{"id":18,"date":"2014-12-05T14:04:58","date_gmt":"2014-12-05T14:04:58","guid":{"rendered":"http:\/\/lab-dev.research.sickkids.ca\/sevan-hopyan-lab\/?page_id=6"},"modified":"2026-04-01T18:06:02","modified_gmt":"2026-04-01T18:06:02","slug":"home","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/ellis\/","title":{"rendered":"Home"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/2&#8243;]<section class=\"shortcode-action-box table no-line fadeIn animate-element\"><div class=\"\"><h3 style=\"text-align: center\"><span style=\"color: #3f9c35\">OUR MISSION<\/span><\/h3>\n<p>&nbsp;<\/p>\n<h3 style=\"text-align: center\">We aim to discover basic mechanisms that control gene expression and epigenetic reprogramming. We strive to apply this knowledge through manipulation of\u00a0induced pluripotent stem (iPS) cells to model human disease and test potential therapies for personalized medicine.<\/h3>\n<p style=\"text-align: center\"><span style=\"color: #ffffff\">a<\/span><\/p>\n<\/div><\/section><div class=\"gap\" style=\"line-height: 20px; height: 20px;\"><\/div>[\/vc_column][vc_column width=&#8221;1\/2&#8243;]<section class=\"shortcode-action-box table no-line fadeIn animate-element\"><div class=\"\"><h3 style=\"text-align: center\"><span style=\"color: #3f9c35\">TOP SUSTAINABILITY RATING FOR THE ELLIS LAB<\/span><\/h3>\n<p style=\"text-align: center\"><a class=\"dt-pswp-item\" href=\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2024\/10\/Screenshot-2024-09-10-at-9.55.40-AM.png\" data-dt-img-description=\"\" data-large_image_width=\"1090\" data-large_image_height=\"841\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2613\" src=\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2024\/10\/Screenshot-2024-09-10-at-9.55.40-AM.png\" alt=\"\" width=\"291\" height=\"225\" \/><\/a><\/p>\n<\/div><\/section><div class=\"gap\" style=\"line-height: 30px; height: 30px;\"><\/div>[\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243; css=&#8221;.vc_custom_1495049971265{padding-bottom: 25px !important;background-color: #f2f2f2 !important;}&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1735588513709{padding-top: 10px !important;padding-right: 15px !important;padding-bottom: 15px !important;padding-left: 15px !important;}&#8221;]<\/p>\n<h4 style=\"text-align: center\"><a class=\"dt-single-image\" href=\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2015\/01\/James-Ellis-for-website-e1420729500473.jpg\"><br \/>\n<\/a><a class=\"dt-single-image\" href=\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2020\/09\/Ellis-James_Developmental-Biology-11SEP2020_MG_6667.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2253 size-full\" src=\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2020\/09\/Ellis-James_Developmental-Biology-11SEP2020_MG_6667.jpeg\" alt=\"\" width=\"200\" height=\"300\" \/><\/a><\/h4>\n<h4 style=\"text-align: left\">James Ellis, PhD<\/h4>\n<h6 style=\"text-align: left\"><strong>Senior Scientist<br \/>\n<\/strong><a href=\"https:\/\/www.sickkids.ca\/en\/research\/research-programs\/developmental-stem-cell-cancer-biology\/\" target=\"_blank\" rel=\"noopener noreferrer\">Developmental, Stem Cell &amp; Cancer Biology<\/a><br \/>\n<span style=\"font-weight: normal\">The Hospital for Sick Children (SickKids)<\/span><\/h6>\n<h6><strong>Professor<br \/>\n<\/strong><a href=\"http:\/\/www.moleculargenetics.utoronto.ca\/#our-research-focus\" target=\"_blank\" rel=\"noopener noreferrer\">Department of Molecular Genetics<\/a><br \/>\nThe University of Toronto<\/h6>\n<p>[\/vc_column_text]<div class=\" ubtn-ctn-center \"><a class=\"ubtn-link ult-adjust-bottom-margin ubtn-center ubtn-custom \" href=\"https:\/\/orcid.org\/0000-0002-4400-0091\" title=\"ORCID\" target=\"_blank\" rel=\"noopener\" ><button type=\"button\" id=\"ubtn-2322\"  class=\"ubtn ult-adjust-bottom-margin ult-responsive ubtn-custom ubtn-no-hover-bg  none  ubtn-center   tooltip-69d9a2ee13b63\"  data-hover=\"\" data-border-color=\"\" data-bg=\"#3f9c35\" data-hover-bg=\"\" data-border-hover=\"\" data-shadow-hover=\"\" data-shadow-click=\"none\" data-shadow=\"\" data-shd-shadow=\"\"  data-ultimate-target='#ubtn-2322'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;width:150px;min-height:35px;padding:10px 10px;border:none;background: #3f9c35;color: #ffffff;\"><span class=\"ubtn-hover\" style=\"background-color:\"><\/span><span class=\"ubtn-data ubtn-text \" >ORCID<\/span><\/button><\/a><\/div><div class=\" ubtn-ctn-center \"><a class=\"ubtn-link ult-adjust-bottom-margin ubtn-center ubtn-custom \" href=\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2025\/06\/Ellis-CV-2025-for-lab-website.pdf\" title=\"Download CV\" target=\"_blank\" rel=\"noopener\" ><button type=\"button\" id=\"ubtn-2472\"  class=\"ubtn ult-adjust-bottom-margin ult-responsive ubtn-custom ubtn-no-hover-bg  none  ubtn-center   tooltip-69d9a2ee13c19\"  data-hover=\"\" data-border-color=\"\" data-bg=\"#3f9c35\" data-hover-bg=\"\" data-border-hover=\"\" data-shadow-hover=\"\" data-shadow-click=\"none\" data-shadow=\"\" data-shd-shadow=\"\"  data-ultimate-target='#ubtn-2472'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;width:150px;min-height:35px;padding:10px 10px;border:none;background: #3f9c35;color: #ffffff;\"><span class=\"ubtn-hover\" style=\"background-color:\"><\/span><span class=\"ubtn-data ubtn-text \" >Download CV<\/span><\/button><\/a><\/div>[\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;2046&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow&#8221; onclick=&#8221;link_image&#8221; css_animation=&#8221;fadeIn&#8221;][vc_column_text]<\/p>\n<h3 style=\"text-align: left\"><\/h3>\n<p>Ongoing research in our group centers on disease modeling and drug screening using induced Pluripotent Stem (iPS) cells. Initially we used a novel EOS reporter vector to reprogram patient fibroblasts into iPS cells and more recently we perform CRISPR gene editing to create isogenic cell pairs. Next, Neural Progenitor Cells (NPC) are generated to produce neurons for defining phenotypes and expression patterns that are related to Rett syndrome (RTT) and autism spectrum disorder (ASD).<\/p>\n<p>We also collaborate with the Mital lab to evaluate the cardiomyocyte phenotype of pediatric cardiomyopathies. Drug testing is then performed to rescue the patient-specific in vitro phenotypes. Overall, our goal is to utilize reprogramming technology to repurpose or identify novel drugs for personalized medicine.[\/vc_column_text]<div class=\"gap\" style=\"line-height: 15px; height: 15px;\"><\/div>[\/vc_column][vc_column width=&#8221;1\/4&#8243; css=&#8221;.vc_custom_1495050045460{background-color: #f2f2f2 !important;}&#8221;][vc_column_text css=&#8221;.vc_custom_1749485067103{padding-top: 10px !important;padding-right: 15px !important;padding-bottom: 10px !important;padding-left: 15px !important;}&#8221;]<\/p>\n<h4>Recent Publications<\/h4>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-026-70550-9\" target=\"_blank\" rel=\"noopener\">Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components<\/a>. Callaghan NI. et al., 2026. <strong>Nature Communications<\/strong><\/li>\n<li><a href=\"https:\/\/www.jacc.org\/doi\/10.1016\/j.jacbts.2026.101491\" target=\"_blank\" rel=\"noopener\">Abnormal Lipid Signaling Characterizes Diastolic Dysfunction in Pediatric Cardiomyopathy<\/a>. Turinsky AL. et al., 2026. <strong>JACC: Basic to Translational Science<\/strong>, 11(3):101491<\/li>\n<li><span data-olk-copy-source=\"MessageBody\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1934590925001845?dgcid=author\" target=\"_blank\" rel=\"noopener\">Diversifying the iPSC reference line concept<\/a>. Ellis J. et al., 2025. <strong>Cell Stem Cell<\/strong>, 32(6):873-877<\/span><\/li>\n<li><a href=\"https:\/\/www.cell.com\/stem-cell-reports\/fulltext\/S2213-6711(25)00322-4\" target=\"_blank\" rel=\"noopener\">Hypersynchronous iPSC-derived SHANK2 neuronal networks are rescued by mGluR5 agonism<\/a>. McCready FP. et al., 2025. <strong>Stem Cell Reports<\/strong>, 102718<\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-37339-6\" target=\"_blank\" rel=\"noopener\">Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models<\/a>. Rodrigues D.C. et al., 2023. <strong>Nature Communications,\u00a0<\/strong>14:1896<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]<\/p>\n<p>[vc_row][vc_column width=&#8221;1\/2&#8243;]<section class=\"shortcode-action-box table no-line fadeIn animate-element\"><div class=\"\"><h2><\/h2>\n<h2><\/h2>\n<h3 style=\"text-align: left\"><strong><span style=\"color: #3f9c35\"><span data-olk-copy-source=\"MessageBody\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 The Ellis Lab is not hiring in 2026.<\/span><\/span><\/strong><\/h3>\n<p style=\"text-align: center\"><span style=\"color: #ffffff\">a<\/span><\/p>\n<\/div><\/section><div class=\"gap\" style=\"line-height: 20px; height: 20px;\"><\/div>[\/vc_column][vc_column width=&#8221;1\/2&#8243;]<section class=\"shortcode-action-box table no-line fadeIn animate-element\"><div class=\"\"><\/div><\/section>\n<p>[\/vc_column][\/vc_row][vc_row][vc_column]<div class=\"gap\" style=\"line-height: 25px; height: 25px;\"><\/div><div class=\"twentytwenty-container\" data-orientation=\"horizontal\" data-offset=\"0.4\"><img loading=\"lazy\" decoding=\"async\" class=\"preload-me\" src=\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2015\/01\/Dae-sung-image1blurred.jpg\" width=\"1600\" height=\"663\"  alt=\"HEADER IMAGE\"><img loading=\"lazy\" decoding=\"async\" class=\"preload-me\" src=\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2015\/05\/Dae-sung-imageCPA-revised-text.jpg\" width=\"1600\" height=\"663\"  alt=\"Beautiful mind of an autistic child\"><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243; css=&#8221;.vc_custom_1495049971265{padding-bottom: 25px !important;background-color: #f2f2f2 !important;}&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1735588513709{padding-top: 10px !important;padding-right: 15px !important;padding-bottom: 15px !important;padding-left: 15px !important;}&#8221;] James Ellis, PhD Senior Scientist Developmental, Stem Cell &amp; Cancer Biology The Hospital for Sick Children (SickKids) Professor Department of Molecular Genetics The University of Toronto [\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;2046&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow&#8221; onclick=&#8221;link_image&#8221; css_animation=&#8221;fadeIn&#8221;][vc_column_text] Ongoing research&hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Home - Ellis Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/ellis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Home\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243; css=&#8221;.vc_custom_1495049971265{padding-bottom: 25px !important;background-color: #f2f2f2 !important;}&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221; css=&#8221;.vc_custom_1735588513709{padding-top: 10px !important;padding-right: 15px !important;padding-bottom: 15px !important;padding-left: 15px !important;}&#8221;] James Ellis, PhD Senior Scientist Developmental, Stem Cell &amp; Cancer Biology The Hospital for Sick Children (SickKids) Professor Department of Molecular Genetics The University of Toronto [\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;2046&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow&#8221; onclick=&#8221;link_image&#8221; css_animation=&#8221;fadeIn&#8221;][vc_column_text] Ongoing research&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/ellis\/\" \/>\n<meta property=\"og:site_name\" content=\"Ellis Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-01T18:06:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2024\/10\/Screenshot-2024-09-10-at-9.55.40-AM.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1090\" \/>\n\t<meta property=\"og:image:height\" content=\"841\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/ellis\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/ellis\/\",\"name\":\"Home - Ellis Lab\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/ellis\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/ellis\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/ellis\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2024\/10\/Screenshot-2024-09-10-at-9.55.40-AM.png\",\"datePublished\":\"2014-12-05T14:04:58+00:00\",\"dateModified\":\"2026-04-01T18:06:02+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/ellis\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lab.research.sickkids.ca\/ellis\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/ellis\/#primaryimage\",\"url\":\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2024\/10\/Screenshot-2024-09-10-at-9.55.40-AM.png\",\"contentUrl\":\"https:\/\/lab.research.sickkids.ca\/ellis\/wp-content\/uploads\/sites\/4\/2024\/10\/Screenshot-2024-09-10-at-9.55.40-AM.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/ellis\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lab.research.sickkids.ca\/ellis\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Home\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/ellis\/#website\",\"url\":\"https:\/\/lab.research.sickkids.ca\/ellis\/\",\"name\":\"Ellis Lab\",\"description\":\"Induced pluripotent stem cells\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lab.research.sickkids.ca\/ellis\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Home - Ellis Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lab.research.sickkids.ca\/ellis\/","og_locale":"en_US","og_type":"article","og_title":"Home","og_description":"[vc_row][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243; 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