{"id":654,"date":"2020-07-03T14:43:51","date_gmt":"2020-07-03T14:43:51","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/cvus\/?page_id=654"},"modified":"2020-09-25T15:42:05","modified_gmt":"2020-09-25T15:42:05","slug":"clinical-studies-additional","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/cvus\/clinical-studies-additional\/","title":{"rendered":"Clinical Studies – Additional"},"content":{"rendered":"

<\/div><\/div><\/span>

Other ongoing clinical studies<\/h2><\/span>
<\/div><\/div><\/div>

Return to the Health-care providers and researchers page to view more ongoing clinical studies.<\/u><\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>

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\n\n\n\n\n\n\n\n\n
Study title<\/strong><\/th>\nStudy objective<\/strong><\/th>\n<\/tr>\n<\/thead>\n
Quantification of ventricular functi<\/span><\/span>o<\/span><\/span>n in hearts with pressure and\/or volume overload and their acute re<\/span><\/span>s<\/span><\/span>ponse to cardiac interventions<\/span><\/span><\/td>\nEvaluate the end-systolic and end-diastolic pressure-volume relationship as well as stroke work, and <\/span><\/span>elastance<\/span><\/span>\u00a0and diastolic myocardial\u00a0<\/span><\/span>stiffness as a method of quantifying ventricular function<\/span><\/span><\/td>\n<\/tr>\n
Ultrafast Ultrasound Imaging: Application in P<\/span><\/span>a<\/span><\/span>ediatric Cardiology<\/span><\/span><\/td>\nAim 1: We will validate UFUS non-invasive methods against gold-standard invasive pressure measurements and tissue characterization by cardiac MRI. <\/span><\/span><\/p>\n

Aim 2: We will define maturational changes in UFUS parameters during normal growth in comparison to changes in patients with suspected LV or RV DD. Aim 3: We will define myocardial perfusion and myocardial stiffness in 2 specific congenital heart defect populations (transposition of great arteries and hypoplastic left heart syndrome) before and after surgery.<\/span><\/span>\u00a0<\/span><\/td>\n<\/tr>\n

Brain perfusion in congenital heart disease: Ultrafast Ultrasound Imaging & MRI (<\/span><\/span>cola<\/span><\/span>. Birgit\u00a0<\/span><\/span>Erlt<\/span><\/span>\u00a0Wagner)<\/span><\/span><\/td>\nEstablish reference values of cerebral blood flow (CBF) and cerebral resistivity indexes (RI) in healthy newborns and congenital heart defects (TGA and HLHS) for both Ultrafast Ultrasound and Magnetic Resonance perfusion imaging<\/span><\/span>\u00a0<\/span><\/td>\n<\/tr>\n
Validation of electromechanical delay assessment by ultrafast ultrasound imaging with electrophysiology studies<\/span><\/span>\u00a0<\/span><\/td>\nCompare the myocardium mechanical activation mapping as obtained by electromechanical wave imaging (ultrafast imaging) with the gold standard of electrical activation during an invasive electrophysiology study.<\/span><\/span>\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":264,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-654","page","type-page","status-publish","hentry"],"yoast_head":"\nClinical Studies - Additional - Cardiovascular Ultrasound Research Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/cvus\/clinical-studies-additional\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinical Studies - 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