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2025\/07\/EnRICH-Lab-2025_resized-200x132.jpg 200w, https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2025\/07\/EnRICH-Lab-2025_resized-400x264.jpg 400w, https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2025\/07\/EnRICH-Lab-2025_resized-600x396.jpg 600w, https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2025\/07\/EnRICH-Lab-2025_resized-800x528.jpg 800w, https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2025\/07\/EnRICH-Lab-2025_resized-1200x792.jpg 1200w\" sizes=\"(max-width: 800px) 100vw, 1200px\" \/><\/span><\/div><\/div><div class=\"fusion-text fusion-text-2\"><p><span style=\"color: #000000\">The EnRICH Lab in 2025, from left to right: Veronica Lai, Ami Baba, Martin Offringa, Atushi Patel, Andrea Chiaramida<\/span><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last fusion-column-no-min-height\" style=\"--awb-bg-blend:overlay;--awb-bg-size:cover;--awb-margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-3\"><p><span style=\"color: #000000\">SickKids\u2019 Principal Investigator <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/www.sickkids.ca\/en\/staff\/o\/martin-offringa\/\" target=\"_blank\" rel=\"noopener\"><strong>Dr. Martin Offringa<\/strong><\/a><strong>\u2019s<\/strong><\/span> program of research is captured under the <strong>Enhancing Research Impact in Child Health (EnRICH)<\/strong> program.<\/span><\/p>\n<p><span style=\"color: #000000\">In 2026, health research is questioned by the public. Does it really advance health and improve health outcomes? Are the efforts not <a style=\"color: #000000\" href=\"http:\/\/www.thelancet.com\/series\/research\"><strong>wasted by design, conduct and reporting?<\/strong><\/a><\/span><\/p>\n<p><span style=\"color: #000000\">In response to these questions, new initiatives in partnership with patients, researchers, policymakers and other key stakeholders are underway. They all aim to strengthen the research enterprise and improve the quality and usefulness of scientific studies in biomedicine and beyond.<\/span><\/p>\n<p><span style=\"color: #000000\"><strong>Clinical research in children<\/strong> poses particular methodological, ethical and practical challenges. In the last 10 years, the paucity of safety and efficacy data informing the rational use of medicines has been recognized. New regulations have been implemented in the USA and in Europe which mandate proper clinical evaluations in children before any new drug can be labelled and licensed for adults.<\/span><\/p>\n<p><span style=\"color: #000000\">To inform decisions, whether at the bedside or policy level, researchers need to ensure their studies generate information that is <strong>reliable and relevant to decision makers.<\/strong> Current challenges include<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\">adequate study sample sizes and contained risk of bias<\/span><\/li>\n<li><span style=\"color: #000000\">qualified, responsive, and child and family relevant outcomes<\/span><\/li>\n<li><span style=\"color: #000000\">short term and long-term participants\u2019 safety with clear roles of data monitoring committees and harmonized ethics review of research protocols<\/span><\/li>\n<li><span style=\"color: #000000\">appropriate engagement of children and families from study design to reporting to implementation of results<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000\">And so, while more research is needed, we need to embrace <strong>new conceptual and methodological advances in the design, conduct and reporting of child health research<\/strong>.<\/span><\/p>\n<p><span style=\"color: #000000\">The work of the EnRICH Research Group and Network aims to enhance child health through the discovery and implementation of innovative methods that transform the way we design, conduct, and report child health clinical research. In addition, the EnRICH program offers training opportunities in this field.<\/span><\/p>\n<p><span style=\"color: #000000\">In 2026, the EnRICH research agenda focuses on three (3) critical areas for paediatric research: develop and apply the methodology needed for (1) the selection, measurement, and reporting of <b>valid, discriminative, and feasible outcomes<\/b> in <i>Precision Child Health<\/i> research (<a style=\"color: #000000\" title=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Flab.research.sickkids.ca%2Fenrich%2Fresearch-projects%2Ftorch-2020%2F&amp;data=05%7C02%7Cami.baba%40sickkids.ca%7C4c5d0ae88a2e4ae1f1f508dcc06857fd%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638596801578192387%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&amp;sdata=Cyi5fvSwzP5pAua9JNuPy9cywYDkF03k1IeBwq48PHE%3D&amp;reserved=0\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Flab.research.sickkids.ca%2Fenrich%2Fresearch-projects%2Ftorch-2020%2F&amp;data=05%7C02%7Cami.baba%40sickkids.ca%7C4c5d0ae88a2e4ae1f1f508dcc06857fd%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638596801578192387%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&amp;sdata=Cyi5fvSwzP5pAua9JNuPy9cywYDkF03k1IeBwq48PHE%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #64a0c8\">see TORCH<\/span><\/a>); (2) innovative design and conduct of clinical efficacy studies and comparative effectiveness trials in Paediatric Diseases, e.g.<\/span><a title=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Flab.research.sickkids.ca%2Fenrich%2Fresearch-projects%2Finform-rare%2F&amp;data=05%7C02%7Cami.baba%40sickkids.ca%7C4c5d0ae88a2e4ae1f1f508dcc06857fd%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638596801578202816%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&amp;sdata=kkpUzr38qEgMZ5jcG2MyHZ8nvpAPnUCfjUdIkvlqCpM%3D&amp;reserved=0\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Flab.research.sickkids.ca%2Fenrich%2Fresearch-projects%2Finform-rare%2F&amp;data=05%7C02%7Cami.baba%40sickkids.ca%7C4c5d0ae88a2e4ae1f1f508dcc06857fd%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638596801578202816%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&amp;sdata=kkpUzr38qEgMZ5jcG2MyHZ8nvpAPnUCfjUdIkvlqCpM%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener\"> <span style=\"color: #64a0c8\">Registry Based Trials in Rare Diseases<\/span><\/a>, <a title=\"Original URL: https:\/\/lab.research.sickkids.ca\/enrich\/research-projects\/spor-innovative-pediatric-clinical-trials-project-ipct\/ Click to follow link.\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Flab.research.sickkids.ca%2Fenrich%2Fresearch-projects%2Fspor-innovative-pediatric-clinical-trials-project-ipct%2F&amp;data=05%7C02%7Cami.baba%40sickkids.ca%7C4c5d0ae88a2e4ae1f1f508dcc06857fd%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638596801578210224%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&amp;sdata=ABjBzmhwlzOo4BYDDwwXqVW11Ch4opt6LIfyrx8HjWM%3D&amp;reserved=0\"><span style=\"color: #64a0c8\">RCTs of common Emergency Department conditions<\/span><\/a>, <span style=\"color: #000000\">and (3) sufficient child health research reporting:<\/span> <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" title=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Flab.research.sickkids.ca%2Fenrich%2Freporting-standards%2F&amp;data=05%7C02%7Cami.baba%40sickkids.ca%7C4c5d0ae88a2e4ae1f1f508dcc06857fd%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638596801578216459%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&amp;sdata=W1i4H6fPnvTcdhAG6k9YWXzyoMmvL3NL3MuFe%2B9IuI8%3D&amp;reserved=0\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Flab.research.sickkids.ca%2Fenrich%2Freporting-standards%2F&amp;data=05%7C02%7Cami.baba%40sickkids.ca%7C4c5d0ae88a2e4ae1f1f508dcc06857fd%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638596801578216459%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&amp;sdata=W1i4H6fPnvTcdhAG6k9YWXzyoMmvL3NL3MuFe%2B9IuI8%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener\"><b>two new research reporting standards<\/b><\/a><\/span>.<\/p>\n<p><span style=\"color: #000000\">For an overview of current projects, <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/lab.research.sickkids.ca\/enrich\/research-projects\"><strong>click here<\/strong><\/a><\/span>.<\/span><\/p>\n<p><span style=\"color: #000000\">Updated February 2026<\/span><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":241,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-8","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>About Us - EnRICH Team<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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