{"id":7,"date":"2018-04-05T20:26:54","date_gmt":"2018-04-05T20:26:54","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/cfit\/?page_id=7"},"modified":"2024-09-30T18:47:24","modified_gmt":"2024-09-30T18:47:24","slug":"program-for-individualized-cystic-fibrosis-therapy","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/cfit\/","title":{"rendered":"Program for Individualized Cystic Fibrosis Therapy"},"content":{"rendered":"
<\/span><\/div>

Cystic Fibrosis Research at SickKids<\/h1>\n

Our focus is personalized medicine.<\/h2>\n

SickKids has partnered with Cystic Fibrosis Canada and the SickKids Foundation to develop the Program for Individualized CF Therapy (CFIT).<\/p>\n

The CFIT Program is developing tools and technologies for personal medicine in CF.<\/h3>\n

This includes model systems and platforms for in vitro testing of drug responses for people living with cystic fibrosis.<\/p>\n

Our program has two major goals:<\/h3>\n
    \n
  1. Develop laboratory based tools that will help predict who will respond to CFTR modulators -like ORKAMBI\u00ae. We are currently seeking to enroll participants with F508del\/F508del prior to starting a CFTR modulator<\/li>\n
  2. Help in therapy discovery efforts for individuals who have two copies of rare cystic fibrosis-causing mutations.<\/li>\n<\/ol>\n

    We are currently seeking to enroll the following:<\/h2>\n
      \n
    1. CF participants with the F508del-CFTR mutation who are soon to start CFTR modulator therapy (our Program can’t pay for the drug)<\/li>\n
    2. CF patients who have two identical copies of one of the following mutations for which a CF modulator is not available:<\/li>\n<\/ol>\n