{"id":18,"date":"2018-01-19T17:31:52","date_gmt":"2018-01-19T17:31:52","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/casca\/?page_id=18"},"modified":"2023-10-11T18:52:41","modified_gmt":"2023-10-11T18:52:41","slug":"publications","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/casca\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Publications using CASCA Platforms:<\/h2>\n

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Front Immunol<\/a>. 2023 May 19;14:1183273. doi: 10.3389\/fimmu.2023.1183273. eCollection 2023. The human Stat1 gain-of-function T385M mutation causes expansion of activated T-follicular helper\/T-helper 1-like CD4 T cells and sex-biased autoimmunity in specific pathogen-free mice<\/strong>.<\/a> Scott O, Visuvanathan S, Reddy E, Mahamed D, Gu B, Roifman CM, Cohn RD, Guidos CJ, Ivakine EA.\u00a0PMID: 37275873<\/span><\/span><\/p>\n

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Proc Natl Acad<\/a> Sc<\/a>i<\/a> U S A<\/a>. 2023 Jan 24;120(4):e2208176120. doi: 10.1073\/pnas.2208176120. Epub 2023 Jan 18. Distinct and opposite effects of leukemogenic Idh<\/em> and Tet2<\/em> mutations in hematopoietic stem and progenitor cells. <\/a><\/strong>\u00a0Fortin J, Chiang MF, Meydan C, Foox J, Ramachandran P, Leca J, Lemonnier F, Li WY, Gams MS, Sakamoto T, Chu M, Tobin C, Laugesen E, Robinson TM, You-Ten A, Butler DJ, Berger T, Minden MD, Levine RL, Guidos CJ, Melnick AM, Mason CE, Mak TW. PMID: 36652477<\/p>\n

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iScience<\/a>. 2022 Mar 26;25(4):104166. doi: 10.1016\/j.isci.2022.104166. eCollection 2022 Apr 15. Characterization of adipose depot-specific stromal cell populations by single-cell mass cytometry.<\/a> <\/strong>Lee JH, Ealey KN, Patel Y, Verma N, Thakkar N, Park SY, Kim JR, Sung HK. PMID: 35434565<\/p>\n

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Nat Immunol<\/a>. 2022 Aug;23(8):1273-1283. doi: 10.1038\/s41590-022-01262-7. Epub 2022 Jul 14. Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy<\/strong>. <\/a>\u00a0Boukhaled GM, Gadalla R, Elsaesser HJ, Abd-Rabbo D, Quevedo R, Yang SYC, Guo M, Wang BX, Noamani B, Gray D, Lau SCM, Taylor K, Aung K, Spreafico A, Hansen AR, Saibil SD, Hirano N, Guidos C, Pugh TJ, McGaha TL, Ohashi PS, Sacher AG, Butler MO, Brooks DG. PMID: 35835962<\/p>\n

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Immunity<\/a>.<\/strong> 2022 Dec 13;55(12):2369-2385.e10. doi: 10.1016\/j.immuni.2022.10.020. Epub 2022 Nov 11. <\/span>The transcription factor IRF2 drives interferon-mediated CD8+<\/sup> T cell exhaustion to restrict anti-tumor immunity.<\/a><\/strong>\u00a0<\/strong> Lukhele S, Rabbo DA, Guo M, Shen J, Elsaesser HJ, Quevedo R, Carew M, Gadalla R, Snell LM, Mahesh L, Ciudad MT, Snow BE, You-Ten A, Haight J, Wakeham A, Ohashi PS, Mak TW, Cui W, McGaha TL, Brooks DG. <\/span>PMID: 36370712<\/span><\/span><\/p>\n

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Nat Commun<\/a>. 2021 Feb 16;12(1):1054. doi: 10.1038\/s41467-021-21233-0. Biological and therapeutic implications of a unique subtype of NPM1 mutated AML. <\/a><\/strong>Mer AS, Heath EM, Madani Tonekaboni SA, Dogan-Artun N, Nair SK, Murison A, Garcia-Prat L, Shlush L, Hurren R, Voisin V, Bader GD, Nislow C, Rantalainen M, Lehmann S, Gower M, Guidos CJ, Lupien M, Dick JE, Minden MD, Schimmer AD, Haibe-Kains B. PMID: <\/span>33594052<\/span><\/p>\n

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Mol Cell<\/a>. 2021 Apr 1;81(7):1469-1483.e8. doi: 10.1016\/j.molcel.2021.01.038. Epub 2021 Feb 19. PMID: 33609448 DNA hypomethylating agents increase activation and cytolytic activity of CD8+<\/sup> T\u00a0cells. <\/a><\/strong>\u00a0Loo Yau H, Bell E, Ettayebi I, de Almeida FC, Boukhaled GM, Shen SY, Allard D, Morancho B, Marhon SA, Ishak CA, Gonzaga IM, da Silva Medina T, Singhania R, Chakravarthy A, Chen R, Mehdipour P, Pommey S, Klein C, Amarante-Mendes GP, Roulois D, Arribas J, Stagg J, Brooks DG, De Carvalho DD.<\/p>\n

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Immunity<\/a>. 2021 Mar 9;54(3):526-541.e7. doi: 10.1016\/j.immuni.2021.01.003. Epub 2021 Jan 29. Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection. <\/a><\/strong>\u00a0Xu W, Snell LM, Guo M, Boukhaled G, Macleod BL, Li M, Tullius MV, Guidos CJ, Tsao MS, Divangahi M, Horwitz MA, Liu J, Brooks DG. PMID: 33515487<\/p>\n

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J Exp Med<\/a>. 2020 Dec 7;217(12):e20191473. doi: 10.1084\/jem.20191473. A network of immune and microbial modifications underlies viral persistence in the gastrointestinal tract. <\/a><\/strong>Macleod BL, Elsaesser HJ, Snell LM, Dickson RJ, Guo M, Hezaveh K, Xu W, Kothari A, McGaha TL, Guidos CJ, Brooks DG. PMID: 32880629<\/p>\n

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Cancer Res<\/a>. 2020 Dec 15;80(24):5606-5618. doi: 10.1158\/0008-5472.CAN-20-0624. Epub 2020 Sep 16. Cancers from Novel Pole<\/em>-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade.<\/strong> <\/a>Galati MA, Hodel KP, Gams MS, Sudhaman S, Bridge T, Zahurancik WJ, Ungerleider NA, Park VS, Ercan AB, Joksimovic L, Siddiqui I, Siddaway R, Edwards M, de Borja R, Elshaer D, Chung J, Forster VJ, Nunes NM, Aronson M, Wang X, Ramdas J, Seeley A, Sarosiek T, Dunn GP, Byrd JN, Mordechai O, Durno C, Martin A, Shlien A, Bouffet E, Suo Z, Jackson JG, Hawkins CE, Guidos CJ, Pursell ZF, Tabori U. PMID: 32938641<\/p>\n

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Methods Mol Biol.<\/a> 2019;1989:47-54. doi: 10.1007\/978-1-4939-9454-0_4. Method for Tagging Antibodies with Metals for Mass Cytometry Experiments.<\/strong>\u00a0<\/a>Chang SG, Guidos CJ. PMID: 31077098<\/p>\n

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Front Oncol<\/a>. 2019 May 17;9:415. doi: 10.3389\/fonc.2019.00415. eCollection 2019. Validation of CyTOF Against Flow Cytometry for Immunological Studies and Monitoring of Human Cancer Clinical Trials. <\/a><\/strong>\u00a0Gadalla R, Noamani B, MacLeod BL, Dickson RJ, Guo M, Xu W, Lukhele S, Elsaesser HJ, Razak ARA, Hirano N, McGaha TL, Wang B, Butler M, Guidos CJ, Ohashi PS, Siu LL, Brooks DG. PMID: 31165047<\/p>\n

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Sci Immunol<\/a>. 2019 Dec 13;4(42):eaax8189. doi: 10.1126\/sciimmunol.aax8189. GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment<\/strong>.\u00a0<\/a> Halaby MJ, Hezaveh K, Lamorte S, Ciudad MT, Kloetgen A, MacLeod BL, Guo M, Chakravarthy A, Medina TDS, Ugel S, Tsirigos A, Bronte V, Munn DH, Pugh TJ, De Carvalho DD, Butler MO, Ohashi PS, Brooks DG, McGaha TL. PMID: 31836669<\/p>\n

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Cell Rep.<\/a> 2018 Oct 16;25(3):702-714.e6. doi: 10.1016\/j.celrep.2018.09.056. Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast. <\/a><\/strong>\u00a0An Y, Adams JR, Hollern DP, Zhao A, Chang SG, Gams MS, Chung PED, He X, Jangra R, Shah JS, Yang J, Beck LA, Raghuram N, Kozma KJ, Loch AJ, Wang W, Fan C, Done SJ, Zacksenhaus E, Guidos CJ, Perou CM, Egan SE. PMID: 30332649<\/p>\n

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Clin Cancer Res<\/a>. 2018 Nov 15;24(22):5685-5696. doi: 10.1158\/1078-0432.CCR-18-0554. Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma<\/strong>. <\/a>\u00a0Toker A, Nguyen LT, Stone SC, Yang SYC, Katz SR, Shaw PA, Clarke BA, Ghazarian D, Al-Habeeb A, Easson A, Leong WL, McCready DR, Reedijk M, Guidos CJ, Pugh TJ, Bernardini MQ, Ohashi PS. \u00a0Epub 2018 Jul 31. PMID: 30065096<\/p>\n

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Oncogene<\/a>. 2018 May;37(20):2630-2644. doi: 10.1038\/s41388-017-0122-y. Epub 2018 Feb 28. Functional screening of FGFR4-driven tumorigenesis identifies PI3K\/mTOR inhibition as a therapeutic strategy in rhabdomyosarcoma<\/strong>. <\/a>\u00a0McKinnon T, Venier R, Yohe M, Sindiri S, Gryder BE, Shern JF, Kabaroff L, Dickson B, Schleicher K, Chouinard-Pelletier G, Menezes S, Gupta A, Zhang X, Guha R, Ferrer M, Thomas CJ, Wei Y, Davani D, Guidos CJ, Khan J, Gladdy RA. PMID: 29487419<\/p>\n

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Immunity<\/a>. 2018 Oct 16;49(4):678-694.e5. doi: 10.1016\/j.immuni.2018.08.002. Epub 2018 Oct 9. CD8+<\/sup> T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity. <\/a><\/strong>Snell LM, MacLeod BL, Law JC, Osokine I, Elsaesser HJ, Hezaveh K, Dickson RJ, Gavin MA, Guidos CJ, McGaha TL, Brooks DG. PMID: 30314757<\/p>\n

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J Rheumatol<\/a>. 2016 Nov;43(11):2079-2082. doi: 10.3899\/jrheum.160425.<\/span> Gamma<\/b> Delta<\/b> T<\/b> Cell<\/b> Subset<\/b> V<\/b> Gamma<\/b> 2<\/b>+ Expansion<\/b> Associated<\/b> with Longterm<\/b> Infliximab<\/b> Treatment<\/b> in a Patient<\/b> with Ankylosing<\/b> Spondylitis<\/b>.<\/a> Gracey E, Qaiyum Z, Kuruvilla J, Inman RD. PMID: 27803350<\/span><\/span> <\/span><\/p>\n<\/div>

<\/div><\/div><\/div>
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