{"id":616,"date":"2015-01-23T13:57:58","date_gmt":"2015-01-23T13:57:58","guid":{"rendered":"http:\/\/lab-dev.research.sickkids.ca\/sevan-hopyan-lab\/?page_id=616"},"modified":"2015-01-23T13:57:58","modified_gmt":"2015-01-23T13:57:58","slug":"dr-akitsu-hotta","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/ellis\/people\/dr-akitsu-hotta\/","title":{"rendered":"Dr. Akitsu Hotta"},"content":{"rendered":"
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Dr. Akitsu Hotta \u2013\u00a0Postdoctoral Fellow, 2006-2010<\/span><\/h4>\n

Akitsu Hotta received his PhD in Nagoya, Japan. His studies of retrovirus vector derived transgenic chickens were funded by the Japan Scholarship Foundation. Since moving to Toronto, he has raised the bar of our speed cloning records. Hotta’s research is largely focused on new vector designs for stem cell specific expression, but he is also active in the globin and Rett syndrome gene therapy projects.<\/p>\n

He is famous in the lab for learning the hard way how to securely lock a bike in Toronto.<\/p>\n

 <\/p>\n

Next Position
\n<\/strong>Assistant Professor,\u00a0Center for iPS Cell Research and Application (CiRA)<\/a>,\u00a0Kyoto University, Japan.<\/p>\n

 <\/p>\n

Selected Publications<\/strong>
\nCheung AY, Horvath LM, Grafodatskaya D, Pasceri P, Weksberg R,\u00a0Hotta A<\/strong>, Carrel L, Ellis J. (2011)\u00a0Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation<\/a>. Human Molecular Genetics. 20(11):2103-15.<\/p>\n

Fussner E, Djuric U, Strauss M,\u00a0Hotta A<\/strong>, Perez-Iratxeta C, Lanner F, Dilworth FJ, Ellis J, Bazett-Jones DP. (2011)\u00a0Constitutive heterochromatin reorganization during somatic cell reprogramming<\/a>. EMBO Journals. 30(9):1778-89.<\/p>\n

Hotta A<\/strong>, Cheung AY, Farra N, Garcha K, Chang WY, Pasceri P, Stanford WL, Ellis J. (2009)\u00a0EOS lentiviral vector selection system for human induced pluripotent stem cells<\/a>. Nature Protocols. 4:1828-1844.<\/p>\n

Hotta A<\/strong>, Cheung AY, Farra N, Vijayaragavan K, S\u00e9guin CA, Draper JS, Pasceri P, Maksakova IA, Mager DL, Rossant J, Bhatia M, Ellis J. (2009)\u00a0Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency<\/a>. Nature Methods. 6:370-376. Featured on cover art.<\/p>\n

Hotta A<\/strong>\u00a0and Ellis J. (2008)\u00a0Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states<\/a>. Journal of Cellular Biochemistry. 105:940-948. Featured on cover art.<\/p>\n

Buzina A*, Lo MY*, Moffett A*, \u00a0Hotta A,<\/strong>\u00a0Fussner E, Bharadwaj RR, Pasceri P, Garcia-Martinez JV, Bazett-Jones DP, Ellis J. 2008.\u00a0Beta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapy<\/a>. *Equal first authors. PLOS Genetics. 4:e1000051.<\/p>\n

Ellis J,\u00a0Hotta A<\/strong>, Rastegar M. (2007)\u00a0Retrovirus silencing by an epigenetic TRIM<\/a>. Cell. 131:13-14.<\/p>\n

Hotta A<\/strong>, Saito Y, Kyogoku K, Kawabe Y, Nishijima K, Kamihira M, Iijima S. (2006)\u00a0Characterization of transient expression system for retroviral vector production<\/a>. Journal of Bioscience and Bioengineering. 101:361-368.<\/p>\n

Hotta A<\/strong>, Kamihira M, Itoh K, Morshed M, Kawabe Y, Ono K, Matsumoto H, Nishijima K, Iijima S. (2004)\u00a0Production of anti-CD2 chimeric antibody by recombinant animal cells<\/a>. Journal of Bioscience and Bioengineering. 98:298-303.<\/p>\n

Ono K, Kamihira M, Kuga Y, Matsumoto H,\u00a0Hotta A,<\/strong>\u00a0Itoh T, Nishijima K, Nakamura N, Matsuda H, Iijima S. (2003)\u00a0Production of anti-prion scFv-Fc fusion proteins by recombinant animal cells<\/a>. Journal of Bioscience and Bioengineering. 95:231-238.<\/p>\n

<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Akitsu Hotta received his PhD in Nagoya, Japan. His studies of retrovirus vector derived transgenic chickens were funded by the Japan Scholarship Foundation. Since moving to Toronto, he has raised the bar of our speed cloning records. Hotta’s research is largely focused on new vector designs for stem cell specific expression, but he is also…<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":492,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-616","page","type-page","status-publish","hentry","description-off"],"yoast_head":"\nDr. Akitsu Hotta - Ellis Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/ellis\/people\/dr-akitsu-hotta\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr. Akitsu Hotta\" \/>\n<meta property=\"og:description\" content=\"Akitsu Hotta received his PhD in Nagoya, Japan. 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