{"id":2085,"date":"2021-02-18T23:51:23","date_gmt":"2021-02-18T23:51:23","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/dimaras\/?page_id=2085"},"modified":"2022-10-20T18:57:53","modified_gmt":"2022-10-20T18:57:53","slug":"riverboat","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/dimaras\/research\/riverboat\/","title":{"rendered":"Research Into Visual Endpoints RB Health Outcomes After Treatment (RIVERBOAT)"},"content":{"rendered":"<p><span data-contrast=\"auto\">The overall goal of this effort is to organize the first and largest international multicenter, multi-racial and ethnic consortium of retinoblastoma (RB) survivors to study health outcomes and interrogate genotype-phenotype correlations of disease presentation.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">No organized systematic approach has been undertaken to assess acute toxicities and long-term outcomes of\u00a0<\/span><span data-contrast=\"auto\">intra-<\/span><span data-contrast=\"auto\">vitreal<\/span><span data-contrast=\"auto\">\u00a0chemotherapy<\/span><span data-contrast=\"auto\">\u00a0and\u00a0<\/span><span data-contrast=\"auto\">intra-arterial chemotherapy<\/span><span data-contrast=\"auto\">\u00a0or the biologic determinants of aggressive disease presentation, which drives therapeutic decisions, and in turn, health outcomes.\u00a0<\/span><span data-contrast=\"auto\">As a\u00a0result\u00a0p<\/span><span data-contrast=\"auto\">ediatric oncology and ophthalmology investigators\u00a0<\/span><span data-contrast=\"auto\">have gathered\u00a0<\/span><span data-contrast=\"auto\">to form the <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03932786\" target=\"_blank\" rel=\"noopener noreferrer\">Research\u00a0Into\u00a0Visual Endpoints and RB Health Outcomes After Treatment (RIVERBOAT)<\/a> Consortium to:\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"18\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">D<\/span><span data-contrast=\"auto\">efine acute toxicity and visual outcomes in\u00a0<\/span><span data-contrast=\"auto\">retinoblastoma<\/span><span data-contrast=\"auto\">\u00a0survivors and compare patient-centered psychosocial and neurocognitive outcomes in survivors with normative data and sibling controls<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"18\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">C<\/span><span data-contrast=\"auto\">reate the first\u00a0Clinically-Annotated\u00a0Patient Tissues to Analyze gene\u00a0<\/span><span data-contrast=\"auto\">INteractions<\/span><span data-contrast=\"auto\">\u00a0to assess biologic correlates of disease and to facilitate future research: RIVERBOAT- CAPTAIN Biorepository<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"18\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">U<\/span><span data-contrast=\"auto\">sing the RIVERBOAT-CAPTAIN biorepository, determine the interplay between specific RB1 mutation type and the role of additional modifier genes in determining tumor phenotypes that drive treatment decisions.\u00a0<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">This project\u00a0<\/span><span data-contrast=\"auto\">will positively impact survivors of\u00a0<\/span><span data-contrast=\"auto\">retinoblastoma<\/span><span data-contrast=\"auto\">\u00a0by:<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"19\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">A<\/span><span data-contrast=\"auto\">ssessing short and long-term outcomes of contemporary therapy<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"19\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">E<\/span><span data-contrast=\"auto\">stablishing a\u00a0clinically-annotated\u00a0biorepository for genomic research<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"19\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"auto\">E<\/span><span data-contrast=\"auto\">xamining molecular pathogenesis of disease presentation<\/span><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;134233279&quot;:true,&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<p>For more information about this project please contact: <a href=\"mailto:retinoblastoma.research@sickkids.ca\" target=\"_blank\" rel=\"noopener noreferrer\">retinoblastoma.research@sickkids.ca<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The overall goal of this effort is to organize the first and largest international multicenter, multi-racial and ethnic consortium of retinoblastoma (RB) survivors to study health outcomes and interrogate genotype-phenotype correlations of disease presentation.\u00a0\u00a0 No organized systematic approach has been undertaken to assess acute toxicities and long-term outcomes of\u00a0intra-vitreal\u00a0chemotherapy\u00a0and\u00a0intra-arterial chemotherapy\u00a0or the biologic determinants of aggressive  [&#8230;]<\/p>\n","protected":false},"author":99,"featured_media":0,"parent":16,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2085","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO 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