{"id":3301,"date":"2018-03-02T22:12:18","date_gmt":"2018-03-02T22:12:18","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/derry\/?page_id=3301"},"modified":"2025-05-28T12:50:31","modified_gmt":"2025-05-28T12:50:31","slug":"home","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/derry\/","title":{"rendered":"Home"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_3 1_3 fusion-one-third fusion-column-first\" style=\"--awb-bg-size:cover;width:33.333333333333%;width:calc(33.333333333333% - ( ( 4% ) * 0.33333333333333 ) );margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:35px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-image-element in-legacy-container\" style=\"--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-glow imageframe-1 hover-type-zoomin\" style=\"-webkit-box-shadow: 0 0 3px rgba(0,0,0,0.3);box-shadow: 0 0 3px rgba(0,0,0,0.3);\"><a href=\"https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2023\/08\/IMG_6624-800x533.jpg\" class=\"fusion-lightbox\" data-rel=\"iLightbox[a988591289a02091e45]\" data-title=\"The Derry Lab\" title=\"The Derry Lab\"><img decoding=\"async\" width=\"400\" height=\"267\" src=\"https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2023\/08\/IMG_6624-400x267.jpg\" alt class=\"img-responsive wp-image-4186\" srcset=\"https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2023\/08\/IMG_6624-200x133.jpg 200w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2023\/08\/IMG_6624-400x267.jpg 400w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2023\/08\/IMG_6624-600x400.jpg 600w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2023\/08\/IMG_6624-800x533.jpg 800w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2023\/08\/IMG_6624-1200x800.jpg 1200w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2023\/08\/IMG_6624.jpg 1620w\" sizes=\"(max-width: 800px) 100vw, 600px\" \/><\/a><\/span><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:40px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_2_3 2_3 fusion-two-third fusion-column-last\" style=\"--awb-bg-size:cover;width:66.666666666667%;width:calc(66.666666666667% - ( ( 4% ) * 0.66666666666667 ) );\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1\"><h3>In the Derry Lab we use the model organism <em>Caenorhabditis elegans<\/em>, a tiny nematode worm, to study gene functions in the context of when and where development intersects disease. The big questions we are interested in answering are:<\/h3>\n<ul>\n<li>\n<h3><span style=\"color: #3ad6bc\"><strong>How cells make life or death decisions?<\/strong><\/span><\/h3>\n<\/li>\n<li>\n<h3><strong><span style=\"color: #3ad6bc\">How are\u00a0signaling thresholds regulated in development and disease?<\/span><\/strong><\/h3>\n<\/li>\n<li>\n<h3><span style=\"color: #3ad6bc\"><strong>How do biological tubes develop?<\/strong><\/span><\/h3>\n<\/li>\n<li>\n<h3><span style=\"color: #3ad6bc\"><strong>Protein aggregates in transgenerational inheritance.<\/strong><\/span><\/h3>\n<\/li>\n<\/ul>\n<h3>To achieve these goals we collaborate with colleagues in Canada and around the world.<\/h3>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:40px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:0px;--awb-padding-right:0px;--awb-padding-bottom:0px;--awb-padding-left:0px;--awb-background-color:rgba(255,255,255,0.54);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_2 1_2 fusion-one-half fusion-column-first\" style=\"--awb-bg-size:cover;width:50%;width:calc(50% - ( ( 4% ) * 0.5 ) );margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:40px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-image-element fusion-image-align-center in-legacy-container\" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><div class=\"imageframe-align-center\"><span class=\" fusion-imageframe imageframe-glow imageframe-2 hover-type-zoomin\" style=\"-webkit-box-shadow: 0 0 3px rgba(0,0,0,0.3);box-shadow: 0 0 3px rgba(0,0,0,0.3);\"><a class=\"fusion-no-lightbox\" href=\"https:\/\/lab.research.sickkids.ca\/derry\/ccm\/\" target=\"_self\"><img decoding=\"async\" width=\"300\" height=\"200\" alt=\"CCM\" src=\"https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/5-300x200.jpg\" class=\"img-responsive wp-image-3411\" srcset=\"https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/5-200x133.jpg 200w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/5-400x267.jpg 400w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/5-600x400.jpg 600w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/5-800x533.jpg 800w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/5-1200x800.jpg 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><\/span><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:10px;margin-bottom:10px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-one\" style=\"--awb-margin-top-small:10px;--awb-margin-right-small:0px;--awb-margin-bottom-small:10px;--awb-margin-left-small:0px;\"><h1 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\"><h3 style=\"text-align: center\">CCM<\/h3><\/h1><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_2 1_2 fusion-one-half fusion-column-last\" style=\"--awb-bg-size:cover;width:50%;width:calc(50% - ( ( 4% ) * 0.5 ) );\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:40px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-image-element fusion-image-align-center in-legacy-container\" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><div class=\"imageframe-align-center\"><span class=\" fusion-imageframe imageframe-glow imageframe-3 hover-type-zoomin\" style=\"-webkit-box-shadow: 0 0 3px rgba(0,0,0,0.3);box-shadow: 0 0 3px rgba(0,0,0,0.3);\"><a class=\"fusion-no-lightbox\" href=\"https:\/\/lab.research.sickkids.ca\/derry\/signaling-development\/\" target=\"_self\"><img decoding=\"async\" width=\"300\" height=\"200\" alt=\"Signalling\" src=\"https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/9-300x200.jpg\" class=\"img-responsive wp-image-3415\" srcset=\"https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/9-200x133.jpg 200w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/9-400x267.jpg 400w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/9-600x400.jpg 600w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/9-800x533.jpg 800w, https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/04\/9-1200x800.jpg 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><\/span><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:10px;margin-bottom:10px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-one\" style=\"--awb-margin-top-small:10px;--awb-margin-right-small:0px;--awb-margin-bottom-small:10px;--awb-margin-left-small:0px;\"><h1 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\"><h3 style=\"text-align: center\">Cell Signaling &amp; Cancer Biology<\/h3><\/h1><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"--awb-bg-size:cover;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\">\n\t\t\t\t<p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t\t<sr7-module data-alias=\"slider102\" data-id=\"23\" id=\"SR7_23_1\" class=\"rs-ov-hidden\" data-version=\"6.7.55\">\n\t\t\t\t\t<sr7-adjuster><\/sr7-adjuster>\n\t\t\t\t\t<sr7-content>\n\t\t\t\t\t\t<sr7-slide id=\"SR7_23_1-9\" data-key=\"9\">\n\t\t\t\t\t\t\t<sr7-bg id=\"SR7_23_1-9-1\" class=\"sr7-layer\"><noscript><img decoding=\"async\" src=\"https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/revslider\/Home_Slider\/pic-6.jpg\" alt=\"\" title=\"pic-6.jpg\"><\/noscript><\/sr7-bg>\n\t\t\t\t\t\t<\/sr7-slide>\n\t\t\t\t\t<\/sr7-content>\n\t\t\t\t\t<image_lists style=\"display:none\">\n\t\t\t\t\t\t<img data-src=\"\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/revslider\/Home_Slider\/pic-6.jpg\" data-libid=\"2447\" title=\"pic-6.jpg\" width=\"0\" height=\"0\" 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class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"class_list":["post-3301","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Home - Derry Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/derry\/\" \/>\n<meta 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