{"id":3276,"date":"2018-03-02T16:16:00","date_gmt":"2018-03-02T16:16:00","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/derry\/?page_id=3276"},"modified":"2021-05-07T15:15:36","modified_gmt":"2021-05-07T15:15:36","slug":"cell-size","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/derry\/cell-size\/","title":{"rendered":"CELL SIZE"},"content":{"rendered":"

Cell Size<\/h2><\/h1><\/div>

The foray into cell size control was stimulated by a hallway conversation between Dr. Derry and Dr. Ran Kafri<\/a>, who has vibrant research program in this area.<\/p>\n

\"Rachel\"<\/span>Is there a molecular program that determines how long we live? The question of how cell size scales with lifespan is the focus of Rachel Webster\u2019s project, who is co-supervised by Dr. Kafri and Dr. Derry. \u00a0In collaboration with the Dor lab and the Jerusalem Zoo we have observed a strong negative correlation between the size of tissue-specific cells with an organism\u2019s lifespan, suggesting that these two seemingly unrelated traits are controlled by a single pathway. The mTOR pathway has emerged independently from both lifespan and cell size studies as a potential master regulator, and as such we are using worms to define the role of mTOR activity in longevity and cell size. We are using the tools of genetics and cell biology to investigate how nucleolar size scales with cell size and lifespan of a multicellular organism (C. elegans<\/em>). Gene editing technologies such as CRISPR\/Cas9 are being employed to manipulate the spatiotemporal expression of key regulatory proteins in signaling pathways to ask how cell size affects lifespan.<\/p>\n<\/div>

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<\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"class_list":["post-3276","page","type-page","status-publish","hentry"],"yoast_head":"\nCELL SIZE - Derry Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/derry\/cell-size\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CELL SIZE\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/derry\/cell-size\/\" \/>\n<meta property=\"og:site_name\" content=\"Derry Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2021-05-07T15:15:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lab.research.sickkids.ca\/derry\/wp-content\/uploads\/sites\/11\/2018\/02\/Untitled-design-5-150x150.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/derry\/cell-size\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/derry\/cell-size\/\",\"name\":\"CELL SIZE - 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