{"id":239,"date":"2019-01-30T14:50:11","date_gmt":"2019-01-30T14:50:11","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/enrich\/?page_id=239"},"modified":"2026-02-06T20:03:19","modified_gmt":"2026-02-06T20:03:19","slug":"torch-2020","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/enrich\/research-projects\/torch-2020\/","title":{"rendered":"TORCH"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"--awb-bg-size:cover;--awb-margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-image-element fusion-image-align-center in-legacy-container\" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><div class=\"imageframe-align-center\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"2002\" height=\"891\" alt=\"TORCH logo\" title=\"TORCH2021 (002)\" src=\"https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2021\/06\/TORCH2021-002.png\" class=\"img-responsive wp-image-1060\" srcset=\"https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2021\/06\/TORCH2021-002-200x89.png 200w, https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2021\/06\/TORCH2021-002-400x178.png 400w, https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2021\/06\/TORCH2021-002-600x267.png 600w, https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2021\/06\/TORCH2021-002-800x356.png 800w, https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2021\/06\/TORCH2021-002-1200x534.png 1200w, https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2021\/06\/TORCH2021-002.png 2002w\" sizes=\"(max-width: 800px) 100vw, 1200px\" \/><\/span><\/div><\/div><div class=\"fusion-text fusion-text-1\"><p style=\"text-align: center\"><span style=\"color: #3366ff\">Follow us <a style=\"color: #3366ff\" href=\"https:\/\/twitter.com\/Torch_research\" target=\"_blank\" rel=\"noopener noreferrer\">@TORCH_research<\/a><\/span>\u00a0 \u00a0<img decoding=\"async\" class=\"alignnone wp-image-685\" src=\"https:\/\/lab.research.sickkids.ca\/enrich\/wp-content\/uploads\/sites\/76\/2020\/05\/Twitter_Social_Icon_Square_Color-200x200.png\" alt=\"Twitter logo\" width=\"25\" height=\"25\" \/><\/p>\n<p><span style=\"color: #000000\">Toronto Outcomes Research in Child Health (TORCH) is an inter-disciplinary paediatric collaborative led by scientists and divisional representatives at\u00a0<a style=\"color: #000000\" href=\"http:\/\/www.sickkids.ca\/Research\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">The Hospital for Sick Children<\/a>. TORCH facilitates the use of rigorous outcomes in child health research and in bedside care by focusing on the methodology behind the selection, measurement, analysis, benchmarking, and reporting of child health outcomes.<\/span><\/p>\n<p><span style=\"color: #000000\">Updated February 2026<\/span><\/p>\n<\/div><div class=\"accordian fusion-accordian\" style=\"--awb-border-size:1px;--awb-icon-size:13px;--awb-content-font-size:17px;--awb-icon-alignment:left;--awb-hover-color:#f9f9f9;--awb-border-color:#cccccc;--awb-background-color:#ffffff;--awb-divider-color:#e0dede;--awb-divider-hover-color:#e0dede;--awb-icon-color:#ffffff;--awb-title-color:#333333;--awb-content-color:#747474;--awb-icon-box-color:#0046ad;--awb-toggle-hover-accent-color:#a0ce4e;--awb-title-font-family:Arial, Helvetica, sans-serif;--awb-title-font-weight:400;--awb-title-font-style:normal;--awb-title-font-size:17px;--awb-content-font-family:Arial, Helvetica, sans-serif;--awb-content-font-style:normal;--awb-content-font-weight:400;\"><div class=\"panel-group fusion-toggle-icon-boxed\" id=\"accordion-239-1\"><div class=\"fusion-panel panel-default panel-8472b8e50e62ecf9e fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#333333;--awb-content-color:#747474;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_8472b8e50e62ecf9e\"><a aria-expanded=\"false\" aria-controls=\"8472b8e50e62ecf9e\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-239-1\" data-target=\"#8472b8e50e62ecf9e\" href=\"#8472b8e50e62ecf9e\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">About Us<\/span><\/a><\/h4><\/div><div id=\"8472b8e50e62ecf9e\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_8472b8e50e62ecf9e\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><span style=\"color: #000000\">TORCH was founded in 2015 by Dr. Martin Offringa, Senior Scientist in the Child Health Evaluative Sciences (CHES) program. It serves as a local\u00a0<em>paediatric outcomes platform<\/em>\u00a0that advances outcome selection and reporting in paediatric health research and health system evaluation through the networking and collaboration with other established outcome groups and stakeholders in Canada and across the world.<\/span><\/p>\n<ul>\n<li><strong><span style=\"color: #000000\">Director (2015-Present):<\/span> <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/lab.research.sickkids.ca\/enrich\/about-us\/our-team\/\" target=\"_blank\" rel=\"noopener noreferrer\">Martin Offringa, MD, PhD<\/a><\/span><\/strong><\/li>\n<li><span style=\"color: #000000\"><strong>Research Lead (2017-Present)<\/strong>:<\/span> <span style=\"color: #64a0c8\"><strong><a style=\"color: #64a0c8\" href=\"https:\/\/lab.research.sickkids.ca\/enrich\/about-us\/our-team\/\" target=\"_blank\" rel=\"noopener noreferrer\">Nancy Butcher, PhD<\/a><\/strong><\/span><\/li>\n<li><strong><span style=\"color: #000000\">Project Manager (2021-Present):<\/span><span style=\"color: #64a0c8\"> <a style=\"color: #64a0c8\" href=\"https:\/\/lab.research.sickkids.ca\/enrich\/about-us\/our-team\/\" target=\"_blank\" rel=\"noopener noreferrer\">Ami Baba, MRes<\/a><\/span><\/strong><\/li>\n<\/ul>\n<p><span style=\"color: #000000\">Ongoing collaborations with organizations and initiatives include:<\/span><\/p>\n<ul>\n<li><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"http:\/\/www.comet-initiative.org\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #64a0c8\">COMET Initiative<\/span><\/strong><\/a> <\/span><span style=\"color: #000000\">(The Core Outcome Measures in Effectiveness Trials Initiative)<\/span><\/li>\n<li><span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/www.cosmin.nl\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>COSMIN <\/strong><\/a><\/span><span style=\"color: #000000\">(COnsensus-based Standards for the selection of health Measurement Instruments)<\/span><\/li>\n<li><a href=\"https:\/\/www.camh.ca\/en\/science-and-research\/institutes-and-centres\/cundill-centre-for-child-and-youth-depression\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #3366ff\"><span style=\"color: #64a0c8\">Cundill Centre for Child and Youth Depression<\/span><\/span><\/strong><\/a>, <span style=\"color: #000000\">Centre for Addiction and Mental Health (<a style=\"color: #000000\" href=\"https:\/\/www.camh.ca\/\">CAMH<\/a>)<\/span><\/li>\n<li><span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.equator-network.org\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #64a0c8\">EQUATOR Network<\/span><\/strong><\/a><\/span> <span style=\"color: #000000\">(Enhancing the QUAlity and Transparency Of health Research)<\/span><\/li>\n<li><a href=\"https:\/\/www.ichom.org\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #3366ff\"><span style=\"color: #64a0c8\">ICHOM<\/span><\/span><\/strong><\/a> <span style=\"color: #000000\">(The International Consortium for Health Outcomes Measurement)<\/span><\/li>\n<li><a href=\"http:\/\/neoepoch.com\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><span style=\"color: #3366ff\"><span style=\"color: #64a0c8\">neoEPOCH<\/span><\/span><\/strong><\/a> <span style=\"color: #000000\">(Neonatal Electronic health record data for Point Of Care Health)<\/span><\/li>\n<li><span style=\"color: #3366ff\"><strong><a style=\"color: #3366ff\" href=\"https:\/\/www.healthmeasures.net\/index.php?option=com_content&amp;view=category&amp;layout=blog&amp;id=147&amp;Itemid=806\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #64a0c8\">PROMIS<\/span><\/a><\/strong><\/span> <span style=\"color: #333333\">(Patient-Reported Outcomes Measurement Information System)<\/span><\/li>\n<li><strong><a href=\"https:\/\/neonatal.cochrane.org\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #64a0c8\">Cochrane Neonatal<\/span><\/a><\/strong><\/li>\n<li><strong><span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/www.informrare.ca\" target=\"_blank\" rel=\"noopener\">INFORM-RARE<\/a><\/span><\/strong><\/li>\n<\/ul>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-02e677cbc31f29558 fusion-toggle-no-divider fusion-toggle-boxed-mode\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_02e677cbc31f29558\"><a aria-expanded=\"false\" aria-controls=\"02e677cbc31f29558\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-239-1\" data-target=\"#02e677cbc31f29558\" href=\"#02e677cbc31f29558\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">Our Vision and Mission<\/span><\/a><\/h4><\/div><div id=\"02e677cbc31f29558\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_02e677cbc31f29558\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><span style=\"color: #0046ad\"><strong>Vision<\/strong><\/span><\/p>\n<p><span style=\"color: #000000\">To enhance child health by ensuring children are given safe and effective treatments based on evidence that addresses\u00a0<strong>relevant and accurate child health research and health system performance <em>outcomes<\/em>.<\/strong><\/span><\/p>\n<p><span style=\"color: #0046ad\"><strong>Mission<\/strong><\/span><\/p>\n<p><span style=\"color: #000000\">To create and seize opportunities to improve paediatric research and health system performance\u00a0<em>outcomes<\/em> by:<\/span><\/p>\n<ol>\n<li style=\"list-style-type: none\">\n<ol>\n<li><span style=\"color: #000000\"><strong>Raising awareness<\/strong> on the importance of meaningful outcome selection, measurement, and reporting in children;<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Providing methodology<\/strong> to select, measure, and report truthful, discriminative, and feasible outcomes in child health research; and<\/span><\/li>\n<li><span style=\"color: #000000\"><strong>Supporting engagement<\/strong> with research ethics boards, funders, journal editors, regulators, and health system administrators to critically appraise outcome selection, measurement, and reporting.\u00a0<\/span><\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-80f5b69578334160f fusion-toggle-no-divider fusion-toggle-boxed-mode\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_80f5b69578334160f\"><a aria-expanded=\"false\" aria-controls=\"80f5b69578334160f\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-239-1\" data-target=\"#80f5b69578334160f\" href=\"#80f5b69578334160f\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">Scope of Activities<\/span><\/a><\/h4><\/div><div id=\"80f5b69578334160f\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_80f5b69578334160f\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><strong><span style=\"color: #0046ad\">1. Raise awareness:<\/span><\/strong><\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><span style=\"color: #000000\">of the importance of selecting and measuring <em>Core Outcome Sets<\/em> in child health;<\/span><\/li>\n<li><span style=\"color: #000000\">of the importance of completely and transparently describing outcomes in clinical trials protocols and publications.\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong><span style=\"color: #0046ad\">2. Provide methodology:<\/span><\/strong><\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><span style=\"color: #000000\">develop <em>Core Outcome Sets<\/em> for a range of pediatric diseases (&#8220;what&#8221; and &#8220;how&#8221; to measure outcomes);\u00a0<\/span><\/li>\n<li><span style=\"color: #000000\">improve clinical trial <em>outcome reporting<\/em> through the generation and implementation of CONSORT and SPIRIT-Outcomes Extensions (see below).\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong><span style=\"color: #0046ad\">3. Support engagement:<\/span><\/strong><\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><span style=\"color: #000000\">translate new insights to research and health system evaluation practice in collaboration with <em>child health research stakeholders<\/em> including research ethics boards, funders, regulators, journal editors, governments, and health system administrators;<\/span><\/li>\n<li><span style=\"color: #000000\">promote uptake and use of <em>Core Outcome Set<\/em> selection and measurement methods in paediatric clinical trials and healthy system evaluation;<\/span><\/li>\n<li><span style=\"color: #000000\">network with existing outcome and research organizations and initiatives.\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-e5834edcd897b2f93 fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#333333;--awb-content-color:#747474;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_e5834edcd897b2f93\"><a aria-expanded=\"false\" aria-controls=\"e5834edcd897b2f93\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-239-1\" data-target=\"#e5834edcd897b2f93\" href=\"#e5834edcd897b2f93\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">Current Projects<\/span><\/a><\/h4><\/div><div id=\"e5834edcd897b2f93\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_e5834edcd897b2f93\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<h2><span style=\"color: #0046ad\"><strong>Core Outcome Sets<\/strong><\/span><\/h2>\n<p><span style=\"color: #000000\"><em>Core Outcome Sets<\/em> represent the minimum outcomes that should be measured and reported in all clinical trials of a specific health condition and are also suitable for use in clinical audit or research other than randomised trials. The development and implementation of a Core Outcome Set makes it easier for trial results to be compared, contrasted and combined, ultimately improving patient and health system outcomes and reducing research waste.<\/span><\/p>\n<p><span style=\"color: #000000\"><strong><em>Sets in development<\/em><\/strong><strong><em>:<\/em><\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\"><strong>Adolescent depression &#8211; <\/strong><\/span><strong><a href=\"https:\/\/www.in-roads.org\/\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #64a0c8\"><span style=\"color: #64a0c8\">IN-ROADS (The International Network for Research Outcomes in Adolescent Depression Studies)<\/span><\/span><\/a><\/strong>\n<ul>\n<li><span style=\"color: #000000\">Study protocol:<span style=\"color: #64a0c8\"> <a style=\"color: #64a0c8\" href=\"https:\/\/www.jaacap.org\/article\/S0890-8567(20)31348-4\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">Monga et al 2020\u00a0<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Literature review protocol: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/doi.org\/10.1136\/bmjopen-2018-024191\" target=\"_blank\" rel=\"noopener noreferrer\">Monsour et al 2019<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Literature review: <\/span><span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/www.jclinepi.com\/article\/S0895-4356(20)30202-X\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">Mew et al 2020<\/a><\/span><\/li>\n<li><span style=\"color: #000000\">Instrument appraisal studies:<\/span><span style=\"color: #64a0c8\"> <a style=\"color: #64a0c8\" href=\"https:\/\/jaacap.org\/article\/S0890-8567(20)32050-5\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">Stallwood et al 2020<\/a><\/span><\/li>\n<\/ul>\n<\/li>\n<li><span style=\"color: #000000\"><strong>Paediatric anxiety &#8211; <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/www.compactinitiative.com\" target=\"_blank\" rel=\"noopener\">Core Outcomes and Measures for Pediatric Anxiety Clinical Trials (COMPACT)<\/a><\/span><\/strong><\/span>\n<ul>\n<li><span style=\"color: #000000\">Study preregistration:<\/span> <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0890856723000643?via%3Dihub\">Monga et al 2023<\/a><\/span><\/li>\n<li><span style=\"color: #000000\">Scoping review protocol:<\/span>\u00a0<a href=\"https:\/\/bmjopen.bmj.com\/content\/12\/10\/e063404\"><span style=\"color: #64a0c8\">Patton et al 2022<\/span><\/a><\/li>\n<\/ul>\n<\/li>\n<li><span style=\"color: #000000\"><strong>Paediatric inguinal hernia repair<\/strong><\/span>\n<ul>\n<li><span style=\"color: #000000\">Literature review protocol: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/bmjopen.bmj.com\/content\/13\/12\/e077452\">Maat et al 2023<\/a><\/span><\/span><\/li>\n<\/ul>\n<\/li>\n<li><span style=\"color: #000000\"><strong>Neonatal necrotising enterocolitis<\/strong><\/span>\n<ul>\n<li><span style=\"color: #000000\">Literature review protocol: <a href=\"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-023-07413-x\"><span style=\"color: #64a0c8\">Klerk et al 2023<\/span><\/a><\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><span style=\"color: #000000\"><strong><em>Recently developed sets:<\/em><\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\"><strong>Mucopolysaccharidoses (MPS)<\/strong><\/span>\n<ul>\n<li><span style=\"color: #64a0c8\"><span style=\"color: #000000\">Study protocol:<\/span> <a style=\"color: #64a0c8\" href=\"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-021-05791-8\">Howie et al 2021<\/a><\/span><\/li>\n<li><a href=\"https:\/\/www.informrare.ca\/inform-mps\"><span style=\"color: #64a0c8\">Core outcome set<\/span><\/a><\/li>\n<\/ul>\n<\/li>\n<li><span style=\"color: #000000\"><strong>Paediatric appendicitis<\/strong><\/span>\n<ul>\n<li><span style=\"color: #000000\">Study protocol: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/bmjopen.bmj.com\/content\/9\/5\/e028861\" target=\"_blank\" rel=\"noopener noreferrer\">Knaapen et al 2019<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Literature review: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/doi.org\/10.1186\/s13063-015-0783-1\" target=\"_blank\" rel=\"noopener noreferrer\">Hall et al 2015<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Core outcome set: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/journals.lww.com\/annalsofsurgery\/Abstract\/9000\/International_Core_Outcome_Set_for_Acute_Simple.93804.aspx\" target=\"_blank\" rel=\"noopener noreferrer\">Knaapen et al 2020<\/a><\/span><\/span><\/li>\n<\/ul>\n<\/li>\n<li><span style=\"color: #000000\"><strong>\u00a0<\/strong><strong>Rare metabolic diseases (MCAD and PKU)<\/strong><\/span>\n<ul>\n<li><span style=\"color: #000000\">Study protocol: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/doi.org\/10.1186\/s13063-017-2327-3\" target=\"_blank\" rel=\"noopener noreferrer\">Potter et al 2017<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Literature review:<span style=\"color: #64a0c8\"> <a style=\"color: #64a0c8\" href=\"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-019-1276-1\" target=\"_blank\" rel=\"noopener noreferrer\">Pugliese et al 2020<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Core outcome set: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/pediatrics.aappublications.org\/content\/148\/2\/e2020037747\" target=\"_blank\" rel=\"noopener\">Pugliese et al 2021<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Patient and family engagement:<\/span> <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/researchinvolvement.biomedcentral.com\/articles\/10.1186\/s40900-021-00304-y\" target=\"_blank\" rel=\"noopener\">Vanderhout et al 2021<\/a><\/span><\/li>\n<\/ul>\n<\/li>\n<li><span style=\"color: #000000\"><strong>Children with feeding tubes and neurological impairment<\/strong><\/span>\n<ul>\n<li><span style=\"color: #000000\">Literature review:<span style=\"color: #64a0c8\"> <a style=\"color: #64a0c8\" href=\"https:\/\/doi.org\/10.1542\/peds.2015-3967\" target=\"_blank\" rel=\"noopener noreferrer\">Kapadia et al 2016<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Core outcome set: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/dmcn.14326\" target=\"_blank\" rel=\"noopener noreferrer\">Joachim et al 2020<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">COS Video: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/www.youtube.com\/watch?v=GJLCLEaRTw8\" target=\"_blank\" rel=\"noopener noreferrer\">YouTube<\/a><\/span><\/span><\/li>\n<\/ul>\n<\/li>\n<li><span style=\"color: #000000\"><strong>Neonatal opioid abstinence syndrome <\/strong><\/span>\n<ul>\n<li><span style=\"color: #000000\">Study protocol: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/doi.org\/10.1186\/s13063-016-1666-9\" target=\"_blank\" rel=\"noopener noreferrer\">Kelly et al 2016<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Literature review: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/link.springer.com\/article\/10.1186\/s13063-020-4183-9\" target=\"_blank\" rel=\"noopener noreferrer\">Shan et al 2020<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Core outcome set: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/doi.org\/10.1542\/peds.2020-0018\" target=\"_blank\" rel=\"noopener noreferrer\">Kelly et al 2020<\/a><\/span><\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li><span style=\"color: #64a0c8\"><strong><a style=\"color: #64a0c8\" href=\"https:\/\/www.ichom.org\/portfolio\/overall-pediatric-health\/\" target=\"_blank\" rel=\"noopener noreferrer\">ICHOM Overall Paediatric Standard Set<\/a><\/strong><\/span>\n<ul>\n<li><a href=\"https:\/\/doi.org\/10.1136\/archdischild-2020-320345\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #64a0c8\">Algure\u0301n et al 2020<\/span><\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><em><span style=\"color: #000000\"><strong>Reviews of Core Outcome Sets:<\/strong><\/span><\/em><\/p>\n<ul>\n<li><span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"http:\/\/www.comet-initiative.org\/Studies\/Details\/1659\" target=\"_blank\" rel=\"noopener noreferrer\">Development standards of pediatric core outcome sets: A methodological review<\/a><\/span><\/li>\n<li><span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/can01.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fabs%2Fpii%2FS0895435622003274%3Fvia%253Dihub&amp;data=05%7C02%7Cachiara%40sickkids.ca%7Cdc98376c99a24b8b8abf08dc10648551%7C3961553ff47e49eb9f6ccf8518914e9a%7C0%7C0%7C638403271155772518%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=X9hsOjZyiAfqaCV23V3yjqNBKKCBAzrt0NxwWgKPCyc%3D&amp;reserved=0\" target=\"_blank\" rel=\"noopener\">Pediatric core outcome sets had deficiencies and lacked child and family input: A methodological review<\/a><\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000\"><strong><em>Commentaries and Letters to the Editor on the Importance of Core Outcome Sets: <\/em><\/strong><\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\">Needed: guidance for reporting knowledge synthesis studies on measurement properties of outcome measurement instruments in health research.<\/span>\u00a0(<a href=\"https:\/\/bmjopen.bmj.com\/content\/8\/7\/e022829.responses\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #64a0c8\">Butcher et al 2020<\/span><\/a>)<\/li>\n<li><span style=\"color: #000000\">Counting what counts in trials 2.0: Response to \u201cTrials for depressive disorder in adolescents: the emperor\u2019s new clothes\u201d<\/span> (<span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/doi.org\/10.1016\/j.jclinepi.2020.08.010\" target=\"_blank\" rel=\"noopener noreferrer\">Butcher et al 2020<\/a><\/span>)<\/li>\n<li><span style=\"color: #000000\">From research to practice: the importance of outcome selection, measurement, and reporting in pediatric mental health research (<span style=\"color: #3366ff\"><a style=\"color: #3366ff\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0890856719319252?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #64a0c8\">Monga et al 2020<\/span><\/a><\/span>)<\/span><\/li>\n<li><span style=\"color: #000000\">Counting what counts: the case for harmonized outcomes in child and youth mental health research (<span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0890856719301844?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">Szatmari et al 2019<\/a><\/span>)<\/span><\/li>\n<\/ul>\n<h2><span style=\"color: #0046ad\"><strong>InsPECT: SPIRIT-Outcomes &amp; CONSORT-Outcomes<\/strong><\/span><\/h2>\n<p><span style=\"color: #000000\">Inadequate outcome reporting in clinical trials is a well-documented problem that impedes the ability of researchers to evaluate, replicate, and build upon study findings, which in turn impacts evidence-based clinical and policy decision making.<\/span><\/p>\n<p><span style=\"color: #000000\">To facilitate harmonized reporting of outcomes in published trial protocols and reports, TORCH is leading the development of new outcome-specific reporting extensions to the <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/www.spirit-statement.org\/\" target=\"_blank\" rel=\"noopener noreferrer\">SPIRIT<span style=\"color: #64a0c8\"> (Sta<\/span>ndard Protocol Items: Recommendations for Interventional Trials) <\/a><\/span>and <a style=\"color: #000000\" href=\"http:\/\/www.consort-statement.org\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #3366ff\"><span style=\"color: #64a0c8\">CONSORT (Consolidated Standards of Reporting Trials)<\/span><\/span><\/a> reporting guidelines, known as the <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/lab.research.sickkids.ca\/enrich\/reporting-standards\/spirit-outcomes\/\" target=\"_blank\" rel=\"noopener noreferrer\">SPIRIT-Outcomes<\/a> <\/span>and <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/lab.research.sickkids.ca\/enrich\/reporting-standards\/consort-outcomes\/\" target=\"_blank\" rel=\"noopener noreferrer\">CONSORT-Outcomes<\/a> <\/span>reporting guidelines, respectively.<\/span><\/p>\n<p><span style=\"color: #000000\">The SPIRIT and CONSORT-Outcomes reporting extensions will provide the first evidence-informed and consensus-based standards focused on outcome reporting in clinical trials that can be applied across diverse disease areas, populations, and outcome types. They have the potential to benefit trialists, systematic reviewers, journal editors, medical writers, and patient groups.<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\">Study protocol: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/doi.org\/10.1186\/s13063-019-3248-0\" target=\"_blank\" rel=\"noopener noreferrer\">Butcher et al 2019<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Literature review protocol:<\/span> <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/doi.org\/10.1136\/bmjopen-2018-023001\" target=\"_blank\" rel=\"noopener noreferrer\">Butcher et al 2019<\/a><\/span><\/li>\n<li><span style=\"color: #000000\">Literature review:<\/span> <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-020-04440-w\" target=\"_blank\" rel=\"noopener noreferrer\">Butcher et al 2020<\/a>\u00a0<\/span><\/li>\n<li><span style=\"color: #000000\">SPIRIT-Outcomes 2022: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2799547\">Butcher et al 2022<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">CONSORT-Outcomes 2022: <a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2799401\"><span style=\"color: #64a0c8\">Butcher et al 2022<\/span><\/a><\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000\">As part of the InsPECT project, we are also assessing the <strong>current standard of outcome reporting in published clinical trials and cohort studies<\/strong>:<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000\">Adolescent depression trials: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/bmcmedresmethodol.biomedcentral.com\/articles\/10.1186\/s12874-020-01019-6\" target=\"_blank\" rel=\"noopener noreferrer\">Monsour et al 2020<\/a>\u00a0<\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Cohort studies of neurodevelopmental outcomes in children born extremely preterm: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/doi.org\/10.1136\/archdischild-2019-318144\" target=\"_blank\" rel=\"noopener noreferrer\">Ding et al 2020<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Neonatal trials: <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/publications.aap.org\/pediatrics\/article\/152\/3\/e2022060751\/193775\/Heterogeneity-and-Gaps-in-Reporting-Primary\">Baba et al 2023<\/a><\/span> and <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/publications.aap.org\/pediatrics\/article\/152\/3\/e2022060765\/193774\/Strengthening-Reporting-of-Neonatal-Trials\">Webbe et al 2023<\/a><\/span><\/span><\/li>\n<li><span style=\"color: #000000\">Registry-based randomized controlled trials:<\/span> <span style=\"color: #64a0c8\"><a style=\"color: #64a0c8\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S089543562300104X\">Baba et al 2023<\/a><\/span><\/li>\n<\/ul>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-1f21d0efae8840de5 fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#333333;--awb-content-color:#747474;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_1f21d0efae8840de5\"><a aria-expanded=\"false\" aria-controls=\"1f21d0efae8840de5\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-239-1\" data-target=\"#1f21d0efae8840de5\" href=\"#1f21d0efae8840de5\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">Contact<\/span><\/a><\/h4><\/div><div id=\"1f21d0efae8840de5\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_1f21d0efae8840de5\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><span style=\"color: #000000\">Please email<\/span><span style=\"color: #64a0c8\">\u00a0<a style=\"color: #64a0c8\" href=\"mailto:enrich.network@sickkids.ca\">enrich.network@sickkids.ca<\/a>\u00a0<\/span><span style=\"color: #000000\">if you are interested in learning more or becoming involved with any of these initiatives.<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":241,"featured_media":0,"parent":59,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-239","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - 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