{"id":1736,"date":"2016-02-27T01:32:23","date_gmt":"2016-02-27T01:32:23","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/?page_id=1736"},"modified":"2025-01-15T14:35:18","modified_gmt":"2025-01-15T14:35:18","slug":"team","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/","title":{"rendered":"Team"},"content":{"rendered":"

The Heart of the Lab<\/h1><\/h1><\/div><\/div><\/div><\/div><\/div>
\"Paul<\/div><\/div>
Paul Delgado Olgu\u00edn, PhD<\/span>Principal Investigator<\/span><\/div><\/div>
<\/a><\/a><\/div><\/div><\/div>

Senior Scientist<\/strong><\/p>\n

Translational Medicine Program, SickKids Research Institute<\/a><\/p>\n

Associate Professor<\/strong><\/p>\n

Department of Molecular Genetics, University of Toronto<\/a><\/p>\n<\/div><\/div><\/div>

\"Lijun<\/div><\/div>
Lijun Chi, PhD<\/span>Research Associate<\/span><\/div><\/div>
<\/a><\/div><\/div><\/div>

Translational Medicine, SickKids Research Institute<\/p>\n

Dr. Chi enormously contributes in multiple aspects to all the projects in our lab. In addition, Dr. Chi is investigating the function of histone methyltransferases that form part of epigenetic silencing complexes in the development of cardiovascular precursor cells and their descendants.<\/p>\n<\/div><\/div><\/div>

\"Jielin<\/div><\/div>
Jielin Yang<\/span>Clinical Research Project Assistant<\/span><\/div><\/div>
<\/div><\/div><\/div>

Translational Medicine, SickKids Research Institute<\/span><\/p>\n

Jielin is investigating the link between chromatin structure and gene expression dynamics during cardiac maturation. By generating and cross-referencing multiple transcriptomics and epigenomics datasets from mouse cardiomyocytes with mutations in various chromatin modifiers, Jielin aims to uncover the basis of the heart’s adaptation during the fetal to postnatal transition. <\/p>\n<\/div><\/div><\/div>

\"Amalia<\/div><\/div>
Amalia Caballero<\/span>PhD Candidate<\/span><\/div><\/div>
<\/a><\/div><\/div><\/div>

Department of Molecular Genetics, U of T<\/p>\n

Amalia is investigating how obesity during pregnancy affects gene expression in the early developing embryo. Amalia employs single-cell genome wide approaches to uncover regulatory mechanisms of disease programming.<\/p>\n<\/div><\/div><\/div>

\"Adar<\/div><\/div>
Adar Aharon-Yariv<\/span>PhD Candidate<\/span><\/div><\/div>
<\/a><\/div><\/div><\/div>

Department of Molecular Genetics, U of T<\/p>\n

Adar is delving into the interplay between transcription factors and chromatin modifiers that control cardiac metabolism. Adar is applying multiple epigenomics approaches to map transcription factor occupancy and chromatin structure in regulatory elements controlling cardiac metabolism in homeostasis and heart failure.<\/span> <\/span><\/span><\/p>\n<\/div><\/div><\/div>

\"Amaury<\/div><\/div>
Amaury Aguilar Lomas<\/span>PhD Candidate<\/span><\/div><\/div>
<\/a><\/div><\/div><\/div>

Biochemical Sciences. Fellow student co-supervised with Dr. Mayra Furlan-Magaril at <\/span>Universidad Nacional Aut\u00f3noma de M\u00e9xico<\/span><\/p>\n

Amaury is focused on deciphering the elements that make it possible for regulatory elements located far apart in the DNA, to come together and regulate gene expression in developing endothelial cells and cardiomyocytes. Amaury applies chromatin conformation capture approaches to endothelial cells in mutant mouse models to reveal mechanisms of cardiovascular development. <\/p>\n<\/div><\/div><\/div>

\"Daniel<\/div><\/div>
Daniel Patolsky<\/span>MSc Student<\/span><\/div><\/div>
\n<\/div><\/div><\/div>

Department of Molecular Genetics, U of T<\/p>\n

Daniel is investigating the consequences of ectopic activation of a family of RNA binding proteins in the heart. Daniel is developing gain-of-function systems to identify mRNAs bound by these proteins and reveal their effect on translation. Daniel\u2019s work will provide insight into the post-transcriptional control of cardiomyocyte growth in both health and in response to pathological stimuli. <\/p>\n<\/div><\/div><\/div>

\"Hamna<\/div><\/div>
Hamna Ammar<\/span>Undergraduate Student<\/span><\/div><\/div>
\n<\/div><\/div><\/div>

Honors Bachelor of Science, Health & Disease, Animal Physiology at Woodsworth College, U of T<\/p>\n

Hamna is characterizing the cardiac phenotype of mouse embryos in which the histone methyltransferase Ezh2 is inactive in a subpopulation of cardiac progenitor cells. Hamna also uses genetic tools to label and isolate mutant cardiac progenitors and their descendants to analyze gene expression and chromatin structure at single cell resolution.<\/span><\/p>\n<\/div><\/div><\/div>

\"Bei<\/div><\/div>
Bei Yan<\/span>Undergraduate Student<\/span><\/div><\/div>
\n<\/div><\/div><\/div>

Honors Bachelor of Science, Neuroscience, Immunology, Physiology, <\/span>U of T<\/span><\/p>\n

Bei is developing a loss-of-function model to investigate the consequences of abnormal activation of transcription factors upon the deletion of epigenetic repressors in cardiomyocytes. Bei is testing the efficiency of morpholino oligonucleotides to knock down suppressors of cardiac metabolism, aiming to prevent cardiac deterioration and progression toward heart failure. <\/p>\n<\/div><\/div><\/div>

\"Cristina<\/div><\/div>
Cristina Mate<\/span>Administrative Coordinator<\/span><\/div><\/div>
\n<\/div><\/div><\/div>

Translational Medicine, SickKids Research Institute<\/p>\n

Cristina is our point of contact for logistics, onboarding, and navigating the Research Institute\u2019s policy.<\/p>\n<\/div><\/div><\/div><\/div><\/div>

Alumni<\/div><\/h2><\/div>

Research Fellows<\/h3><\/h1><\/div>

\n

Abdalla Ahmed, PhD<\/span>

\n<\/span><\/b><\/p>\n

Abdalla discovered a pathway controlled via histone demethylation and that is dysregulated to initiate cardiac deterioration leading to heart failure.<\/span><\/p>\n

<\/span><\/b>Present position: <\/b>Consultant, biotech industry<\/span><\/p>\n<\/div>

Graduate Students<\/h3><\/h1><\/div>

Ling Zhong, MD, PhD<\/b><\/p>\n

Fellow student supervised by Professor Ming Li at the Peking Union Medical College. Graduated with a PhD in Internal Medicine<\/p>\n

Jibran Nehal Syed<\/b><\/p>\n

Graduated from the MSc program in the Department of Molecular Genetics, U of T<\/p>\n

Thesis:<\/b> The Polycomb Group Protein L3MBTL2 Controls Postnatal and Pathological Cardiac Hypertrophy<\/span><\/i><\/p>\n

Position after graduation:<\/b> Consultant, biotech industry<\/span><\/p>\n

Quetzalcoatl Escalante Covarrubias, PhD<\/b><\/p>\n

Fellow student supervised by Dr. Lorena Aguilar-Arnal. Graduated from the Biomedical Sciences program, Universidad Nacional Aut\u00f3noma de M\u00e9xico<\/p>\n

Abdalla Ahmed, PhD<\/b><\/span><\/p>\n

Graduated from the PhD Program in the Department of Molecular Genetics at U of T Abdalla investigated the earliest effects of obesity during pregnancy on the developing heart and the molecular events that program an increased risk of adult-onset heart disease.<\/p>\n

Thesis:<\/b> <\/span><\/span><\/span>Transcriptional Origins of Adult Cardiac Disease in Response to Maternal<\/span> Obesity<\/span><\/a><\/span><\/span>.<\/span><\/i><\/p>\n

Position after graduation:<\/b> Research Fellow, The Hospital for Sick Children<\/span><\/p>\n

Anna Roy<\/b><\/p>\n

Graduated from the MSc program in the Department of Molecular Genetics, U of T<\/p>\n

Thesis:<\/b> CCCTC-binding Factor (Ctcf) is Required for Mouse Cardiovascular Development.<\/span><\/i><\/span><\/p>\n

Position after graduation:<\/b> Project Coordinator, The Hospital for Sick Children<\/span><\/p>\n

Sandra Vuong<\/b><\/p>\n

Graduated from the MSc program in the Department of Molecular Genetics, U of T<\/p>\n

Thesis:<\/b> Loss of L3mbtl2 in Cardiac Progenitor Cells Causes Subtle Defects in the Developing Heart Leading to Cardiac Dysfunction in Adulthood.<\/span><\/i><\/span><\/p>\n

Position after graduation:<\/b> MD Candidate, Australia<\/span><\/p>\n<\/div>

Undergraduate Research Students<\/h3><\/h1><\/div>

Raina Cui<\/b><\/p>\n

Research Student, Advanced Research Project in Molecular Genetics, U of T<\/span><\/span><\/p>\n

Jasmine Li<\/b>

\n<\/span><\/span><\/span><\/span><\/p>\n

Research Student, Advanced Research Project in Molecular Genetics, U of T<\/span><\/span><\/p>\n

Position after graduation: <\/b>Student MSc program in Genetic Counseling, U of T<\/span><\/p>\n

Sofia Wang<\/span>

\n<\/span><\/span><\/b><\/span><\/p>\n

Position after graduation:<\/b> PhD Student in the Department of Molecular Genetics, U of T<\/span>

\n<\/span><\/b><\/p>\n

Mabel Yang<\/b><\/p>\n

Research Student, Special Research Project, Department of Molecular Genetics, U of T<\/span>

\n<\/span><\/b><\/p>\n

Evonne Anin<\/b><\/p>\n

Research Student<\/span>

\n<\/span><\/b><\/p>\n

Etri Kocaqi<\/b><\/p>\n

Position after graduation: <\/b>Medical School, McMaster University<\/span>

\n<\/span><\/b><\/p>\n

Dorothy Lee<\/b><\/p>\n

Position after graduation: <\/b>Student in the PhD program in the <\/span>Department of Physiology, U of T<\/span>

\n<\/span><\/b><\/p>\n

Tao Wang<\/b><\/p>\n

Position after graduation:<\/b> <\/span>Student in the MSc program in the <\/span><\/span>Department of Physiology, U of T<\/span><\/p>\n

Meaghan Leslie<\/b><\/p>\n

Position after graduation:<\/b> Graduate Student in the MSc program in the <\/span>Department of Molecular Genetics, U of T<\/span><\/p>\n

Ryan Tracey<\/b><\/p>\n

Alicia Jarosz<\/b><\/p>\n

Position after graduation:<\/b> MD Candidate, University of Alberta<\/span><\/p>\n<\/div>

Volunteers<\/h3><\/h1><\/div>

Sina Fatehi Someeh<\/b><\/p>\n

Position after graduation: <\/b>Student in the MSc program in the <\/span>Department of Medical Science, U of T<\/span><\/p>\n


<\/b><\/p>\n

Angela Chen<\/b><\/p>\n

Position after graduation: <\/b>Undergraduate Student, U of T<\/span><\/p>\n


<\/b><\/p>\n

Angela An Qi Duan<\/span>
<\/b><\/p>\n

Position after graduation: <\/b>Student in the MSc program in the <\/span>Department of Medical Science, U of T<\/span><\/p>\n<\/div>

<\/div><\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":127,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-1736","page","type-page","status-publish","hentry"],"yoast_head":"\nTeam - Delgado-Olguin Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Team\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/\" \/>\n<meta property=\"og:site_name\" content=\"Delgado-Olguin Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-15T14:35:18+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"21 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/\",\"name\":\"Team - Delgado-Olguin Lab\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/#website\"},\"datePublished\":\"2016-02-27T01:32:23+00:00\",\"dateModified\":\"2025-01-15T14:35:18+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Team\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/#website\",\"url\":\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/\",\"name\":\"Delgado-Olguin Lab\",\"description\":\"Transcriptional control of cardiovascular development and disease\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Team - Delgado-Olguin Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/","og_locale":"en_US","og_type":"article","og_title":"Team","og_url":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/","og_site_name":"Delgado-Olguin Lab","article_modified_time":"2025-01-15T14:35:18+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"21 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/","url":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/","name":"Team - Delgado-Olguin Lab","isPartOf":{"@id":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/#website"},"datePublished":"2016-02-27T01:32:23+00:00","dateModified":"2025-01-15T14:35:18+00:00","breadcrumb":{"@id":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/team\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/"},{"@type":"ListItem","position":2,"name":"Team"}]},{"@type":"WebSite","@id":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/#website","url":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/","name":"Delgado-Olguin Lab","description":"Transcriptional control of cardiovascular development and disease","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/wp-json\/wp\/v2\/pages\/1736","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/wp-json\/wp\/v2\/users\/127"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/wp-json\/wp\/v2\/comments?post=1736"}],"version-history":[{"count":102,"href":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/wp-json\/wp\/v2\/pages\/1736\/revisions"}],"predecessor-version":[{"id":4776,"href":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/wp-json\/wp\/v2\/pages\/1736\/revisions\/4776"}],"wp:attachment":[{"href":"https:\/\/lab.research.sickkids.ca\/delgado-olguin\/wp-json\/wp\/v2\/media?parent=1736"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}