{"id":824,"date":"2023-03-07T22:11:20","date_gmt":"2023-03-07T22:11:20","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/christopher-pearson\/?page_id=824"},"modified":"2026-07-30T16:59:34","modified_gmt":"2026-07-30T16:59:34","slug":"publications","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/christopher-pearson\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Read our latest published papers and see what we have shared with the world.<\/span><\/span><\/strong><\/span><\/p>\n<\/div>

<\/i><\/i><\/span>2025<\/span><\/a><\/h2><\/div>
\n
    \n
  1. Striatal pathology in Spinocerebellar Ataxia Type 1 mice: A comparative study with Huntington’s disease<\/a><\/span><\/li>\n
  2. FGF14 repeat length and mosaic interruptions: modifiers of spinocerebellar ataxia 27B?<\/a><\/span><\/li>\n
  3. Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes<\/a><\/span><\/li>\n
  4. Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes<\/a><\/span><\/li>\n
  5. Interventionally targeting somatic CAG expansions can be a rapid disease-modifying therapeutic avenue: Preclinical evidence<\/a><\/span><\/li>\n
  6. Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5<\/a><\/span><\/li>\n<\/ol>\n<\/div><\/div><\/div>

    <\/i><\/i><\/span>2024<\/span><\/a><\/h2><\/div>
    \n
      \n
    1. C9orf72<\/i> repeat expansion creates the unstable folate-sensitive fragile site FRA9A<\/a><\/li>\n
    2. Huntingtin is an RNA binding protein and participates in NEAT1<\/i>-mediated paraspeckles<\/a><\/li>\n
    3. Stability of Mosaic Divergent Repeat Interruptions in X-Linked Dystonia-Parkinsonism<\/a><\/li>\n
    4. Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy<\/a><\/li>\n
    5. Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum<\/a><\/li>\n<\/ol>\n<\/div><\/div><\/div>

      <\/i><\/i><\/span>2023<\/span><\/a><\/h2><\/div>
      \n
        \n
      1. Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability<\/a><\/span><\/li>\n
      2. The COVID-19 Applicant: The Rise of Twitter Among Matched Neurosurgery Applicants<\/a><\/span><\/li>\n
      3. Pathogenic CANVAS-causing but not nonpathogenic RFC1 DNA\/RNA repeat motifs form quadruplex or triplex structures<\/a><\/span><\/li>\n
      4. Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum<\/a><\/span><\/li>\n
      5. Mosaic divergent repeat interruptions in XDP influence repeat stability and disease onset<\/a><\/span><\/li>\n<\/ol>\n<\/div><\/div><\/div>

        <\/i><\/i><\/span>2022<\/span><\/a><\/h2><\/div>
        \n
          \n
        1. Fragile sites, chromosomal lesions, tandem repeats, and disease<\/a><\/li>\n
        2. De novo<\/i>\u00a0mutations, genetic mosaicism and human disease<\/a><\/li>\n
        3. Genome-wide tandem repeat expansions contribute to schizophrenia risk<\/a><\/li>\n
        4. CAG repeat-binding small molecule improves motor coordination impairment in a mouse model of Dentatorubral-pallidoluysian atrophy<\/a><\/li>\n
        5. Advancing genomic technologies and clinical awareness accelerates discovery of disease-associated tandem repeat sequences<\/a><\/li>\n<\/ol>\n<\/div><\/div><\/div>

          <\/i><\/i><\/span>2021<\/span><\/a><\/h2><\/div>
          \n
            \n
          1. FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability<\/a><\/span><\/li>\n
          2. ATRX proximal protein associations boast roles beyond histone deposition<\/a><\/span><\/li>\n
          3. Genome sequencing identifies rare tandem repeat expansions and copy number variants in Lennox-Gastaut syndrome<\/a><\/span><\/li>\n
          4. Erratum: Experimental characterization of vertical-axis wind turbine noise [J. Acoust. Soc. Am. 137, EL111 (2015)]<\/a><\/span><\/li>\n
          5. FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG\/CTG repeats<\/a><\/span><\/li>\n
          6. FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders<\/a><\/span><\/li>\n
          7. Special Issue: DNA Repair and Somatic Repeat Expansion in Huntington’s Disease<\/a><\/span><\/li>\n<\/ol>\n<\/div><\/div><\/div><\/div><\/div>
            See full list of Dr. Pearson’s publications on PubMed<\/span><\/a><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":363,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-824","page","type-page","status-publish","hentry"],"yoast_head":"\nPearson Lab Publications | Scientific Research & Peer-Reviewed Studies<\/title>\n<meta name=\"description\" content=\"Browse publications from the Pearson Lab featuring research on repeat expansion diseases, genome instability, DNA repair, neurodegeneration, and therapeutic development.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/christopher-pearson\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" 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