{"id":1292,"date":"2015-04-13T14:07:19","date_gmt":"2015-04-13T14:07:19","guid":{"rendered":"http:\/\/lab-dev.research.sickkids.ca\/sevan-hopyan-lab\/?page_id=1292"},"modified":"2020-01-27T14:36:13","modified_gmt":"2020-01-27T14:36:13","slug":"shuyuan-yao","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/ellis\/people\/shuyuan-yao\/","title":{"rendered":"Shuyuan Yao"},"content":{"rendered":"

Shuyuan Yao \u2013 PhD Student, 1999-2004<\/span><\/h4>\n
\n
\n

Shuyuan Yao had extensive virology experience from his M.Sc. studies in China and worked as a technician at the Scripps Institute in San Diego before moving to Toronto. Yao\u2019s PhD thesis focused on chromatin modifications associated with retrovirus and lentivirus vector silencing, with a strong side interest in the use of insulator elements to block silencing.<\/p>\n

After a quiet and determined start in the lab, while becoming the first person in Toronto to master the chromatin immunoprecipitation (ChIP) technique, he settled down and wouldn\u2019t stop talking.<\/p>\n

Funded by Stem Cell Network and Sick Kids Restracomp Awards.<\/p>\n

Next position<\/strong>
\nPostdoctoral fellow, Scripps Institute, San Diego, CA<\/p>\n

 <\/p>\n

Selected Publications:<\/strong>
\nEllis J,\u00a0Yao S<\/strong>. (2005)\u00a0Retrovirus silencing and vector design: relevance to normal and cancer stem cells?<\/a>\u00a0Current Gene Therapy. 5:367-373.<\/p>\n

Dalle B,* Rubin J*, Alkan O, Sukonnik T, Pasceri P,\u00a0Yao S<\/strong>, Pawliuk R, Leboulch P, Ellis J. (2005)\u00a0eGFP reporter genes silence LCR\u03b2-globin transgene expression via CpG dinucleotides<\/a>. Molecular Therapy. 11:591-599. * Equal first authors.<\/p>\n

Yao S<\/strong>, Sukonnik T, Kean T, Bharadwaj R, Pasceri P, Ellis J. (2004)\u00a0Retrovirus Silencing, Variegation, Extinction and Memory are controlled by a dynamic interplay of multiple epigenetic modifications<\/a>. Molecular Therapy.10:1 27-37.<\/p>\n

Yao S<\/strong>, Osborne CS, Bharadwaj R.R, Pasceri P, Sukonnik T, Pannell D, Recillas-Targa F, West A.G, Ellis J. (2003)\u00a0Retrovirus silencer blocking by the cHS4 insulator is CTCF independent<\/a>. NAR. 31:18 5317-5323.<\/p>\n

Pannell D, Osborne CS,\u00a0Yao S<\/strong>, Sukonnik T, Pasceri P, Karaiskakis A, Okano M, Li E, Lipshitz HD, Ellis J. (2000)\u00a0Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code.<\/a>\u00a0EMBO. 19: 5884-5894.<\/p>\n

<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Shuyuan Yao had extensive virology experience from his M.Sc. studies in China and worked as a technician at the Scripps Institute in San Diego before moving to Toronto. 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