{"id":19,"date":"2014-12-05T15:20:43","date_gmt":"2014-12-05T15:20:43","guid":{"rendered":"http:\/\/lab-dev.research.sickkids.ca\/sevan-hopyan-lab\/?page_id=15"},"modified":"2023-07-25T17:19:31","modified_gmt":"2023-07-25T17:19:31","slug":"research","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/ellis\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

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\"Neurons\"<\/a><\/div>

Induced Pluripotent Stem (iPS) Cells<\/a><\/strong><\/h4>\n

iPS cells generated from patients are in use to study neurodevelopmental disorders including Rett syndrome and autism. We also use iPS cells to model cardiomyopathies as a step towards drug screens for personalized medicine. <\/span><\/p>\n<\/div><\/section>[\/vc_column][vc_column width=”1\/3″]

\"Gene<\/a><\/div>

Post-transcriptional gene regulation<\/a><\/strong><\/h4>\n

We explore post-transcriptional regulation of disease-causing transcripts during in vitro human neurodevelopment. Our approach examines shifts in transcript stability and ribosome engagement, as well as activity-dependent translation in neurons.<\/span><\/p>\n<\/div><\/section>[\/vc_column][vc_column width=”1\/3″]

\"Past<\/a><\/div>

Past Research<\/a><\/strong><\/h4>\n

Until 2008, the lab focus was on Locus Control Region elements of the beta-globin gene and gene silencing of retrovirus and lentivirus vectors in stem cells. Our initial efforts to use iPSC to model lung disease (CF) are being completed by other team members.<\/span><\/p>\n<\/div><\/section>[\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][vc_cta h2=”Thanks to our funding partners for their generous support!” txt_align=”center” shape=”square” color=”white” css=”.vc_custom_1510072224742{background-image: url(https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2015\/02\/Past-Research-image-4.jpg?id=1059) !important;}”][\/vc_cta][\/vc_column][\/vc_row][vc_row][vc_column width=”1\/3″]

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